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PODCAST

The a16z Show

Andreessen Horowitz

The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

technology entrepreneurship

All Episodes

00:24:05

Sarah Rogers: Free Speech, AI Diplomacy, and What...

The a16z Show ·

2026/05/04

Katherine Boyle speaks with Sarah Rogers, Under Secretary for Public Diplomacy, about the intersection of AI, free speech, and global information systems. They discuss how major technological shifts, from the printing press to the internet to AI, have reshaped communication and power, and why this moment may be even more consequential. Recorded at the a16z American Dynamism Summit, the conversation explores the role of public diplomacy in the digital age, the risks of censorship and overregulation,

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00:51:38

Balaji and Taylor Lorenz on AI and Media

The a16z Show ·

2026/05/01

Theo Jaffee speaks with Balaji Srinivasan and Taylor Lorenz about how AI is reshaping media, trust, and online communication. Building on prior public disagreements between the two, the conversation revisits core tensions around media, technology, and power in a rapidly changing information environment. They discuss the breakdown of traditional information systems, the rise of AI-generated content, and why new models for verifying identity and truth may be necessary. The conversation lays out

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00:29:13

Workday’s Last Workday? AI and the Future of...

The a16z Show ·

2026/04/30

Elena Burger speaks with Joe Schmidt, partner on the enterprise team at a16z, about the future of enterprise software in the age of AI. Using Workday as a case study, they discuss why many of today’s most important enterprise systems feel broken, how platform shifts reshape entire categories, and what an AI-native replacement might look like.The conversation covers the limits of legacy SaaS, why “AI revenue” may be overstated, and how agents could fundamentally change how companies manage

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00:57:43

The Shift in Global Drug Development

The a16z Show ·

2026/04/29

Theo Jaffee and Gabriel Dickinson speak with Cremieux about China’s rapid rise to the top of global clinical trial output. They discuss the regulatory reforms that accelerated China’s progress, the surge in novel drug development, and what the US would need to change to stay competitive in biomedical innovation.Resources: Follow Cremieux on X: https://x.com/cremieuxrecueil Follow Theo on X: https://x.com/theojaffee Follow Gabriel on X: https://x.com/gbrl_dick Stay Updated:Find a16z on YouTube:

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00:20:02

John and Patrick Collison on Stripe's Growth, Agent...

The a16z Show ·

2026/04/28

This interview with Stripe cofounders John and Patrick Collison originally aired on TBPN. They discuss Stripe's 34% growth and new employee tender offer, how agent commerce and stablecoins may require high-throughput blockchains built for millions of transactions per second, and why the economics of software are shifting from mass-produced products to bespoke, on-demand systems cooked fresh at the moment of use. Resources: Follow TBPN on Twitter: https://x.com/tbpn Follow Patrick Collison on

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01:09:06

Ben Horowitz on Venture Capital and AI

The a16z Show ·

2026/04/27

Anjney Midha, founder of AMP PBC, speaks with Ben Horowitz, cofounder of a16z, about how venture capital changed from a small, relationship-driven business into a scalable system for backing new technology companies. They discuss network effects, firm design, leadership, culture, and how AI is reshaping both the capital race and the kinds of companies that can be built now. Resources: Follow Ben on X: https://x.com/bhorowitz Follow Anjney on X: https://x.com/AnjneyMidha Watch more from CS 153:

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01:00:30

AI Inside the Enterprise

The a16z Show ·

2026/04/24

Steven Sinofsky, board partner at a16z, Aaron Levie, CEO of Box, and Martin Casado, general partner at a16z, discuss the reality of AI inside enterprises. They cover the gap between Silicon Valley and the rest of the world, why most AI initiatives fail in large organizations, and how agents, infrastructure, and workflows are evolving beyond the hype.Resources: Follow Aaron Levie on X: https://twitter.com/levie Follow Steve Sinofsky on X: https://twitter.com/stevesi Follow Martin Casado on X:

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00:48:47

Martin Shkreli on AI, Pharma, and What Actually Matters

The a16z Show ·

2026/04/23

Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk through the future of computing, the limits of “vibe coding,” and why biotech and pharma remain some of the toughest industries to get right.Resources: Follow Martin on X: https://x.com/MartinShkreli Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show

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02:01:33

Balaji Srinivasan: Prove Correct, Not Just Go Direct

The a16z Show ·

2026/04/22

Erik Torenberg and Theo Jaffee speak with Balaji Srinivasan, angel investor, entrepreneur, and author of The Network State, about how AI is transforming media, eroding trust, and reshaping how information is created and verified. They discuss why systems like hiring, journalism, and online communication are breaking under synthetic content, and what replaces them. The conversation also examines the role of cryptography, on-chain data, and new models of proof in rebuilding trust

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01:07:18

Marc Andreessen: Monitoring the Situation and the...

The a16z Show ·

2026/04/21

Erik Torenberg and Theo Jaffee speak with Marc Andreessen, cofounder and general partner at a16z, about the launch of Monitoring the Situation (MTS), a new, always-on media network on X. They discuss the rise of the “current thing,” how narratives spread in real time, and why internet-native media is reshaping politics, culture, and attention.Resources: Follow Marc X: https://x.com/pmarca Follow Eric on X: https://x.com/eriktorenberg Follow Theo on X: https://x.com/theojaffee Follow MTS on X:

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00:47:05

Rethinking Git for the Age of Coding Agents with...

The a16z Show ·

2026/04/20

Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler, about why Git's user interface has barely changed since 2005, how GitButler is rethinking version control for both humans and AI agents, and what the "next GitHub" might actually look like. They cover parallel branches, agent-optimized CLI design, the future of code review, and why the best engineers of the future will be the best writers. Resources: Follow Scott Chacon on X: https://twitter.com/chacon Follow Matt

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00:58:45

Network Effects, AI Costs, and the Future of Consumer...

The a16z Show ·

2026/04/19

This episode originally aired on The Kevin Rose Show. Kevin Rose speaks with Anish Acharya, general partner at a16z, about how AI is rewriting the rules of consumer software, the defensibility of network effects in a world where anyone can spin up an app in 48 hours, and why the real threat to consumer founders may be the cost of inference, not competition. They also discuss model pricing, the future of the four-day work week, and peptides. Resources: Follow Anish on X:

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01:04:01

The System Behind Self-Driving: Waymo’s Dmitri Dolgov

The a16z Show ·

2026/04/17

Waymo is now delivering hundreds of thousands of fully autonomous rides each week — but getting there required more than better models. It meant building a complete system for training, evaluating, and deploying a driver in the real world. In this episode — originally aired on the Cheeky Pint podcast — Waymo Co-CEO Dmitri Dolgov joins John Collison to break down how self-driving actually works today: from sensor fusion across LiDAR, radar, and cameras, to simulation, “critic” models, and the role of

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00:34:12

Technology, Culture, and the Next AI Interface with...

The a16z Show ·

2026/04/16

Erik Torenberg and Anish Acharya, general partners at a16z, speak with signüll about how technology reshapes culture, relationships, and the products we build. The conversation covers tacit knowledge versus intellectual knowledge, dating apps and their effect on human connection, AI relationships, why Claude feels artisan while other models feel utilitarian, and what consumer founders should actually care about.Resources: Follow signüll on X: https://twitter.com/signulll Follow Anish Acharya on

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01:39:18

Replit's CEO on Vibe Coding, Wealth Building, and...

The a16z Show ·

2026/04/15

Jack Neel speaks with Amjad Masad, CEO at Replit, about how AI is making it easier than ever to build and ship software without a technical background. They discuss Replit's rise from a browser-based coding tool to a platform generating $250 million in annual revenue, why Masad turned down a $1 billion acquisition offer, and his case for why AI represents empowerment rather than existential risk. This episode originally aired on The Jack Neel Podcast.Follow Amjad Masad on X:

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00:29:43

Ben Horowitz on AI Infrastructure, Economics and The...

The a16z Show ·

2026/04/14

Recorded live at the a16z Fintech Connect conference in Deer Valley, Alex Rampell speaks with Ben Horowitz, cofounder and general partner at a16z, about how AI has rewritten the fundamental rules of software competition, why crypto infrastructure will become essential in an AI-dominated world, and what the future holds for venture capital. Resources: Follow Alex Rampell on X: https://twitter.com/arampell Follow Ben Horowitz on X: https://twitter.com/bhorowitz Stay Updated:Find a16z on YouTube:

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00:54:39

Building Agents at Home: Parenting, Work, and...

The a16z Show ·

2026/04/13

Katherine Boyle and Sarah Wang speak with Jesse Genet, a startup founder and family builder, about building 11 AI agents while homeschooling four young children. Jesse runs agents across roles ranging from coding to curriculum planning to household management, and she shares how agent architecture, logging systems, and “benevolent neglect” parenting have changed her life as both a founder and a mother. Resources: Follow Jesse Genet on X: https://twitter.com/jessegenet Follow Katherine Boyle on X:

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00:31:23

What Running Windows at Microsoft Taught Steven...

The a16z Show ·

2026/04/10

Theo Jaffee speaks with Steven Sinofsky, board partner at a16z and former president of the Windows division at Microsoft, about Apple's 50th anniversary, the cultural differences that separated Apple and Microsoft, why the MacBook Neo puts Windows laptops in a difficult position, and what the history of computing design reveals about where hardware and software are headed.Resources: Follow Steven Sinofsky on X: https://twitter.com/stevesi Follow Theo Jaffee on X:

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01:39:00

Who Controls AI Acceleration? Vitalik Buterin and...

The a16z Show ·

2026/04/09

Eddy Lazzarin speaks with Vitalik Buterin, founder of Ethereum, and Guillaume Verdon, founder and CEO of Extropic, about whether AI progress can or should be steered, the risks of concentrated power, and what open source and decentralization mean for who benefits from increasingly powerful systems. This episode originally aired on the a16z crypto podcast. Resources: Follow Vitalik Buterin on X: https://twitter.com/VitalikButerin Follow Guillaume Verdon on X: https://twitter.com/GillVerd Follow

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00:59:37

The Agent Era: Building Software Beyond Chat with Box...

The a16z Show ·

2026/04/08

Erik Torenberg, Steve Sinofsky, and Martin Casado speak to Aaron Levie, CEO at Box, about what happens to enterprise software when agents become the primary users. They discuss why coding agents succeed where other knowledge work agents struggle, what abstraction layers mean for the workforce, and how data access and systems of record must change in an agent-first world.Resources: Follow Aaron Levie on X: https://twitter.com/levie Follow Steve Sinofsky on X: https://twitter.com/stevesi Follow

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1,198 results

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