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PODCAST

Smart Biotech Scientist | The CMC and Biomanufacturing Podcast for Bioprocess Development and Manufacturing Leaders

David Brühlmann - CMC Development Leader, Bioprocess Expert, Business Strategist

The go-to CMC and bioprocessing podcast for process development scientists and CMC leaders scaling biologics into regulatory-ready therapies with less trial and error.Practical, execution-focused guidance on CMC development, tech transfer, scale-up, GMP readiness, CDMO partnerships, and manufacturing economics.Hosted by Dr. David Brühlmann, CMC strategist, former Bioprocess Innovation Manager at Merck, PhD in glycoengineering, and close to 20 years of biomanufacturing experience. Smart Biotech

science life sciences

All Episodes

22:35

81: Regenerating Muscles: The Future of Autologous...

Smart Biotech Scientist | The CMC and... ·

2024/08/20

Send us a Text Message.Discover how scientists are transforming lives through innovative muscle regeneration therapy. In this captivating episode, Deana Mohr, CEO and co-founder of MUVON Therapeutics, spin-off from the University of Zurich, unveils her groundbreaking autologous muscle regeneration technology for treating stress urinary incontinence.Learn how this minimally invasive treatment harnesses the power of a patient's own cells to restore muscle function, offering hope to millions. Di...

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20:14

80: Think Before You Build: Holistic Approaches to...

Smart Biotech Scientist | The CMC and... ·

2024/08/15

Send us a Text Message.Ever wondered why some biotech facilities thrive while others struggle Alfredo Martínez Mogarra, a Bioprocess Engineer with over 30 years of experience and Chief Operations Manager at VIVEbiotech, reveals the secrets to successful biotech manufacturing.In this eye-opening episode, Alfredo shares critical insights on bridging the gap between lab-scale processes and industrial production.You will get:Strategies for seamless scale-up and risk mitigation in bioprocess devel...

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24:24

79: Think Before You Build: Holistic Approaches to...

Smart Biotech Scientist | The CMC and... ·

2024/08/13

Send us a Text Message.Ever wondered what it takes to build a large-scale biotech manufacturing facility? Alfredo Martínez Mogarra, a seasoned Bioprocess Engineer with over 30 years of experience and Chief Operations Manager at VIVEbiotech, reveals the secrets behind successful biotech facility design and scale-up. He has been at the forefront of transforming bench processes into industrial realities.In this eye-opening episode, Alfredo shares critical insights on navigating the complex world...

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18:10

78: Cell Factories Explained: How Synthetic Biology...

Smart Biotech Scientist | The CMC and... ·

2024/08/08

Send us a Text Message.Unlock the secrets of cell factories and discover how cutting-edge technologies are revolutionizing biopharmaceutical production. In this episode, we welcome Mauro Torres, a postdoctoral researcher at the University of Manchester, who takes us on a fascinating journey through the complex world of protein manufacturing.Mauro Torres explains the intricate steps involved in the secretory pathway, from gene expression to protein export, likening it to a sophisticated car ma...

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23:00

77: Cell Factories Explained: How Synthetic Biology...

Smart Biotech Scientist | The CMC and... ·

2024/08/06

Send us a Text Message.Unlock the secrets of cell factories with Mauro Torres, a postdoctoral researcher at the University of Manchester who brings cutting-edge insights into protein production. Discover how the concept of cell factories has evolved from basic insulin extraction to groundbreaking treatments for genetic disorders and cancer. We reveal the challenges faced by biotech scientists in bioprocess development and offers a fascinating analogy between car manufacturing and cellular pro...

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23:29

76: Transforming Single-Cell Analysis With Impedance...

Smart Biotech Scientist | The CMC and... ·

2024/08/01

Send us a Text Message.Curious about the latest innovations in cell analysis technology? Join us in this episode with Furkan Gökçe, New Business Development Manager at Amphasys, as we delve into the fascinating world of Impedance Flow Cytometry (IFC).Furkan shares how IFC is revolutionizing single-cell analysis by providing faster, more precise, and high-resolution data.Key Takeaways:Real-Time Precision: Discover how IFC allows for real-time, label-free assessments of cells, providing detaile...

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17:24

75: Transforming Single-Cell Analysis With Impedance...

Smart Biotech Scientist | The CMC and... ·

2024/07/30

Send us a Text Message.Ever wondered how single-cell analysis could revolutionize bioprocessing? Join us in this episode as we delve into the cutting-edge world of impedance flow cytometry.Furkan Gökçe, New Business Development Manager at Amphasys, shares his insights on the transformative power of this technology in the biotech industry. With a background in engineering and physics, Furkan provides a unique perspective on tackling the complexities of biological systems.Key Takeaways:Enhanced...

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17:17

74: Bead-Based Assays: The Power of High-Throughput...

Smart Biotech Scientist | The CMC and... ·

2024/07/25

Send us a Text Message.Dive into the transformative world of bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech, where high-throughput screening meets cutting-edge biotechnological advancements.Join us as we chat with Sebastian, a seasoned scientist and entrepreneur who has revolutionized the workflow of high-throughput screening of titer, glycosylation, and aggregation with innovative bead-based assays.Key Takeaways:Streamlined Workflow: Learn how a simplified sample ...

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19:18

73: Bead-Based Assays: The Power of High-Throughput...

Smart Biotech Scientist | The CMC and... ·

2024/07/23

Ready to revolutionize your lab work? Join us as we dive deep into bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech.Discover how these tiny beads are making a massive impact on biotech research and development — for titer, glycan, and aggreation screening — and how this developability screening platform can enhance your antibody discovery, antibody engineering and lead optimization.In this episode, you’ll learn:Speed and Simplicity: How bead-based assays offer unmatc...

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21:59

72: Effective Outsourcing: How Small Biotech...

Smart Biotech Scientist | The CMC and... ·

2024/07/18

How do small biotech companies make strategic decisions with limited resources? This episode dives deep into the art of prioritization and outsourcing to achieve success.Join us as we speak with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, a seasoned biotech scientist with years of experience in both large and small biotech companies. Mark shares his invaluable insights on navigating the complexities of bioprocess development and outsourcing.In this episode, we ex...

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18:32

71: Effective Outsourcing: How Small Biotech...

Smart Biotech Scientist | The CMC and... ·

2024/07/16

Are you navigating the complex world of bioprocess CMC development and manufacturing in a small biotech company?Our latest episode is a must-listen! Join us as we sit down with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, who shares invaluable insights on overcoming the unique challenges faced by small biotech firms.In this episode, we explore:The critical communication strategies needed for successful outsourcing to CDMOs.How small biotechs can leverage their agi...

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15:31

70: Glycoanalytics Explained: Analysing and Designing...

Smart Biotech Scientist | The CMC and... ·

2024/07/11

In this insightful episode, we explore the cutting-edge field of glycoengineering and its transformative impact on biopharmaceutical drug design. Join us as we chat with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, to uncover the nuances of chemoenzymatic glycogen engineering and its potential to revolutionize therapeutics.Key Takeaways:Understanding Glycoengineering: Discover the three main approaches—genetic, metabolomic, and chemoenzymatic—f...

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18:09

69: Glycoanalytics Explained: Analysing and Designing...

Smart Biotech Scientist | The CMC and... ·

2024/07/09

Uncover the hidden science behind creating safer, more effective biological drugs! Dive into glycoanalytics and glycoengineering, the secret weapons revolutionizing biopharma.Join us as we talk with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, who breaks down the complexities of glycosylation and its pivotal role in drug development.Key Takeaways:Critical Quality Attributes: Understand how glycans influence the function and structure of biophar...

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28:53

68: How Process Mapping Transforms Knowledge...

Smart Biotech Scientist | The CMC and... ·

2024/07/04

Join us as we explore the pivotal role of process mapping in biotech knowledge management. Our guest, Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, shares invaluable insights into leveraging technology to streamline operations.Key Insights:Identifying Critical Process Knowledge: Learn strategies to identify and manage vital process knowledge essential for optimal performance.Transitioning from Implicit to Explicit Knowledge: Disco...

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14:22

67: How Process Mapping Transforms Knowledge...

Smart Biotech Scientist | The CMC and... ·

2024/07/02

Want to turn your biotech chaos into streamlined success? Learn from expert Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, on how process mapping can transform your knowledge management and elevate your business performance.Key Takeaways:Eliminate Scope Creep: Learn how to maintain focus in projects despite shifts and changes, improving productivity and reducing frustration.Bridge Experience Gaps: Understand how process mapping cre...

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16:08

66: Freezing and Thawing Cells: the Science Behind...

Smart Biotech Scientist | The CMC and... ·

2024/06/27

Get ready to dive into the fascinating world of cryopreservation!In this episode, we welcome Mark Davison, an experienced entrepreneur and CEO of Grant Instruments, leaders in laboratory equipment, to explore the intricate science of freezing and thawing cells.Mark brings his wealth of experience to demystify this crucial process, revealing how cutting-edge technology ensures precision and reliability in preserving biological samples.Key Takeaways:Mastering Precision: Learn how data acquisiti...

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24:15

65: Freezing and Thawing Cells: the Science Behind...

Smart Biotech Scientist | The CMC and... ·

2024/06/25

Picture a world where we can freeze cells and bring them back to life perfectly intact.In this episode, we're joined by Mark Davison, a leading expert in cryopreservation and CEO of Grant Instruments to uncover the intricate science of freezing and thawing cells. From basic principles to advanced techniques, we delve into how cryopreservation is revolutionizing biotechnology and cell therapies.Key Takeaways:Cell Survival Secrets: Discover why water is both a friend and foe in preserving cell ...

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21:52

64: Why Sound Waves Are the Future of Gene Therapy...

Smart Biotech Scientist | The CMC and... ·

2024/06/20

Could sound waves be the revolutionary key to gene therapy manufacturing? In this episode, Gabriel Dumy, CTO and Co-founder at Kolibri, reveals how acoustic waves are set to transform cell harvesting and gene transfection processes, making biomanufacturing more efficient and less damaging to cells.Kolibri is a company revolutionizing the way we grow and engineer cells at scale using acoustic waves.Key Takeaways:Real-Time Cell Harvesting: Discover how reconfigurable acoustic waves enable non-d...

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25:27

63: Why Sound Waves Are the Future of Gene Therapy...

Smart Biotech Scientist | The CMC and... ·

2024/06/18

Are sound waves the key to revolutionizing gene therapy? In this groundbreaking episode, we sit down with Gabriel Dumy, CTO and Co-founder at Kolibri, a company revolutionizing the way we grow and engineer cells at scale using acoustic waves.Gabriel shares the challenges facing modern bioproduction and unveils an exciting solution that's setting the stage for the future of gene therapy.Key Takeaways:Enhanced Cell Productivity: Discover how acoustic waves minimize shear stress, significantly b...

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15:16

62: Magnetic Bead Technology: The New Era in...

Smart Biotech Scientist | The CMC and... ·

2024/06/13

Dive into the future of bioprocessing with Nils Brechmann, Marketing Manager at MAGic BioProcessing and co-inventor of the process applications, as we explore how magnetic bead technology is transforming downstream processing.MAGic BioProcessing is a biotech company from Uppsala, Sweden, that develops magnetic-based recovery of biologicals.Key Takeaways:Streamlined Purification: Discover how magnetic beads enable simultaneous clarification and capture, boosting efficiency.Cost Savings: Learn ...

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209 results

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