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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

05:12

Stroke Risk, Stent Benefit, Surgical Uncertainty 🧠✨🔧

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/22

New NEJM insights on asymptomatic carotid stenosis 🧠🔍 The CREST-2 trials offer a landmark update: intensive medical therapy remains the cornerstone, while carotid stenting shows selective benefit when performed by expert operators. Endarterectomy, however, provides no significant advantage over modern medical management. With stricter blood-pressure and LDL targets, plus expanding use of PCSK9 inhibitors, the future of stroke prevention is increasingly precision-driven, medically optimized,

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06:26

UPFs, Diets, Disease: The Global Drift 🍔➡️🌍➡️⚠️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/21

The new Lancet Series on ultra-processed foods offers a striking insight: as UPFs rise globally, traditional whole-food diets decline—bringing nutrient imbalance, overeating, toxic exposures, and hyper-palatable formulations that quietly reshape health trajectories. 🍔➡️⚠️ Across more than 100 prospective studies and multiple trials, higher UPF intake consistently links to obesity, type 2 diabetes, cardiovascular disease, kidney disease, depression, and higher all-cause mortality. 📉🩺 The

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04:50

Groceries, Guidance, Gains 🛒📞📉 — How DASH Delivery...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/20

Home-delivered DASH-patterned groceries paired with dietitian counseling meaningfully lowered blood pressure and LDL cholesterol among Black adults living in food deserts 🥗📉—as demonstrated in the GoFresh randomized trial (JAMA). An accompanying editorial highlights why future "food-as-medicine" programs must prioritize underconsumed, health-promoting foods and align with modern evidence favoring higher-fat DASH/Mediterranean patterns 🌱🫒. A powerful reminder: the right groceries can be

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04:57

Hemodialysis, Cardiovascular Burden, Therapeutic Hope...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/19

🩺 New insights in hemodialysis care. A major New England Journal of Medicine study reports that daily supplementation with long-chain omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) led to a 43% reduction in serious cardiovascular events among adults receiving maintenance hemodialysis. 🐟💙 In a population where traditional cardioprotective therapies often fall short, these findings open a fresh path for investigation — and perhaps, future practice. 📉🔬 A confirmatory trial

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07:03

💊 Oral, Potent, Proven — Enlicitide Redefines LDL...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/18

🚀 A milestone moment in lipid therapeutics! The new JAMA trial on the oral PCSK9 inhibitor Enlicitide reports a ~60% reduction in LDL-C, with parallel decreases in ApoB and Lp(a)—all on top of maximally tolerated statin therapy. For individuals with heterozygous familial hypercholesterolemia (HeFH)—where reaching LDL targets remains a persistent challenge—this represents a major advance. An oral agent matching the potency of injectable PCSK9 inhibitors could reshape adherence, access, and

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03:07

One Cup of Coffee. Less Atrial Fib/Flutter. More Life...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/17

☕ DECAF Trial insight! A new JAMA study shows that daily caffeinated coffee may lower recurrence of atrial fibrillation compared with abstinence. Patients drinking ~1 cup/day had 47% recurrence vs 64% with abstinence (HR 0.61, p=0.01) 📉💓 No major safety concerns—challenging long-held beliefs that coffee is proarrhythmic. 💡Takeaway: For many patients with AF, enjoying their morning brew may be both safe and possibly beneficial. #AtrialFibrillation #Cardiology #JAMA #ClinicalTrials #HeartHealth

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04:42

Beyond the Culprit: Complete Revascularisation •...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/16

🚨 New insights from The Lancet 🚨 A major individual-patient-data meta-analysis (6 RCTs, 8,836 patients) shows that complete revascularisation in acute myocardial infarction significantly reduces cardiovascular death, all-cause mortality, and recurrent MI. 💓📉 Benefits were consistent across age, sex, STEMI/NSTEMI, and lesion characteristics — strengthening the case for a more comprehensive approach beyond the culprit lesion alone. 🔬🩺 A powerful reminder: treating the whole heart saves

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02:31

Olezarsen Cuts Triglycerides. Calms Pancreas. Changes...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/15

🧬 New NEJM data on Olezarsen! In patients with severe hypertriglyceridemia, monthly RNA-targeted therapy delivered major triglyceride reductions (−62% to −72%) and a significant drop in acute pancreatitis risk (rate ratio 0.15). ✨ Improvements extended to ApoC-III, remnant cholesterol, and non-HDL cholesterol, with consistent benefits across both CORE-TIMI trials. 💡 A promising step forward in precision lipid therapy and pancreatitis prevention.

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03:16

MI Aftercare: The Beat Goes On—With or Without...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/14

📘 New Evidence from NEJM In a large meta-analysis of 17,801 patients with preserved LVEF after MI, beta-blockers did not reduce death, recurrent MI, or heart failure. Event rates were low, and outcomes were similar with or without therapy. 🫀📊 This clarifies practice for a growing post-MI population with LVEF ≥50%—precision matters more than tradition. 🎯 Full study: New England Journal of Medicine (2025). #Cardiology 💙 #ClinicalEvidence #MI #HeartHealth

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03:02

NOAC Monotherapy Wins in Afib with Drug Eluting...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/13

📢 ADAPT AF-DES Trial — A Safer Path Forward! In patients with atrial fibrillation beyond 1 year after drug-eluting stent implantation, NOAC monotherapy delivered striking benefits over combination therapy. ✅ Lower net adverse clinical events ✅ Marked reduction in major/CRNM bleeding ✅ Similar ischemic protection A beautifully simple strategy with meaningful impact. Published in NEJM (2025). 💊🛡️📉💓

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03:53

OCEAN Trial: Ablate Afib. Assess. Anticoagulate? 🌊

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/12

🌊 OCEAN Trial offers fresh insight into antithrombotic therapy after successful AF ablation. In 1284 patients followed for 3 years, event rates were remarkably low 🌟. Rivaroxaban did not show superiority over aspirin for preventing stroke, systemic embolism, or covert embolic events, while bleeding risk was higher with anticoagulation. 🧠 96% had no new infarcts on MRI at follow-up. Published in NEJM (2025) — a valuable contribution to nuanced AF post-ablation care.

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05:27

Dr RR Baliga's Philosophical Discourses: John Locke...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/11

🧠 John Locke: Experience • Liberty • Toleration Born a physician-philosopher, Locke championed empiricism — the idea that knowledge begins with experience, not dogma. His tabula rasa shaped modern psychology, while his Two Treatises of Government defined rights, consent, and freedom that echo through modern democracies. For clinicians, his legacy reminds us to: 🔹 Trust observation and evidence over authority 🔹 Respect patient autonomy and informed consent 🔹 Foster pluralism and toleration in

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04:52

Evolocumab in Primary Prevention." 🧬🛡️🎯 LDL: Down...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/10

🚀 VESALIUS-CV delivers powerful evidence: in high-risk patients without prior MI or stroke, evolocumab significantly reduced 3-point MACE by 25% and 4-point MACE by 19%, with LDL-C lowered to a median of 45 mg/dL. 💡 These results expand the horizon of prevention, showing that deep LDL reduction is both safe and effective in averting first cardiovascular events. 🫀 Strong science. Clear signal. A new chapter in preventive cardiology. #Cardiology #LDL #Prevention #VESALIUSCV

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04:48

Capillary Clues, Clinical Wins: Targeting Capillary...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/09

🫀 Septic Shock, Refined at the Fingertips ⏱️ A powerful new JAMA (2025) trial brings us one step closer to truly personalized resuscitation. The ANDROMEDA-SHOCK-2 study shows that targeting capillary refill time (CRT) — a simple bedside sign — can shorten time on organ support vs usual care, without increasing mortality. Key insight: Sometimes the most elegant solutions are low-tech, high-touch, and right at the bedside. 🧠 Precision 🤚 Physiology 💡 Pragmatism #Sepsis #CriticalCare

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04:38

SOFA-2 ICU Unveiled 🧠⚙️📊 3 Million Patients, 9...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/08

🚨 SOFA-2 arrives — a thoughtful evolution in critical care scoring 🧠🫁🫀 After nearly 30 years, the SOFA score has been modernized using data from >3.3 million ICU patients across 9 countries. The updated SOFA-2 incorporates contemporary respiratory and cardiovascular supports (HFNC, NIPPV, vasopressors, ECMO) and refines thresholds while preserving simplicity and bedside usability. A meaningful step forward in describing organ dysfunction — with room for future biologically grounded

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04:15

SOFA-2 Unveiled 🧠⚙️🌍-📊🩺🚨 — Critical Care Enters a New...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/07

SOFA-2 is here — a major advance in assessing organ dysfunction in critical illness 🧠🫁❤️ Three decades after the original SOFA score, this updated framework reflects modern ICU practice — integrating contemporary organ support (ventilation, vasopressors, RRT), delirium recognition, and global feasibility across resource settings 🌍📊 Validated in 3.3M+ ICU patients across 9 countries — a remarkable effort in global critical care science 🏥📈 A powerful step forward in our shared language of

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05:01

💔 Peripartum Cardiomyopathy: Detect Early • Treat...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/06

💔 Peripartum Cardiomyopathy: When a Mother's Heart Fights for Two Peripartum cardiomyopathy is a leading yet often missed cause of maternal morbidity and mortality—striking late in pregnancy or months postpartum. Early suspicion, timely echo, and guideline-directed therapy save lives. 🩺 🧠 Bromocriptine, careful anticoagulation, and multidisciplinary care are reshaping outcomes, but global disparities persist. 🌍 Let's amplify awareness, strengthen systems, and protect mothers everywhere

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05:00

Rethinking "default arterial lines" in the ICU 🧠🚑

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/06

Rethinking "default lines" in the ICU 🧠🚑 A landmark NEJM trial shows that in patients with shock, deferring arterial catheterization and using automated cuff monitoring was noninferior for 28-day mortality — and reduced catheter-related complications. A gentle reminder: not every sick patient needs a needle to be well cared for. Precision isn't only invasive — sometimes it's thoughtful, measured, humane. 🌿💡 #CriticalCare #ICU #NEJM #Shock #Hemodynamics #PatientSafety

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04:19

Light Pollution, Circadian Disruption, Cardiac...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/05

🌙 Bright Nights, Higher Heart Risk ❤️‍🩹 New findings in JAMA Network Open highlight that greater exposure to artificial light at night is associated with significantly increased risks of coronary artery disease, myocardial infarction, heart failure, atrial fibrillation, and stroke — independent of sleep duration, lifestyle factors, and genetics. 💡 Clinical takeaway: Protecting circadian rhythms is cardiovascular prevention. Darker nights = healthier hearts. 🛌 Simple steps: blackout

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04:23

Rethinking Immune Aging: It Starts Sooner Than We...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/05

The immune clock starts earlier than we think ⏳🧬 A landmark Nature study shows that immune aging begins quietly in midlife — decades before clinical frailty. Using >16M single-cell profiles and longitudinal vaccine responses, researchers found: • Stable, early transcriptional drift in naïve & memory T cells • A subtle TH2 shift that may weaken antiviral antibody quality • Reduced IgG class-switching to repeat flu antigens (e.g., B/Phuket) • No acceleration from CMV infection despite

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