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PODCAST

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and

science life sciences

All Episodes

16:43

116: Revolutionizing Biologics Development with Hyper...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/19

Send us a textThe intersection of artificial intelligence and biology presents immense opportunities for transforming bioprocess development. As the biotech industry continues to evolve, data-driven innovations are critical to optimizing biologics manufacturing. High-quality datasets stand at the forefront of this transformation, empowering researchers to make informed predictions and advance therapeutic discoveries. As AI tools become more commoditized, the focus shifts toward generating rob...

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19:49

115: Revolutionizing Biologics Development with Hyper...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/17

Send us a textBioprocess development is transforming the biotech industry, driving innovations in life-changing therapies. Success hinges on simplifying complex mechanisms and adopting advanced technologies. By integrating high-throughput screening and artificial intelligence, we can streamline workflows, reduce trial-and-error, and speed up biologics development. Embracing cutting-edge tools empowers scientists to maximize biology's potential, delivering efficient and impactful biotech solut...

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18:08

114: Weighing of Single-Use Bag Systems: Why...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/12

Send us a textIs your bioprocess facility wasting precious time and resources on traditional weighing system calibrations? In this eye-opening episode, Anders Tvegaard, COO of Eilersen Electric, reveals how digital load cell innovation is revolutionizing bioprocess monitoring and validation.Discover why weighing systems aren't the commodity technology you might think they are, and how choosing the right solution can dramatically reduce deviations and maintenance costs. Anders shares groundbre...

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22:22

113: Weighing of Single-Use Bag Systems: Why...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/10

Send us a textWhat do furniture manufacturing and bioprocess weighing have in common? In this fascinating episode, Anders Tvegaard, COO of Eilersen Electric Digital Systems shares the remarkable story of how his company evolved from solving a furniture maker's wood humidity measurement problems to revolutionizing pharmaceutical manufacturing.Fifty years ago, a simple request to build a more robust scale for weighing wood in sofa production led to the development of groundbreaking contactless ...

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23:41

112: AI Meets Biology: Why Domain Expertise Still...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/05

Send us a textCan artificial intelligence revolutionize drug development and reduce the staggering 90% failure rate in clinical trials? In this insightful episode, Lars Brandén, Director of Biology at Kolibri, shares his vision for the future of personalized medicine.Drawing from his extensive experience bridging academia and industry, Lars explores how AI models could transform our understanding of human disease by simulating body-wide cell signaling. He reveals an innovative approach to dru...

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19:08

111: AI Meets Biology: Why Domain Expertise Still...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/03

Send us a textIn this episode, we explore the delicate dance between artificial intelligence and biological research with Lars Brandén, Director of Biology at Kolibri. From his early fascination with gene therapy to pioneering high-throughput screening centers at prestigious institutions, Lars shares invaluable insights on bridging the gap between academic innovation and industrial application.What sets this conversation apart is Lars' compelling perspective on why the popular "agile developm...

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16:24

110: Spinning Like Earth: Designing Low-Shear...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/28

Send us a textCould Earth's gentle movements hold the key to scaling up cell therapy production? In this fascinating episode, cellular biologist and entrepreneur Olivier Detournay (CSO of Cellura) reveals how his groundbreaking bioreactor design, inspired by geophysics, is transforming difficult cell culture processes.By mimicking natural planetary motions, his team at Celura has developed a low-shear stress bioreactor that elegantly solves common scale-up challenges.Key takeaways for biotech...

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19:27

109: Spinning Like Earth: Designing Low-Shear...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/26

Send us a textWhat if the secret to growing sensitive cells lies in mimicking Earth's own movement? In this fascinating episode, cellular biologist Olivier Detournay, CSO of Cellura, reveals how studying planetary motion led to a groundbreaking bioreactor design that could transform cell therapy manufacturing.Drawing inspiration from geophysics research on magma flows, Olivier and his colleagues developed a revolutionary impeller-free bioreactor that creates gentle, uniform mixing through pre...

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26:35

108: From 1 Billion to 100: How AI is Cracking the...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/21

Send us a textIn this captivating episode, we dive deep into the groundbreaking intersection of artificial intelligence and enzyme engineering with David Schönauer, founder and CEO of Aminoverse.From university lab benches to pioneering AI-driven enzyme discovery, David shares how his startup is transforming the biotech landscape by making enzyme development faster, more predictable, and increasingly efficient.Highlights:Discover how AI is revolutionizing enzyme prediction and design, potenti...

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19:11

107: From 1 Billion to 100: How AI is Cracking the...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/19

Send us a textEver wondered how scientists find the perfect enzyme among billions of possibilities? In this fascinating episode of the Smart Biotech Scientist podcast, host David Brühlmann sits down with David Schönauer, CEO of Aminoverse, who's revolutionizing enzyme engineering through artificial intelligence.As a biotech entrepreneur who transformed his academic passion into a groundbreaking startup, Schönauer shares how his company is solving one of biotechnology's biggest challenges: eff...

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19:51

106: From Proteins to Cell Therapy: Why ATMPs Aren't...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/14

Send us a textIn this insightful episode, Technical Development Leader at Flagship Pioneering Oliver Kraemer reveals why developing Advanced Therapy Medicinal Products (ATMPs) require a fundamental shift in thinking from traditional biologics development.Drawing from his extensive experience across Boehringer Ingelheim, Sanofi, and BMS, Kraemer challenges conventional wisdom about process development timing and demonstrates why early integration of process considerations is crucial for ATMP s...

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21:52

105: From Proteins to Cell Therapy: Why ATMPs Aren't...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/12

Send us a textIn this eye-opening episode, we explore the intricate landscape of Advanced Therapy Medicinal Products (ATMPs) with Oliver Kraemer, a technical development leader at Flagship Pioneering.Drawing from his extensive experience at industry giants like BMS, Sanofi, and Boehringer Ingelheim, Oliver challenges conventional wisdom about automation in cell and gene therapy while illuminating the crucial differences between biologics and ATMPs.Key Takeaways for Biotech Scientists:Discover...

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17:17

104: One-Stop Shop vs. Specialist CDMO: A Scientist's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/07

Send us a textWant to peek behind the curtain of a leading Contract Development and Manufacturing Organization (CDMO)? In this inspiring episode, KBI Biopharma's Chief Scientific Officer Sigma Mostafa reveals the intricate world of bioprocess development and manufacturing.Sigma shares game-changing insights into accelerating biologics development without compromising quality. She also unveils how KBI is leveraging AI and machine learning to revolutionize everything from protein sequence analy...

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24:01

103: One-Stop Shop vs. Specialist CDMO: A Scientist's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/05

Send us a textIn this insightful episode, we're joined by Sigma Mostafa, Chief Scientific Officer at KBI Biopharma, who shares crucial insights on selecting the right CDMO partner for biotech development.Sigma brings a unique blend of scientific rigor and practical experience to the discussion, having worked on both sides of the CDMO relationship.Key Takeaways:Why harvest steps deserve more attention in bioprocess developmentThe truth about one-stop-shop CDMOs versus specialized partnersCriti...

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15:17

102: PAT Revolution: Decoding Your Bioprocess Like...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/31

Send us a textStruggling to unravel the complexities of your bioprocess? Prepare for a paradigm shift as we dive into the world of Process Analytical Technology (PAT) with Katharina Dahlmann who is Application and PAT Expert at Hamilton.This eye-opening episode dissects how PAT is redefining biologics manufacturing, balancing its immense potential against real-world implementation hurdles. Katharina navigates us through the intricate journey of scaling up, from micro-bioreactors to large-scal...

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23:12

101: PAT Revolution: Decoding Your Bioprocess Like...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/29

Send us a textUnlock the hidden potential of your bioprocess! In this eye-opening episode, David Brühlmann sits down with Katharina Dahlmann, Application and PAT Expert at Hamilton, to explore the game-changing world of Process Analytical Technology (PAT).Discover how PAT is revolutionizing biotech by providing unprecedented insights into cell behavior and process dynamics. Katharina challenges conventional wisdom, revealing that what we think we know about our processes may just be the tip o...

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18:01

100: From Raw Data to Actionable Insights: Unlocking...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/24

Send us a textImagine predicting your bioprocess outcomes as easily as checking the weather forecast. Sound impossible? Not anymore. In this insightful episode, we dive deep into the world of digital twins and process models with Fabian Feidl, co-founder and CTO of DataHow.Discover how these cutting-edge tools are reshaping the biotech landscape, from simplifying complex processes to enabling personalized medicine. Fabian shares invaluable insights on implementing data-driven approaches, even...

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22:00

99: From Raw Data to Actionable Insights: Unlocking...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/22

Send us a textAre you ready to decode the future of bioprocessing? In this eye-opening episode, we dive deep into the world of digital bioprocess development with Fabian Feidl, co-founder and CTO of DataHow.Discover how cutting-edge process models are transforming the biotech industry, bridging the gap between raw data and actionable insights.Key takeaways:Learn how process models can streamline development, reduce costs, and accelerate time-to-market for groundbreaking therapies.Explore the ...

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17:59

98: The Biomanufacturing Revolution: Bringing...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/17

Send us a textAre you ready to dive into the cutting-edge world of biomanufacturing? In this episode, strategic consultant James Ryall unveils the staggering potential of bio-based products to revolutionize industries. From cultured meat to human breast milk, discover how cells are becoming the ultimate manufacturing facilities.James shares invaluable insights on scaling challenges, regulatory hurdles, and the critical importance of early preparation for biotech startups. Learn why biomanufac...

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24:24

97: The Biomanufacturing Revolution: Bringing...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/10/15

Send us a textIn this captivating episode, host David Brühlmann welcomes James Ryall, a strategic consultant with over two decades of experience in cell biology and regenerative medicine. From his groundbreaking work in skeletal muscle research to revolutionizing cultured meat production, James shares his fascinating journey through academia and industry.Discover how he's now helping biotech startups align their technical strategies with commercial outcomes, accelerating their path to market....

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184 results

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