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PODCAST

Springer Nature

Springer Nature

Welcome to the Springer Nature Soundcloud page! Here you will find several podcasts from our journals across a range of scientific subjects, including Gene Pod, ModPath Chat, Pediapod, Hereditypod and Brainpod.

science

All Episodes

00:11:15

Early Career Investigator Spotlight: Matthew W. Harer

Springer Nature ·

2021/11/18

Caffeine administration has been associated with reduced rates of Acute Kidney Injury (AKI) in preterm neonates but the effect of caffeine on renal oxygenation is unknown. In this episode, we meet this month's highlighted Early Career Investigator, Dr. Matthew Harer from the University of Wisconsin School of Medicine and Public Health. He has been investigating the potential use of Near Infrared Spectroscopy (NIRS), a non-invasive means of continuously measuring tissue oxygenation to assess the

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00:19:55

Re-evaluating tumors of purported specialized...

Springer Nature ·

2021/11/11

The host is joined by Dr. Andres Acosta from the Brigham and Women Hospital. Dr Acosta discusses, on behalf of a distinguished group of coauthors, their recent somewhat provocative modern pathology publication proposing that mesenchymal neoplasms of the prostate are morphologically and molecularly heterogeneous lesion that include neoplasms that harbor genetic aberrations seen in specific mesenchymal tumors arising in other anatomic sites, such as soft tissue and the uterus.

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00:24:50

A genomic approach to oceanography

Springer Nature ·

2021/11/03

Can we really understand ancient shifts in oceanic currents by looking at the population genetics of migratory species? Find out in this episode, as Dr Jurjan van der Zee (University of Groningen) discusses his search for a warm-water corridor between the Atlantic and Indian oceans in the genomes of green turtles.

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00:09:43

Astrocyte-neuron signaling in the mesolimbic dopamine...

Springer Nature ·

2021/11/02

Star-shaped cells called astrocytes are the most abundant cells to be found in the human brain. In the past, they’d been thought to play a supporting role to neurons, such as providing metabolic support, but recently they’re also emerging as stars of information processing. They can respond to neurotransmitters and release neuroactive substances that then affect synaptic transmission and plasticity. Michelle Corkrum is a child neurology resident at Columbia University and is one of the authors of a

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00:10:49

SARS-CoV-2 vaccine testing and trials in the...

Springer Nature ·

2021/10/29

Early on in the SARS-CoV-2 pandemic, the majority of infected children were either asymptomatic or had mild COVID-19 disease, prompting many to demand a higher acceptable risk threshold for pediatric vaccines. More recently, as children begin to make up a larger proportion of the infected population and following evidence of the mental and physical toll exacted by the pandemic on children, a pediatric vaccine is now more pressing. But challenges to widespread vaccine uptake remain. In this episode

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00:05:35

The potential impact of a PRS-based breast cancer...

Springer Nature ·

2021/10/29

Polygenic risk scores (PRS) can be an important tool in breast cancer patients to help stratify individuals into levels of disease risk. The clinical utility of PRS is still being evaluated, but what hasn't yet been evaluated is how to communicate such results to patients, and how they respond to their PRS scores. On this month’s GenePod, Tatiane Yanes, a post-doctoral researcher at the University of Queensland and a genetic counselor at the Queensland Children’s Hospital, discusses how a team of

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00:26:50

Substituting cells for cosmic stars, the sky is the...

Springer Nature ·

2021/10/26

In this special “Meet the Expert” episode, two distinguished guests from Johns Hopkins University discuss their pioneering approach of applying methodologies, initially developed for astronomy, to the assessment of biomarkers of tumor microenvironment (TME). The guests are Dr. Janis Taube, director of Dermatopathology at Hopkins, and a co-Director of the TME Core at the Bloomberg-Kimmel Institute of Immunotherapy and Dr. Alex Szalay, Bloomberg Distinguished Professor of Astronomy and Computer

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00:19:12

Counting Mitoses: SI(ze) matters!

Springer Nature ·

2021/10/12

In this episode, Dr. Ian Cree, Head of The WHO Tumour Classification discusses his team's recent open access publication in Modern Pathology. Historically, mitotic figures counting has been done by expressing the number of mitoses per n high power fields (HPFs), ignoring the fact that microscope fields may differ substantially, even at the same high power (×400) magnification. Dr. Cree and coauthors remind all of this variation and its implication on the accuracy of our diagnostic and tumor grading

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00:13:46

Resisting the Tilapia Lake Virus

Springer Nature ·

2021/10/06

Nile tilapia are the third most important farmed fish worldwide, but the emergence of the Tilapia Lake Virus (TiLV) threatens its sustainable production. In this episode, Dr Agustin Barría (The Roslin Institute) discusses his recent collaboration, where they used a natural outbreak of TiLV to investigate the genetic architecture of disease resistance. In this episode we explore the recent Heredity paper: “A major quantitative trait locus affecting resistance to Tilapia lake virus in farmed Nile

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00:09:18

Where are therapeutics succeeding/where is research...

Springer Nature ·

2021/09/30

Researchers are still laying the groundwork in the search for therapeutics that target the mechanism for genetic disorders leading to new treatments. On this month’s GenePod, authors of two recently published articles in Genetics in Medicine discuss where trials for such molecules are succeeding and where there is still more research to be done to determine the efficacy and safety of new treatments. Ravi Savairayan, professor of genetics at the Murdoch Children’s Research Institute discusses the

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00:18:06

Regression predicts Sentinel Lymph Node (SLN) status

Springer Nature ·

2021/09/14

The prognostic significance of regression has long been a matter of debate. Our guest, Professor Richard Scolyer, co-director of the Melanoma Institute Australia discussed his team’s recent findings on the prognostic value of regression, and the presence of regression and/or tumor infiltrating lymphocytes (TIL) in primary cutaneous melanomas predicted sentinel lymph node (SLN) status and survival outcomes.

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00:15:45

Chorioamnionitis induces changes in ovine pulmonary...

Springer Nature ·

2021/09/13

Chorioamnionitis is an intrauterine infection of the placenta and fetal membranes. It is the leading cause of preterm delivery and is a common risk factor for adverse pulmonary outcomes such as bronchopulmonary dysplasia. There is evidence to suggest that the first negative impacts on pulmonary development occur in utero in the presence of chorioamnionitis. In this episode, we meet assistant professors Niki Reynaert and Tim Wolfs from Maastricht University in the Netherlands. Together they studied

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00:09:58

Juvenile idiopathic arthritis: effects of different...

Springer Nature ·

2021/09/13

Juvenile idiopathic arthritis (JIA) is one of the most common inflammatory joint diseases in children. Previous studies have shown that in the oligoarticular subtype of this disease, T cells play a central role in pathogenesis. T cell inhibitory receptors (IRs) seem to play an important role in the development of tolerance and recognition of self and non-self antigens. Ligands binding to these IRs inhibit T cell function and modulate the course of the immune response. In this episode, we meet this

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00:08:11

Neurobiology of loneliness: a systematic review

Springer Nature ·

2021/09/13

Loneliness is a subjective experience, but neuroscientists define it as a distress that arrives from a discrepancy between perceived and desired social relationships. There may be an evolutionary benefit to the feeling of loneliness; we’re a social species, and feeling lonely might have sent us to seek out other humans, which has been very important for survival. Moreover, if gone unaddressed and isolation worsens, health effects of loneliness have been shown to double mortality rates. It's linked

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00:09:41

Experts create ACMG’s first evidence-based clinical...

Springer Nature ·

2021/09/13

Congenital anomalies (CA), developmental delay (DD), and intellectual disability (ID) are among the most common indicators in children that lead to genetic testing. Identification of an underlying diagnosis for CA or DD/ID can be consequential to care management and long-term prognosis for the child. But there has been no evidence-based guideline for clinicians to refer to that supports the use of exome or genome sequencing as a first-line or second-line test for the evaluation of pediatric patients

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00:20:37

A Novel Prognostic Score for NSCLC following...

Springer Nature ·

2021/08/31

Dr. Sabina Berezowka, from the university of Lausanne Switzerland, discusses with our host her team’s recent study describing a novel “Prognostic Score” for assessing tumor regression following Neaodjuvant therapy in non-small cell lung cancer (NSCLC). The proposed combined prognostic score (PRSC) performed better than pTNM staging and previously published Major Pathologic Response (MPR) approach. Study by Berezowka et al, A prognostic score for non-small cell lung cancer resected after neoadjuvant

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00:17:51

DDIT3 Immunohistochemical expression as a diagnostic...

Springer Nature ·

2021/08/20

Dr. Jason Hornick discusses his team recent study finding that a monoclonal antibody directed against the N-terminus of DDIT3 is a highly sensitive and specific for high-grade MLPS. DDIT3 immunostains could replace molecular genetic testing in many cases, although limited labeling may be seen in a range of other tumor types.

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00:26:46

A MODPATH Chat with Dr. Victor Reuter: The Digital...

Springer Nature ·

2021/08/12

Always a visionary, Dr. Reuter was one of the earliest Anatomic Pathologists to embrace and advance the genomic and more recently the digital transformation of our field. In this episode of Meet The Expert series, Dr. Reuter shares his perspective and vision on the current and future impact of digital pathology.

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00:20:35

TRIM63 as a biomarker for MiT family RCC

Springer Nature ·

2021/08/12

In this episode Dr. Rohit Mehra of University of Michigan discusses the utility of TRIM63 as a diagnostic marker to distinguish MiTF-RCC from other renal tumor subtypes with overlapping morphology. In combination with TFE3/TFEB FISH, TRIM63 RNA-ISH assays can improve the accuracy and efficiency of MiTF-RCC diagnosis. Associated article: TRIM63 is a sensitive and specific biomarker for MiT family aberration-associated renal cell carcinoma. https://www.nature.com/articles/s41379-021-00803-z

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00:19:35

Artificial intelligence for advance requesting of IHC...

Springer Nature ·

2021/08/12

Dr. Clare Verrill and Andrea Chatrian of Oxford University in England discuss their team’s study on AI for advance ordering of IHC in difficult prostate biopsy. Their elegant work shows that an AI tool making automated IHC request prior to the pathologist read of H&E could create leaner workflow and result in pathologist time savings and shorten overall Turnaround time from accession to final diagnosis. Associated article: Artificial intelligence for advance requesting of immunohistochemistry in

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