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PODCAST

Biopedia

Vince"s Podcasts

Biology is a fascinating subject which is well worth exploring. Its scope stretches from individual DNA strands and viruses to blue whales, metapopulations and the biosphere. We will shine the spotlight on a different biological concept in every episode. Topics I"ve covered in the past include the origins of cell theory, Dollo"s law and the Anthropocene; however, there is still plenty more to discover. Our focus will range from the very smallest scales to the very largest; from virions to the Gaia

science life sciences

All Episodes

00:02:28

Announcement- Website

Biopedia ·

2021/01/13

Hi everyone, Vince here with a quick update- the podcast now has an accompanying website! From now on, you can head to 'www.biopedia.co.uk' to access all our episodes, as well as a blog featuring some extra content. Thank you all for continuing to listen to the show and I'm excited to add new content!

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00:04:35

15- The Adaptive Landscape

Biopedia ·

2021/01/10

The adaptive landscape is an important method for biologists, ecologists, and geneticists to visualise the process of evolution. But what is it, and how does it work? This week, we’re going to discuss what the adaptive landscape actually is, so while there are going to be some sources listed, there's also a bit of general discussion as well. Some sources for this episode: 1) Martin, C. H. and Wainwright, P. C. (2013), Multiple fitness peaks on the adaptive landscape drive adaptive radiation in the

en

00:03:54

14a- The Function of NRAMP1

Biopedia ·

2021/01/06

Bonus episode! In the main episode on Sunday, I briefly mentioned NRAMP1, a mutation in which can influence how susceptible someone is to the leprosy bacterium, Mycobacterium leprae. But what exactly is the NRAMP1 protein and why is it important? Sources for this episode: 1) Cannone-Hergaux, F., Calafat, J., Richer, E., Cellier, M., Grinstein, S., Borregaard, N. and Gros, P. (2002), Expression and subcellular localisation of NRAMP1 in neutrophil granules. Blood 100(1): 268- 275. 2) Forbes, J. R. and

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00:05:56

14- Leprosy and 'The Leper King'

Biopedia ·

2021/01/03

Happy new year! In our inaugural episode of 2021, we’re going to go back to the 1100s and focus on the famous case of the Leper King Baldwin IV, who ruled as king of Jerusalem from 1174 to 1185. What exactly is leprosy, and what causes it? We’ll use the test case of Baldwin as an opening to talking a bit about the bug Mycobacterium leprae and how exactly leprosy works. Sources for this episode: 1) Abel, L., Sánchez, F. O., Oberti, J., Thuc, N. V., Van Hoa, L., Lap, V. D., Skamene, E., Lagrange, P.

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00:04:24

13- Rewind: Amino Acids

Biopedia ·

2020/12/27

Proteins are often mentioned on the show, but what about the building blocks that they consist of? This week, we’re going to tackle amino acids in our second rewind episodes. There are some topics that naturally branch off from this one, such as interactions between amino acids and how DNA encodes for different ones, but they will probably be topics for future episodes. Sources for this episode: 1) Campbell, N. A., Urry, L. A., Cain, M. L., Wasserman, S. A., Minorsky, P. V. and Reece, J. B. (2018),

en

00:06:12

12- The Wnt Signalling Network

Biopedia ·

2020/12/20

Building on our discussion of both signalling pathways and G-protein coupled receptors from a few weeks ago, this week we’re going to discuss the Wnt signalling pathway- a pathway which is crucial in aspects of development and can have widespread impacts on the cell. It all sounds rather intimidating, but there’s actually surprisingly few steps involved in this pathway- and we’re only going to be focusing on one part of the signalling network, which makes life a lot less complicated! Sources for

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00:03:53

11- Rewind: Cell Theory

Biopedia ·

2020/12/13

In the first of our ‘Rewind’ episodes, we go back to basics and discuss cells- where they came from and the famous cell theory of 1839, which is still present in textbooks today. There are more stories than we can cover which lead up to cell theory, so just see this as an introductory episode until when and if we can come back to these famous names and discoveries. Sources for this episode: 1) Silver (1987), Virchow, the Heroic Health Model in Medicine: Health Policy by Accolade. AJPH 77(1): 82- 88

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00:06:10

10- The Lamellipodium

Biopedia ·

2020/12/06

As discussed in previous episodes, the actin cytoskeleton is vital to allow cells to move. But what about the specifics? In this episode, we’re going to be dissecting the lamellipodium- a meshwork actin structure that some cells use to move. Sources for this episode: 1) Alberts, Johnson, Lewis, Raff, Roberts, and Walter (2008), Molecular Biology of the Cell, Fifth Edition. Abingdon: Garland Science, Taylor and Francis Group LLC. 2) Berro, Michelot, Blanchoin, Kovar and Martiel (2007), Attachment

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00:02:51

9- The Platypus’ Larger Cousin

Biopedia ·

2020/11/29

We’re all familiar with the platypus, but it still has surprises up its sleeve. On the show today, we get to know its bumper-sized cousin- Obdurodon tharalkooschild. Sources for this episode: 1) Dell’Amore, C., National Geographic (2013), Giant Platypus Found, Shakes Up Evolutionary Tree (online) [Accessed 17/11/2020].2) Pian, R., Archer, M. And Hand, S. J. (2013), A new, giant platypus, Obdurodon tharalkooschild, sp. nov. (Monotremata, Ornithorhynchidae), from the Riversleigh, World Heritage Area,

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00:06:19

8- Orca Population History

Biopedia ·

2020/11/22

Killer whales are an icon of the world's oceans. However, genetic studies show that they haven't always been doing so well- especially during the last Ice Age. What's the story? And what relevance does the millennia-old plight of the orca have today? On the podcast today, we're going to use a genetic study from 2014 to explore just that. Sources for this episode: 1) Moura, A. E. et al (2014), Killer Whale Nuclear Genome and mtDNA Reveal Widespread Population Bottleneck during the Last Glacial

en

00:03:49

7- Localised mRNA and Cell Polarity

Biopedia ·

2020/11/15

On the podcast today, we cover the concept of localised mRNA, which can be relevant to cell polarity. Sources for this episode: 1) Martin, K. C. And Ephrussi, A. (2009), mRNA Localisation: Gene Expression in the Spatial Dimension. Cell 136: 719- 730.

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00:05:39

6- Persister Cells

Biopedia ·

2020/11/08

Antibiotic resistance we’ve all heard of by now, but what about antibiotic persistence? Join us as we explore the phenomenon of persistence, which allows bacterial infections to reappear even after antibiotic treatment. And all while being genetically identical to their susceptible neighbours! Sources for this episode: 1) Balaban, N. Q., Helanie, S., Lewis, K., Ackermann, M., Aldridge, B., Andersson, D. I., Brynildsen, M. P., Bumann, D., Camilli, A., Collins, J. J., Dehio, C., Fortune, S., Ghigo,

en

00:03:36

5- A Projected Range Shift during Global Warming

Biopedia ·

2020/11/03

It is common knowledge that bees as a whole are declining as a result of climate change, although bee decline as a larger topic is not in itself the subject of today's episode. But what about individual species? On the podcast today, we cover a 2019 study which predicted that the Australian small carpenter bee, Ceratina australensis, might go against this trend.... Sources for this episode: Breeze, T. D., Roberts, S. P. M. and Potts, S. G. (2012), The Decline of England's Bees: Policy

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00:03:19

4- GTPases and Actin Remodelling in Yeast

Biopedia ·

2020/11/01

This episode builds on content covered in episode 3, so be sure to check it out if you haven’t listened to it already. This week, we explore an example of the GTPase content we discussed last time. Specifically, we look at the diploid mating of baker’s yeast in stressful environments. Source for this episode: Alberts, Johnson, Lewis Raff, Roberts and Walter (2008), Molecular Biology of the Cell, Fifth Edition. Abingdon: Garland Science, Taylor and Francis Group LLC.

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00:05:31

3- Cell Polarity and GTPases

Biopedia ·

2020/10/30

On the podcast today, we scratch the surface of cell polarity and how enzymes known as GTPases are linked to this process. Sources for this episode: Alberts, Johnson, Lewis Raff, Roberts and Walter (2008), Molecular Biology of the Cell, Fifth Edition, Abingdon: Garland Science, Taylor and Francis Group LLC. Thain, M. And Hickman, M. (2014), The Penguin Dictionary of Biology, 11th edition. London: Penguin Publishing Group. Some of the discussion is also based on my studies.

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00:05:23

2- The Identification of Richard III

Biopedia ·

2020/10/29

It’s genetics time! Back in 2012, a skeleton was unearthed in a car park in Leicester, which was later positively identified as Richard III of England. But how? Join us as we delve into how genetics cracked a 500 year old case wide open... Sources for this episode: King, T. E., Fortes, G. G., Balaresque, P. Thomas, M. G., Balding, D., Delser, P. M., Neumann, R., Parson, W., Knapp, M., Walsh, S., Tonasso, L., Holt, J., Kayser, M., Appleby, J., Forster, P., Ekserdjian, D., Hofreiter, M., and

en

00:03:47

1- Biofilms

Biopedia ·

2020/10/27

Welcome to our first proper episode! This week, we tackle the problem of biofilms- an extracellular matrix which can protect the species inside it and is a source of frustration to doctors and dentists alike. Sources for this episode: Lopez, D. Vlamakis, H. And Kolter, R. (2010), Biofilms. Cold Spring Harbor Perspectives in Biology 2(7): a000398. Short, F. L., Murdoch, S. L. And Ryan, R. P. (2014), Polybacterial human disease: the ills of social networking. Thain, M. And Hickman, M. (2014),

en

00:03:22

0- Introduction

Biopedia ·

2020/10/26

Welcome to Biopedia! This episode is a bit of an explanation as to who I am, what the podcast is all about and some caveats about my schedule.

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00:00:36

Biopedia Trailer

Biopedia ·

2020/10/25

Welcome to Biopedia! This is a podcast that aims to go through various aspects of biology one at a time for listeners of all levels. Enjoy the show!

en

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