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PODCAST

This Week in Parasitism

Vincent Racaniello

TWiP is a monthly netcast about eukaryotic parasites. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct parasites, how they cause illness, and how you can prevent infections.

science life sciences

All Episodes

01:33:11

TWiP 107: Parasites leave a bad taste in my gut

This Week in Parasitism ·

2016/04/11

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiPtastic trio solves the case of the Surfer from Switzerland, and reveal how taste-chemosensory tuft cells in the gut regulate immune responses to parasites. Links for this episode: Taste-chemosensory cells and parasite gut immunity (Science) Image credit Letters read on TWiP 107 This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016 Case study for TWiP 107 Todays case is a fun case about a 45 year old

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02:00:33

TWiP 106: Trematode stormtroopers in snail wars

This Week in Parasitism ·

2016/03/26

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiP triumvirate solves the case of the Missionary in Kenya, and review the finding of a soldier caste in flatworms that parasitize snails. Links for this episode: Social organization in parasitic flatworms (J Parasitol) Image credit Letters read on TWiP 106 This episode is sponsored by ASM Agar Art Contest Case study for TWiP 106 This week's case comes from an ophthalmologist colleague Florian in Switzerland. Swiss female,

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01:53:23

TWiP 105: Survival of the fattest

This Week in Parasitism ·

2016/03/12

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiPanosomes solve the case of the Young Man from Anchorage, and discuss how cestode parasites increase the resistance of brine shrimp to arsenic toxicity. Links for this episode: Trichinella life cycle (pdf) When parasites are good for health (PLoS Path) The Origin of AIDS by Jacques Pepin Letters read on TWiP 105 Case study for TWiP 105 This week's case involves a 32 yo male with several concerns. Spent 6 weeks doing

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01:42:07

TWiP 104: La maladie du sommeil

This Week in Parasitism ·

2016/02/27

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Michael Libman Michael returns to help the TWiP trio solve the case of the Delusional African Expatriate, and discuss the association of natural and induced antibodies in mice with differential susceptibility to secondary cystic echinococcosis. Links for this episode: T. brucei life cycle (pdf) Natural and induced antibodies in echinococcosis (Immunobiol) The collaborative cross Letters read on TWiP 104 Case study for

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01:07:31

TWiP 103: Scroll down, please

This Week in Parasitism ·

2016/02/13

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Michael Libman The TWiP-scholars solve the case of the Housewife from Kolkata, discuss mutations in the IL17 gene associated with cerebral malaria, and hear a case presentation from guest Michael Libman. Links for this episode: IL-17 mutations and risk of cerebral malaria (Inf and Imm) Echinococcosis (CDC) Echinococcus life cycle (pdf) Letters read on TWiP 103 Case study for TWiP 103 This week's case concerns a 42 yo male,

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01:39:53

TWiP 102: Nursing eosinophils

This Week in Parasitism ·

2016/02/06

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiPyzoites solve the case of the Uncommon Parasite, and discuss the role of eosinophils in promoting the growth of Trichinella in skeletal muscle. Links for this episode: Eosinophils and IL-4 support nematode growth (PLoS Path) Balantidiasis (CDC) Letters read on TWiP 102 Case study for TWiP 102 This week's case involves a 24 yo housewife, from a village outside of Calcutta. Comes into a tertiary care hosp, 6 months coughing

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01:51:29

TWiP 101: Is it round or is it flat?

This Week in Parasitism ·

2016/01/23

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The doctors TWiP solve the case of the Woman with White Worms, and explain the role of a secreted growth factor from a carcinogenic parasite in wound healing and angiogenesis. Links for this episode: Wound healing growth factor from carcinogenic parasite (PLoS Path) Opisthorchis (CDC) Opisthorchis life cycle (CDC) Image credit Letters read on TWiP 101 Listener Pick Ramon - Ancient Rome was infested with parasites Case study for

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01:53:07

TWiP 100: Driving past a milestone

This Week in Parasitism ·

2016/01/09

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiP trifecta solves the case of the Woman from Bolivia with Belly Pain, and discuss a method for population modification of malaria mosquitoes using a Cas9-mediated driver gene. Links for this episode: Cas9-mediated drive for population modification of malaria mosquito (PNAS) FAQ: Gene drives (pdf) Image credit Letters read on TWiP 100 Case study for TWiP 100 This week's case is a 27 yo female, native NY, referred to outpatient

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01:39:55

TWiP 99: You get your polar bear from your nana

This Week in Parasitism ·

2015/12/05

The TWiP trifecta solves the case of the Professor Who Went to Brazil, and discuss an amazing case of a tapeworm that turned into a tumor in an AIDS patient. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Do young doctors need more sleep? (Slate) H. nana tumor in AIDS patient (NEJM) Hymenolepiasis (CDC) H. nana lifecycle (CDC/Wikipedia) Image credit Letters read on TWiP 99 Case study for TWiP 99 This week's case is a 53 yo woman visiting family in US,

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01:37:09

TWiP 98: Resistance is not futile

This Week in Parasitism ·

2015/10/31

The TWiP-lets reveal Balamuthia infection in the Children from Peru, and discuss resistance to pyrethroids revealed by RNA sequencing of Anopheles mosquitoes. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Balamuthia (CDC) Pyrethroid resistance in Anopheles (Parasit Vectors) Voltage-gated sodium channels Pyrethroid (Wikipedia) Image credit Letters read on TWiP 98 Case study for TWiP 98 This week's case is a Professor clinician, teacher, researcher. In

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01:26:57

TWiP 97: The seven year itch

This Week in Parasitism ·

2015/10/17

The paratenic hosts reveal a case of scabies in the Traveling Salesman, and discuss a role for natural antibody in protection from infection with Plasmodium. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Parasite Nobel Prizes 2015 Ivermectin story (Nat Rev Micro) Ivermectin target (Brain Res) Gut microbiota and Plasmodium protection (Cell) Natural antibody (virology blog) Image credit Letters read on TWiP 97 Case study for TWiP 97 Daniel has two cases

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01:43:07

TWiP 96: Salivary pharmacopeia

This Week in Parasitism ·

2015/10/03

The TWiPanosomes solve the case about the Young Woman who Went to Belize, and relate how sandfly saliva skews the immune response and increases risk of cutaneous leishmaniasis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Sandfly exposure and risk of cutaneous leishmaniasis (J Inf Dis) TWiP 14: Leishmania Image is L. longipalpis (credit) Letters read on TWiP 96 Case study for TWiP 96 Daniel's patient for this week is male patient referred for

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01:44:57

TWiP 95: Arsenic and Leishmania

This Week in Parasitism ·

2015/09/19

Vincent, Dickson, and Daniel solve the case about the 33 year old Chinese male with watery diarrhea, and discuss whether arsenic in drinking water might lead to treatment failures for Leishmania infections. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: TWiP 17: Entamoeba histolytica Arsenic exposure and Leishmania treatment outcomes (PLoS NTD) TWiP 14: Leishmania Letters read on TWiP 95 This episode is sponsored by ASMGAP. Case study for TWiP 95 Daniel's

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01:41:57

TWiP 94: Loa hanging fruit

This Week in Parasitism ·

2015/09/05

Vincent, Dickson, and Daniel solve the case about the man from El Salvador, discuss the use of tyrosine kinase inhibitors to treat onchocerciasis and filariasis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Targeting filarial tyrosine kinases (J Inf Dis) Onchocerciasis on TWiP 24 Filariasis on TWiP TWiP 25 Image shows c-abl kinase bound to imatinib (red) Image credit What good are ticks? Letters read on TWiP 94 Case study for TWiP 94 Daniel's patient

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01:29:23

TWiP 93: A fishy tale unfolds

This Week in Parasitism ·

2015/08/08

Vincent, Dickson, and Daniel solve their fishy tale, and present a new case study for your consumption. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Freezing and the quality of sushi (Clin Inf Dis) Anisakis biology (CDC) Image credit Letters read on TWiP 93 Case study for TWiP 92 April 2015 a 177 lb 5ft10in 39 yo man seen as outpatient in ID clinic, reports 2 y ago had issues with constipation on and off; throat hurts; feels closing when lies down

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01:40:23

TWiP 92: Kleptohaemodeipnonism

This Week in Parasitism ·

2015/07/04

Vincent, Dickson, and Daniel discuss how fluctuation in the price of guinea pig food could help transmission of the agent of Chagas disease, and present a new case study for your consumption. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Ascaris on TWiP 21 Ascaris lumbricoides life cycle (jpg) Child with distended abdomen due to Ascaris (jpg) Bottlenecks and Chagas disease (Proc Biol Soc) Letters read on TWiP 92 Case study for TWiP 92 A 20 yo Japanese

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01:29:23

TWiP 91: Born to deform

This Week in Parasitism ·

2015/06/20

Vincent, Dickson, and Daniel review how Viagra might be used to block transmission of Plasmodium falciparum, and introduce a new case study. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Malaria life cycle (jpg) cAMP regulates gametocyte infected erythrocyte deformability (PLoS Path) P. falciparum in bone marrow (Blood) Image credit Letters read on TWiP 91 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to

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02:01:27

TWiP 90: A carbuncle is a large furuncle

This Week in Parasitism ·

2015/05/30

Vincent, Dickson, and Daniel discuss identification of an erythrocyte protein essential for invasion of Plasmodium falciparum, and introduce a new case study. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Dermatobia hominis (Wikipedia) Plasmodium falciparum erythrocyte invasion (Science) Plasmodium life cycle (TWiP #10) Letters read on TWiP 90 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free)

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01:34:31

TWiP 89: Day TWiPers

This Week in Parasitism ·

2015/05/16

Vincent, Dickson, and Daniel reveal last week's case study and introduce a new one concerning a patient who traveled to Belize. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Neurocysticercosis (TWiP 6) Cysticercosis (CDC) Sarah Lane's neurocysticercosis Letters read on TWiP 89 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

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01:53:37

TWiP 88: French foreign lesion

This Week in Parasitism ·

2015/05/02

Vincent, Dickson, and Daniel discuss how a secreted protein from the protozoan parasite Theileria transforms its host cells via a cellular proto-oncogene. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Leishmania (TWiP #14) Transformation by a prolyl isomerase (Nature) Theileria.org Prolyl isomerase (Wikipedia) Image from Transformation & Oncogenesis Letters read on TWiP 88 Contact Send your questions and comments (email or mp3 file)

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