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PODCAST

Talking Biotech with Dr. Kevin Folta

Talking Biotech is a weekly podcast that uncovers the stories, ideas and research of people at the frontier of biology and engineering. Each episode explores how science and technology will transform agriculture, protect the environment, and feed 10 billion people by 2050. Interviews are led by Dr. Kevin Folta, a professor of molecular biology and genomics.

science life sciences

All Episodes

44:27

Dr. Asaf Hellman: Methylation of DNA, Relationship to...

Talking Biotech with Dr. Kevin Folta ·

2022/06/18

Epigenetic regulation of gene expression occurs via many mechanisms. One method is the methylation of regulatory sequences that control the expression of specific genes. Methylation is the addition of a small methyl group to specific bases of the DNA helix. Addition of a methyl group can change how the DNA blueprint is accessed and expressed. Today's guest is Prof. Asaf Hellman. His group has found relationships between the methylation state of DNA and expression of genes associated with

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43:06

Dr. Tim Errington: Addressing the Issue of Scientific...

Talking Biotech with Dr. Kevin Folta ·

2022/06/10

Recent reports criticized the lack of reproducibility in scientific publications, and this has profound effects on the public's trust in research results. Today's interview is with Tim Errington, Director of Research at the Center for Open Science. The Center for Open Science has devised a series of strategies and tools that can help improve reproducibility, as well as offer collateral benefits to scientists.

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33:29

Dr. Mathias Uhlen: The Human Protein Atlas

Talking Biotech with Dr. Kevin Folta ·

2022/06/04

Proteins define the structure and function of cells. The human genome encodes tens of thousands of proteins, yet we know surprisingly little about most of their functions. The Human Protein Atlas uses labor-intensive methods to identify the tissue localization of a significant catalog of human proteins. The reasoning is that if we know where a protein is expressed, we can begin to infer roles in cellular processes. The Human Protein Atlas is an open source resource of over 15 million images

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43:24

Dr. Dietrich Stephan: New Drugs that Repair Broken Genes

Talking Biotech with Dr. Kevin Folta ·

2022/05/28

Many diseases do not have cures, yet from deleterious mutations in the genome. Many of these are rare disorders that do not benefit from extensive research or drug development. Current therapies mask symptoms more than solve the basis of the disorder. Dietrich Stephan of NewBase describes a novel custom drug design platform that shows amazing potential in animal models. A small oligonucelotide with a specific backbone can bind to its complementary sequence in DNA or RNA, derailing RNA

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51:43

Jon Guy: An Owner's Manual for the Mind

Talking Biotech with Dr. Kevin Folta ·

2022/05/21

We are bombarded by claims, and have access to the most information in human history, instantly. How do we sort it out? What is real and what's not? Who do we trust? These are major questions today, and affect everything from public health to the foundations of democracy in the USA. From the news to the internet to the dinner table we are immersed in suspect information. How do we recognize and address conspiratorial thinking? What mistakes do we make when analyzing a problem? How can

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37:48

Meredith Fensom: Update on Self-Limiting Mosquitoes

Talking Biotech with Dr. Kevin Folta ·

2022/05/14

Mosquitoes are the world's most dangerous animals, vectoring dozens of diseases. One of the major disease vectors is Ades aegypti, an invasive insect with an ever-expanding range. Municipalities have turned to insecticides for control, which can impact beneficial insects. Sterile insect techniques, performed by mutagenizing mosquitoes to sterility, can work well in controlling insect populations. Over the last decade, Oxitec has advanced technologies that use a molecular techniques to

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51:05

Dr. Oki O'Connor: New Drugs Targeting Dangerous...

Talking Biotech with Dr. Kevin Folta ·

2022/05/07

Heart attack and stroke are leading causes of death worldwide. Current treatments are aimed at prevention-- using various medications to control the health of the circulatory system. This week's podcast speaks with Dr. Oki O'Connor, Co-CEO of Underdog Pharmaceuticals. Dr. O'Connor discusses the cellular basis of atherosclerosis, and how modified cholesterol play a central role in its development. We then discuss the ability of a cyclical carbohydrate called cyclodextrin to sequester

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44:44

Dr. Awais Khan: Breeding the Next Amazing Apple

Talking Biotech with Dr. Kevin Folta ·

2022/04/30

Apples are a beloved fruit, with over 8000 varieties available worldwide. The apples in the grocery store represent just a tiny section of apple genetic potential, a few flavors that ship well and can be stored for a long period of time. But today in the genomics era new tools seek to speed the breeding of apples to create new varieties, flavors, and disease resistance packages. The goal is to help farmers and consumers produce the next generation of superior apple varieties. With Dr

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61:08

Dr. Michael Levin: Biological Plasticity,...

Talking Biotech with Dr. Kevin Folta ·

2022/04/23

The process of animal development is a complex coordination of different genes through time. At least that's what we thought. Dr. Michael Levin from Tufts University is forcing us to rethink these processes, with impacts in medicine, cancers, correction of developmental defects and limb regeneration. ,

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46:46

Dr. Brandon McFadden: Consumer Sentiment and Gene...

Talking Biotech with Dr. Kevin Folta ·

2022/04/16

Gene editing with CRISPR/Cas, TALEN or other tools allows scientists to make directed and precise changes in DNA. The technologies promise to transform agriculture and medicine. But the application of these technologies hinges on consumer sentiment. Dr. Brandon Mc Fadden is an agricultural economist that specializes in understanding what makes consumers tick. We have a conversation about gene editing, public sentiment, and how it varies between agriculture and medicine.

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31:30

Joe Landolina: Stopping Bleeding with Algal-Based...

Talking Biotech with Dr. Kevin Folta ·

2022/04/09

A significant number of fatalities are due to blood loss following accidents, injuries or medical procedures. While many methods can stop catastrophic bleeds, they take time and are not always successful. This episode explores the process of inducing bleeding cessation with Joe Landolina of Cresilon. The company has devised a polymer from algae that is applied topically, and immediately stops the bleed. The science behind this innovation and potential applications are discussed.

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49:41

Dr. Felicia Wu: Fungal Toxins in Food

Talking Biotech with Dr. Kevin Folta ·

2022/04/02

Mycotoxins are carcinogenic compounds that arise from specific fungal infections in various crop plants, with corn and peanut being key examples. In the industrialized world, governments monitor relevant crops carefully, and install strict thresholds for presence of these dangerous compounds. But what about Developing World? Today's podcast interviews Dr. Felicia Wu, Professor at Michigan State University. Dr. Wu has analyzed the risk associated with mycotoxins, and has studied how

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41:52

Dr. Olly Peoples: Plastics and Fuels from Camelina

Talking Biotech with Dr. Kevin Folta ·

2022/03/26

Camelina (Camelina sativa) is an oilseed brassica that grows fast and produces many seeds. It grows in marginal soil and great resistance to disease and environmental stress. That said, it is an ideal plant to use as a factory to produce a variety of metabolites that may be used in applications such as fuels and plastics, as well as a sources of healthy food oils and animal nutrition products. Their resilience as a crop and rapid growth means that they may offer farmers an off-season

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46:32

Dr. Arvinda Nath: Endogenous Retroviruses and Disease

Talking Biotech with Dr. Kevin Folta ·

2022/03/19

Upon sequencing the human genome, scientists were surprised to find that it is composed of about 8% viral sequence. These fossils are relics of ancient primate infections where retroviruses incorporated into the chromosome and became part of the human lineage. While these viral elements have contributed positively to speciation and development of specific human traits, they also have the capacity to become pathogenic. Dr. Advinda Nath is the Clinical Director of the National Institute of

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40:21

Melanie Trecek-King: Evaluating Scientific Claims

Talking Biotech with Dr. Kevin Folta ·

2022/03/12

We are bombarded with information, but do we know what sources to trust and how to evaluate specific claims? Melanie Tercek-King joins the podcast to discuss some fundamentals of critical thinking, and implement her tool kit to evaluate which claims have merit, and which might be best disregarded.

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57:49

Dr. Robert Paarlberg: Resetting the Table

Talking Biotech with Dr. Kevin Folta ·

2022/03/05

In his new book Dr. Robert Paarlberg describes the current state of the food system, focusing on issues like industrial farming, organic farming, restaurants, biotechnology, and how technology will impact farming in the future. In today's podcast we discuss some of the critical points of the book and what food and farming may look like in the future.

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32:29

Dr. Monika Gulia-Nuss: Biotech and Tick Vectored Disease

Talking Biotech with Dr. Kevin Folta ·

2022/02/26

Ticks are significant disease vectors, with an emerging scope of pathologies associated with tick bites. New technologies have accelerated the ability to genetically engineer ticks, creating new opportunities to understand gene function in ticks, as well as potentially use gene editing to control numbers or affect disease vectoring. Dr. Monika Gulia-Nuss (University of Nevada, Reno) and Dr. Jason Rasgon (Penn State University) describe tick disease transmission, new transformation

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77:36

Dr. Anne Simon: Plant Viruses / X Files Science

Talking Biotech with Dr. Kevin Folta ·

2022/02/19

Dr. Anne Simon is an expert in plant viruses. She describes some of the current threats to plant biology, and discusses ways that viruses may be used to work for us, rather than against us. She also discusses her time as a technical advisor to The X Files series, and how that experience helped her to share science. Follow Dr. Simon on Twitter here!

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38:16

Jesus Martin-Garcia: New Therapies for HERV-Based...

Talking Biotech with Dr. Kevin Folta ·

2022/02/13

Human Endogenous Retroviruses (HERVs) comprise 8% of the human genome and are relics of ancient infections, some dating back to pre-human primates. These resident viral elements can be awakened by viral infections, and have been shown to be tightly associated with diseases like Multiple Sclerosis (MS) and Amyotrophic Lateral Sclerosis (ALS). New data suggest a role for HERVs in the neurological symptoms of long COVID. Today's podcast features a conversation with Jesus Martin-Garcia, CEO

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14:08

Talking Biotech Podcast Changes and Future

Talking Biotech with Dr. Kevin Folta ·

2022/02/13

As we enter our eighth year, the podcast is partnering with Colabra, experts in laboratory IT that will help and accelerate your R&D. You won't see changes in content, but you'll see improvements in website, podcast quality, transcripts and other improvements for the listener. I'm grateful for such substantial listenership and the opportunity to have this forum for my passion of sharing science.# COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your

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486 results

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