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PODCAST

Talking Biotech with Dr. Kevin Folta

Talking Biotech is a weekly podcast that uncovers the stories, ideas and research of people at the frontier of biology and engineering. Each episode explores how science and technology will transform agriculture, protect the environment, and feed 10 billion people by 2050. Interviews are led by Dr. Kevin Folta, a professor of molecular biology and genomics.

science life sciences

All Episodes

37:21

Cancer Misinformation - Dr. Skyler Johnson

Talking Biotech with Dr. Kevin Folta ·

2022/11/12

"Cancer" is the generic term applying to any one of many cellular proliferative disorders that threaten normal physiology. Various cancers have specific etiologies and require expertise in detection and treatment. New therapies are as innovative as they are promising, and a once dreaded prognosis now may have increased opportunity for cure, with better therapies on the horizon. But as it goes, with innovation comes resistance, and false information about cancer and its treatment flourish

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48:20

Livestock, Climate Change, and Attacks on a Scientist...

Talking Biotech with Dr. Kevin Folta ·

2022/11/05

Animal agriculture contributes greenhouse gases that can influence climate change. One source in particular is cattle, as ruminant livestock produce methane from their specialized digestion, which is an especially potent greenhouse gas. Dr. Frank Mitloehner of the University of California Davis is an air quality expert in the area of ruminant biology. His research examines ways to mitigate the impact of livestock on climate, and his outreach efforts ensure that the information reaches the

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37:43

A Gene-Edited Vaccine Against Malaria - Dr. Stefan Kappe

Talking Biotech with Dr. Kevin Folta ·

2022/10/29

The mosquito is the most deadly animal on earth. It vectors a plasmodium, a eukaryotic parasite that invades the liver of the host and ultimately attacks red blood cells. There are some therapies and preventatives, but a durable vaccine would be a game changer in the Developing World. Dr. Stefan Kappe and his team have developed a vaccine based on the weakened plasmodium parasite. They used CRISPR/Cas9 gene editing to disrupt genes required for life cycle progression, so the vaccinated

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62:57

Seralini's Lumpy Rats - Ten Years Later

Talking Biotech with Dr. Kevin Folta ·

2022/10/22

Ten years ago the biotech world froze and horrific images of three tumor-ridden rats penetrated the media. Social media erupted with messages of fear, and anti-biotech activists celebrated the scientific publication that conclusively linked biotech crops and an associated herbicide to cancer and early death. But at the same time a scientific community noted the shortcomings of the work. Eventually the paper was retracted, and independent research commissioned by the European Union failed to

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47:37

New Therapeutics for Novel Problems through...

Talking Biotech with Dr. Kevin Folta ·

2022/10/08

Dr. Betsy O'neill, VP of External Innovation at Horizon Therapeutics describes how strategic partnerships can assist biotech startups in moving new therapies through development to deployment. She discusses her company's collaborative approach, and how working together can assist in efforts to navigate the challenging business and regulatory environment.

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28:50

The Long COVID HERV Connection - Dr. Claudia Matteucci

Talking Biotech with Dr. Kevin Folta ·

2022/10/01

Human endogenous retroviruses (HERVs) are genome-resident relics of ancient infections. They comprise 8% of the human genome, and are activated by viral infections. Proteins like HERV-W and HERV-K accumulate following infections and have been causally connected to Multiple Sclerosis and Amyotrophic Lateral Sclerosis. Scientists have now observed that SARS-CoV2 infection also induces expression of specific HERV proteins. Prof. Claudia Matteucci discusses the role of HERVs and their tie to

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30:43

Purple Tomatoes and Health - Dr. Cathie Martin

Talking Biotech with Dr. Kevin Folta ·

2022/09/24

Anthocyanins are a class of plant pigments associated with healthful qualities in food. While research continues to assess their true health benefits in vivo, there is no question that the attractive fruits stimulate the senses and bring novelty to the diet. Dr. Cathie Martin of the John Innes Center in Norwich, England discusses the technology behind the purple tomato, its potential benefits to animal health, its effects on tomato shelf life, and the recent USDA nod to release of the

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40:02

Rapid Detection of Sexually Transmitted Infections...

Talking Biotech with Dr. Kevin Folta ·

2022/09/17

Sexually transmitted infections like chlamydial and gonorrhea are making a comeback, especially with younger demographics. Part of the problem is the stigma of examination and testing. These are not trivial infections, and can result in more complicated syndromes, which could include sterility or issues reproductive health. Early, discrete, confidential detection is key. Today's guest is Dr. Anna Dixon. She's the Chief Technology Officer of Binx Health. Her company has devised a

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42:21

The Gut-Brain Axis: What it is, associated problems...

Talking Biotech with Dr. Kevin Folta ·

2022/09/10

Communication between the digestive system and brain is much more intricate than previously thought. The digestive epithelium is laced with sensors that monitor the contents of the gut, reporting back to the brain, stimulating appropriate hormones and digestive action to guide motility, chemistry, and absorption. This network is frequently referred to as the 'second brain' because of the dense neurophysiology at work. Recently it has been hypothesized that dysfunction in the gut-brain axis

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33:06

Dr. Nikolay Kandul: Precision Insect Control with...

Talking Biotech with Dr. Kevin Folta ·

2022/09/03

Insects cause massive losses in human health and agriculture. Scientists have implemented Sterile Insect Technique for over 50 years, a process to suppress populations by introducing genetically-damaged insects into natural settings. Upon mating, the offspring. Scientists have now used gene editing techniques to selectively suppress the Spotted Wing Drosophila, a costly pest in agricultural contexts. Today's podcast is an interview with Dr. Nikolay Kandul, a scientist working with a team

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44:29

Dr. Alison Van Eenennaam: Update on Animal Genome...

Talking Biotech with Dr. Kevin Folta ·

2022/08/27

While the vast majority of gene editing efforts have been confined to crop plants, animal gene editing holds tremendous promise. Efforts have demonstrated that naturally-occurring alleles could be reconstituted using site-specific nucleases, creating hornless dairy cattle and beef cattle with sex ratios skewed towards a higher proportion of males. These breakthroughs are just a sample of the powerful technology. Dr. Alison Van Eenennaam is a Cooperative Extension Specialist at the

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52:03

Dr. Liang Schweizer: Creating Targeted Antibodies in...

Talking Biotech with Dr. Kevin Folta ·

2022/08/20

Immunotherapies represent a powerful suite of treatments that co-opt the immune system to target deleterious cellular conditions. They have been effective with a series of cancers and other disorders. The problem is that development of new antibodies can be challenging for several technical reasons, but also because no two people are alike. Dr. Liang Schweizer of HiFiBio describes how her company is using single-cells and microfluidics to identify new antibodies that may be mobilized

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40:07

Celine Halioua: Extending Health and Life, Starting...

Talking Biotech with Dr. Kevin Folta ·

2022/08/13

Dogs are a recent species, and because of their close associations with humans have diverged into hundreds of breeds with specific behaviors, sizes and builds. There also is a great range in life expectancy and anticipated disease. Dogs therefore provide an excellent model to study aging and aging-related disorders, as well as understand the genetics and associated factors of aging. Celine Halioua, the CEO of Loyal, joins the podcast to discuss research into dog genetics and the factors

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48:17

Dr. Mallory Embree: Optimizing Animal Microbiomes

Talking Biotech with Dr. Kevin Folta ·

2022/08/06

A microbiome is described as a population of bacteria, fungi, protists and viruses that inhabit a specific environment. Animals, including humans, are composed of many microbiomes featuring trillions of microbes. There are different microbiomes found throughout the animal digestive tract, each with important roles in animal digestion, feed conversion, overall health. Dr. Mallory Embree is the co-founder and CSO of Native Microbials. Her company has explored relationships between microbial

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45:24

Dr. Shelley McGuire and Gabe Ignetti: Glyphosate in...

Talking Biotech with Dr. Kevin Folta ·

2022/07/30

This week's podcast has two parts. In the first section University of Idaho lactation specialist Dr. Shelley McGuire discusses the recent paper that claims to have found the herbicide glyphosate in breast milk. In the second half Gabe Ignetti from the Ecomodernist Society of North America discusses an environmental movement that embraces science, including biotechnology and nuclear power.

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33:23

Dr. Erica Barnell: Stool-Based Detection of Colon Cancer

Talking Biotech with Dr. Kevin Folta ·

2022/07/23

Colorectal cancer is one of the leading causes of cancer death, but is remarkably treatable if caught early. Unfortunately, because of the invasive nature of the colonoscopy, many elect not to have this procedure done in a regular and timely manner. Colorectal cancers advance from normal cells through several distinct neoplasias, each with distinct patterns of gene expression. Today's guest is Dr. Erica Barnell from Geneoscopy. They have devised a test to identify evidence of precancerous

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38:10

Dr. Scott Franklin: Microalgae - Factories for...

Talking Biotech with Dr. Kevin Folta ·

2022/07/16

The foundation of many modern consumer products begins with petroleum. Fossil fuels contain the building blocks of higher-complexity polymers, and are used in the creation of everything from high performance plastics in medical devices to your computer screen. But using petroleum use is not sustainable and has impacts in climate and pollution. What if the same molecular polymer backbones could be produced using biological organisms? Dr. Scott Franklin from Checkerspot explains how

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35:54

Joel Rurik: CAR-T Therapies to Reverse Cardiac Fibrosis

Talking Biotech with Dr. Kevin Folta ·

2022/07/09

Injury to organs frequently results in impaired function due to the formation of scar tissue. Heart attacks and chronic high blood pressure can induce the formation of pathogenic fibroblasts, cells that lose their original function, yet maintain some structural element of the injured tissue. The formation of fibrogenic tissue affects a significant portion of the population, and contributes to decline associated with many diseases, such as congestive heart failure or liver cirrhosis. A new

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26:23

Dr. Sandra Pritzkow: Prions and Chronic Wasting Disease

Talking Biotech with Dr. Kevin Folta ·

2022/07/02

Prion disorders are rare neurological diseases where a protein within the nervous system converts to a pathological form. The change in conformation affects other proteins, recruiting them to the misshapen, deleterious type. Chronic wasting disease is a neurological disease of deer, caused by prion conversion. In this episode Dr. Sandra Pritzkow from University of Texas Health - Houston describes prion related disease, and specifically the atypical transmission elements of chronic wasting

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47:06

Dr. Liza Dunn: Biotech, Pesticides, Toxicology and Food

Talking Biotech with Dr. Kevin Folta ·

2022/06/25

Specific chemistries are used to protect crops from insects, weeds, fungi and other microbes. Legacy issues with some older pesticides led to restrictions or bans on their use. Unfortunately, suspicion remains around contemporary solutions, even though today's chemistries are highly specific, with low toxicity to non-target organisms, including humans. Use of crop protection compounds is critical to all agriculture, including organic production. However, activist groups continue to

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486 results

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