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PODCAST

Talking Biotech with Dr. Kevin Folta

Talking Biotech is a weekly podcast that uncovers the stories, ideas and research of people at the frontier of biology and engineering. Each episode explores how science and technology will transform agriculture, protect the environment, and feed 10 billion people by 2050. Interviews are led by Dr. Kevin Folta, a professor of molecular biology and genomics.

science life sciences

All Episodes

33:06

Dr. Nikolay Kandul: Precision Insect Control with...

Talking Biotech with Dr. Kevin Folta ·

2022/09/03

Insects cause massive losses in human health and agriculture. Scientists have implemented Sterile Insect Technique for over 50 years, a process to suppress populations by introducing genetically-damaged insects into natural settings. Upon mating, the offspring. Scientists have now used gene editing techniques to selectively suppress the Spotted Wing Drosophila, a costly pest in agricultural contexts. Today's podcast is an interview with Dr. Nikolay Kandul, a scientist working with a team

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44:29

Dr. Alison Van Eenennaam: Update on Animal Genome...

Talking Biotech with Dr. Kevin Folta ·

2022/08/27

While the vast majority of gene editing efforts have been confined to crop plants, animal gene editing holds tremendous promise. Efforts have demonstrated that naturally-occurring alleles could be reconstituted using site-specific nucleases, creating hornless dairy cattle and beef cattle with sex ratios skewed towards a higher proportion of males. These breakthroughs are just a sample of the powerful technology. Dr. Alison Van Eenennaam is a Cooperative Extension Specialist at the

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52:03

Dr. Liang Schweizer: Creating Targeted Antibodies in...

Talking Biotech with Dr. Kevin Folta ·

2022/08/20

Immunotherapies represent a powerful suite of treatments that co-opt the immune system to target deleterious cellular conditions. They have been effective with a series of cancers and other disorders. The problem is that development of new antibodies can be challenging for several technical reasons, but also because no two people are alike. Dr. Liang Schweizer of HiFiBio describes how her company is using single-cells and microfluidics to identify new antibodies that may be mobilized

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40:07

Celine Halioua: Extending Health and Life, Starting...

Talking Biotech with Dr. Kevin Folta ·

2022/08/13

Dogs are a recent species, and because of their close associations with humans have diverged into hundreds of breeds with specific behaviors, sizes and builds. There also is a great range in life expectancy and anticipated disease. Dogs therefore provide an excellent model to study aging and aging-related disorders, as well as understand the genetics and associated factors of aging. Celine Halioua, the CEO of Loyal, joins the podcast to discuss research into dog genetics and the factors

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48:17

Dr. Mallory Embree: Optimizing Animal Microbiomes

Talking Biotech with Dr. Kevin Folta ·

2022/08/06

A microbiome is described as a population of bacteria, fungi, protists and viruses that inhabit a specific environment. Animals, including humans, are composed of many microbiomes featuring trillions of microbes. There are different microbiomes found throughout the animal digestive tract, each with important roles in animal digestion, feed conversion, overall health. Dr. Mallory Embree is the co-founder and CSO of Native Microbials. Her company has explored relationships between microbial

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45:24

Dr. Shelley McGuire and Gabe Ignetti: Glyphosate in...

Talking Biotech with Dr. Kevin Folta ·

2022/07/30

This week's podcast has two parts. In the first section University of Idaho lactation specialist Dr. Shelley McGuire discusses the recent paper that claims to have found the herbicide glyphosate in breast milk. In the second half Gabe Ignetti from the Ecomodernist Society of North America discusses an environmental movement that embraces science, including biotechnology and nuclear power.

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33:23

Dr. Erica Barnell: Stool-Based Detection of Colon Cancer

Talking Biotech with Dr. Kevin Folta ·

2022/07/23

Colorectal cancer is one of the leading causes of cancer death, but is remarkably treatable if caught early. Unfortunately, because of the invasive nature of the colonoscopy, many elect not to have this procedure done in a regular and timely manner. Colorectal cancers advance from normal cells through several distinct neoplasias, each with distinct patterns of gene expression. Today's guest is Dr. Erica Barnell from Geneoscopy. They have devised a test to identify evidence of precancerous

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38:10

Dr. Scott Franklin: Microalgae - Factories for...

Talking Biotech with Dr. Kevin Folta ·

2022/07/16

The foundation of many modern consumer products begins with petroleum. Fossil fuels contain the building blocks of higher-complexity polymers, and are used in the creation of everything from high performance plastics in medical devices to your computer screen. But using petroleum use is not sustainable and has impacts in climate and pollution. What if the same molecular polymer backbones could be produced using biological organisms? Dr. Scott Franklin from Checkerspot explains how

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35:54

Joel Rurik: CAR-T Therapies to Reverse Cardiac Fibrosis

Talking Biotech with Dr. Kevin Folta ·

2022/07/09

Injury to organs frequently results in impaired function due to the formation of scar tissue. Heart attacks and chronic high blood pressure can induce the formation of pathogenic fibroblasts, cells that lose their original function, yet maintain some structural element of the injured tissue. The formation of fibrogenic tissue affects a significant portion of the population, and contributes to decline associated with many diseases, such as congestive heart failure or liver cirrhosis. A new

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26:23

Dr. Sandra Pritzkow: Prions and Chronic Wasting Disease

Talking Biotech with Dr. Kevin Folta ·

2022/07/02

Prion disorders are rare neurological diseases where a protein within the nervous system converts to a pathological form. The change in conformation affects other proteins, recruiting them to the misshapen, deleterious type. Chronic wasting disease is a neurological disease of deer, caused by prion conversion. In this episode Dr. Sandra Pritzkow from University of Texas Health - Houston describes prion related disease, and specifically the atypical transmission elements of chronic wasting

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47:06

Dr. Liza Dunn: Biotech, Pesticides, Toxicology and Food

Talking Biotech with Dr. Kevin Folta ·

2022/06/25

Specific chemistries are used to protect crops from insects, weeds, fungi and other microbes. Legacy issues with some older pesticides led to restrictions or bans on their use. Unfortunately, suspicion remains around contemporary solutions, even though today's chemistries are highly specific, with low toxicity to non-target organisms, including humans. Use of crop protection compounds is critical to all agriculture, including organic production. However, activist groups continue to

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44:27

Dr. Asaf Hellman: Methylation of DNA, Relationship to...

Talking Biotech with Dr. Kevin Folta ·

2022/06/18

Epigenetic regulation of gene expression occurs via many mechanisms. One method is the methylation of regulatory sequences that control the expression of specific genes. Methylation is the addition of a small methyl group to specific bases of the DNA helix. Addition of a methyl group can change how the DNA blueprint is accessed and expressed. Today's guest is Prof. Asaf Hellman. His group has found relationships between the methylation state of DNA and expression of genes associated with

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43:06

Dr. Tim Errington: Addressing the Issue of Scientific...

Talking Biotech with Dr. Kevin Folta ·

2022/06/10

Recent reports criticized the lack of reproducibility in scientific publications, and this has profound effects on the public's trust in research results. Today's interview is with Tim Errington, Director of Research at the Center for Open Science. The Center for Open Science has devised a series of strategies and tools that can help improve reproducibility, as well as offer collateral benefits to scientists.

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33:29

Dr. Mathias Uhlen: The Human Protein Atlas

Talking Biotech with Dr. Kevin Folta ·

2022/06/04

Proteins define the structure and function of cells. The human genome encodes tens of thousands of proteins, yet we know surprisingly little about most of their functions. The Human Protein Atlas uses labor-intensive methods to identify the tissue localization of a significant catalog of human proteins. The reasoning is that if we know where a protein is expressed, we can begin to infer roles in cellular processes. The Human Protein Atlas is an open source resource of over 15 million images

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43:24

Dr. Dietrich Stephan: New Drugs that Repair Broken Genes

Talking Biotech with Dr. Kevin Folta ·

2022/05/28

Many diseases do not have cures, yet from deleterious mutations in the genome. Many of these are rare disorders that do not benefit from extensive research or drug development. Current therapies mask symptoms more than solve the basis of the disorder. Dietrich Stephan of NewBase describes a novel custom drug design platform that shows amazing potential in animal models. A small oligonucelotide with a specific backbone can bind to its complementary sequence in DNA or RNA, derailing RNA

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51:43

Jon Guy: An Owner's Manual for the Mind

Talking Biotech with Dr. Kevin Folta ·

2022/05/21

We are bombarded by claims, and have access to the most information in human history, instantly. How do we sort it out? What is real and what's not? Who do we trust? These are major questions today, and affect everything from public health to the foundations of democracy in the USA. From the news to the internet to the dinner table we are immersed in suspect information. How do we recognize and address conspiratorial thinking? What mistakes do we make when analyzing a problem? How can

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37:48

Meredith Fensom: Update on Self-Limiting Mosquitoes

Talking Biotech with Dr. Kevin Folta ·

2022/05/14

Mosquitoes are the world's most dangerous animals, vectoring dozens of diseases. One of the major disease vectors is Ades aegypti, an invasive insect with an ever-expanding range. Municipalities have turned to insecticides for control, which can impact beneficial insects. Sterile insect techniques, performed by mutagenizing mosquitoes to sterility, can work well in controlling insect populations. Over the last decade, Oxitec has advanced technologies that use a molecular techniques to

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51:05

Dr. Oki O'Connor: New Drugs Targeting Dangerous...

Talking Biotech with Dr. Kevin Folta ·

2022/05/07

Heart attack and stroke are leading causes of death worldwide. Current treatments are aimed at prevention-- using various medications to control the health of the circulatory system. This week's podcast speaks with Dr. Oki O'Connor, Co-CEO of Underdog Pharmaceuticals. Dr. O'Connor discusses the cellular basis of atherosclerosis, and how modified cholesterol play a central role in its development. We then discuss the ability of a cyclical carbohydrate called cyclodextrin to sequester

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44:44

Dr. Awais Khan: Breeding the Next Amazing Apple

Talking Biotech with Dr. Kevin Folta ·

2022/04/30

Apples are a beloved fruit, with over 8000 varieties available worldwide. The apples in the grocery store represent just a tiny section of apple genetic potential, a few flavors that ship well and can be stored for a long period of time. But today in the genomics era new tools seek to speed the breeding of apples to create new varieties, flavors, and disease resistance packages. The goal is to help farmers and consumers produce the next generation of superior apple varieties. With Dr

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61:08

Dr. Michael Levin: Biological Plasticity,...

Talking Biotech with Dr. Kevin Folta ·

2022/04/23

The process of animal development is a complex coordination of different genes through time. At least that's what we thought. Dr. Michael Levin from Tufts University is forcing us to rethink these processes, with impacts in medicine, cancers, correction of developmental defects and limb regeneration. ,

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