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PODCAST

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and

science life sciences

All Episodes

19:11

107: From 1 Billion to 100: How AI is Cracking the...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/19

Send us a textEver wondered how scientists find the perfect enzyme among billions of possibilities? In this fascinating episode of the Smart Biotech Scientist podcast, host David Brühlmann sits down with David Schönauer, CEO of Aminoverse, who's revolutionizing enzyme engineering through artificial intelligence.As a biotech entrepreneur who transformed his academic passion into a groundbreaking startup, Schönauer shares how his company is solving one of biotechnology's biggest challenges: eff...

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19:51

106: From Proteins to Cell Therapy: Why ATMPs Aren't...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/14

Send us a textIn this insightful episode, Technical Development Leader at Flagship Pioneering Oliver Kraemer reveals why developing Advanced Therapy Medicinal Products (ATMPs) require a fundamental shift in thinking from traditional biologics development.Drawing from his extensive experience across Boehringer Ingelheim, Sanofi, and BMS, Kraemer challenges conventional wisdom about process development timing and demonstrates why early integration of process considerations is crucial for ATMP s...

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21:52

105: From Proteins to Cell Therapy: Why ATMPs Aren't...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/12

Send us a textIn this eye-opening episode, we explore the intricate landscape of Advanced Therapy Medicinal Products (ATMPs) with Oliver Kraemer, a technical development leader at Flagship Pioneering.Drawing from his extensive experience at industry giants like BMS, Sanofi, and Boehringer Ingelheim, Oliver challenges conventional wisdom about automation in cell and gene therapy while illuminating the crucial differences between biologics and ATMPs.Key Takeaways for Biotech Scientists:Discover...

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17:17

104: One-Stop Shop vs. Specialist CDMO: A Scientist's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/07

Send us a textWant to peek behind the curtain of a leading Contract Development and Manufacturing Organization (CDMO)? In this inspiring episode, KBI Biopharma's Chief Scientific Officer Sigma Mostafa reveals the intricate world of bioprocess development and manufacturing.Sigma shares game-changing insights into accelerating biologics development without compromising quality. She also unveils how KBI is leveraging AI and machine learning to revolutionize everything from protein sequence analy...

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24:01

103: One-Stop Shop vs. Specialist CDMO: A Scientist's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/05

Send us a textIn this insightful episode, we're joined by Sigma Mostafa, Chief Scientific Officer at KBI Biopharma, who shares crucial insights on selecting the right CDMO partner for biotech development.Sigma brings a unique blend of scientific rigor and practical experience to the discussion, having worked on both sides of the CDMO relationship.Key Takeaways:Why harvest steps deserve more attention in bioprocess developmentThe truth about one-stop-shop CDMOs versus specialized partnersCriti...

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15:17

102: PAT Revolution: Decoding Your Bioprocess Like...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/31

Send us a textStruggling to unravel the complexities of your bioprocess? Prepare for a paradigm shift as we dive into the world of Process Analytical Technology (PAT) with Katharina Dahlmann who is Application and PAT Expert at Hamilton.This eye-opening episode dissects how PAT is redefining biologics manufacturing, balancing its immense potential against real-world implementation hurdles. Katharina navigates us through the intricate journey of scaling up, from micro-bioreactors to large-scal...

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23:12

101: PAT Revolution: Decoding Your Bioprocess Like...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/29

Send us a textUnlock the hidden potential of your bioprocess! In this eye-opening episode, David Brühlmann sits down with Katharina Dahlmann, Application and PAT Expert at Hamilton, to explore the game-changing world of Process Analytical Technology (PAT).Discover how PAT is revolutionizing biotech by providing unprecedented insights into cell behavior and process dynamics. Katharina challenges conventional wisdom, revealing that what we think we know about our processes may just be the tip o...

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18:01

100: From Raw Data to Actionable Insights: Unlocking...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/24

Send us a textImagine predicting your bioprocess outcomes as easily as checking the weather forecast. Sound impossible? Not anymore. In this insightful episode, we dive deep into the world of digital twins and process models with Fabian Feidl, co-founder and CTO of DataHow.Discover how these cutting-edge tools are reshaping the biotech landscape, from simplifying complex processes to enabling personalized medicine. Fabian shares invaluable insights on implementing data-driven approaches, even...

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22:00

99: From Raw Data to Actionable Insights: Unlocking...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/22

Send us a textAre you ready to decode the future of bioprocessing? In this eye-opening episode, we dive deep into the world of digital bioprocess development with Fabian Feidl, co-founder and CTO of DataHow.Discover how cutting-edge process models are transforming the biotech industry, bridging the gap between raw data and actionable insights.Key takeaways:Learn how process models can streamline development, reduce costs, and accelerate time-to-market for groundbreaking therapies.Explore the ...

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17:59

98: The Biomanufacturing Revolution: Bringing...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/17

Send us a textAre you ready to dive into the cutting-edge world of biomanufacturing? In this episode, strategic consultant James Ryall unveils the staggering potential of bio-based products to revolutionize industries. From cultured meat to human breast milk, discover how cells are becoming the ultimate manufacturing facilities.James shares invaluable insights on scaling challenges, regulatory hurdles, and the critical importance of early preparation for biotech startups. Learn why biomanufac...

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24:24

97: The Biomanufacturing Revolution: Bringing...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/15

Send us a textIn this captivating episode, host David Brühlmann welcomes James Ryall, a strategic consultant with over two decades of experience in cell biology and regenerative medicine. From his groundbreaking work in skeletal muscle research to revolutionizing cultured meat production, James shares his fascinating journey through academia and industry.Discover how he's now helping biotech startups align their technical strategies with commercial outcomes, accelerating their path to market....

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19:53

96: AI in Bioprocess Development: The Game-Changer...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/10

Send us a textAre you ready to revolutionize your bioprocess development? Join David Brühlmann as he interviews Belma Alispahic, Chief Scientific Officer and Co-Founder of AnalysisMode, who unveils the game-changing potential of AI in biopharma.Discover how AI is transforming the industry, from drug discovery to manufacturing, and learn why it's no longer optional but essential for success.Key takeaways:Leverage AI to streamline experiments, reduce costs, and accelerate your path to marketGai...

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20:37

95: AI in Bioprocess Development: The Game-Changer...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/08

Send us a textIs AI the secret weapon biotech scientists have been waiting for? In this eye-opening episode, we dive deep into the world of AI-driven bioprocess development with Belma Alispahic, Chief Scientific Officer and Co-Founder of AnalysisMode. Discover how AI is transforming the biotech landscape, from reducing downtime by 50% to unlocking unprecedented levels of precision in process optimization.Key takeaways:Learn how AI can slash experiment time by up to 80%, saving you valuable re...

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19:31

94: From Lab Coat to LinkedIn: Benjamin McLeod's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/03

Send us a textIn this electrifying episode, we dive deep into the future of biotech with biotech influencer Benjamin McLeod. From quantum AI mapping cellular interactions to the game-changing potential of process analytical technology, Ben, who is also a Cell & Gene Therapy Segment Lead at NanoMosaic, unveils how artificial intelligence is set to transform the cell and gene therapy landscape.Discover why LinkedIn is becoming the new frontier for biotech networking and career advancement. ...

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24:04

93: From Lab Coat to LinkedIn: Benjamin McLeod's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/01

Send us a textDiscover how a failed optometry dream led Benjamin McLeod to become a leading voice in cell and gene therapy. In this eye-opening episode, Ben, who is a Cell & Gene Therapy Segment Lead at NanoMosaic, shares his unconventional path from lab work to LinkedIn stardom, revealing how he bridges the gap between R&D and marketing in biotech.Learn how Ben's weekly science memes evolved into valuable content that attracts both lab techs and CEOs alike.Key takeaways:Gain insider ...

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16:29

92: Mass Transfer Secrets: Mastering Bubbles and kLa...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/09/26

Send us a textEver wondered why your perfectly optimized lab process falls apart at industrial scale?Mass transfer experts Lars Puiman and Rik Volger from the University of Delft reveal the hidden world of oxygen transfer and aeration that can make or break your production.Dive into the crucial differences between lab-scale and industrial-scale bioreactors, and discover why your DO sensor might be fooling you. Learn how CFD simulations and innovative downscaling techniques can revolutionize y...

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16:37

91: Mass Transfer Secrets: Mastering Bubbles and kLa...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/09/24

Send us a textUnlock the mysteries of oxygen transfer in bioreactors with mass transfer experts Lars Puiman and Rik Volger from the University of Delft. In this eye-opening episode, dive deep into the crucial world of kLa (oxygen mass transfer coefficient) and its impact on bioprocess scale-up.Discover why understanding kLa is essential for optimizing cell growth and product formation in bioreactors. Learn practical strategies to enhance oxygen transfer, from manipulating bubble size to lever...

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25:14

90: Scale-Up Secrets: Cracking the Code of AAV...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/09/19

Send us a textDive into the cutting-edge world of gene therapy as we unravel the complexities of AAV production. In this insightful episode, Ahmed Youssef, a seasoned AAV expert and Senior Process Development Manager at Ascend, explains how you can navigate the complex world of AAV scale-up and learn why thinking outside the box is crucial for success.Key takeaways:Leverage early expert advice to ensure your therapeutic's long-term viabilityExplore innovative technologies like doggy bone DNA ...

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20:08

89: Scale-Up Secrets: Cracking the Code of AAV...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/09/17

Send us a textUnlock the mysteries of AAV manufacturing in this eye-opening episode! Ahmed, a seasoned AAV expert and Senior Process Development Manager at Ascend, reveals insider strategies for biotech scientists navigating the complex world of gene therapy production.Discover why quality is the cornerstone of successful AAV development and how to avoid costly missteps in the journey from lab to clinic.Key takeaways:Learn to design a robust AAV manufacturing process that stands up to regulat...

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16:38

88: The Swiss Army Knife of Biotech: Unleashing the...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/09/12

Send us a textUnlock the secret weapon of biotech success! In this eye-opening episode, host David Brühlmann reveals how fractional CTOs are revolutionizing drug development, inspired by Michael Jordan's approach to greatness. Learn how this innovative strategy can slash timelines, mitigate risks, and give your biotech company a competitive edge.Discover the game-changing benefits of fractional expertise:Gain rapid access to broad biotech knowledge, navigating complex challenges with ease.Sla...

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175 results

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