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PODCAST

Sigma Nutrition Radio

Discussions about the science of nutrition, dietetics and health. The podcast that educates through nuanced conversations, exploring evidence and cultivating critical thinking. Hosted by Danny Lennon.

health & fitness nutrition

All Episodes

42:57

#504: Vegetable Oil vs. Saturated Fat – Analysis of...

Sigma Nutrition Radio ·

2023/12/05

Links: Go to episode page (with study links) Receive Sigma's email newsletter Subscribe to PREMIUM - get study notes to this episode About This Episode: In 1959 a landmark clinical trial, often referred to as the LA Veterans Study, began with the aim to investigate the effects of replacing dietary saturated fats with polyunsaturated fats, on the progression of atherosclerosis and cardiovascular outcomes. This was an eight-year clinical trial in 846 domiciled male veterans in the US. The diets

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43:04

#503: Lyon Diet Heart Study – Canola Oil,...

Sigma Nutrition Radio ·

2023/11/28

Links: Go to episode page (with resources) Subscribe to Premium Learn more about Sigma Nutrition About This Episode: The Lyon Diet Heart Study (LDHS) is often cited as one of the pivotal studies that helped establish the Mediterranean diet as a recognized and recommended dietary pattern for cardiovascular health. A clinical trial conducted in Lyon, France, the LDHS showed significant reduction in cardiac death could be achieved in secondary prevention patients using a dietary intervention

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40:52

#502: Sydney Diet-Heart Study – Is Linoleic Acid...

Sigma Nutrition Radio ·

2023/11/21

Links: Go to episode page (with study links) Subscribe to Premium Past episodes referenced: Episodes 493, 481 & 317 Further reading: How Diet Influences Heart Disease Risk About This Episode: The Sydney Diet-Heart Study was a clinical trial conducted in the 1960s and 1970s that aimed to examine the hypothesis that reducing saturated fat intake in the diet would lead to a reduced risk of heart disease. However, it really only gained attention after a more recent re-analysis by Ramsden et al., which

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10:38

Addressing Some Criticisms of Nutritional...

Sigma Nutrition Radio ·

2023/11/14

Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium. About This Episode Nutritional epidemiology has faced strong criticism over time. While some of the methodological limitations are fair, often there are criticisms that are misguided and inaccurate. In this episode, Danny touches on a few examples of the misunderstandings of the field and how such claims can be addressed in a more accurate manner. Links:

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01:13:29

#501: Sex-based Training Recommendations:...

Sigma Nutrition Radio ·

2023/11/07

Links: Go to episode page (with study links) Subscribe to PREMIUM Receive emails from Sigma Nutrition Sigma's Recommended Resources About This Episode: The field of research exploring sex differences in exercise response has yielded intriguing findings, shedding light on the complex interplay between biology, physiology, and training adaptations. One of the fundamental areas of investigation pertains to sex disparities in strength, power, and hypertrophy. Historically, it’s been well-established

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01:19:26

#500 – The Big Unanswered Questions in Nutrition Science

Sigma Nutrition Radio ·

2023/10/31

Links: Subscribe to PREMIUM to get study notes to this episode Go to episode page to see background detail & links See our recommended resources for further learning Previous episodes referenced: SNP17: Is Personalized Nutrition Superior to General Nutrition Advice? 414: Will Machine Learning Overtake Traditional Nutrition Research Methods? 469: Chrononutrition – New Findings & Updated Views About This Episode: To mark the 500th episode of the podcast, Danny and Alan take a look at some of the

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01:02:05

#499: How Sensory Cues Impact Food Choice & Behavior...

Sigma Nutrition Radio ·

2023/10/24

Links: Subscribe to PREMIUM Go to episode page (with further reading links) Receive our weekly emails About This Episode: Sensory cues, comprising taste, smell, texture, and appearance, serve as the initial drivers that influence our food preferences and liking for particular items. These sensory cues can be both inherent, such as the natural sweetness of fruit, and learned, as in the association between a particular aroma and a favorite dish. One crucial aspect of this research is delving into

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17:36

The PREDIMED Trial – Controversy, Criticisms, &...

Sigma Nutrition Radio ·

2023/10/17

Links: Subscribe to PREMIUM Go to episode page Learn more about the podcast Sigma's recommended resources About This Episode: PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain. The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events. But the study did face criticisms and controversies over methodological issues,

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35:39

#498: The PROPEL Trial & Weight Loss Interventions in...

Sigma Nutrition Radio ·

2023/10/10

Links: Subscribe to PREMIUM Go to episode page (with linked studies) Receive the weekly Sigma email newsletter Recommended resources About this Episode: The PROPEL (Promoting Successful Weight Loss in Primary Care in Louisiana) trial was a cluster-randomized weight loss trial, specifically tailored to address the pressing health concerns of an underserved population in Louisiana, where obesity rates have reached alarming levels. The core of the intervention comprises a pragmatic, high-intensity

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01:08:14

#497: Are Food Frequency Questionnaires Reliable?

Sigma Nutrition Radio ·

2023/10/03

Links: Go to episode page Subscribe to PREMIUM Recommended resources Receive Sigma's free email newsletter Learn more about the podcast About This Episode: Food frequency questionnaires (FFQs) have been widely employed in nutrition research to assess dietary intake patterns among study participants. However, debates surrounding the reliability of FFQs have persisted both inside and outside the academic community. These debates primarily revolve around issues related to measurement error, recall

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17:48

SNP21: Sick Individuals and Sick Populations

Sigma Nutrition Radio ·

2023/09/26

Links: Subscribe to Premium Sigma recommended resources Learn more about the podcast About this episode: In 1985 a paper titled “Sick Individuals and Sick Populations” was published in the International Journal of Epidemiology. The paper, authored by eminent epidemiologist Geoffrey Rose, can be considered as seminal and important because it brilliantly raised the concept of the “prevention paradox” and challenged traditional approaches to public health and preventive medicine. The paper’s insights

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01:01:14

#496: ATBC Cancer Prevention Study – Crucial Lessons

Sigma Nutrition Radio ·

2023/09/19

Links: Go to episode page Subscribe to PREMIUM Get our free weekly emails Learn more about Sigma Nutrition Radio About This Episode: The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) stands as a seminal and pioneering research endeavor within the domain of epidemiology and cancer prevention. Conducted in Finland, the study aimed to examine the potential protective effects of alpha-tocopherol (vitamin E) and beta-carotene supplementation against the occurrence of various cancer

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35:27

#495: Circadian Clocks in Muscle & Exercise as a Time...

Sigma Nutrition Radio ·

2023/09/12

Links: Episode page with extra resources Subscribe to PREMIUM Receive our free weekly emails Learn more about Sigma Nutrition Radio About this Episode: The field of circadian biology has long been associated with regulating diurnal physiological processes, notably the sleep-wake cycle. However, recent advances have unveiled a broader role for circadian clocks across various tissues, including skeletal muscle. Within this context, the investigation of circadian clocks within the skeletal muscle

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54:33

#494: Multiple Risk Factor Intervention Trial

Sigma Nutrition Radio ·

2023/09/05

Links: Go to episode page (with study links & resources) Subscribe to PREMIUM Receive our weekly newsletter More episodes on cholesterol & heart disease About This Episode: The Multiple Risk Factor Intervention Trial (MRFIT) was a groundbreaking clinical trial conducted in the 1970s and 1980s. Its main objective was to investigate the relationship between various risk factors and the incidence of heart disease. The study aimed to determine whether modifying risk factors, such as high blood

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58:50

#493: The Keys Equation – How Dietary Fats Impact...

Sigma Nutrition Radio ·

2023/08/29

Links: Go to episode page (with resources for this episode) Subscribe to PREMIUM Join the Sigma email newsletter Learn more about Sigma Nutrition Radio About this Episode: One of the most important and influential papers in nutrition science is one by Ancel Keys and his colleagues that was published in The Lancet in 1957. This seminal paper examined the relationship between dietary fat intake and serum cholesterol levels. The researchers investigated how different types of fats in the diet

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13:24

SNP20: The Cumulative Exposure Model of LDL-C & Heart...

Sigma Nutrition Radio ·

2023/08/22

This is a Premium-exclusive episode, so here you'll only hear a preview. In order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium. About This Episode: It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans. One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure

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01:06:19

#492: How Does Weight Cycling Impact Long-term Health?

Sigma Nutrition Radio ·

2023/08/15

Links: Resources and info for this episode Subscribe to PREMIUM Receive Danny's weekly email newsletter About This Episode: Losing at least 5% of one’s initial body weight is associated with improvements in glycaemic control, blood pressure, triglyceride levels, and other positive outcomes. Due to these reasons, it is typically recommended that individuals classified as overweight or obese should engage in effective weight loss interventions. However, despite the potential for clinically

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01:02:53

#491: Do High Protein Intakes Cause Insulin Resistance?

Sigma Nutrition Radio ·

2023/08/08

Links: Episode Resources Subscribe to PREMIUM Receive our weekly newsletter About This Episode: There has been interest in, and debate about, how protein intake impacts metabolic health, particularly in relation to insulin resistance and type 2 diabetes risk. Recently, there has been interest in higher protein intakes as an intervention in diabetes, owing to a variety of potential mechanisms. For example, the satiety value of protein, the promotion of insulin secretion by protein, and imapcts on

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58:00

#490: How Does Exercise Impact Beta-cell Function in...

Sigma Nutrition Radio ·

2023/08/01

Links: Go to episode page Subscribe to PREMIUM Receive our free weekly emails About This Episode: The management of type 2 diabetes has long been a challenge, but a new study conducted by researcher Mark Lyngbaek and his colleagues has the potential to add important considerations to the approach to treatment. Titled the “DOSE-EX” randomized clinical trial, their study uncovers the impact of exercise and weight loss on beta-cell function, a key factor in diabetes progression. DOSE-EX is a

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31:39

What is a Causal Risk Factor? (AMA with Alan)

Sigma Nutrition Radio ·

2023/07/25

Links: Subscribe to PREMIUM Episode page Receive Sigma emails About this Episode: We've just released a lengthy 'ask me anything' episode, where Dr. Alan Flanagan addressed specific listener questions, over on the Sigma Nutition Premium feed. In this episode, you'll hear one detailed answer from that AMA, in which Alan discusses the concept of "causal risk factors". This is a term that is regularly mentioned on the podcast, and has a very specific and important meaning. This episode will give you

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