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PODCAST

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and

science life sciences

All Episodes

16:54

87: The Hidden Pitfalls of Bioprocess Development:...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/09/10

Send us a textUnlock the secrets of successful bioprocess development with host David Brühlmann as he shares hard-won lessons from his 15+ years of experience leading technology transfers and technology innovation projects.Discover why prioritizing process development is crucial for transforming groundbreaking science into life-changing therapies. In this eye-opening episode, you'll learn:How to avoid costly mistakes in technology transfer and scale-up, saving you time and resourcesStrategies...

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23:01

86: Bioprocess 4.0: Integrated Continuous...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/09/05

Send us a textWhat if your biomanufacturing facility could run itself, optimize its own processes, and operate non-stop? This isn't science fiction – it's the cutting-edge reality Professor Massimo Morbidelli is helping to create.In this captivating episode, the bioprocessing pioneer unveils how AI, continuous manufacturing, and revolutionary machine learning techniques are transforming the industry landscape.As a Professor Emeritus at ETH Zurich and Politecnico di Milano, and a co-founder of...

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24:04

85: Bioprocess 4.0: Integrated Continuous...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/09/03

Send us a textImagine a world where biologic drugs are produced faster, cheaper, and with unprecedented precision.In this episode, we dive into that future with Professor Massimo Morbidelli, a trailblazer in bioprocessing innovation. As a Professor Emeritus at ETH Zurich and Politecnico di Milano, and a co-founder of ChromaCon (now YMC) and DataHow, Massimo Morbidelli has been at the forefront of bioprocess innovation. He is currently the recipient of the ERC Advanced Grant Continuous Digital...

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23:17

84: The Hidden Potential of Shake Flasks: What Every...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/29

Send us a textAre your shake flasks holding back your bioprocess development? Discover how to transform them into smart bioreactors! In this game-changing episode, we talk with Jens Bayer about the groundbreaking DOTS platform. He is a deep tech entrepreneur and seasoned commercial leader, currently serving as Chief Commercial Officer at Scientific Bioprocessing.Jens reveals how this cutting-edge technology is bridging the gap between simple shake flasks and complex bioreactors, offering scie...

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18:25

83: The Hidden Potential of Shake Flasks: What Every...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/27

Send us a Text Message.Are shake flasks outdated relics or untapped goldmines of bioprocess development? In this eye-opening episode, we dive deep with Jens Bayer, a deep tech entrepreneur and seasoned commercial leader, currently serving as Chief Commercial Officer at Scientific Bioprocessing.Jens shatters common misconceptions about shake flasks, revealing why they remain indispensable tools in both industry and research settings.Discover:Why shake flasks are irreplaceable for rapid, cost-e...

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17:58

82: Regenerating Muscles: The Future of Autologous...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/22

Send us a Text Message.Dive into the cutting-edge world of autologous cell-based therapy with Deana Mohr, CEO and co-founder of MUVON Therapeutics, spin-off from the University of Zurich. In this eye-opening episode, discover how MUVON Therapeutics’ innovative approach to muscle regeneration is revolutionizing treatments for stress urinary incontinence and beyond.Learn how her team is tackling the challenges of bringing personalized medicine to market at scale, from navigating complex regulat...

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22:35

81: Regenerating Muscles: The Future of Autologous...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/20

Send us a Text Message.Discover how scientists are transforming lives through innovative muscle regeneration therapy. In this captivating episode, Deana Mohr, CEO and co-founder of MUVON Therapeutics, spin-off from the University of Zurich, unveils her groundbreaking autologous muscle regeneration technology for treating stress urinary incontinence.Learn how this minimally invasive treatment harnesses the power of a patient's own cells to restore muscle function, offering hope to millions. Di...

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20:14

80: Think Before You Build: Holistic Approaches to...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/15

Send us a Text Message.Ever wondered why some biotech facilities thrive while others struggle Alfredo Martínez Mogarra, a Bioprocess Engineer with over 30 years of experience and Chief Operations Manager at VIVEbiotech, reveals the secrets to successful biotech manufacturing.In this eye-opening episode, Alfredo shares critical insights on bridging the gap between lab-scale processes and industrial production.You will get:Strategies for seamless scale-up and risk mitigation in bioprocess devel...

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24:24

79: Think Before You Build: Holistic Approaches to...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/13

Send us a Text Message.Ever wondered what it takes to build a large-scale biotech manufacturing facility? Alfredo Martínez Mogarra, a seasoned Bioprocess Engineer with over 30 years of experience and Chief Operations Manager at VIVEbiotech, reveals the secrets behind successful biotech facility design and scale-up. He has been at the forefront of transforming bench processes into industrial realities.In this eye-opening episode, Alfredo shares critical insights on navigating the complex world...

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18:10

78: Cell Factories Explained: How Synthetic Biology...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/08

Send us a Text Message.Unlock the secrets of cell factories and discover how cutting-edge technologies are revolutionizing biopharmaceutical production. In this episode, we welcome Mauro Torres, a postdoctoral researcher at the University of Manchester, who takes us on a fascinating journey through the complex world of protein manufacturing.Mauro Torres explains the intricate steps involved in the secretory pathway, from gene expression to protein export, likening it to a sophisticated car ma...

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23:00

77: Cell Factories Explained: How Synthetic Biology...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/06

Send us a Text Message.Unlock the secrets of cell factories with Mauro Torres, a postdoctoral researcher at the University of Manchester who brings cutting-edge insights into protein production. Discover how the concept of cell factories has evolved from basic insulin extraction to groundbreaking treatments for genetic disorders and cancer. We reveal the challenges faced by biotech scientists in bioprocess development and offers a fascinating analogy between car manufacturing and cellular pro...

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23:29

76: Transforming Single-Cell Analysis With Impedance...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/01

Send us a Text Message.Curious about the latest innovations in cell analysis technology? Join us in this episode with Furkan Gökçe, New Business Development Manager at Amphasys, as we delve into the fascinating world of Impedance Flow Cytometry (IFC).Furkan shares how IFC is revolutionizing single-cell analysis by providing faster, more precise, and high-resolution data.Key Takeaways:Real-Time Precision: Discover how IFC allows for real-time, label-free assessments of cells, providing detaile...

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17:24

75: Transforming Single-Cell Analysis With Impedance...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/30

Send us a Text Message.Ever wondered how single-cell analysis could revolutionize bioprocessing? Join us in this episode as we delve into the cutting-edge world of impedance flow cytometry.Furkan Gökçe, New Business Development Manager at Amphasys, shares his insights on the transformative power of this technology in the biotech industry. With a background in engineering and physics, Furkan provides a unique perspective on tackling the complexities of biological systems.Key Takeaways:Enhanced...

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17:17

74: Bead-Based Assays: The Power of High-Throughput...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/25

Send us a Text Message.Dive into the transformative world of bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech, where high-throughput screening meets cutting-edge biotechnological advancements.Join us as we chat with Sebastian, a seasoned scientist and entrepreneur who has revolutionized the workflow of high-throughput screening of titer, glycosylation, and aggregation with innovative bead-based assays.Key Takeaways:Streamlined Workflow: Learn how a simplified sample ...

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19:18

73: Bead-Based Assays: The Power of High-Throughput...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/23

Ready to revolutionize your lab work? Join us as we dive deep into bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech.Discover how these tiny beads are making a massive impact on biotech research and development — for titer, glycan, and aggreation screening — and how this developability screening platform can enhance your antibody discovery, antibody engineering and lead optimization.In this episode, you’ll learn:Speed and Simplicity: How bead-based assays offer unmatc...

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21:59

72: Effective Outsourcing: How Small Biotech...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/18

How do small biotech companies make strategic decisions with limited resources? This episode dives deep into the art of prioritization and outsourcing to achieve success.Join us as we speak with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, a seasoned biotech scientist with years of experience in both large and small biotech companies. Mark shares his invaluable insights on navigating the complexities of bioprocess development and outsourcing.In this episode, we ex...

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18:32

71: Effective Outsourcing: How Small Biotech...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/16

Are you navigating the complex world of bioprocess CMC development and manufacturing in a small biotech company?Our latest episode is a must-listen! Join us as we sit down with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, who shares invaluable insights on overcoming the unique challenges faced by small biotech firms.In this episode, we explore:The critical communication strategies needed for successful outsourcing to CDMOs.How small biotechs can leverage their agi...

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15:31

70: Glycoanalytics Explained: Analysing and Designing...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/11

In this insightful episode, we explore the cutting-edge field of glycoengineering and its transformative impact on biopharmaceutical drug design. Join us as we chat with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, to uncover the nuances of chemoenzymatic glycogen engineering and its potential to revolutionize therapeutics.Key Takeaways:Understanding Glycoengineering: Discover the three main approaches—genetic, metabolomic, and chemoenzymatic—f...

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18:09

69: Glycoanalytics Explained: Analysing and Designing...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/09

Uncover the hidden science behind creating safer, more effective biological drugs! Dive into glycoanalytics and glycoengineering, the secret weapons revolutionizing biopharma.Join us as we talk with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, who breaks down the complexities of glycosylation and its pivotal role in drug development.Key Takeaways:Critical Quality Attributes: Understand how glycans influence the function and structure of biophar...

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28:53

68: How Process Mapping Transforms Knowledge...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/04

Join us as we explore the pivotal role of process mapping in biotech knowledge management. Our guest, Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, shares invaluable insights into leveraging technology to streamline operations.Key Insights:Identifying Critical Process Knowledge: Learn strategies to identify and manage vital process knowledge essential for optimal performance.Transitioning from Implicit to Explicit Knowledge: Disco...

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175 results

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