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PODCAST

Two Onc Docs

This is Sam and Karine, and we are Two Onc Docs! We both graduated from our Heme/Onc fellowships in 2021 and became board certified in both Hematology and Oncology. Our mission with Two Onc Docs is to create short board review episodes that you can listen to on your drive to work, while you make your morning coffee, or between pages on call. This is intended to be a supplement to other established board studying resources for busy trainees. *This podcast is intended to be an educational resource for

health & fitness medicine

All Episodes

15:52

Preparing for Fellowship 101

Two Onc Docs ·

2025/06/30

This week’s episode will be focusing on how to prepare for the start of heme/onc fellowship! We will go over some general advice on how to succeed, study tips and resources we used throughout fellowship as well as some tips on how to stay academically productive during training if you are planning for an academic career.

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12:33

ASCO 2025 Plenary: SERENA-6

Two Onc Docs ·

2025/06/24

This week’s episode will be focusing on one of the 2025 plenary sessions: SERENA-6, Camizestrant, a novel selective estrogen receptor degrader (SERD) + CDK 4/6i for tx of emergent ESR1 during 1L endocrine-based therapy + ahead of progression in stage 4 HR+/Her-2 negative breast cancer. We discuss the trial design, endpoints, results, safety concerns, and how it fits into current practice.

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12:58

Ovarian Cancer 2025 UPDATE

Two Onc Docs ·

2025/06/16

This week’s episode will be focusing on Ovarian Cancer with 2025 updates since we last covered this topic in 2022. We will go over all important details on the risk factors, presentation, diagnosis, staging & treatment options for both localized and metastatic disease.

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12:59

ASCO Annual Meeting 2025 GU Updates

Two Onc Docs ·

2025/06/09

This week’s episode will be focusing on exciting data in GU presented at the 2025 ASCO Annual Meeting in prostate (including prognostication of PSA response in mCSPC, AMPLITUDE - PARPi in mCSPC), RCC (including updates in KN-564, CM-214 and PDIGREE), and finally bladder CA (with updates in NIAGARA and EV-302) among others.

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11:28

ASCO 2025 Preview

Two Onc Docs ·

2025/05/27

This week’s episode will be focusing on exciting data to come at the ASCO Annual Meeting 2025 starting with the plenary sessions, then a special focus on the GU abstracts, including prostate CA, renal cell carcinoma, bladder CA, and a quick shout-out for some of the medical education sessions.

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15:51

Hepatocellular Carcinoma (HCC) 2025 UPDATE

Two Onc Docs ·

2025/05/12

This week’s episode will be focusing on hepatocellular carcinoma (HCC). We will go over important details on assessing liver function, staging of HCC and loco-regional as well as systemic treatment options for HCC.

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29:22

Stem Cell Transplant (SCT) Part 2 2025 UPDATE

Two Onc Docs ·

2025/05/05

This week’s episode will be focusing on Hematopoietic Stem Cell Transplant. We welcome our guest Dr. Jeff Auletta, Senior Vice President, National Marrow Donor Program, and Chief Scientific Director,Center for International Blood and Marrow Transplant Research. Part 2 discusses conditioning regimens, graft-vs-host disease, toxicities, and Dr. Auletta's career path.

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26:50

Stem Cell Transplant (SCT) Part 1 2025 UPDATE

Two Onc Docs ·

2025/04/28

This week’s episode will be focusing on Hematopoietic Stem Cell Transplant. We welcome our guest Dr. Jeff Auletta, Senior Vice President, National Marrow Donor Program, and Chief Scientific Director,Center for International Blood and Marrow Transplant Research. Part 1 discusses important basics including what a transplant is, types of transplant & associated risks, types of donors, how to find a donor, and barriers/inequities of finding a donor.

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10:41

Testicular Cancer 2025 UPDATE Part 2 (Non-Seminoma)

Two Onc Docs ·

2025/04/22

This week’s episode is part 2 of testicular cancer 2025 updates. We had the honor of interviewing Dr. Larry Einhorn a true legend when it comes to the management of non-seminoma last year, released 4/22/2024, but today, we will be repeating a quick overview of the staging and management for initial treatment of non-seminoma as well as refractory disease.

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12:01

Testicular Cancer 2025 UPDATE Part 1 (Seminoma)

Two Onc Docs ·

2025/04/14

This week’s episode is part 1 of testicular cancer 2025 updates. We had the honor of interviewing Dr. Larry Einhorn a true legend when it comes to the management of testicular CA last year, released in April 2024, but today, we will be repeating a quick overview of risk factors and staging for testicular cancer, as well as the management of seminoma.

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12:42

Chronic Lymphocytic Leukemia (CLL) 2025 UPDATE

Two Onc Docs ·

2025/03/31

This week’s episode will be focusing on an update of CLL. We will go over important details on the presentation, diagnosis, prognostic factors, and treatment options for initial and refractory disease, as well as key toxicities.

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34:53

Metastatic Prostate Cancer x Dr. Charles Ryan 2025...

Two Onc Docs ·

2025/03/24

We are so excited to welcome back Dr. Charles (Chuck) Ryan for our 2025 prostate cancer updates. Dr. Ryan is an internationally recognized GU oncologist and prostate cancer expert, seeing patients at MSK in NYC, and co-host of the podcast 'The Good News About Cancer'. This episode will cover metastatic prostate cancer including board review pearls & key toxicities of treatments, upcoming exciting research in PCa, and advice for trainees/early career faculty.

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35:49

Localized Prostate Cancer x Dr. Charles Ryan 2025 UPDATE

Two Onc Docs ·

2025/03/18

We are so excited to welcome Dr. Charles (Chuck) Ryan for our 2025 prostate cancer updates. Dr. Ryan is an internationally recognized GU oncologist and prostate cancer expert, seeing patients at Memorial Sloan Kettering in NYC. This episode will cover localized prostate cancer, risk factors, staging, role of PET PSMA, risk stratification, treatments, as well as introduce biochemical recurrence.

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23:45

Metastatic Colon Cancer 2025 UPDATE

Two Onc Docs ·

2025/03/11

Today’s episode is focusing on what you need to know regarding metastatic colon cancer. This will include the need to know about molecular studies, treatment, and surgery for oligometastatic disease. There has been three breakthroughs since we last covered this topic in the treatment of metastatic CRC based on molecular findings that we will go over today.

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21:07

Localized Colon Cancer 2025 UPDATE

Two Onc Docs ·

2025/03/03

Today’s episode is focusing on what you need to know regarding early stage colorectal cancer (CRC) as of 2025. The last time we covered this topic was in 2023 and things continue to change. We will go over all the important details on the diagnosis, presentation, diagnostic work-up, role of ctDNA, staging, treatment, and surveillance of localized CRC.

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19:22

Multiple Myeloma 2025 x Dr. Vincent Rajkumar Part 2

Two Onc Docs ·

2025/02/24

We are so honored to welcome back Dr. S. Vincent Rajkumar, Professor of Medicine at the Mayo Clinic in Rochester, Minnesota. He is also Editor-In-Chief of Blood Cancer Journal and the Chairperson of the Board of the International Myeloma Foundation. This week’s episode will be focusing on additional pearls for the treatment of Multiple Myeloma including options for refractory disease, as well as advice for trainees.

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13:22

ASCO GU 2025 Takeaways

Two Onc Docs ·

2025/02/18

Today we will be discussing a few of the exciting abstracts presented at ASCO GU (Feb 13-15 2025) for prostate CA (TALAPRO-2), bladder CA (EV-302, CM-274, NIAGARA), and RCC (COSMIC-313, KIM-1).

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10:46

ASCO GU 2025 Preview

Two Onc Docs ·

2025/02/10

Today we will be discussing exciting data to come at ASCO GU (Feb 13-15 2025) in terms of research for prostate CA, bladder CA, RCC and other rarer GU tumors.

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17:34

Multiple Myeloma 2025 x Dr. Vincent Rajkumar Part 1

Two Onc Docs ·

2025/02/03

We are so honored to welcome Dr. S. Vincent Rajkumar, Professor of Medicine at the Mayo Clinic in Rochester, Minnesota. He is also Editor-In-Chief of Blood Cancer Journal and the Chairperson of the Board of the International Myeloma Foundation. This week’s episode will be focusing on Multiple Myeloma symptoms, diagnostic criteria, work-up and initial treatment.

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34:24

Small Cell Lung Cancer 2025 x Dr. Stephen Liu Part 2

Two Onc Docs ·

2025/01/27

This week’s episode will be focusing on additional details for Extensive Stage Small Cell Lung Cancer (SCLC), options for relapsed/refractory disease & advice for trainees. We are so excited to welcome back Dr. Stephen Liu international expert for lung cancer, Director of Thoracic Oncology & Developmental Therapeutics at Georgetown Lombardi Cancer Center and Co-Host of the IASLC Podcast.

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