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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

31:41

Going Beyond Time Barriers: Arutha Kulasinghe on the...

Mendelspod Podcast ·

2022/10/07

Arutha Kulasinghe was pumped for the AGBT (Advances in Genome Biology and Technology) Conference this year. He is the Principal Investigator for the Clinical-oMx Lab at the University of Queensland. Dr. Kulasinghe has pioneered spatial transcriptomics using digital spatial profiling approaches in the Asia-Pacific region, contributing to world-first studies for lung, head, and neck cancer and COVID-19. Not gathering last year due to the pandemic, the AGBT conference has became a kind of revival

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44:03

Invitae’s Data Manager, Farid Vij, on New Genome...

Mendelspod Podcast ·

2022/09/22

One thinks of Invitae as a leading genetic testing company that has worked to improve clinical quality while bringing prices down. And they are, and they have. But after listening to today's show, you will see that their vision is bigger than that.Farid Vij is the President and General Manager of Data at Invitae. A year ago Invitae bought a company he co-founded called Ciitizen which was focused on providing patients with access to their complete medical records. This is a public episode. If

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24:20

Satellite Bio out with a New Tissue Based Approach to...

Mendelspod Podcast ·

2022/08/25

Satellite Bio is named descriptively for the way its platform works. Out of stealth in the past few months with what you might call a middle ground approach to generative medicine between stem cell therapy and organ transplant, the company takes its name from the tissue therapy constructs they surgically implant in patients. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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41:32

We Have to Get Sequencing Back to Moore’s Law: Gilad...

Mendelspod Podcast ·

2022/06/23

There was a tweet thread at the end of the recent Advances in Genome Biology and Technology (AGBT) conference where researchers took a moment of silence for all the sequencing companies that have announced big plans at the conference and then died. It was clearly aimed at this year’s sequencing tools entrant and buzz-generating Ultima Genomics. The company emerged from stealth the week before AGBT announcing the $100 genome with a purse of $600 million backed by funders including Khosla Ventures,

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35:33

RNA Therapeutics: A New Paradigm for Drug...

Mendelspod Podcast ·

2022/06/16

Has the pandemic unleashed the molecule of RNA to be the new future of drug development?Tim Mercer is the Director of the BASE Lab at the University of Queensland which has recently become one of Australia’s leading national facilities for the manufacture and research of RNA technologies. Tim is the next guest in our series on enzymatic DNA synthesis which he says is "a quantum shift” in our ability to synthesize DNA.Tim then goes on to explore the future of mRNA vaccines and other RNA

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54:08

The System is Working. We Need More Engagement, Says...

Mendelspod Podcast ·

2022/06/09

Heidi Rehm’s talents for genomics are legendary. Our field has devoured them like a hungry beast.Discovering an appreciation for the natural logic of genetics in her early school years, Heidi would later learn she was good at the standardization of genomic databases for clinical use. This would make her a pioneering superstar of genomic medicine. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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41:42

The Promise of Exosomes Now Realized, Says Paul...

Mendelspod Podcast ·

2022/06/02

The area of early cancer detection continues to become ever more exciting these days. Each month more companies add liquid biopsies to their product offering as new technologies advance and are able to recognize cancer with increased sensitivity and specificity, particularly from cell-free DNA in the blood. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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58:41

Lee Cronin on Origin of Life, Genomics, Aliens and More

Mendelspod Podcast ·

2022/06/01

While we’re able to sit outside on a warm summer’s night under the ocean of stars, let us contemplate some of the bigger questions. We’re very excited to start out our twelfth season of the podcast with the chemist, Lee Cronin, from the University of Glasgow. Lee published an original and fundamental theory about the universe in the weeks after we taped which has profound implications for the question about the origin of life and could have some interesting applications in genomics. This is a public

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50:19

Eric Green on the Future of the NHGRI

Mendelspod Podcast ·

2022/05/28

Dr. Eric Green has been the Director of the National Human Genome Research Institute (NHGRI) at the National Institutes of Health (NIH) since 2009. Two years ago, he and his colleagues at the Institute came up with a strategic plan for the next ten years. Today we discuss the plan with the director and get his outlook on the future of human genomics.Dr. Green says human genomics can be roughly divided into four chapters. This is a public episode. If you'd like to discuss this with other

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30:03

5-Base Sequencing: Jonas Korlach and Tomi Pastinen

Mendelspod Podcast ·

2022/05/25

Pacific Biosciences has introduced a new method for detecting DNA methylation simultaneously with DNA sequencing. They are calling it 5-base sequencing.Today on the program, Jonas Korlach, PacBio’s Chief Scientific Officer, and Tomi Pastinen, the Director of the Genomic Medicine Center at Children’s Mercy Research Institute in Kansas City join us to describe the new breakthrough and connect it to clinical possibilities. This is a public episode. If you'd like to discuss this with other subscribers

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37:08

More Cancer Patients Die from Infections than Cancer,...

Mendelspod Podcast ·

2022/05/18

Alec Ford is passionate about his message. No wonder. There's an astounding fact in cancer medicine that is little known and could make a big difference. More cancer patients are dying from infections than they are from their cancers. And Alec's company has the technology to do something about it. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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31:22

Some of the Lowest Hanging Fruits in Precision...

Mendelspod Podcast ·

2022/05/10

One of the underrated but true successes of precision medicine has been pharmacogenomics. Beginning in the ’90s with the approval of the drug Herceptin for HER2 positive breast cancer, tailoring drugs to genotype has been one of the less controversial areas of our field and will only continue to build on the early promise of sequencing the human genome.Today we talk Michelle Whirl-Carrillo, Director of PharmGKB, a one-stop go-to for pharmacogenomics data that has been funded by the NIH since 2000

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37:14

John Nelson of GE Research Talks Vaccines on Demand,...

Mendelspod Podcast ·

2022/04/14

Today we talk with John Nelson, Senior Principal Scientist at GE Research and veteran in the field of DNA synthesis. On January 7th, 2020, two weeks before the first cases of the coronavirus were reported in the U.S, John and a team of scientists and engineers proposed a new project to DARPA called NOW, or Nucelic Acids on Demand Worldwide. The goal of the project, now fully underway, is to deliver DNA-based vaccines anywhere in the world in three days. This is a public episode. If you'd like to

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39:29

A New Generation Comfortable Doing a Thousand Things...

Mendelspod Podcast ·

2022/04/07

“I’ve seen a lot of revolutions. Now we’re at the beginning of spatial biology, and I think it has the chance to transform life science similar to next gen sequencing, but even more. It’s going to have more ramifications that spread through more disciplines than any of the revolutions I’ve seen in a while.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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45:22

Enabling a New Age of Unbiased Proteomics Discovery:...

Mendelspod Podcast ·

2022/03/31

Are we now entering the age of proteomics the way we did with genomics thirty years ago?We were told we should talk to today’s guest by four people in one week. He’s Omid Farokhzad, CEO and Founder of Seer Inc. When we did, we understood why.Seer offers its customers the chance to “see the proteome in a way that’s never been possible before.” So what does that mean? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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35:17

The Rise of MRD Testing and the Field of...

Mendelspod Podcast ·

2022/03/17

"There's an entire field of fragmentomics with a whole lot of people working on it. The DNA which is shed into the bloodstream has a certain length. The length of ctDNA is shorter than cfDNA, and depending on where the cancer cell is located, the fragment size and pattern is different. So you can actually deduce information about the tissue of origin from the fragment length and pattern. And that's just the beginning." This is a public episode. If you'd like to discuss this with other

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28:08

The Invention of Enzymatic DNA Synthesis with Sylvain...

Mendelspod Podcast ·

2022/03/03

The DNA synthesis space is seeing some real creativity and disruption this past year. One newcomer, in particular, is shaking things up.Sylvain Gariel is the co-founder and chief operating officer of DNA Script, who has recently launched the world’s first benchtop enzymatic DNA synthesizer. In today's show, Sylvain, co-inventor of the new system, tells how he met his co-inventors at a French gas company and came to invent a whole new way of writing DNA. This is a public episode. If you'd like to

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30:25

Akoya Biosciences Launches New Integrated Spatial...

Mendelspod Podcast ·

2022/02/24

Even though Brian McKelligon calls himself a rookie CEO, he comes to the top position at Akoya Biosciences with a veteran’s resume. His path to one of spatial biology’s hottest companies in 2022 worked him up the ranks of some of the top names in life science tools: Affymetrix, Ingenuity, Ion Torrent, and 10X Genomics. Last year Brian led Akoya through an IPO and this year the company has launched a new integrated product line called the Phenocycler-Fusion which they are calling the fastest

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31:11

Harlan Robins on How T-cell Focused COVID Vaccines...

Mendelspod Podcast ·

2022/02/16

Harlan Robins is the Chief Scientific Officer at Adaptive Biotechnologies in Seattle. In 2014, Harlan and his brother Chad co-founded Adaptive as a spinout from the Fred Hutchinson Cancer Center where Harlan had served as the head of computational biology. Adaptive has been developing what they call "immune medicine" mainly in the area of cancer. When the corona virus pandemic hit, they came out with the world’s first T cell-based COVID diagnostic. The test has garnered them a lot of data on T

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39:15

Twist Bioscience: A New Kind of DNA Synthesis Company

Mendelspod Podcast ·

2022/02/10

“DNA is changing everything for the better,” says today’s guest, Emily Leproust, CEO of Twist Bioscience. Twist has emerged at the heart of what a New York Times Magazine write-up recently headlined The Gene Synthesis Revolution. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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532 results

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