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PODCAST

OncoPharm

OncoPharm is a podcast dedicated to all things oncology pharmacy. Most episodes cover updates and recent publications concerning the use of medications in caring for patients with cancer. Periodically, episodes drop devoted to Landmark Clinical Trials in oncology and Fundamentals of Oncology Pharmacy.

science

All Episodes

00:16:13

Trimodality Treatment For Bladder Cancer

OncoPharm ·

2023/05/18

A recent paper serves as a good prompt to discuss trimodality treatment for muscle-invasive bladder cancer and the data supporting its use. Zlotta et al: https://doi.org/10.1016/S1470-2045(23)00170-5

en

00:22:57

GAIA-CLL13 & COSMIC-313

OncoPharm ·

2023/05/11

Today's Pod discusses... 1) A large trial comparing 4 different CLL treatments GAIA-CLL13: https://www.nejm.org/doi/full/10.1056/NEJMoa2213093 2)Adding Cabozantinib + Nivo/Ipo vs. Nivo/Ipi in intermediate/poor risk mRCC COSMIC-313: https://www.nejm.org/doi/full/10.1056/NEJMoa2212851 3) A potential future biomarker for predicting response to PD-(L)1 targeted therapies Functional PD-1/PD-L1 Engagement: https://pubmed.ncbi.nlm.nih.gov/?term=36821809

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00:13:16

SUNLIGHT

OncoPharm ·

2023/05/04

Talking 3rd-line treatment of metastatic colon cancer. Tipiracil-trifluridine + bevacizuamb vs. tipiracil-trifluridine alone. And a bit on the theory of "bevacizumab beyond progression." SUNLIGHT: https://www.nejm.org/doi/full/10.1056/NEJMoa2214963

en

00:18:59

QuANTUM First (Quizartinib 1st Line in AML)

OncoPharm ·

2023/04/27

Quizartinib vs. Placebo(?) + Chemo in newly diagnosed AML. We add a bit of context about quizartinib's history leading up to this study preview possible role in therapy if approved in the future. Link: https://doi.org/10.1016/S0140-6736(23)00464-6

en

00:12:24

ICI + Bacterial Supplementation

OncoPharm ·

2023/04/20

We take a peak at an intriguing study (n = 29) that gave some metastatic RCC patients receiving nivolumab + ipilimumab a supplement of a bacterium (n = 19) and a control group. We discuss what to look for in the future studies that are likely to follow with similar methods.

en

00:12:37

Neoadjuvant Chemo In Breast Cancer

OncoPharm ·

2023/04/13

The Landmarks of OncoPharm series returns to discuss NSABP's B18 story of neoadjuvant vs. adjuvant AC in stages I & II breast cancer from 1998. B18: https://pubmed.ncbi.nlm.nih.gov/?term=36989610 Flashback Flashforeward: https://pubmed.ncbi.nlm.nih.gov/?term=36989608

en

00:20:26

Olanzapine & Pembrolizumab (endometrial, urothelial)...

OncoPharm ·

2023/04/06

Lots of updates: Olanzapine increases weight gain, QOL in some advanced cancer: https://pubmed.ncbi.nlm.nih.gov/?term=36977285 Chemotherapy Toxicity - When Less is More: https://www.nejm.org/doi/full/10.1056/NEJMcibr1202395 Pembro + Chemo improves PFS > chemo alone in advanced endometrial cancer: https://www.nejm.org/doi/full/10.1056/NEJMoa2302312 Enfortumab vedotin + pembrolizumab gets an accelerated approval for cisplatin-ineligible patients with urothelial carcinoma. Safety signals seen.

en

00:17:25

[Re-release] Tales of Brave Iressa (2017)

OncoPharm ·

2023/03/30

With new Pod this week, we're re-releasing the 2nd episode from way back in 2017 that provides a historical overview of how the use of EGFR TKIs changed from their use in all NSLCLC to only with activating mutations.

en

00:12:05

Linezolid vs. Vanc In Neutropenic Fever

OncoPharm ·

2023/03/23

Not that you always need extended gram positive coverage, but if you did... As is often the case with this Pod, this is mostly providing historical context. Link: https://doi.org/10.1086/500139

en

00:12:18

Chemo-Induced Ovarian Dysfunction

OncoPharm ·

2023/03/16

Prompted by a recent JCO review article (link below), it seemed like a good idea to discuss risks of ovarian dysfunction in women of childbearing potential, what drugs have the highest risk, and fertility preservation techniques. Review article: https://pubmed.ncbi.nlm.nih.gov/?term=29620997 Cyclophosphamide dose equivalent calculator: https://www.oncofertilityrisk.com/CED.html

en

00:10:54

S1801 (Neoadjuvant Pembro In Melanoma)

OncoPharm ·

2023/03/09

We review a clever study looking at neoadjvuant & adjuvant pembrolizumab vs. only adjuvant pembrolizumab in melanoma. Link: 10.1056/NEJMoa2211437 We also discuss some updates on abemaciclib and osimertinib

en

00:11:27

DA-EPOCH (R)

OncoPharm ·

2023/03/02

Landkarmks of OncoPharm: Dose-Adjusted EPOCH (+ R) This episode focuses on the pharmacodynamic rationale for the protocol and delivery, not so much the details of the literature supporting its use. Wilson et al 2002, Blood: https://doi.org/10.1182/blood.V99.8.2685

en

00:11:28

Cannabis Use With ICIs

OncoPharm ·

2023/02/24

Cannabinoids appear to impact immune system function, so could cannabis use blunt the effect of immune checkpoint inhibitors? I don't know, brah. Maybe? Review: https://pubmed.ncbi.nlm.nih.gov/?term=35749680 Cannabis associated with poorer ORR: https://doi.org/10.1634/theoncologist.2018-0383 Cannabis associated with poorer TTP & OS: https://doi.org/10.3390/cancers12092447

en

00:12:18

Instant KarMMa

OncoPharm ·

2023/02/16

Ide-Cel vs. "standard" treatment in relapsed/refreactory multiple myeloma study - the KarMMa-3 trial - is discussed. Link: https://www.nejm.org/doi/full/10.1056/NEJMoa2213614

en

00:19:58

CodeBreak200 And Elderly AML Survival

OncoPharm ·

2023/02/09

CodeBreak200: docetaxel vs. sotorasib in 2nd-line metastatic NSCLC (KRAS-G12C). A new safety signal emerges. https://doi.org/10.1016/S0140-6736(23)00221-0 A new survival prediction model for elderly patients with AML not receiving intensive therapy. https://doi.org/10.1002/cncr.34609

en

00:17:58

Adjuvant Pembrolizumab (NSCLC), Elacestrant, &...

OncoPharm ·

2023/02/02

First - despite what you'll hear - it is pirTobrutinib, not pirobrutinib. Second - lots of great information on the current state of targeted therapies in adjuvant NSCLC and on two exciting new drugs: elacestrant and pirtobrutinib.

en

00:10:40

HER2 Targeting Era Of Colorectal Cancer Begins

OncoPharm ·

2023/01/26

Tucatinib's FDA-approval (with trastuzumab) for HER2 amplified metastatic colorectal cancer launches a new era of targeted therapy in colorectal cancer. Targeting HER2 (amplified in ~3-5% of advanced colorectal cancers) in colorectal cancer will likely evolve over the coming years, so a brief history on how it has evolved so far may be helpful.

en

00:12:34

Adjuvant Interferon In Melanoma

OncoPharm ·

2023/01/19

The Landmarks in OncoPharm series returns to discuss adjuvant interferon in melanoma. ECOG 1684: https://pubmed.ncbi.nlm.nih.gov/?term=36649675 Commentary on E1684: https://ascopubs.org/doi/abs/10.1200/JCO.22.02354

en

00:19:40

Breast Cancer In A Nutshell

OncoPharm ·

2023/01/12

Broad, big picture overview of breast cancer and its treatment. Ambitious. Do not recommend listening at 1.5x

en

00:20:35

Mosunetuzumab And Same-day Pegfilgrastim w/ ddAC

OncoPharm ·

2023/01/05

New Year - New Drug, mosunetuzumab (a CD3-CD20 T-cell engager) is approved for r/r Follicular Lymphoma. And an intriguing retrospective cohort study found a higher rate of neutropenia with same-day pegfilgrastim in patients receiving dose-dense AC. Link: https://doi.org/10.1177/10781552221148116

en

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