Immune

01:37:33

Immune 26: Measles erases immune memory

Immune ·

2019/11/28

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Michael Mina Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Measles virus infection diminishes pre-existing antibodies (Science) Public epitope #1 (TWiV 342) Incomplete reconstitution of B cell pools after measles

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01:22:29

Immune 25: Remembrance of antigen encounters past

Immune ·

2019/11/01

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CD8+ T cell memory needs microbiome derived fatty acids (Immune) Image credit: Principles of Virology 4e Time stamps by Jolene. Thanks! Letters read on Immune 25 Weekly

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01:29:23

Immune 24: Unlucky IL-13

Immune ·

2019/09/19

The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode New type of T helper cell drives anaphylaxis (Science) Image credit Time stamps by Jolene. Thanks! Letters read on Immune 24 Weekly Science Picks Cindy- Lasker Award 2019 Vincent- Eleanor's Breakthrough video Music

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01:27:12

Immune 23: How to tell a mouse from a mouse

Immune ·

2019/08/14

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Genetic variation in laboratory mice (Immunity) Time stamps by Jolene. Thanks! Vaccines and Your Child Letters read on Immune 23 Weekly Science Picks Steph- University of Alaska budget crisis Cindy- 90% survival following

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01:18:23

Immune 22: Engineering B cells

Immune ·

2019/07/31

Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Engineering B cells to produce antiviral antibodies (Sci Immun) Time stamps by Jolene. Thanks! Letters read on Immune 22 Weekly Science Picks Steph- Breath of fresh air Cindy- Biologist found dead Vincent- Nobel Prizes and

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01:27:17

Immune 21: Islets of Langelhans

Immune ·

2019/06/12

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Dual receptor lymphocytes and type I diabetes (Cell) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Unique Scientists Cindy- Researcher app Vincent- STLR

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01:28:11

Immune 20: In defense of death

Immune ·

2019/05/29

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis. Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Inflammasome activation triggers blood clotting (Immunity) Rotavirus and Nlrp9b inflammasome (Nature) Societal Amnesia and vaccines by Cindy Leifer Image credit Letters read on Immune 20 Time stamps by Jolene. Thanks! Weekly

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01:16:33

Immune 19: Mom's the word

Immune ·

2019/04/17

The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease. Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Maternal immunization protects offspring (Sci Trans Med) Diversity of herpesvirus in neonates (TWiV 540) Mariana Mazzucato on Freakonomics Letters read on Immune 19 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- iNaturalist Cindy- Taking a break is also hard

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01:20:35

Immune 18: Biting off more TCR than you can chew

Immune ·

2019/03/27

The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Trogocytosis for T cell antigen discovery (Nat Methods) Trogocytosis (J Immunol) Orphan T cell receptors (Cell) Letters read on Immune 18 Time stamps by Jolene. Thanks! Weekly Science Picks Steph-

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01:08:23

Immune 17: Feed a macrophage, starve a tumor

Immune ·

2019/02/13

The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Darwin Day Metabolic rewiring of macrophages by CpG (Nat Immunol) Letters read on Immune 17 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Pregnant Scholar Cindy- Anti-vaxxers vaccinating against measles Vincent- Center for Science in the Public Interest Music by Steve

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01:12:43

Immune 16: B is for Bursa

Immune ·

2019/01/19

The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Role of B cells in Marek's disease pathogenesis (PNAS) In ovo vaccination (YouTube) First chickens lacking B cells (PNAS)

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01:26:27

Immune 15: Happy neu-trophil year

Immune ·

2018/12/22

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Slings enable neutrophil rolling (Nature) Sling video (La Jolla Inst Allergy Immunol) Neutrophil extracellular traps kill bacteria (Science) Neutrophil review

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01:20:17

Immune 14: Braking bad

Immune ·

2018/11/14

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode 2018 Nobel Prize in Medicine 2018 Nobel Prize in Medicine (pdf) What's in a name?(Can Res Inst) Checkpoint inhibitor failures(Nature) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph-

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01:17:01

Immune 13: Do no harm

Immune ·

2018/10/20

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Host lncRNA binds RIG-I (Cell) Microbe Art at virology blog Letters read on Immune 13 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- That's Pediatrics

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01:11:39

Immune 12: Systems immunology

Immune ·

2018/09/19

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Immune system development in newborns (Cell) Dead parrots and live wildcats (TWiV 185) Pathogenesis card game (JAMA) Letters read on Immune 12 Weekly Science Picks Steph- Kaleidoscopean Cindy- 500 women scientists Vincent- NIH budget increase 2019 Music by Steve

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01:08:33

Immune 11: Immunomimetic designer cells

Immune ·

2018/08/18

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections. Hosts: Vincent Racaniello and Cynthia Leifer Become a patron of Immune! Links for this episode Immunomimetic designer cells (Cell) Antimicrobial drug resistance (NIH) Image credit Letters read on Immune 11 Science Picks Cindy - No Tdap link to autism Vincent- Unpaywall Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology

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01:15:39

Immune 10: Immune goes viral

Immune ·

2018/07/21

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Rebecca Lynch Become a patron of Immune! Links for this episode Lynch Laboratory Immune merchandise Image credit Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

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01:35:11

Immune 9: Neither mice nor lamprey lie

Immune ·

2018/06/20

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Lamprey VLR responseto influenza virus (eLife) VLR-basedimmunity (Ann Rev Immunol) How the Immune System Works A Commotion in the Blood Immune merchandise Image credit Letters readon Immune 9 Weekly Science

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01:19:29

Immune 8: Staying warm with γδ T cells

Immune ·

2018/05/25

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode γδ17 T cells, T cell homeostasis and thermoregulation (Nat Immunol) γδ17 T cells cells at epithelial barriers(Nat Rev Immunol) Image credit Letters readon Immune 8 Weekly Science Picks Steph- Polycystic ovary syndrome and anti-Mullerian hormone

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01:13:05

Immune 7: Contradictory complements in Alzheimer's...

Immune ·

2018/04/18

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Complement and microglia cause synapse loss in Alzheimer's(Science) Superresolution structured illumination microscopy Image credit Weekly Science Picks Steph- Social Media for Social Change in Scienceand Structured Illumination Microscopy video

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