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PODCAST

Longevity Roadmap

Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.

health & fitness alternative health

All Episodes

27:12

26: Ask The Doctor P2 of 2

Longevity Roadmap ·

2023/08/21

In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. This is Part 2. Listen to episode 24 to hear part 1. 00:01:31 - Question about taking naps to make up for not enough sleep 00:03:06 - REM Sleep and Deep Non-REM Sleep 00:11:54 - Shift work is very detrimental to to health

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05:44

25: Heart Rate Variability (HRV)

Longevity Roadmap ·

2023/08/16

Buck discusses Heart Rate Variability (HRV). What is it? Why does it matter and how can it effect your overall health in this mini Sapio with Buck Joffrey episode. 00:00:31 - Medicine 3.0: Taking medicine into your own hands 00:01:15 - What is Heart Rate Variability (HRV) anyway? 00:02:16 - The Autonomic Nervous System 00:02:37 - The Parasympathetic Nervous System 00:03:32 - Lower Hrv Has Been Linked To An Increased Risk Of Cardiovascular Diseases 00:04:18 - Ways To Increase Your HRV

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43:35

24: Ask The Doctor P1 of 2

Longevity Roadmap ·

2023/08/14

In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. Part 2 will drop next week as episode 26. 0:01:11 - Question about Continuous Glucose Monitoring and Repatha® 0:04:34 - Where is the glucose coming from in the morning? 0:07:07 - Blood Glucose Spike in the sauna 0:09:43 -

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05:49

23: Jet Lag and Melatonin

Longevity Roadmap ·

2023/08/09

Planning a trip? Jet lag can be a serious impediment to making the most of it. Buck discusses jet lag; what it is and strategies to beat it including the use of Melatonin. 00:00:25 - Desynchronosis - Disruption To Your Circadian Rhythm 00:01:05 - Melatonin 00:02:39 - Bright Light Exposure Is Really Important To Resetting Your Circadian Clock 00:04:48 - Some Negative Effects Of Chronic Melatonin Use

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34:20

22: Battle of Cardio IQs Part 2

Longevity Roadmap ·

2023/08/07

Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. This is Part 2. If you missed Part 1, check out episode 20. 0:01:16 - Metabolic Markers and Cardiovascular Risk 0:01:55 - Framingham Risk 0:06:08 - Hemoglobin A1C 0:08:00 - C-peptide 0:09:07 - Homocysteine and the methylation cycle 0:11:50 - Methyl Protect® 0:13:46 - Why is Vitamin D important? 0:21:34 - APOE Genotype 0:24:35 - Alzheimer's Disease Risk 0:28:57 -

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05:43

21: Why Did Bronny James Collapse?

Longevity Roadmap ·

2023/08/02

Scary news last week when Bronny James, the 18 year old son of Lebron and Savannah James collapsed during a workout at USC. It has been reported that James suffered a cardiac arrest. In September 2022 another seemingly healthy and fit USC basketball player, Vince Iwuchukwu also suffered cardiac arrest. Thankfully USC was prepared and in both cases they were able to get these young athlete's hearts beating again. Buck discusses why and how it happens. 0:00:11 - Bronny James’ cardiac arrest 0:00:53

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48:18

20: Battle of Cardio IQs Part 1

Longevity Roadmap ·

2023/07/31

Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. Part 2 will drop as Episode 22. 0:01:31 - What exactly is a Cardio IQ? 0:03:15 - the cost of Cardio IQ 0:05:18 -Lipid panel, Total Cholesterol, HDL, Triglycerides, LDL Cholesterol 0:08:29 - HDL the so-called good cholesterol 0:13:55 - Lipoproteins 0:15:42 - LDL Particle Number 0:22:46 - Apolipoproteins 0:25:40 - Apolyte protein tag 0:27:48 - Apolipoprotein B or

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10:10

19: Snoring and Sleep Apnea: Just Noise or Silent...

Longevity Roadmap ·

2023/07/26

In this episode Buck discusses snoring and sleep apnea and why they should be taken seriously. 0:01:17 - Snoring And Sleep Apnea 0:01:45 - Up To 20% Of The Population Has Clinically Relevant Sleep Apnea 0:02:52 - Central Sleep Apnea 0:03:12 - Obstructive Sleep Apnea 0:03:34 - Sleep Apnea Is The Enemy Deep Sleep 0:03:59 - Increased Risk Of Diseases Associated With Sleep Apnea 0:05:32 - Sleep Apnea Screening 0:05:56 - Epworth Sleepiness Scale https://epworthsleepinessscale.com/about-the-ess/ 0:06:16

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52:03

18: Could This Simple Blood Test Revolutionize Early...

Longevity Roadmap ·

2023/07/24

Buck talks with GRAIL President Josh Ofman, MD, MSHS, about their groundbreaking Multi-cancer early detection (MCED) technology and it's promise as a significant new tool in the war on cancer. 0:00:00 - Advancements in Cancer Detection Technology 0:00:35 - GRAIL Galleri test 0:02:11 - About Dr. Josh Ofman 0:05:14 - Cancer really is a disease of the genome 0:12:35 - Various guidelines for early detection of certain cancers 0:16:45 - Cancer Detection in Blood Biology 0:19:03 - Cell-Free DNA 0:23:38 -

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05:13

17: Is Your Diet Coke Killing You?

Longevity Roadmap ·

2023/07/19

In this Sapio Short Buck discusses the news last week that the World Health Organization (WHO) has declared the artificial sweetener Aspartame a "a possible carcinogen". So what does this classification mean for you and how worried should you be? 0:00:13 - World Health Organization classified aspartame as a possible carcinogenic substance 0:02:03 - Group 2B - the possibly carcinogenic to humans category 0:03:18 - WHO concedes that the upper limit for safe daily consumption of aspartame is

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01:09:59

16: Ask the Doctor

Longevity Roadmap ·

2023/07/17

In this episode, Alan Viglione, MD joins Buck to answer some of our audience questions. 0:01:08 - How To Prevent The Dawn Phenomenon Or Rise Of Sugar Levels During Sleep Or Early Morning 0:04:44 - Hemoglobin A1C 0:08:00 - What Is Gluconeogenesis? 0:14:24 - Managing Dawn Phenomenon 0:18:04 - A Question About Geroprotectant Supplements 0:19:37 - Nicotinamide Riboside As A Precursor to NAD+ 0:26:02 - What Is A Senolytic? 0:29:29 - Benefits Of Senolytics 0:30:27 - Promising Potential Of Quercetin

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36:57

15: Essentials of Female Hormone Replacement

Longevity Roadmap ·

2023/07/13

In this episode Buck continues his conversation with Rob Hamilton MD from Prestige Regenerative Medicine - this time discussing Female Hormone Replacement. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. 0:01:14 - Overview Of Some Of The Hormonal Issues That Women Go Through Throughout Their Life 0:03:33 - Average Age When Women Experience Menopause And Perimenopause 0:06:51 - Pharmaceuticals Developed To Address Menopausal Symptoms In

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57:04

14: Essentials of Male Hormone Replacement

Longevity Roadmap ·

2023/07/12

Buck discusses Male Hormone Replacement with Rob Hamilton, MD from Prestige Regenerative Medicine. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. Human Growth Hormone is also discussed in this hour-long discussion. 0:00:12 - Rob Hamilton’s Background 0:04:44 - What Happens With These Kinds Of Male Sex Hormones Over Time? 0:05:46 - Declining Testosterone Levels In Men Aged 35 To 40 0:09:23 - Testosterone Is An Anabolic Hormone 0:11:17 -

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24:04

13: Reprogramming Your Brain with Ketamine and...

Longevity Roadmap ·

2023/07/05

In part two of a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. 0:00:29 - What Is Psilocybin? 0:01:42 - The Serotonergic Effects Of Psilocybin 0:04:08 - Exploring The Effects Of Microdosing Psilocybin 0:09:16 - Microdosing And Euphoria 0:12:03 - Exploring Psychedelic Microdosing 0:15:31 - The Fadiman Protocol 0:17:10 - The Stamets Protocol 0:19:59 - Microdosing Ketamine And Serotonergic Function

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01:07:12

12: Reprogramming Your Brain with Ketamine and...

Longevity Roadmap ·

2023/07/04

In this is a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. Part 2 will be online for our regular Wednesday episode drop. 0:00:39 - About Dr. Michael Mantz 0:02:47 - Studying With Famous Herbalists In Utah 0:06:46 - Dr. Mantz's Integrative Approach Combining Nutrition, Exercise And Supplements 0:08:21 - Dr. Mantz's Current Practice: The Santa Barbara Integrative Medicine 0:08:43 - Ketamine Assisted Psychotherapy 0:11:06 - What Are Psychedelics? 0:12:49 -

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15:43

11: Fountain of Youth or Just a Dry Sauna?

Longevity Roadmap ·

2023/06/28

Buck discusses studies on the effect of saunas for overall health and longevity. 0:01:35 - What's The Big Deal With Saunas? 0:02:03 - Kuopio Ischemic Heart Disease Study 0:04:44 - Sauna Benefits For The Body 0:04:53 - Heat Shock Proteins 0:07:30 - Increased Expression Of Brain Derived Neurotrophic Factor 0:09:05 - Saunas And Longevity 0:11:08 - Blood Glucose Spikes While In The Sauna 0:12:19 - Optimal Timing For Sauna Usage

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23:02

10: Longevity Pillar 6: Being Social Helps You Live...

Longevity Roadmap ·

2023/06/26

Buck and Montecito Concierge Medicine’s Alan Viglione explore compelling studies revealing the profound impact of social connections on our longevity. Join us as we uncover the fascinating evidence that demonstrates how fostering relationships can unlock the secret to a longer, more fulfilling life. 0:00:09 - Last Pillar Of Longevity: Social Relationships 0:01:11 - Tribal Societies And The Common Goal Of Survival 0:01:29 - Human Beings Are Fundamentally Social Creatures 0:03:41 - Social

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13:57

9: Taurine: An Ingredient in Energy Drinks that May...

Longevity Roadmap ·

2023/06/21

Buck discusses with Executive Producer Ben Hyatt a study that appeared June 9th, 2023 in Science magazine that linked Taurine with healthy aging and increased lifespan in animal studies. 0:01:30 What we knew about Taurine before the study. 0:03:22 What is Taurine? 0:03:39 What new information did we learn from the study? 0:06:30 Why do multiple models matter when it comes to studies? 0:07:04 What is the mechanism between improvements in health span and longevity? 0:07:30 Cellular Senescence - what

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47:37

8: Longevity Pillar 5: Personalized Diagnostics to...

Longevity Roadmap ·

2023/06/19

Shownotes: 1:02 What is Diagnostics when it comes to medicine? 2:35 What are some of the traditional Diagnostics used in Medicine 2.0? 4:11 - Summarize the basic screenings you should be getting starting at based on Medicine 2.0 guidelines 6:09 Why are PSA screenings controversial? 8:19 - Cardiovascular testing - medicine 2.0 8:53 - Medicine 3.0 9:26 What’s a Cardio IQ? 18:10 Genetic Screening 19:40 MTHFR Gene Mutation 21:58 APOE e3 and e4 23:00 ACTN Gene 24:06 Galleri® Test 27:27 Whole Body MRI

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22:48

7: Metformin: Miracle Longevity Drug or Hype?

Longevity Roadmap ·

2023/06/15

Shownotes: 0:01:04 Metformin and Diabetes 0:02:48 Metformin Monotherapy 0:06:46 Are There Any Geroprotective Benefits From Taking Metformin? 0:10:50 Benefits of Rapamycin and 0:12:14 Acarbose and Sugar Metabolism 0:16:28 SGL2 inhibitor Jardiance 0:20:37 Glucose Monitoring and Metformin

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