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PODCAST

Springer Nature

Springer Nature

Welcome to the Springer Nature Soundcloud page! Here you will find several podcasts from our journals across a range of scientific subjects, including Gene Pod, ModPath Chat, Pediapod, Hereditypod and Brainpod.

science

All Episodes

00:11:41

Severe intraventricular hemorrhage in a rabbit model...

Springer Nature ·

2022/08/02

Intraventricular hemorrhage (IVH) occurs in around 45% of infants born below 26 weeks gestational age, causing significant lifelong morbidity and mortality. However, there is currently no effective treatment. In part, this is due to the lack of well-characterised representative preterm animal models with long-term follow up. In this episode, we meet our highlighted Early Career Investigator Olga Romantsik, from Lund University in Sweden. She and her team used an established preterm rabbit pup

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00:50:02

Mendel to Modern Genetics

Springer Nature ·

2022/07/27

On the 20th July, The Genetics Society held a fantastic Garden Party to celebrate the 200th birthday of Gregor Mendel: a man regarded by many as the "father of modern genetics". In this episode we showcase a talk given on the day by Prof. Alison Woollard (University of Oxford) titled: ‘Mendel to Modern Genetics’. You can find a recording of the full event on the Genetics Society’s YouTube Channel: https://www.youtube.com/watch?v=zP8hB4ijAEc&t=3426s You can also find the Heredity Special Issue -

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00:15:21

Heterogeneity of molecular alterations in CRC with...

Springer Nature ·

2022/07/22

In a subset of patients with metastatic colorectal cancer (mCRC), the peritoneum is the predominant site of dissemination. While cure can be achieved by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), this procedure is associated with long-term morbidity and high relapse rates. In this episode of ModPath CHAT, Drs. Siesing and Jirstrom from Lund University in Sweden discuss their recent study in Modern Pathology on the topic. Multi-region immunohistochemical

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00:17:21

A Risk Stratification Model for Low Stage Uterine...

Springer Nature ·

2022/07/07

Uterine leiomyosarcoma is the most common uterine mesenchymal malignancy. The majority present at stage I with variable clinical outcome. In this episode of ModPath Chat, Dr. David Chapel discusses his recently published multi-institutional study proposing a novel risk stratification model (shown below) for low stage uterine leiomyosarcoma. Risk score = (coagulative necrosis)(1) + (mitoses > 25 per 2.4mm2)(2) + (atypical mitoses)(2) + (lymphovascular invasion)(3) + (serosal abutment)(5)

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00:12:17

Maternal early exposure to violence, psychopathology,...

Springer Nature ·

2022/07/05

A recent study reported that 53% of mothers reported exposure to violence when they were children. And there is evidence that these experiences negatively impact the health and development of their offspring later on. Associations between maternal exposure to violence, psychopathology and children's mental health outcomes is well documented. However, the pre- and postnatal programming pathways between early exposure to violence, maternal psychopathology and children's cognitive and developmental

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00:22:19

A promising role for methylome and copy number...

Springer Nature ·

2022/06/23

In this episode the audience will enjoy a great discussion of the growing potential of methylome and copy number profiling, a technique well established for the classification of brain tumors, in bone and soft tissue tumors diagnosis. Nuclear overexpression of FOS and FOSB have emerged as a reliable surrogate markers to detect rearrangements of the transcription factors FOS and FOSB in osteoid osteoma and osteoblastoma. Limitations in specificity and sensitivity remains with some osteosarcoma

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00:17:36

Meiosis and the evolution of sex chromosomes

Springer Nature ·

2022/06/22

The XY sex-determination system of therian mammals has persisted for over 160 million years: but why? In this episode Aurora Ruiz-Herrera (Autonomous University of Barcelona) and Paul Waters (University of New South Wales) discuss the evolution of sex chromosomes and role of meiosis. This episode explores the recent Heredity paper: “Fragile, unfaithful and persistent Ys—on how meiosis can shape sex chromosome evolution” https://www.nature.com/articles/s41437-022-00532-2

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00:09:34

What’s wrong with my experiment?: The impact of...

Springer Nature ·

2022/06/16

Sometimes, when researchers are conducting an experiment, the results are confusing. Maybe the control group of animals doesn’t behave the way a control should in theory be behaving. Maybe a researcher repeats a study and sees results that are unusually different from the first time around. The answers to these issues might lie in something called ‘hidden variables,’ according to a new study titled, “What’s wrong with my research? The impact of hidden variables on neuropsychopharmacology

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00:20:58

Asian oriole museomics

Springer Nature ·

2022/06/02

The genetic material locked within museum collections could help us better understand and conserve the world around us. In this episode PhD student Mario Ernst (Natural History Museum, Berlin) and Dr Knud Jønsson (Natural History Museum of Denmark) explain how, as they tell us about their work on a charismatic group of birds: the Asian orioles. This episode explores the recent Heredity paper: “Utilizing museomics to trace the complex history and species boundaries in an avian-study system of

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00:13:34

April: miRNA expression in the pediatric dilated...

Springer Nature ·

2022/05/25

Dilated cardiomyopathy (DCM) is a rare but serious condition of children and often progresses to heart failure. The outcomes for children with DCM are poor, with 50% of pediatric patients dying or needing a heart transplant within 5 years of diagnosis. In this episode, Geoff Marsh meets professor Carmen Sucharov from the University of Colorado Anschutz campus and the director of the Pediatric Cardiology Research Laboratories. She and her team have been studying the regulation of micro-RNAs and

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00:07:04

A scientific approach to navigating the academic job...

Springer Nature ·

2022/05/09

Kirstie Cummings and Sofia Beas are both new assistant professors in the department of neurobiology at the University of Alabama, Birmingham. When they met, they discussed the job application process, their support network, and their own personal processes, and they decided to write an article that could serve as a resource for candidates from different backgrounds, many of whom might not have the same resources that Dr. Cummings and Dr. Beas did. The result was their paper, “A Scientific Approach

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00:15:23

Image-based assessment of extracellular mucin in...

Springer Nature ·

2022/05/04

Dr. Inti Zlobec, professor of digital pathology at the Institute of Pathology in the University of Bern, discusses her team’s recent publication in Modern Pathology on the role of image analysis in assessing area of extracellular mucin and predicting consensus molecular subtypes (CMS) in colorectal carcinoma. The utilized deep learning algorithm had an excellent agreement with pathologists’ estimates of mucin areas. Coupled with MSI, mucinous area estimates may predict CMS classification using only

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00:11:32

The fetal immune response to maternal SARS-CoV-2...

Springer Nature ·

2022/04/19

Thousands of women have been infected with SARS-CoV2 during the COVID-19 pandemic. While very few of these infections have been shown to transmit vertically from mother to offspring, it remains unclear what effect, if any, a mother's SARS-CoV2 infection has on fetal development. In this episode, we interview Dr Brian Kalish, from the University of Toronto and the Hospital for Sick Children to discuss a study he set up looking into this question, by characterising the composition and cell-type

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00:23:23

Grey reef shark demographics

Springer Nature ·

2022/04/13

Hidden within shark genomes are clues to the evolution of marine biodiversity hotspots. In this episode, Dr Paolo Momigliano (University of Vigo), tells us about his work on the grey reef shark: from fishing in the tropical waters of the Coral Triangle to detailed demographic modelling. This episode explores the recent Heredity paper: “Genomic insights into the historical and contemporary demographics of the grey reef shark” https://www.nature.com/articles/s41437-022-00514-4 To find out about the

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00:27:58

DP, WSI, AI, DL: The Alphabet Soup of the Third...

Springer Nature ·

2022/04/06

Traditional pathology have played an integral role in the delivery of diagnosis, semi-quantitative or qualitative assessment of protein expression, and classification of disease. Technological advances have recently paved the way for the development of digital pathology-based approaches for quantitative pathologic assessments, namely whole slide imaging (WSI) and artificial intelligence (AI)–based solutions, allowing us to explore and extract information beyond human visual perception. In this

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00:18:21

Recast: Getting to know Heredity

Springer Nature ·

2022/03/30

In this episode we revisit an inspiring episode that answers the question: why should you publish in Heredity?

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00:13:09

Galápagos giants

Springer Nature ·

2022/03/16

The giant tortoises of the Galápagos archipelago form one of the most iconic evolutionary systems in the world. But is all as it appears? Join Dr Evelyn Jensen (Newcastle University) and discover how museum specimens are reshaping our understanding of this famous radiation. This episode explores the recent Heredity paper: “A new lineage of Galapagos giant tortoises identified from museum samples” https://www.nature.com/articles/s41437-022-00510-8

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00:09:17

Identification of THC impairment using functional...

Springer Nature ·

2022/02/23

Driving while under the influence of THC, known as drugged driving, is becoming more of an issue as more states legalize cannabis for both medical and recreational use around the country. THC is known to impair cognitive and psychomotor performance and thus impair driving. Jodi Gilman is a neuroscientist and an associate professor of psychiatry at Mass General Hospital and Harvard Medical School, and she’s one of the authors of a new study in the journal Neuropsychopharmacology. She says that

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00:11:07

Wild barley relatives

Springer Nature ·

2022/02/23

Barley is one of the world’s oldest and most important cultivated cereal grains. But it’s long history of domestication has resulted in greatly reduced genetic diversity, which isn’t ideal for plant breeding efforts. So, in this episode, Che-Wei Chang and Prof. Karl Schmid (University of Hohenheim) discuss their quest to find useful genetic variation in wild barley relatives. This episode explores the recent Heredity paper: “Physical geography, isolation by distance and environmental variables

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00:11:09

Whole-exome sequencing of epilepsy after acute...

Springer Nature ·

2022/02/17

Twenty-five percent of children who survive acute symptomatic seizures as neonates go on to develop epilepsy. Whilst there are several known risk factors, currently not enough is known about the mechanisms behind the development of epilepsy following neonatal brain injury, and thus it is not yet possible to reliably predict the individual risk of developing this disease in this group of patients. In this episode, we speak to Adam Numis from UC San Francisco. He and his team used whole exome

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457 results

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