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PODCAST

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and

science life sciences

All Episodes

23:29

76: Transforming Single-Cell Analysis With Impedance...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/08/01

Send us a Text Message.Curious about the latest innovations in cell analysis technology? Join us in this episode with Furkan Gökçe, New Business Development Manager at Amphasys, as we delve into the fascinating world of Impedance Flow Cytometry (IFC).Furkan shares how IFC is revolutionizing single-cell analysis by providing faster, more precise, and high-resolution data.Key Takeaways:Real-Time Precision: Discover how IFC allows for real-time, label-free assessments of cells, providing detaile...

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17:24

75: Transforming Single-Cell Analysis With Impedance...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/30

Send us a Text Message.Ever wondered how single-cell analysis could revolutionize bioprocessing? Join us in this episode as we delve into the cutting-edge world of impedance flow cytometry.Furkan Gökçe, New Business Development Manager at Amphasys, shares his insights on the transformative power of this technology in the biotech industry. With a background in engineering and physics, Furkan provides a unique perspective on tackling the complexities of biological systems.Key Takeaways:Enhanced...

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17:17

74: Bead-Based Assays: The Power of High-Throughput...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/25

Send us a Text Message.Dive into the transformative world of bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech, where high-throughput screening meets cutting-edge biotechnological advancements.Join us as we chat with Sebastian, a seasoned scientist and entrepreneur who has revolutionized the workflow of high-throughput screening of titer, glycosylation, and aggregation with innovative bead-based assays.Key Takeaways:Streamlined Workflow: Learn how a simplified sample ...

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19:18

73: Bead-Based Assays: The Power of High-Throughput...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/23

Ready to revolutionize your lab work? Join us as we dive deep into bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech.Discover how these tiny beads are making a massive impact on biotech research and development — for titer, glycan, and aggreation screening — and how this developability screening platform can enhance your antibody discovery, antibody engineering and lead optimization.In this episode, you’ll learn:Speed and Simplicity: How bead-based assays offer unmatc...

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21:59

72: Effective Outsourcing: How Small Biotech...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/18

How do small biotech companies make strategic decisions with limited resources? This episode dives deep into the art of prioritization and outsourcing to achieve success.Join us as we speak with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, a seasoned biotech scientist with years of experience in both large and small biotech companies. Mark shares his invaluable insights on navigating the complexities of bioprocess development and outsourcing.In this episode, we ex...

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18:32

71: Effective Outsourcing: How Small Biotech...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/16

Are you navigating the complex world of bioprocess CMC development and manufacturing in a small biotech company?Our latest episode is a must-listen! Join us as we sit down with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, who shares invaluable insights on overcoming the unique challenges faced by small biotech firms.In this episode, we explore:The critical communication strategies needed for successful outsourcing to CDMOs.How small biotechs can leverage their agi...

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15:31

70: Glycoanalytics Explained: Analysing and Designing...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/11

In this insightful episode, we explore the cutting-edge field of glycoengineering and its transformative impact on biopharmaceutical drug design. Join us as we chat with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, to uncover the nuances of chemoenzymatic glycogen engineering and its potential to revolutionize therapeutics.Key Takeaways:Understanding Glycoengineering: Discover the three main approaches—genetic, metabolomic, and chemoenzymatic—f...

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18:09

69: Glycoanalytics Explained: Analysing and Designing...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/09

Uncover the hidden science behind creating safer, more effective biological drugs! Dive into glycoanalytics and glycoengineering, the secret weapons revolutionizing biopharma.Join us as we talk with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, who breaks down the complexities of glycosylation and its pivotal role in drug development.Key Takeaways:Critical Quality Attributes: Understand how glycans influence the function and structure of biophar...

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28:53

68: How Process Mapping Transforms Knowledge...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/04

Join us as we explore the pivotal role of process mapping in biotech knowledge management. Our guest, Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, shares invaluable insights into leveraging technology to streamline operations.Key Insights:Identifying Critical Process Knowledge: Learn strategies to identify and manage vital process knowledge essential for optimal performance.Transitioning from Implicit to Explicit Knowledge: Disco...

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14:22

67: How Process Mapping Transforms Knowledge...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/07/02

Want to turn your biotech chaos into streamlined success? Learn from expert Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, on how process mapping can transform your knowledge management and elevate your business performance.Key Takeaways:Eliminate Scope Creep: Learn how to maintain focus in projects despite shifts and changes, improving productivity and reducing frustration.Bridge Experience Gaps: Understand how process mapping cre...

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16:08

66: Freezing and Thawing Cells: the Science Behind...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/06/27

Get ready to dive into the fascinating world of cryopreservation!In this episode, we welcome Mark Davison, an experienced entrepreneur and CEO of Grant Instruments, leaders in laboratory equipment, to explore the intricate science of freezing and thawing cells.Mark brings his wealth of experience to demystify this crucial process, revealing how cutting-edge technology ensures precision and reliability in preserving biological samples.Key Takeaways:Mastering Precision: Learn how data acquisiti...

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24:15

65: Freezing and Thawing Cells: the Science Behind...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/06/25

Picture a world where we can freeze cells and bring them back to life perfectly intact.In this episode, we're joined by Mark Davison, a leading expert in cryopreservation and CEO of Grant Instruments to uncover the intricate science of freezing and thawing cells. From basic principles to advanced techniques, we delve into how cryopreservation is revolutionizing biotechnology and cell therapies.Key Takeaways:Cell Survival Secrets: Discover why water is both a friend and foe in preserving cell ...

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21:52

64: Why Sound Waves Are the Future of Gene Therapy...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/06/20

Could sound waves be the revolutionary key to gene therapy manufacturing? In this episode, Gabriel Dumy, CTO and Co-founder at Kolibri, reveals how acoustic waves are set to transform cell harvesting and gene transfection processes, making biomanufacturing more efficient and less damaging to cells.Kolibri is a company revolutionizing the way we grow and engineer cells at scale using acoustic waves.Key Takeaways:Real-Time Cell Harvesting: Discover how reconfigurable acoustic waves enable non-d...

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25:27

63: Why Sound Waves Are the Future of Gene Therapy...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/06/18

Are sound waves the key to revolutionizing gene therapy? In this groundbreaking episode, we sit down with Gabriel Dumy, CTO and Co-founder at Kolibri, a company revolutionizing the way we grow and engineer cells at scale using acoustic waves.Gabriel shares the challenges facing modern bioproduction and unveils an exciting solution that's setting the stage for the future of gene therapy.Key Takeaways:Enhanced Cell Productivity: Discover how acoustic waves minimize shear stress, significantly b...

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15:16

62: Magnetic Bead Technology: The New Era in...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/06/13

Dive into the future of bioprocessing with Nils Brechmann, Marketing Manager at MAGic BioProcessing and co-inventor of the process applications, as we explore how magnetic bead technology is transforming downstream processing.MAGic BioProcessing is a biotech company from Uppsala, Sweden, that develops magnetic-based recovery of biologicals.Key Takeaways:Streamlined Purification: Discover how magnetic beads enable simultaneous clarification and capture, boosting efficiency.Cost Savings: Learn ...

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19:22

61: Magnetic Bead Technology: The New Era in...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/06/11

Dive into the latest episode as we explore how magnetic bead technology is revolutionizing downstream processing, promising higher yields and greater purity.Our guest, Nils Brechmann, Marketing Manager at MAGic BioProcessing and co-inventor of the process applications, shares his insights on overcoming industry challenges and the future of purification. MAGic BioProcessing is a biotech company from Uppsala, Sweden, that develops magnetic-based recovery of biologicals.Key Takeaways:Discover ho...

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20:37

60: Next-Generation Sequencing: Transforming Science...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/06/06

Unlock the future of epigenetics and join us for an insightful conversation with Jonathon Hill as he delves into the groundbreaking world of next-generation sequencing (NGS) and its transformative impact on science and medicine. Jonathon Hill is the VP of Science and Technology and a co-founder of Wasatch BioLabs and Associate Professor of Cell Biology and Physiology at Brigham Young University.Discover how cutting-edge nanopore technology is overcoming the limitations of traditional methods ...

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16:46

59: Next-Generation Sequencing: Transforming Science...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/06/04

Curious about the latest advancements in next-generation sequencing (NGS) and how they are revolutionizing science and medicine?In this episode, we delve into the cutting-edge developments of NGS with our expert guest, Jonathon Hill, VP of Science and Technology and a co-founder of Wasatch BioLabs and Associate Professor of Cell Biology and Physiology at Brigham Young University, who has been at the forefront of this transformative field.Key Takeaways:Discover how NGS is empowering scientists...

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19:08

58: Crafting a Solid CMC Strategy: Key Factors and...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/05/30

Dive into the realm of biotech with our latest episode as we unravel the enigma of Quality by Design (QbD) with Matthias Müllner, CEO of & Co-Founder bespark*bio, a company empowering viral vector-based medicines.Discover how integrating QbD principles early in your development cycle can revolutionize your approach to producing safe, high-quality products consistently. From understanding critical quality attributes to designing robust manufacturing processes, we illuminate the transformat...

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17:14

57: Crafting a Solid CMC Strategy: Key Factors and...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/05/28

Join us for an insightful episode as we dive into the world of bioprocess CMC development strategies with Matthias Müllner, CEO of & Co-Founder bespark*bio, a company empowering viral vector-based medicines.Matthias shares his wealth of knowledge on avoiding common pitfalls in developing robust Chemistry, Manufacturing, and Controls (CMC) strategies. He also emphasizes the critical elements that ensure your biotech product's success.Key Takeaways:Start Strong: Establishing a comprehensive...

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184 results

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