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PODCAST

Cannabinoid and Psychedelic Pharmacology and Drug Development

Jim Mitchell and Google NotebookLM

Explore Cannabinoid and Psychedelic Pharmacology with AI-Powered Learning.Welcome to a groundbreaking approach to mastering cannabinoid and psychedelic pharmacology and the FDA drug development pathway! This podcast series, powered by Google’s Notebook LM, offers a cutting-edge, AI-guided learning experience tailored for formal classes or self-directed study.Each 30-day series delves deep into the science of cannabinoid and psychedelic pharmacology, exploring molecular signaling pathways,

science chemistry

All Episodes

17:47

30 Day Psychedelic Pharmacology Podcast - Day 24...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the fascinating relationship between psychedelics and neuroinflammation, focusing on how these substances interact with the brain's immune system. The discussion delves into the role of the serotonin 5HT2A receptor and microglia in regulating inflammation, and how psychedelics might help treat conditions like depression and neurodegenerative disorders. The episode also compares psychedelics with traditional anti-inflammatory drugs and examines the therapeutic process,

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17:04

30 Day Psychedelic Pharmacology Podcast - Day 23...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the safety and toxicology of psychedelic substances, with a particular focus on MDMA and LSD. The discussion covers key mechanisms of action through the 5HT2A receptor, potential risks like neurotoxicity and serotonin syndrome, and the importance of careful monitoring in clinical settings. The episode delves into how different psychedelics interact with the brain, including their effects on the default mode network and neuroplasticity. Special attention is given to the

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21:31

30 Day Psychedelic Pharmacology Podcast - Day 22...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores non-hallucinogenic serotonin agonists, a promising new direction in psychedelic research. The discussion focuses on compounds that can potentially deliver therapeutic benefits of psychedelics without causing hallucinations, with particular attention to Psilera's PSIL-006 compound.The conversation covers key topics including:- How these compounds work through partial activation of the 5HT2A receptor- Pre-clinical studies showing anxiety reduction without psychedelic

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18:45

30 Day Psychedelic Pharmacology Podcast - Day 21 Gut...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This episode explores the fascinating connection between the gut microbiome and psychedelic therapy. The discussion delves into how trillions of gut bacteria might influence the effectiveness of psychedelic treatments through their production of metabolites and interaction with serotonin systems. Key topics include the role of the 5-HT2A receptor in psychedelic effects, MDMA's therapeutic potential for PTSD, and the possibility of personalizing psychedelic therapy based on an individual's gut

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16:59

30 Day Psychedelic Pharmacology Podcast - Day 20...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores how psychedelics like psilocybin and MDMA enhance psychotherapy through their effects on brain chemistry and neural pathways. The discussion covers key mechanisms including the 5HT2A receptor, oxytocin release, and connections between the amygdala and prefrontal cortex. The speakers examine how these substances can promote synaptic plasticity and fear extinction, particularly beneficial for conditions like PTSD. They also address important challenges in the field,

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18:34

30 Day Psychedelic Pharmacology Podcast - Day 19...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

In this fascinating episode about novel formulations in psychedelic science, we explore cutting-edge developments in making psychedelic treatments safer and more effective. Key topics include pro-drugs designed for targeted delivery, non-hallucinogenic analogs that maintain therapeutic benefits without intense psychedelic effects, and innovations in dosage control and delivery methods. The discussion also covers the crucial role of the 5HT2A receptor in psychedelic effects, and the importance of

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20:23

30 Day Psychedelic Pharmacology Podcast - Day 18...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the controversies and challenges in psychedelic science, covering key topics including:- MDMA-assisted therapy's potential for PTSD treatment and psilocybin's promise for treatment-resistant depression- The importance of set, setting, and positive intentions in psychedelic experiences- The role of 5-HT2A and NMDA receptors in psychedelic effects, including potential risks like HPPD and neurotoxicity- Legal and cultural considerations, including the evolving regulatory

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19:40

30 Day Psychedelic Pharmacology Podcast - Day 17...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the complex challenges of blinding in psychedelic research studies. The discussion delves into why traditional blinding methods often fall short when studying substances like MDMA, LSD, and DMT. Key topics include:- The role of physical indicators like body temperature changes in MDMA studies- How different psychedelics interact with 5HT2A receptors through "functional selectivity"- The influence of set, setting, and participant expectations on study outcomes- The use

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18:24

30 Day Psychedelic Pharmacology Podcast - Day 16...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores non-serotonergic mechanisms of psychedelics, particularly focusing on ketamine and DMT. The discussion delves into how these substances work beyond traditional serotonin pathways, examining their interactions with NMDA and Sigma-1 receptors. The episode covers the fascinating relationship between ketamine and brain connectivity, neuroplasticity, and its potential therapeutic applications in treating conditions like depression and anxiety. The conversation also explores

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21:21

30 Day Psychedelic Pharmacology Podcast - Day 15 Set...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the fundamental concept of "set and setting" in psychedelic experiences, discussing how both internal mindset and external environment influence therapeutic outcomes. The conversation delves into the scientific mechanisms behind these effects, including how 5-HT2A receptors and the default mode network interact with environmental factors. The discussion includes insights from research studies, explaining how personal intentions and supportive environments can lead to

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13:50

30 Day Psychedelic Pharmacology Podcast - Day 14...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores microdosing psychedelics, focusing on the science behind how these substances interact with brain receptors, particularly the 5HT2A receptor. The hosts discuss how microdosing differs from full doses, with the goal of achieving subtle effects without triggering full psychedelic experiences. They examine current research, potential benefits, and risks, while emphasizing that scientific evidence is still limited and more rigorous studies are needed. The conversation also

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17:53

30 Day Psychedelic Pharmacology Podcast - Day 13...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the relationship between psychedelics and addiction treatment, focusing on how these substances might help reset neural pathways in the brain. The hosts discuss how different psychedelics like LSD, psilocybin, MDMA, and ibogaine interact with various brain receptors, particularly examining their effects on the serotonin system and the brain's reward circuits. They delve into the concept of neuroplasticity and how psychedelics might promote lasting changes in brain

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18:48

30 Day Psychedelic Pharmacology Podcast - Day 12 PTSD

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode discusses the FDA's recent rejection of Lykos's MDMA application for PTSD treatment. The conversation explores the FDA's key concerns, including the need for more long-term data and research on drug interactions. The hosts delve into challenges like designing effective placebo trials, the role of personalized medicine, and the importance of understanding individual variations in treatment response. They also examine safety considerations, ethical concerns, and the future

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20:20

30 Day Psychedelic Pharmacology Podcast - Day 11...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the therapeutic potential of psychedelics for treating depression, comparing them with traditional antidepressants. The discussion covers key mechanisms including 5HT2A receptor interactions, neuroplasticity, and the role of BDNF in brain health. The episode delves into specific psychedelics like MDMA and psilocybin, explaining their effects on brain chemistry and mood regulation. It also addresses important considerations about set and setting, potential risks, and the

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14:54

30 Day Psychedelic Pharmacology Podcast - Day 10 The...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the relationship between psychedelics and the Default Mode Network (DMN) in the brain. The discussion covers how psychedelics, particularly through 5HT2A receptor activation, can reduce DMN activity. The hosts explain that the DMN functions as the brain's "idle mode" during daydreaming and self-reflection, and how psychedelics can disrupt negative thought patterns by affecting this network. They also delve into the molecular mechanisms involving glutamate and GABA

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18:58

30 Day Psychedelic Pharmacology Podcast - Day 9...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the molecular mechanisms of psychedelics and neuroplasticity, diving deep into how these substances interact with brain receptors, particularly the 5HT2A receptor. The discussion covers key topics including:- The role of serotonin and other neurotransmitters in psychedelic effects- How psychedelics like psilocybin can alter brain connectivity and communication between regions- The importance of set and setting in psychedelic experiences- The therapeutic potential for

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21:55

30 Day Psychedelic Pharmacology Podcast - Day 8...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores the molecular mechanisms of psychedelic drugs, focusing on how they interact with the brain's serotonin system, particularly the 5-HT2A receptor. The discussion covers key concepts like functional selectivity, explaining how different psychedelics can produce varying effects despite targeting the same receptor. The episode delves into important brain regions and processes, including the thalamus's role as a sensory gateway, the default mode network's involvement in

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19:01

30 Day Psychedelic Pharmacology Podcast - Day 7 Ibogaine

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode provides an in-depth exploration of Ibogaine, focusing on its unique pharmacological properties and potential in addiction treatment. The discussion breaks down Ibogaine's complex mechanisms of action, particularly its effects on NMDA and kappa opioid receptors, as well as its role in modulating BDNF signaling. The hosts examine both the promising therapeutic potential and serious risks of Ibogaine treatment, including cardiac concerns and the importance of medical supervision

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16:16

30 Day Psychedelic Pharmacology Podcast - Day 6 MDMA

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode explores MDMA's dual nature as both a therapeutic tool and recreational substance, examining its complex interactions with brain chemicals like serotonin, dopamine, and oxytocin. The discussion covers MDMA's mechanisms of action, including how it affects neurotransmitter systems, its potential therapeutic applications particularly for PTSD treatment, and important safety considerations. The episode also delves into emerging research on MDMA-assisted therapy for conditions like

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11:43

30 Day Psychedelic Pharmacology Podcast - Day 5...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/30

This podcast episode provides an in-depth exploration of 5-MeO-DMT, discussing its pharmacological mechanisms and therapeutic potential. The conversation covers how the substance interacts with serotonin receptors (5HT2A and 5HT1A), its effects on synaptic plasticity, and its uniquely rapid metabolism through MAO enzymes. The hosts examine the importance of set and setting in psychedelic experiences, citing the Borkel study from 2024 which found that natural settings and presence of loved ones led

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