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PODCAST

Behind the Genes

Genomics England

We are Genomics England and our vision is to create a world where everyone benefits from genomic healthcare. Introducing our refreshed podcast identity: Behind the Genes, previously known as The G Word. Join us every fortnight, where we cover everything from the latest in cutting-edge research to real-life stories from those affected by rare conditions and cancer. With thoughtful conversations, we take you behind the science. You can also tune in to our Genomics 101 explainer series which breaks

science life sciences

All Episodes

36:19

Adrienne Flanagan: Sarcoma awareness month, part 1

Behind the Genes ·

2022/07/06

"To gain information and insight into these, particularly, rare tumors, we will have to collect them for many, many years." Today on The G Word, Vivienne Parry, our Head of Public Engagement at Genomics England is joined by Professor Adrienne Flanagan. She is the professor of musculoskeletal pathology at UCL and is perhaps the most distinguished academic in this field in Europe. She has made major contributions to the biology of osteoclasts in conditions such as osteopetrosis and made a major

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01:03:57

Professor Robert Weinberg: Why do we get cancer?

Behind the Genes ·

2022/06/30

"Mutations are the price that all animals must pay, starting with jellyfish all the way up to us humans" Today on The G Word, Parker Moss, our Chief Commercial Officer is joined by Professor Robert (Bob) Weinberg. Professor Weinberg is a founding member of the Whitehead Institute for Biomedical Research and is a well-respected Professor in the MIT Department of Biology. He is the author of the legendary paper, the Hallmarks of Cancer, which was one of the most cited papers on life sciences of all

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43:09

Professor Kate Tatton Brown: Knowledge is changing...

Behind the Genes ·

2022/06/23

"We need to think about Genomics and we need to think about education because both are going to massively, massively change, and improve. I think we will be living in a very different space [in 30 years] than we are now...we are at the tip of the Iceberg." In this episode of The G Word, our CEO Chris Wigley is joined by Professor Kate Tatton Brown who is the Clinical Director and Head of the Genomics Education Programme at Health Education England. She's also a consultant in clinical genetics at St

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56:30

Nadeem Sarwar: Drug discovery - why do pharma want my...

Behind the Genes ·

2022/06/16

"...the insights we get from human genetics truly are a gift from nature..." On today's episode of The G Word, Parker Moss, our Chief of Ecosystems and Partnership Officer, is joined by Nadeem Sarwar, the Global Head of Genomic Strategies and Global Head of Digital Therapeutics (DTx) Strategies at Eisai. They discuss the difference between associations and drivers of disease, the importance of knockouts and the benefits of having insights through our DNA. They also discuss the phenomenon of

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21:20

Daphne Koller: Machine learning and multimodal data...

Behind the Genes ·

2022/06/08

“We are now in a world where there is this an abundance of data, which is only the beginning to what we're likely to be able to see in the coming years. At the same time, we have this incredible set of machine learning methods [...]. This seems to be a moment in time when those two tidal waves are about to come together in a way that offers us the opportunity to unlock some of the underlying secrets and complexities that underlie human health and human disease.” This week we are sharing for

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40:01

Dr Genya Dana: The power of genomics

Behind the Genes ·

2022/06/01

“What will be important is to engage with the patient community, it will be a very important process to complement the science that we are doing and to engage with those ultimate end users. That is the beauty of having these conversations with the people who are going to eventually end up adopting the technology.” Today's episode of The G Word is a little different. We are sharing a live recording of a recent discussion at the Public Policy Projects Global Genomics Conference between Chris Wigley,

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44:29

Professor, Sir Munir Pirmohamed: Disease, drugs and...

Behind the Genes ·

2022/05/25

"If we had the same immune system, all of us, then we would be extinct by now" On todays episode of The G Word, our CEO, Chris Wigley, is joined with Professor, Sir Munir Pirmohamed, a British clinical pharmacologist and geneticist. Munir is also the NHS chair of Pharmacogenomics at the University of Liverpool. They discuss the importance of pharmaceutical drug development, understanding genome structures to better identify and predict diseases and how our lifestyle choices can lead to variation

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01:09:43

Greg Elgar: How does clinical whole genome sequencing...

Behind the Genes ·

2022/05/18

"We're taking the native DNA molecule that's actually from the cell and we're reading the sequence of that molecule. That comes with some tremendous, enormous benefits, but it also comes with it some huge challenges." On today's episode of The G Word, we are joined by Parker Moss, our Chief Commercial Officer at Genomics England, and Greg Elgar, the Director of Sequencing Economic England. They discuss techniques such as preparation ahead of sequencing itself and the logistics to get blood and

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35:21

Dalia Kasperaviciute, Alona Sosinsky, Francisco...

Behind the Genes ·

2022/05/11

“I Remember when I got to the stage to introduce Edwin Cuppen, who was the first speaker on the cancer Genomics track, and I was just… it’s happening! It’s happening! We did it!” On today's episode of The G Word, we are joined by the chairs for scientific content at the recent Genomics England Research Summit: Dalia Kasperaviciute, Head of Genomic Data Sciences for Rare Disease; Alona Sosinsky, Scientific Director for Cancer; Francisco Azuaje, Director of Bioinformatics, and Maxine Mackintosh,

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45:56

Angela Saini: The history of race science, the use of...

Behind the Genes ·

2022/05/04

"The vast majority of what we think of as human differences, cultural and linguistic, the act of categorization in science itself, I've come to see as fundamentally fraught and political." On this week's episode we join Diksha Srivastava from our Diverse Data team, Ewan Birney from EMBL-EBI and special guest Angela Saini, a science journalist, broadcaster and the author of best selling books Geek Nation, Inferior, and Superior: The Return of Race Science, published in 2019. Angela's work has

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57:41

Nobel Laureate Harold Varmus: Cancer biology and the...

Behind the Genes ·

2022/04/27

“It's critical that the general public understand that science is a long process, and that science is a process that often begins with the art of the feasible. […] We wouldn't be anywhere without computers, we wouldn't be anywhere without DNA sequencing methods. That not only gives me confidence, but it also makes me feel that there's an awful lot left to do.” In this week’s episode of The G Word, our Chief Ecosystems and Partnership Officer Parker Moss is joined by Harold Varmus, who was

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34:37

Dr Annalisa Jenkins: The role of genomics in...

Behind the Genes ·

2022/04/22

“Patients are absolutely firmly at the centre. That every day we get out of bed, with the patient and their caregivers and families, front of mind. […] You can't be successful in drug development and novel therapeutic development, without engaging the patient communities, as a partner and as a collaborator on the journey.” In this week’s episode of The G Word, our CEO Chris Wigley is joined by Dr Annalisa Jenkins, non-Executive Director at Perspectrum Ltd, Oncimmune, AVROBIO, Affimed, COMPASS

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35:39

Tamsin Berry: The world of life sciences

Behind the Genes ·

2022/04/13

"The big realisation for me working in life sciences is if we didn't have [this] industry, to translate this amazing science that comes out of academic institutions into usable products, then we wouldn't be able to benefit as individuals." We join Chris Wigley and special guest Tamsin Berry in today's episode of, The G Word. Tamsin is Partner at Population Health Partners, and former Director of the UK government’s Office for Life Sciences. They discuss the importance of Life Sciences and what it

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26:06

Sir Patrick Vallance: The evolution and future uses...

Behind the Genes ·

2022/04/06

“The whole area is going to be crucial for everything from monitoring waste, you can think about its use in monitoring biodiversity, such a key area for the future. You can think about the impact of the environment and on the changes in species across the world over time. This is going to be a ubiquitous area of societal discussion.” In this week’s episode of The G Word, our CEO Chris Wigley is joined by Sir Patrick Vallance, the Government’s Chief Scientific Adviser and the Head of Government

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01:05:30

Dr Stanley Crooke: Advancing the health of human...

Behind the Genes ·

2022/03/30

“Let's talk about patients. That's where we have to always begin. This is about patients. I was tremendously impressed with how much the patient advocacy groups had accomplished, that helped us make judgments that are really complex and very dangerous judgments. All that played into the success. Then, of course, it was very rapidly approved around the world.” In this week’s episode of The G Word, Dr Richard Scott, our Chief Medical Officer, is joined by Dr Stanley Crooke, M.D., Ph.D., the founder,

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35:09

Amanda Pichini: Genetic counselling

Behind the Genes ·

2022/03/23

“It's not just talking about a genetic test, testing parents to see if they're carriers after their child's been diagnosed or talking about reproductive options when people want to have another child - it's a lot more than that. It's navigating those difficult decisions in a situation where there’s a genetic risk or someone has been diagnosed with something and they need to know if it's going to have an impact on their life and future.” In this week’s episode of The G Word, Chris Wigley is joined

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52:30

Charles Swanton: The evolution of cancer

Behind the Genes ·

2022/03/16

“The tools that we have at our disposal now are just mind blowing - in terms of what we can do now compared to what we could during my PhD back in the mid 90s, when it would take you about three days to sequence the best part of 1000 base pairs. Now the number of genomes we can use every day, it's just extraordinary.” In this week's episode of The G Word, Parker Moss is joined by Charles Swanton, Cancer Research UK’s Chief Clinician and Senior Group Leader at The Francis Crick Institute. They

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33:04

Catherine Pollard: Why data is important in making...

Behind the Genes ·

2022/03/09

“Clinicians are holding people's lives in their hands, and so for me data is about making sure they have all the information they need about where an individual comes from, their living circumstances and their family history, whilst also having the benefit of what clinical best practise will tell you to do or some of the large pattern analysis you can only do in very large populations.” In this week's episode of The G Word, Chris Wigley is joined by Catherine Pollard, NHSX Director of Tech Policy

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34:29

Dr Misha Kapushesky: Human vs machine learning

Behind the Genes ·

2022/03/02

“There are problems that we as humans have tackled that are extremely amenable to machine learning approaches, challenges like classifying things or, given a lot of data, making a prediction about the next step in that data. I am super excited about machine learning being able to tackle these challenges.” In this week's episode of The G Word, Chris Wigley is joined by Misha Kapushesky, Chief Executive Officer and Founder of Genestack. They discuss making data more accessible, his work with

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36:58

Dr Neil Rajan and Dr Ruth Murphy: Dermatology and...

Behind the Genes ·

2022/02/28

“The first step in the identification of any rare condition is recognising the features that lead to the diagnosis, something that’s easy to do if the person sitting in front of you has classic symptoms. However, in dermatology things are never that simple - somebody’s clinical presentation can be very, very subtle.” In this week's episode of The G Word, Vivienne Parry is joined by Dr Neil Rajan, Honorary Consultant Dermatologist at Newcastle’s Royal Victoria Infirmary and Senior Lecturer at

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