PODCAST

Life sciences knowledge center

Echo Han

science life sciences

All Episodes

00:11:13

Antibody mRNA

Life sciences knowledge center ·

2023/03/05

Antibodies are immunoglobulins produced by B lymphocytes during their differentiation into plasma cells that bind specifically to the corresponding antigen. Antibodies can be divided into five major classes (IgG, IgA, IgM, IgD, IgE), which have a protective effect on the organism. Antibody mRNAs don't require nuclear localisation to mediate protein translation, but can be translated directly into target proteins or immunogenic activation of the immune response in vivo by using genetic sequence of

en-us

00:11:13

Cytokine mRNA

Life sciences knowledge center ·

2023/03/05

Cytokines are low molecular weight soluble proteins produced by cells stimulated by immunogens, mitogens or other factors, including interleukins, interferons (IFN), lymphokines, colony-stimulating factors (CSF), chemokines, monoclonal factors and other factors. https://mrna.creative-biolabs.com/category-cytokine-mrna-455.htm

en-us

00:11:13

In vitro transcription vector

Life sciences knowledge center ·

2023/03/05

In vitro transcription (IVT) is an elegant way to obtain highly pure and uniform mRNA oligonucleotides of lengths ranging from about 15 to several thousand nucleotides.https://mrna.creative-biolabs.com/category-in-vitro-transcription-vector-452.htm

en-us

00:22:26

mRNA products

Life sciences knowledge center ·

2023/03/05

reagents for mRNA delivery, genome editing mRNA, reporter gene mRNA, growth factor mRNA, mRNA kits, enzymes for mRNA research, and nucleotide products for mRNA research https://mrna.creative-biolabs.com/category-mrna-products-443.htm

en-us

00:11:48

mRNA Chemical Synthesis

Life sciences knowledge center ·

2023/03/05

Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time.https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm

en-us

00:11:48

synthetic mRNA

Life sciences knowledge center ·

2023/03/05

Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time.https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm

en-us

00:10:54

iPS Cell Reprogramming by mRNA

Life sciences knowledge center ·

2023/03/05

Non-integrative mRNA reprogramming has proven to be the most efficient and clinically-relevant method for human induced pluripotent stem cells (iPSCs) reprogramming.https://mrna.creative-biolabs.com/custom-ips-cell-reprogramming-by-mrna.htm

en-us

00:11:48

IVT mRNA

Life sciences knowledge center ·

2023/03/05

IVT mRNA can be produced in large-scale amounts in GMP quality, allowing the clinical application of mRNA-based therapies. Due to its safety and high efficiency, IVT mRNA is an especially attractive gene expression system for applications in regenerative medicine, vaccination, cell engineering, and protein replacement therapy.https://mrna.creative-biolabs.com/custom-ivt-synthesis-of-mrna.htm

en-us

00:10:54

IVT Synthesis

Life sciences knowledge center ·

2023/03/05

With the development of IVT methods, synthetic mRNA has become an emerging class of gene therapy.https://mrna.creative-biolabs.com/custom-ivt-synthesis-of-mrna.htm

en-us

00:10:54

RNA-Protein Interactions Analysis

Life sciences knowledge center ·

2023/02/03

NA-protein interactions can have a profound effect on controlling the spatial and temporal localization of mRNA within a cell and non-coding RNA function. https://mrna.creative-biolabs.com/rna-protein-interactions-analysis.htm

en-us

00:10:54

LPR Technology

Life sciences knowledge center ·

2023/02/03

Currently, mRNA-based vaccines are being developed for treating various diseases including cancers. For this purpose, synthetic or in vitro transcribed (IVT) mRNA encoding tumor antigen offers several advantages over plasmid DNA encoding tumor antigen including better delivery and security. Liposomes/Polymer/mRNA ternary complexes termed lipoplyplexes (LPR) can be used to deliver mRNA encoding antigen in vivo. Studies reported the preparation of mannosylated mRNA nanoparticles (Man-LPR) loaded with

en-us

00:10:54

mRNA Technology Platforms

Life sciences knowledge center ·

2023/02/03

Researches show that this approach results in long-lasting clinical remission in cancer patients and protective immunity against infections. Here we make a brief introduction about two technologies widely used in mRNA research.https://mrna.creative-biolabs.com/technologies-platforms.htm

en-us

00:10:54

mRNA Technologies

Life sciences knowledge center ·

2023/02/03

Increasing evidence revealed that mRNA molecules play a significant role in the progression of some diseases, which provides a new sight to use mRNA as a drug for the treatment of genetic diseases.https://mrna.creative-biolabs.com/technology.htm

en-us

00:11:13

Tet-off Regulatory Promoter System

Life sciences knowledge center ·

2023/02/03

The recognition of the importance of mRNA turnover in regulating eukaryotic gene expression has facilitated the development of reliable and rigorous systems to measure changes in mRNA stability accurately in mammalian cells. Considering these concerns, Creative Biolabs provides the tetracycline-regulated (Tet-off) promoter system, which exploits a tetracycline-repressible promoter to explain better mechanisms of mRNA turnover in both tissue culture mammalian cells and

en-us

00:10:54

Tet-off Regulatory Promoter System

Life sciences knowledge center ·

2023/02/03

A more recently developed Tet-off regulatory promoter system offers an alternate strategy that further broadens the application of the pulsing transcriptional approach to study mRNA turnover in mammalian cells. https://mrna.creative-biolabs.com/tet-off-regulatory-promoter-system.htm

en-us

00:11:14

The Pros of mRNA Compared with Recombinant Protein...

Life sciences knowledge center ·

2023/02/03

Cell-free production Uniform physiochemistry of drug substances The same technology for all antibody formats Potential for storage at ambient temperature mRNA half-life confers improved pharmacokinetics Accessibility of intracellular targets Potentially improved tolerability due to patient-specific antibody modification Opportunity to reduce systemic exposure by in situ synthesis Potential of high antibody titers with low doses of drug

en-us

00:11:14

mRNA: A Novel Avenue to Antibody Therapy

Life sciences knowledge center ·

2023/02/03

An elegant solution to circumvent the problems of complex production, purification processes and aberrant post-translational modifications of the monoclonal antibody (mAb), is to deliver the genetic information of the antibody itself.https://mrna.creative-biolabs.com/therapeutic-antibody-coding-mrna.htm

en-us

00:11:13

Advantages of mRNA-Encoded Antibodies

Life sciences knowledge center ·

2023/02/03

mRNA-mediated antibody expression is applicable to oncology as well as infectious diseases and may provide advantages compared to recombinant biologics in certain instances such as short-lived antibody formats. https://mrna.creative-biolabs.com/therapeutic-antibody-coding-mrna.htm

en-us

00:10:54

Therapeutic Antibody-coding mRNA

Life sciences knowledge center ·

2023/02/03

Nowadays, different approaches to turning messenger RNA (mRNA) into a potent therapeutic have been developed. All of them share utilization of specifically designed, instead of endogenous sequences and thorough purification protocols.https://mrna.creative-biolabs.com/therapeutic-antibody-coding-mrna.htm

en-us

00:11:13

mRNA for Regenerative Medicine

Life sciences knowledge center ·

2022/12/23

A full range of services targeting mRNA-based regenerative medicine according to customer's detailed requirements. https://mrna.creative-biolabs.com/mrna-for-regenerative-medicine.htm

en-us

203 results

Life sciences knowledge center

All Episodes

Similar Podcasts

X Minus 1 - Old Time Radio Show

Inception Point Ai

Science, Spoken

WIRED

This Week in Space (Audio)

TWiT

DarshanTalks Podcast

Darshan Kulkarni

The Best of Coast to Coast AM

iHeartPodcasts and Coast to Coast AM