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PODCAST

Sigma Nutrition Radio

Discussions about the science of nutrition, dietetics and health. The podcast that educates through nuanced conversations, exploring evidence and cultivating critical thinking. Hosted by Danny Lennon.

health & fitness nutrition

All Episodes

48:30

#582: GLP-1 Agonists: Side Effects, Management and...

Sigma Nutrition Radio ·

2025/10/28

GLP-1 receptor agonists have emerged as a groundbreaking tool in obesity treatment. In this episode, Dr. Spencer Nadolsky (an obesity specialist) explains how these medications are now yielding unprecedented weight loss outcomes in people with obesity. The discussion centers on GLP-1 agonist drugs like semaglutide and tirzepatide: how they work, how much weight loss they can produce, and why they represent a paradigm shift in obesity management. Importantly, the conversation addresses practical

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01:05:38

#581: What Is Successful Public Nutrition Policy? And...

Sigma Nutrition Radio ·

2025/10/21

Public nutrition policy plays a critical role in shaping population health through laws, guidelines, and programs that influence what people eat. In this episode, Emily Callahan, an expert in nutrition policy, talks about why public nutrition policies often fall short and what “success” looks like. They discuss how evidence-based nutrition interventions can stall due to political or practical barriers, and explore examples ranging from federal food assistance programs to sodium reduction

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01:02:45

#580: Sodium Bicarbonate for Sports Performance –...

Sigma Nutrition Radio ·

2025/10/14

Sodium bicarbonate is one of the most consistently supported ergogenic aids in sports nutrition research, yet its underlying mechanisms and real-world applications remain widely misunderstood. More recent developments have focused on how to optimise both the timing and formulation of supplementation. The “individualised ingestion timing” approach has emerged as a practical strategy, recognising that the time-to-peak blood bicarbonate concentration varies considerably between individuals. Similarly,

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59:28

#579: Is Your Chronotype Hard-Wired or Modifiable?...

Sigma Nutrition Radio ·

2025/10/07

In this episode, we explore the concept of chronotype, which reflects an individual’s biological circadian timing and how it manifests in preferred sleep–wake patterns. Understanding chronotype is important because it differs from simple diurnal preference, which may be shaped by lifestyle or psychological factors rather than biology. We examine how chronotype is measured, from gold-standard laboratory methods to validated questionnaires used in field studies. The discussion also highlights the

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52:30

#578: Creatine For Brain Health: Overhyped Trend or...

Sigma Nutrition Radio ·

2025/09/30

Creatine is best known as a sports supplement for enhancing muscle strength and high-intensity performance. But could it also improve brain health and cognitive function? Or are such claims overhyped? If creatine can support brain health, it could have implications for aging, neurodegenerative diseases, concussion recovery, and mental fatigue. In this podcast episode, Professor Eric Rawson discusses what current science says about creatine’s effects on the brain, including memory, executive

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14:09

Is There a Limit to Energy Expenditure? And What...

Sigma Nutrition Radio ·

2025/09/23

Energy expenditure is one of the most fundamental yet often misunderstood aspects of human physiology. A central question is whether there is a ceiling to how many calories we can burn, and what happens when activity levels approach that limit. Grasping these dynamics is essential for health professionals and researchers, as energy balance directly influences body weight regulation, metabolic health, and athletic performance. Emerging research shows that our bodies regulate calorie burn not in a

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49:38

#577: Ultra-processed vs. Minimally Processed Diets:...

Sigma Nutrition Radio ·

2025/09/16

Recently a new trial was published in Nature Medicine comparing the effect of ultra-processed versus minimally processed diets. Specifically, the UPDATE trial compared these two diets in the context of a healthy dietary pattern (in line with the UK’s EatWell Guide). This eight-week randomized, crossover trial generated a lot of discussion and was largely seen as being a really useful addition to the evidence base, and providing answers to some previously unexamined questions. In this episode the

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53:52

#576: The Social Psychology of Health Beliefs and...

Sigma Nutrition Radio ·

2025/09/09

In this episode, Dr. Matthew Facciani explores how social psychology influences health beliefs and the spread of misinformation. The conversation delves into why people adopt certain nutrition or health beliefs so strongly, how identity and group membership shape our interpretation of evidence, and what makes us susceptible to false or misleading health claims. Dr. Facciani’s interdisciplinary background (spanning neuroscience, psychology, and sociology) allows him to offer a unique

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46:12

#575: How Does Dairy Impact Cardiometabolic Health? –...

Sigma Nutrition Radio ·

2025/09/02

Dairy is often treated as a single food group, yet milk, yogurt, cheese, and butter can have very different effects on health. Some evidence links yogurt to favourable outcomes, while butter is known to raise LDL cholesterol. And then there’s the paradox of cheese: high in saturated fat, but not consistently associated with higher heart disease risk. These complexities raise the question of whether the “dairy matrix” (the combination of nutrients and food structure) explains why not all dairy acts

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50:53

#574: Microplastics & Health: What Do We Know? –...

Sigma Nutrition Radio ·

2025/08/26

They’re in our oceans, our air, our food, and now even in our bodies. Microplastics, once a distant environmental issue, have become a topic of urgent relevance in medicine, public health, and nutrition. The idea that tiny plastic particles are circulating through the food chain and accumulating in human tissues has sparked headlines, speculation, and concern. But how much of this fear is grounded in solid science? And how much is still unknown? As the research into microplastics rapidly grows, so

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55:03

#573: A Philosophy of Elite Performance Nutrition –...

Sigma Nutrition Radio ·

2025/08/12

In this episode, performance nutritionist Daniel Davey discusses how his approach to elite sports nutrition has evolved over his career. Davey reflects on his decade working with top Irish teams (Dublin GAA/football and Leinster Rugby) and how stepping away from those environments led him to rethink the role of a nutrition practitioner. The central theme is a shift from a traditional prescriptive model, where the expert provides meal plans and quick solutions, to a philosophy centered on athlete

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01:09:40

#572: Can You Trust Industry-Funded Nutrition...

Sigma Nutrition Radio ·

2025/08/05

Nutrition science plays a pivotal role in shaping public health advice, but the influence of industry funding on research has become a pressing concern. In this episode we want to examine whether we can trust nutrition studies funded by food and beverage companies, and how you can discern study credibility. The discussion is highly relevant in today’s landscape, where conflicts of interest and bias in research are under scrutiny amidst debates on sugar, processed foods, and diet recommendations. By

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38:27

#571: Is Zone 2 Training Actually Best for Health? –...

Sigma Nutrition Radio ·

2025/07/29

In recent years “Zone 2 training” has gained immense popularity in fitness and health circles, often being proclaimed the “best” cardiovascular training for metabolic health. Zone 2 training is sustained, low-intensity exercise below the lactate threshold that is commonly employed by many elite level endurance athletes, with a variety of proposed performance benefits. This led to interest from health-conscious folks about its ability to improve markers like VO2 max and mitochondrial function,

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56:52

#570: Fructose: Metabolism, Claims & Context for Risk...

Sigma Nutrition Radio ·

2025/07/22

Fructose has often been labeled a uniquely damaging nutrient, blamed for obesity, diabetes, and other metabolic diseases. But does fructose truly have unique harmful effects or are the risks associated with it related to context and quantity? The episode explores how fructose is metabolized in the body, why it gained a reputation for being problematic, and what the scientific evidence says about fructose in our diets. You will gain insight into why fructose was singled out in the past (e.g., its

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08:52

SNP42: Is Vitamin A Good or Bad for Bone Health?

Sigma Nutrition Radio ·

2025/07/15

Vitamin A is often one of the less-discussed micronutrients in relation to bone health, taking a back seat to nutrients like calcium and vitamin D. Yet this fat-soluble vitamin plays a fundamental role in skeletal development, remodeling, and mineral homeostasis. It influences gene expression in both osteoblasts and osteoclasts, and contributes to the regulation of bone turnover throughout the lifespan. But what makes vitamin A particularly interesting, and controversial, is that its effects on bone

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01:16:29

#569: The History of Fat, Cholesterol & Heart Disease

Sigma Nutrition Radio ·

2025/07/08

The idea that saturated fat might be harmful to our health has sparked controversy for decades. In recent years, counter-narratives have surged: suggesting that concerns over saturated fat were overblown, that LDL cholesterol doesn’t matter, or that the original diet-heart hypothesis has been debunked. These claims have become especially popular in online wellness spaces and certain dietary communities, often wrapped in compelling but misleading rhetoric. So what does the best available evidence

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45:01

#568: Does the Maternal Diet Impact Risk of ADHD &...

Sigma Nutrition Radio ·

2025/07/01

To what extent can maternal nutrition during pregnancy influence a child’s later cognitive or behavioural development? While genetic and environmental factors are known to contribute to neurodevelopmental outcomes such as ADHD and autism, growing attention is being paid to the potential role of prenatal exposures, including dietary patterns. Yet, evidence in this area remains limited, and causality is difficult to establish. One recent study aimed to explore this question by analysing how maternal

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01:09:29

#567: Did Big Sugar Hijack the Food Pyramid? Were...

Sigma Nutrition Radio ·

2025/06/24

For decades, dietary guidelines—and the Food Pyramid in particular—have been at the center of heated debates and considerable controversy. These guidelines have often been accused of being influenced by industry interests, oversimplifying nutritional nuance, or even directly contributing to rising obesity and metabolic disease rates. In this episode, we critically assess common claims surrounding the Food Pyramid, including whether it was truly shaped by vested industry interests, if it encouraged

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16:19

SNP41: Do Certain Foods Really Cause Inflammation –...

Sigma Nutrition Radio ·

2025/06/17

Inflammation has become a nutrition buzzword, often used in extreme or misleading ways. This episode aims to clarify what inflammation is, how it relates to diet and health, and whether specific foods truly provoke inflammatory responses in the body. The episode provides a nuanced, evidence-based look at inflammation and diet. It explains the difference between acute and chronic inflammation, outlines the role of chronic low-grade inflammation in disease, and emphasizes that overall dietary patterns

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51:13

#566: Can We Maintain Weight Loss? Pharmacology and...

Sigma Nutrition Radio ·

2025/06/10

GLP-1 receptor agonists have changed the landscape of obesity treatment, offering levels of weight loss once thought unattainable without surgery. But what happens after the weight is lost? And can we really talk about success without talking about maintenance? While much of the public discourse fixates on dramatic weight loss numbers, the harder question is what comes next. Can lifestyle interventions alone sustain weight loss after GLP-1 cessation? How do metabolic adaptations and behavioral

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