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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

06:26

Fatty Liver, Failing Heart, Future Risks 🍔🫀⚠️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/17

Liver, Lipids, and the Left Ventricle 🩸🫀🧬 The NEJM review reminds us that fatty liver isn’t just a liver problem. MASLD drives risk for heart disease, diabetes, kidney dysfunction, and even cancers. 🚨 Cardiovascular disease remains the leading cause of death in MASLD—outpacing cirrhosis and cancer. 🫀💔 With new tools like FIB-4, VCTE, ELF, and promising drugs such as resmetirom and GLP-1/GIP agonists, we’re entering an era where treating the liver can protect the heart. 💊🌱 #MASLD

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04:45

⚖️ Switch or Stay? DOACs vs Warfarin in Frail AF...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/16

🧓💊 The COMBINE-AF substudy offers important guidance for managing frail, elderly, VKA-experienced patients with atrial fibrillation. Switching to standard-dose DOACs reduced stroke/systemic embolism risk and cut intracranial & fatal bleeding 🧠🛡️, but raised gastrointestinal bleeding rates 🍽️🩸—especially with certain agents. Sensitivity analyses show apixaban & edoxaban may offer a safer bleeding profile. These findings highlight the need for shared decision-making ⚖️ and integrated ABC pathway

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03:53

SuperAgers 💪, Super Brains 🧠, Super Insights 🔍

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/16

🧠 Meet the Northwestern SuperAgers—individuals 80+ with memory scores rivaling those decades younger! 📚 They show thicker cortices, more von Economo neurons, fewer neurofibrillary tangles, and remarkable social engagement. 🏆 Their brains offer clues to resisting age-related decline—reshaping how we view aging potential. ✨ #SuperAgers #HealthyLongevity #BrainHealth

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13:16

High Blood Pressure 2025 ACC/AHA Guideline: Measure....

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/15

🚨 Hot off the press! The 2025 ACC/AHA High Blood Pressure Guidelines are here 🩺📊 — bringing sharper strategies to detect, treat & prevent hypertension. From HBPM 🏠 to PREVENT risk scoring 🎯 and protecting against end-organ damage 🫀🧠, these updates empower clinicians & patients alike. Measure it. Manage it. Maintain it. 💪🌟 #Hypertension #Cardiology #Guidelines

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04:27

Hosts, Microbes & Life – The Holobiont Revolution

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/15

🌳 Trees aren’t just trees – they’re bustling holobionts 🌱🧫! New Nature research reveals that living wood hosts vast, specialized microbiomes, with heartwood and sapwood fostering distinct microbial worlds. These microbes shape carbon & nitrogen cycling 🌍, influence tree health 🌳💪, and reflect deep host–microbe coevolution 🧬. Rethinking forests as holobionts could transform conservation, climate strategies, and sustainable forestry. #Nature #Microbiome #Holobiont #Forests

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06:23

💙 Prevent • Protect • Prolong – The Full Spectrum of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/14

💙 Heart failure prevention is a lifelong journey – from identifying those at risk 🩺, to managing pre-HF 🚦, to optimizing care in advanced stages 🫀. This joint HFSA & ASPC statement bridges primary, secondary & tertiary prevention, targeting traditional risks (HTN, diabetes, obesity) ⚠️, non-traditional risks (genetics, SDOH) 🌍, and leveraging tools like biomarkers 🔬, cardiac rehab 🏃, and heart-healthy diets 🥗. Detect early. Act decisively. Prolong life. #HeartHealth #Prevention

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04:34

Gut Microbes, Diet, & Disease 🌿🥗🚫

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/14

🦠 Your gut is home to trillions of microbes shaping digestion, immunity, and even mood! 🌿 This new study of 150 adults over 12 weeks found 📈 higher alpha diversity (p=0.003) and clear shifts in microbiome composition, with Faecalibacterium ↑ and Bacteroides ↓. Such changes could boost metabolic and immune health—but more research is needed for long-term insights. 💡 Nurture your inner ecosystem with smart diet and lifestyle choices! 🥗⚖️ #GutHealth #Microbiome #PrecisionMedicine

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04:07

Shielding the Heart ❤️🛡️: ARNI’s Role in Cardiotoxic...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/13

🚀 Breaking News in Cardio-Oncology! 🫀🎗️ A new randomized trial in European Journal of Heart Failure shows that low-dose sacubitril/valsartan (an angiotensin receptor–neprilysin inhibitor) given before adjuvant therapy in early breast cancer patients completely prevented cancer therapy-related cardiac dysfunction (CTRCD) over 12 months — 0% vs 26.3% in standard care (p=0.006, NNT=3.8). 💡 Why it matters: CTRCD remains a major risk with anthracyclines and HER2-targeted therapy. Early ARNI

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06:03

“Age Less, Live More, Thrive Longer 🧬💪⏳

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/13

🧬 Geroscience is redefining how we think about aging — shifting focus from treating one disease at a time to targeting the biological processes that drive all age-related conditions. From 🍽️ caloric restriction and 💊 metformin, to 🛡️ rapalogs and 🔍 senolytics, the evidence is mounting: intervening in aging biology may improve healthspan, resilience, and quality of life. 📊 The latest JAMA review highlights promising strategies, gaps in clinical evidence, and the urgent need for long-term

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05:40

“Sulfur Signals 🔬 | HFpEF ❤️ | Synergy Unlocked 🔑”

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/12

🚨 New Insights in HFpEF Therapy! 🫀🔬 A groundbreaking JACC: Basic to Translational Science study shows that hydrogen sulfide (H₂S) deficiency is not just a byproduct—but a central driver of cardiometabolic heart failure with preserved ejection fraction (HFpEF). Using human plasma analysis + two robust preclinical models, researchers found: ⚠️ ~80–90% reduction in circulating H₂S 💔 Diastolic dysfunction, fibrosis, vascular impairment linked to low H₂S 💊 H₂S donors (JK-1, DATS) improved heart,

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03:57

Dr RR Baliga's Philosphical Discourses: Al-Ghazali...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/12

🌟 Al-Ghazali (1058–1111 CE) – The “Proof of Islam” 🌟 A Shafi’i jurist, Ash’arite theologian, Sufi mystic, and philosopher, Al-Ghazali transformed Islamic thought by uniting orthodox theology with spiritual depth. 📜✨ From his Tahafut al-Falasifa 🧠🔥 (Incoherence of the Philosophers) challenging Aristotelian science, to his Ihya Ulum al-Din 📖💫 reviving the heart of the Islamic faith, he inspired generations in the Islamic world and beyond—shaping Christian, Jewish, and modern philosophical

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08:12

Fabry Hearts 💖, Hidden Signals 🩺, Bold Solutions 🚀

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/11

💖 Fabry Disease & the Heart 🫀 A rare genetic condition with a big cardiac footprint—Fabry disease can cause left ventricular hypertrophy, arrhythmias, microvascular angina, and heart failure even when ejection fraction is preserved. 🔍 Early detection is key – Genetic testing, advanced imaging (CMR with T1 mapping, strain echocardiography), and awareness of “red flag” signs can change outcomes. 💊 Therapies are evolving – From enzyme replacement therapy to migalastat, and promising gene and

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05:17

Steps, Speed, Strength 💡🚶‍♀️💪 – Boosting Cadence to...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/11

🚶‍♀️💨 Small Steps, Big Gains for Frail Adults! 🏆📈 A new study in PLOS ONE shows that prefrail and frail older adults can safely increase walking cadence — and that even a modest boost of +14 steps/min can raise the odds of hitting a clinically meaningful improvement in the 6-Minute Walk Test by ~10%. 📊 High-intensity walking participants averaged 100 steps/min vs. 77 in casual walkers, with 65% achieving the Minimal Clinically Important Difference (MCID) in functional capacity. 💡

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08:10

💨 Clean Air, Lower Blood Pressure: HEPA’s...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/10

💨 Cleaner Air, Healthier Hearts! 🫀 A new JACC randomized crossover trial shows that in-home HEPA filtration near high-traffic roads can lower systolic blood pressure by ~3 mm Hg in people with elevated baseline BP—even in areas with low PM₂.₅ levels. 🔍 Why it matters: Small BP reductions at the population level translate into meaningful drops in heart attack and stroke risk. The study also highlights the Wilder Principle—those starting with higher BP benefit the most. 🛡️ Takeaway: HEPA air

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07:17

🧠⚖️🍽️ Circuits, Signals, Satiety – Decoding the...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/10

🔬🧠 New Insights into the Brain’s Role in Energy Balance! ⚖️🍽️ Cutting-edge research reveals how the hypothalamus, brainstem, and reward pathways integrate hormonal, neural, and environmental signals to regulate appetite, energy expenditure, and body weight. From POMC & AgRP neurons to the gut–brain axis and dopaminergic reward circuits, this work unravels the mechanisms behind obesity, leptin resistance, and metabolic regulation—and highlights promising targets like GLP-1 receptor agonists for

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06:15

ATTR-CM Under Siege ⚔️ Vutrisiran’s Defense 🛡️...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/09

🚨 New Insights from HELIOS-B 🫀✨ In patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM), the RNA interference therapy vutrisiran not only reduced mortality and cardiovascular events, but also showed measurable benefits in cardiac structure and function over 30 months. 📉 Thinner LV walls & lower LV mass index 💪 Preserved ejection fraction & stroke volume ⚙️ Improved diastolic function – better E/e′ & e′ velocity 🏆 Benefits seen even with substantial tafamidis use These

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05:48

💊 Lithium • 🧠 Memory • 🔄 Reversal

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/09

🧠✨ New hope for Alzheimer’s treatment — A Nature study reveals that low brain lithium levels may drive memory loss, amyloid plaques, and tau tangles. Researchers found that lithium orotate, a form less likely to bind amyloid, restored brain lithium, reduced pathology, and even reversed memory loss in mice — without kidney or thyroid toxicity. 💡 If confirmed in clinical trials, this low-cost, multitarget approach could transform care for millions with Alzheimer’s and potentially benefit older

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06:00

🛠️🏥 Criteria, Care, Centers: ACC 2025 Pericarditis...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/08

🚨 New Guidance Alert! The 🆕 2025 ACC Expert Consensus on Pericarditis is out — and it’s a game-changer. 🔍 Clearer diagnostic criteria 🖥️ Emphasis on multimodality imaging 💊 Refined therapeutic pathways (NSAIDs, colchicine, IL-1 blockers) 🏥 Stronger case for Pericardial Disease Centers Whether you’re managing acute chest pain or complex recurrences, this concise clinical guidance 📘 brings clarity, structure, and strategy. 📎 #Pericarditis #Cardiology #CMR #Guidelines #ACC2025

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05:21

From Mom or Dad? It Makes a Difference whether Growth...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/08

🚀 New in Nature: Groundbreaking study reveals how the origin of your genes — from mom 👩‍🍼 or dad 👨‍🍼 — can push human growth 📏 and metabolism 🔥 in opposite directions! 🧬 Using data from 236,781 people across UK Biobank, Estonian Biobank, and MoBa, researchers uncovered 30+ parent-of-origin effects (POEs), many showing bipolar impacts — boosting traits when inherited from one parent, reducing them from the other. ⚖️ Findings support the parental conflict hypothesis: paternal genes tend to

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03:53

💊 Rx to Fork: Can Doctors Really Prescribe Dinner?

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/07

🚨 New AHA Scientific Statement 🚨 “Food Is Medicine” isn’t just a slogan—it’s a growing clinical movement. 🍎💉 This systematic review of 14 U.S.-based RCTs explores how Produce Prescriptions (PRx), Medically Tailored Groceries (MTG), and Meals (MTM) impact diet, food insecurity, and health outcomes. 📊 Results show improvements in diet quality and food security, with mixed effects on clinical outcomes. 🧠 Key takeaway: We need better-designed, longer-term trials and real-world implementation

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795 results

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