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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

6:23

Mapping the Meta Proteome: John Shon, CTO, Serimmune

Mendelspod Podcast ·

2023/12/05

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comJohn Shon is the Chief Technology Officer at Serimmune, a company specializing in precision immunology. Serimmune maintains a library of over 10 million random peptides that can mimic almost any disease. With this library, they are able to comprehensively map the relationship between antibodies and antigens.What does this mean? Take COVID, for instance; rather than just offering a diagnostic, Serimmune can show

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26:22

Supercharged Killer Cells Effective Against...

Mendelspod Podcast ·

2023/11/28

Our guest today introduced us to a new kind of immunotherapy called Super-NK. Imagine CAR-T, but in this case, the immune cells from the patient are not engineered, but rather “supercharged.” What’s remarkable is that the company is having success with the therapy against neurological conditions such as Alzheimer’s and Parkinson's.Paul Song is the CEO of NKGen Biotech. The company just presented results from a Phase I trial at the 16th Annual Clinical Trials on Alzheimer’s Disease Conference

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6:07

Chris Hall and Rich Chen of Personalis on Next Gen...

Mendelspod Podcast ·

2023/11/21

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comPersonalis, a company launched during the early days of whole genome testing and analysis, is claiming to have the most sensitive MRD testing available to date. They are demonstrating this with the results of their recently released TRACERx study of patients with non-small cell lung cancer. CEO Chris Hall and CMO Rich Chen both join us to profile these exciting results and debut the entrance of Personalis into MRD

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9:27

State of Sequencing 2023: Shawn Baker and Keith Robison

Mendelspod Podcast ·

2023/11/14

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Delivering on last year’s announcements8:50 Illumina14:25 Long reads25:50 PacBio vs Oxford Nanopore31:36 Element38:27 MGI45:47 The rise of proteomics51:20 What next?The end of the year approaches, and we look back today on the state of DNA sequencing with two of our return champions, Shawn Baker, genomics consultant, and…

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43:11

Newborn Sequencing 2023 Part II: What Evidence Is...

Mendelspod Podcast ·

2023/11/07

Chapters:0:00 State of the field: reviewing ICoNS conference22:20 What evidence is enough?Today, we’re joined by a panel of four guests who have all attended the recent International Conference on Newborn Sequencing held at the Royal Institution in London. This discussion serves as the second part in a series we are co-producing with GenomeWeb that began with last month’s panel. At the conference, researchers representing 12 newborn sequencing research programs in the US, the UK, Europe,

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6:36

Lincoln Nadauld on the State of Precision Medicine in...

Mendelspod Podcast ·

2023/10/17

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Precision oncology is standard of care13:50 Culmination Bio23:25 Hopeful about early cancer screening25:45 Biggest challenge for the field?When Lincoln Nadauld began Precision Genomics at Utah-based Intermountain Healthcare, he told the administrators that precision oncology is coming and will be standard of care. He urged them to d…

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6:16

Nothing Is "Undruggable:" Alex Federation, CEO, Talus...

Mendelspod Podcast ·

2023/10/12

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 What are transcription factors?7:00 The MARMOT platform11:22 In the ’90s, people thought kinases were undruggable19:00 Where’s the company at today?We begin today’s show with definitions. What are transcription factors? What is functional proteomics? And what is meant by “undruggable?"According to a study in Nature from las…

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6:29

Mass Spec Advances in a New Age of Proteomics: Rosy...

Mendelspod Podcast ·

2023/10/10

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Attending this year’s Human Proteome Organization (HUPO) conference4:40 Mass spec vs. sequencing8:12 How does the Orbitrap Astral fit into the market?12:55 Customer applicationsThermo Fisher Scientific is a name synonymous with life science tools. They have been at the vanguard of every important trend in our field for decades.…

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6:14

This Is Very Cool: Treating Cancer with Sound

Mendelspod Podcast ·

2023/10/03

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 What does treatment look like?7:25 Light treatment has been approved for years20:10 Could this be a primary therapy for all cancers?25:05 Challenges?We often cover new therapies for cancer. They are usually derived from “chemistry." But what about using “physics” in a non-invasive way for treatment? A new company named SonA…

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34:50

The Future of Clinical Proteomics with Jenny Van Eyk...

Mendelspod Podcast ·

2023/09/27

Chapters:0:00 “It’s a magical time.”9:55 Tracking low-concentration proteins in real-time19:20 What next?24:40 Proteins act in community29:30 Challenges ahead?Many new drugs and clinical diagnostics are being derived from proteins. Today we take our proteomics series into the clinic with Jenny Van Eyk from Cedars Sinai Hospital in Los Angeles and Daniel Hornburg of the proteomics company, Seer. Jenny works at that sweet spot with one foot in the clinic and the other in research,

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41:27

Elinor Karlsson on Darwin’s Ark

Mendelspod Podcast ·

2023/09/18

Today’s show is made free by the generous support of Twist Bioscience. Twist works in service of people changing the world for the better in fields such as medicine, agriculture, industrial chemicals, and data storage. Their unique silicon-based DNA synthesis platform provides precision that is otherwise unavailable. Check out their products at www.twistbioscience.com. And join them as they write the future of science.Chapters:0:00 Pet dogs have complex genetics and phenotypic data8:00

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8:12

Long DNA for Difficult Applications: Dan Lin-Arlow,...

Mendelspod Podcast ·

2023/09/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 World’s longest oligo8:45 Why is it difficult to synthesize long DNA?12:00 Proprietary TdT conjugate16:00 A billion-dollar market24:20 The computation model and its challenges28:35 More customers using generative AIMendelspod is now reader supported. Please consider upgrading to a paid subscription for the price of a couple cof…

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6:07

Next Gen CRISPR Therapies with Trevor Martin, CEO of...

Mendelspod Podcast ·

2023/09/05

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Novel Cas enzymes help overcome CRISPR challenges11:37 New pipeline of therapies will go after novel targets14:52 How does the new platform open up possibilities for new diagnostics?21:05 What risks do you think about?26:47 What are the company’s two-year goals?31:07 On the possibilitiesCRISPR technology is enabling a new generation …

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8:25

13th Season Opener: Mike Snyder on Microsampling and...

Mendelspod Podcast ·

2023/08/24

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com0:00 Latest paper on multi-omics microsampling6:30 Is it useful? Two scenarios13:00 How might entrepreneurs bring this to healthcare?18:15 How do you convince physicians?25:48 Are you a reductionist?31:00 Impact of generative AI38:15 Thoughts on the renaissance in proteomicsWe open our 13th season here at Mendelspod with guest, Mike Snyder, S…

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45:24

Gene Patent Decision at 10 Years, State of Genetic...

Mendelspod Podcast ·

2023/06/15

Ten years ago this week, the Supreme Court unanimously ruled that genes could not be patented. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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33:57

Proteomics Bigger than Genomics, It’s Just Taking...

Mendelspod Podcast ·

2023/06/01

Today we feature Quantum-SI, one of the new wave of proteomics tools companies. The company was founded by serial life science entrepreneur, Jonathan Rothberg, originally as a long read sequencing company. Though the company pivoted to proteomics, they kept the sequencing part. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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39:17

Biden, AI, and DeSci: John Cumbers Previews...

Mendelspod Podcast ·

2023/05/09

SynBioBeta is the largest gathering of the synthetic biology community worldwide. It’s taking place May 23-25 in Oakland, California. John Cumbers is the founder and CEO of the conference, and he joins us to talk about trends in the space and preview this year’s confab.First, we discuss the impact Washington D.C. is having on the field. What doe’s Biden’s love for bio mean for synbio? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes,

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30:38

Proteomics Today Where Genomics Was in the 80s:...

Mendelspod Podcast ·

2023/05/08

It’s a thrilling time to be in proteomics. Today we discuss a recent paper in PLOS One demonstrating how new technology has revealed a novel biomarker for non-small cell lung cancer previously undetected by other methods. The paper could be a model for new proteomics research going forward. Our guests are Margaret Donovan, Product Marketing Manager, and Asim Siddiqui, Senior VP of Research, both at proteomics company, Seer. This is a public episode. If you'd like to discuss this with other

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45:55

Is This New Platform an Answer to the Reproducibility...

Mendelspod Podcast ·

2023/04/27

Philosophers talk about various kinds of knowledge. There is knowing that something is. We learn that the sun is 90 million miles from the Earth. There is also knowing how to do something. This includes skills we learn like riding a bike or cooking spaghetti. Knowing how is different from knowing that. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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30:25

Elegen Pioneers Long DNA Subindustry with CEO Matt Hill

Mendelspod Podcast ·

2023/04/19

Long DNA has arrived. Elegen, a new company based in San Carlos, California, is out this year offering just long DNA. According to their founder and CEO, Matt Hill and today's guest, the company’s product is twenty times more accurate than anything else presently available.What does this mean for the world of biology and the world in general that we're seeing the emergence of a new subindustry devoted specifically to long DNA? This is a public episode. If you'd like to discuss this with other

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532 results

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