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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

11:21

Early Breakfast & the Heart: Global Lessons 🌍🥣🫀

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/04

🌍🥣 Early Breakfast & the Heart 🫀 (Early to Breakfast and Early to Bed Makes You Heart Healthy & Wise!) From the UK to Spain to the US, evidence keeps piling up: skipping or delaying breakfast is more than a lifestyle choice — it’s linked to multimorbidity, subclinical atherosclerosis, and higher cardiovascular & stroke mortality. 🧬 Genes shape when we eat, but habits matter most. 🥐 A hearty, early breakfast may be a simple marker of resilience and healthy aging.

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03:18

Fitness 🏋️, Formate ⚗️, Fireup T Cells 🔥, Fight...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/04

💪 Exercise does more than build strength — it reshapes the gut microbiome to fight cancer. A new Cell study shows that running increases microbiota-derived formate ⚗️, which supercharges CD8 T cell immunity 🛡️ and boosts the effectiveness of immune checkpoint inhibitors 🎯. 🔬 From treadmill mice to human microbiota analyses, the evidence points to formate as a potential biomarker for enhanced cancer therapy. 🏃‍♀️ Move your body, train your microbes, empower your immunity! #Exercise #Microbiome

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07:22

🔥 Inflammation, 🫀 Heart, 🧪 Healing: 2025 ACC...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/03

2025 ACC Scientific Statement on Inflammation & Cardiovascular Disease 🫀🔥. Key insights: ✅ hsCRP is as powerful as LDL in predicting risk. ✅ Low-dose colchicine 💊 now FDA-approved for secondary prevention. ✅ Lifestyle matters—Mediterranean diet 🥗, exercise 🏃, no smoking 🚭. ✅ Future therapies: IL-1 & IL-6 inhibitors, cardioimmunology 🧬. The science is clear—taming inflammation transforms heart health 💡💪. #Cardiology #Inflammation #Prevention #ACC2025

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05:19

Mitochondria, Mistakes, 🧬 InflammAgeing

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/03

🔬 Exciting new insights from Nature (2025)! When mitochondria run low on the right building blocks (deoxyribonucleotides), they mistakenly weave ribonucleotides into their DNA 🧬. The result? Fragile mitochondrial DNA gets expelled, setting off the cGAS–STING pathway and fueling inflammation 🔥—a key feature of ageing and senescence. 🧪 In MGME1-deficient mice, this process drives renal inflammation, while supplementation with deoxyribonucleosides 💊 can calm the storm. ✨ A major step in

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03:04

🎙️🫀 The Asymptomatic Aortic Stenosis Dilemma: Act...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/02

🔍 Two influential viewpoints just dropped in JAMA Cardiology on aortic valve replacement (AVR) in asymptomatic severe aortic stenosis (AS). 🫀 Lindman, Braunwald & Pellikka argue that the time has come to move from “watchful waiting” to early intervention (SAVR/TAVR), citing RCTs showing reduced stroke, heart failure hospitalization, and unplanned CV events. ⚖️ Hillis, McCann & Newby counter that the evidence is not yet strong enough for a universal shift—pointing to trial limitations,

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05:26

🧬 Cancer, 🕰️ Ageing, 🔄 Evolution

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/02

“The Evolution of Cancer and Ageing: A History of Constraint” (Nature Reviews Cancer). Fascinating perspective on how tumour suppression mechanisms that protect us early in life may ironically fuel age-related decline later on. ⚖️ From telomeres 🧬 to stem cells 🌱, and from mole rats 🐀 to tortoises 🐢, evolution has shaped a delicate trade-off between cancer resistance and ageing phenotypes. Interventions like rapamycin 💊 and caloric restriction 🥗 remind us that biology is a balancing act

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07:48

Global Heart Disease Burden 🌎, Shifting Trends 🔄,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/01

🌍 Cardiovascular disease (CVD) remains the leading global killer. 📊 In 2023, CVD caused 19.2M deaths and 437M DALYs (JACC). 🔮 By 2050, projections show 35.6M deaths and 1.14B cases (EJPC) — driven by ageing, hypertension, obesity, and dysglycemia. ⚠️ While age-standardized mortality is projected to fall 30%, the absolute burden will nearly double, with the steepest rise in South & East Asia. ✅ Urgent need for region-specific prevention, hypertension control, and equitable health systems to meet

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04:17

From Africa to India: Roots & Routes of Indian Genes...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/01

🌍 50,000 years of India’s evolutionary history 🇮🇳🧬 New genomic research sequencing 2,762 individuals across India reveals: ✨ A major migration out of Africa ~50,000 years ago 🦴 1–2% ancestry from Neanderthals & Denisovans 🔗 Strong founder effects & endogamy raising recessive disease risk 🧩 >160,000 novel variants unique to India, some linked to immunity & drug response These findings highlight why India’s genetic diversity must be central to global precision medicine 💊🔬 #Genomics #India

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09:05

💉 Lungs, Heart, and Hope: RSV Vaccines in Action

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/30

💉 RSV Vaccines: From NEJM to JAMA, Lungs to Heart! ❤️🫁 Evidence is converging—NEJM, DAN-RSV Trial 🇩🇰, CDC real-world study 🇺🇸, and a powerful JAMA editorial 📰—that bivalent RSV vaccines protect not just against severe respiratory illness but may also lower cardiorespiratory hospitalizations in older adults 👵👴. A new frontier where infection prevention meets cardiovascular health 🌍✨ Kudos to Dr. Tor Biering-Sørensen & Dr. Helen Chu for leading the way! 🙌 #RSV #Vaccines #NEJM #JAMA

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03:14

Dr RR Baliga's Philosophical Discourses: William of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/30

🔍 William of Ockham (c.1287–1347), the Franciscan friar & philosopher, gave us Occam’s Razor ✂️—the call to seek the simplest, most evidence-based explanations. His logic, nominalism & challenge to authority echo in today’s science, ethics & healthcare 🩺📜. A reminder for providers: clarity, parsimony & humility in reasoning can guide better care. 🌍✨ #Wisdom #Healthcare

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12:33

🎙️ Flu Trials Unmasked: Dose, Data & Difference

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/29

🦠💉 Five landmark studies shed new light on influenza vaccines! 🇪🇸 GALFLU (Spain, NEJM): High-dose vaccine cut influenza/pneumonia hospitalizations. 🇩🇰 DANFLU-2 (Denmark, NEJM & JAMA): Neutral primary outcome but signals for fewer CV & HF hospitalizations. 🇨🇳 PANDA II (China, Lancet): In-hospital vaccination lowered mortality & readmissions in acute HF. 📊 JAMA Editorial by Robert Califf: Calls for a true learning health system. ✨ Together, they show small gains per patient can yield huge

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03:38

Longevity 🔑 Genetics 🧬, Metabolism ⚡, and Microbiota 🌱

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/29

🌟 New insights into extreme longevity! 🌟 Our latest read on the multiomics blueprint of a 117-year-old supercentenarian reveals how genetics 🧬, metabolism ⚡, microbiome 🌱, and epigenetics 🕰️ can decouple aging from disease. 📊 Findings: Ultra-short telomeres but no cancer 📉 Protective genetic variants and robust mitochondria 💪 Efficient lipid metabolism (high HDL, low triglycerides) 💧 Low inflammation 🔥 Youth-like microbiome (rich in Bifidobacterium) 🦠 Epigenetic age decades

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07:39

Paclitaxel ⚖️ PAD 🚫 Promise or Peril?

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/28

🚨 New Evidence Alert 🚨 The SWEDEPAD 1 & 2 trials + a powerful Lancet commentary have reshaped how we view paclitaxel-coated devices in peripheral artery disease. 👉 No benefit for amputation or quality of life. 👉 A concerning signal for higher 5-year mortality in claudication. 👉 Registry-based RCTs prove invaluable for real-world insights. ⚖️ Message: Harm may outweigh benefit — time to rethink strategies and explore alternatives like sirolimus. #PAD #ClinicalTrials #Cardiology

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05:14

Huntingtons Disease: From Chorea to Cure 💃🧬💡

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/28

🚨 Breakthrough in Huntington’s Disease 🧬🧠✨ Exciting results from the pivotal Phase I/II AMT-130 gene therapy trial show a 75% slowing of disease progression at 36 months compared to controls. Key functional and cognitive endpoints (cUHDRS, TFC, SWRT, SDMT) also demonstrated significant benefit, alongside biomarker reduction in CSF neurofilament light chain 📊🔑. 💉 Delivered via precision stereotactic neurosurgery, AMT-130 was well-tolerated and shows clear evidence of a dose–response effect

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06:09

🧠💪 From Cravings to Composition: Expanding GLP-1...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/27

🚨 GLP-1 Medicines: Beyond Diabetes! 💉🧠💪 From weight loss to brain health, the future of GLP-1 therapies is unfolding fast! 🌍✨ New agents like retatrutide and MariTide are redefining outcomes in obesity, neurodegeneration, and substance use disorders. 🔬 Oral options, muscle-sparing combos, and triple agonists are here. 🧪 Dive into 15+ FAQs from the latest JAMA 2025 Perspective — formatted with emojis, clinical pearls, and clear takeaways. 📥 Message me if you’d like the .pptx version

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06:37

🫀⚖️ Balance After a Meal: The Autonomic Heart Story

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/26

💡 Fresh insights from a randomized crossover trial in people with Type 2 Diabetes (T2D)! 🍽️🚶‍♂️ High-fat 🥑 and high-carb 🍞 meals, with or without a light post-meal walk, showed no adverse effects on cardiac autonomic modulation or ECG intervals. ✅ Heart rate variability held steady, and walking even gave a gentle boost without risk. 🫀 Key Takeaway: Flexible dietary choices and safe postprandial walking may support everyday life in T2D without destabilizing the heart. #DiabetesCare

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03:28

💥 Force, Fibroblasts & 🫀 Failure

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/25

🚨 New Insights in Dilated Cardiomyopathy (DCM)! 🫀 Fibroblasts aren’t just bystanders — they’re mechanical rheostats shaping disease severity. 🧬 This groundbreaking study shows that blocking p38 signaling halts fibrosis, boosts contractility, and may redefine how we treat DCM. 💥 🧠 Think beyond myocytes. Think collective cell behavior. 🧪 Read the full paper in Science: “Preventing Hypocontractility-Induced Fibroblast Expansion Alleviates DCM” #Cardiology #HeartFailure #Fibrosis #ECM

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07:03

🧠 Dysreflexia Decoded & Pressure Rebooted: Circuits,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/25

🚨 New frontier in #NeuroRehab & #BioelectronicMedicine! Just explored two groundbreaking studies on autonomic dysreflexia and implantable neurostimulation in spinal cord injury (SCI) 🧠💥 ⚡ One reveals the neuronal circuitry driving dangerous BP spikes 🔌 The other shows how epidural stimulation at T11–L1 can restore BP within 2 minutes 💡 Together, they mark a paradigm shift—from managing symptoms to rewiring circuits. #SCI #SpinalCordInjury #Neuroscience #CardiovascularHealth

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04:58

🫀 Coronary Artery Bypass Blues: Does Lower LDL-C Save...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/24

🫀 NEWTON-CABG Trial: Can intensive LDL-C lowering prevent vein graft failure after CABG? 💉 Evolocumab slashed LDL-C by ~50%, but did not improve SVG patency at 2 years. Why? Timing is everything. 🧠 Early SVG failure = thrombosis & hyperplasia—not classic atherosclerosis. LDL-C ≠ magic bullet here. #Cardiology #CABG #LDL #PCSK9 #Evolocumab #CardioTrials #Lipids #HeartHealth #GraftPatency #ClinicalResearch #JACC #TheLancet #SurgeryMeetsPrevention

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07:11

From Rest to Reset: 🛌 The Motor Theory &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/24

🧠💤 Why do we sleep? A groundbreaking Neuron article explores this timeless question through a bold new lens: 🛌 The Motor Theory & Catecholamine Hypothesis of Sleep. Instead of a single “sleep center,” 🧬 sleep emerges from distributed motor control circuits regulating both somatic & autonomic activity. And the “why”? 😴 Suppressing dopamine, noradrenaline & adrenaline may be key to healing our brain, body, & immune system. 📉 Sleep isn’t passive—it’s active neural choreography for recovery

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