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PODCAST

cc: Life Science Podcast

How will AI, CRISPR, CGT and other new technologies impact life science? I"m following my curiosity. Follow along with me. cclifescience.substack.com

science life sciences

All Episodes

36:05

Exploring the Epigenetic Landscape with the Six-Base...

cc: Life Science Podcast ·

2024/09/18

Unlocking the Secrets of the Six-Base GenomeEpigenetics was somewhat vague when I was an undergraduate ( a long time ago). So I was curious to get an update on how we can investigate it more closely and what we are learning. I talked to Tom Charlesworth, Director of Market Strategy and Corporate Development at biomodal, a sequencing technology company focused on epigenetics. Tom explained how modifications beyond the traditional four DNA bases impact gene expression, development, and disease. What

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23:05

A Year in Space: Varda’s Capsule Returns

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2024/09/11

A year ago, Mark Herbert, VP of Biopharma Business Development at Varda Space Industries, joined me on one of the most popular episodes of this podcast. Today, he’s back with some exciting updates on Varda's latest mission, which involved launching a satellite and conducting pioneering drug manufacturing experiments in space. From overcoming regulatory hurdles to making groundbreaking discoveries, Varda’s journey is a glimpse into the future of pharmaceuticals—and it’s happening above our

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27:59

Hydrosomes: Tiny Bubbles with Huge Potential

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2024/08/21

When I first heard about hydrosomes, I honestly thought, “That can’t be real.” Hydrosomes are microscopic bubbles that stay in water without coalescing and rising to the surface. Then I met Nick Jackowetz, the Senior VP and Principal Scientist and the team from Hydrosome Labs at BIO 2024 in San Diego. They answered my questions and I invited Nick to be a guest on the podcast to share the story with you. Hydrosomes are also known as ultrafine bubbles, and they have incredible potential for many

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23:57

From Scientist to Consultant by Way of Curiosity

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2024/08/07

Issa Kildani is the founder and principal consultant at Ambrosia Ventures. Our conversation centered on his journey from metabolic and cardiovascular research into the consulting world. Even if you are not planning on becoming a consultant, one can learn a lot from his approach to acquiring skills and building relationships with customers.Transitioning from Research to ConsultingYou don’t need an MBA to become a consultant. I’m sure it helps in some areas, but there is a lot to be said for rolling

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18:38

Terran Biosciences is Developing New Regimens for...

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2024/06/19

At BIO2024, I spoke Sam Clark, CEO and founder of Terran Biosciences, about their development of new long-duration dosage forms for the treatment of schizophrenia . We discussed the development of prodrugs, the potential of psychedelics, and the journey of founding a biotech company. The Genesis of Terran BiosciencesSam's journey into biotech was personal. Growing up around friends and family members with severe mental illnesses like bipolar disorder and Alzheimer's disease, he saw the limitations

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18:51

iBio's Comprehensive Approach to Antibody-Based...

cc: Life Science Podcast ·

2024/06/12

In this episode, recorded at BIO2024 in San Diego, I had the pleasure of speaking with Martin Brenner, the CEO and CSO of iBio. Our focus was the challenges and innovations in developing antibody-based therapeutics, particularly through their AI-driven discovery platform. Martin shared his insights into the current landscape and future directions of antibody therapies, touching on key aspects such as target selection, engineering challenges, and the role of AI in optimizing therapeutic

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28:44

How Can We Make Sample Collection More Patient-Centric?

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2024/05/29

In this episode of CC Life Science, I had the pleasure of hosting Neil Spooner, the founder and chair of the Patient-Centric Sampling Interest Group (PCSIG). Neil shared his insights into patient-centric sampling and its potential to revolutionize healthcare and clinical trials.Introduction to Patient-Centric SamplingNeil began by explaining the concept of patient-centric sampling, which prioritizes the patient's needs over traditional methods that often inconvenience them. Traditional methods like

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41:21

Communicating Science to Patients, Physicians and the...

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2024/05/22

David Ormesher, the CEO of CGLife, and I had a conversation about communicating science broadly to the public and within the scientific community. David went immediately to the power of storytelling in making science approachable. He highlighted the hero’s journey, the narrative arc used in literature and film, as a powerful tool to engage various audiences, whether they are scientists, physicians, patients, or the general public.That narrative of the hero’s journey applies to patients and

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31:58

A Promising Future for Organoid Research

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2024/05/15

I kept hearing about the use of organoids in clinical trials and elsewhere and was curious to know more. Luckily, I connected with Samantha Nicholson, the Global Technical Marketing Manager for Cell Culture at Millipore Sigma. She has a very cool job. Samantha is a hub, as she calls it, bringing together scientists to make progress in this exciting new area of research. She described her role, the applications of organoids, and their implications for future scientific research and

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22:13

Vertical GPTs Will Change the Buyer's Journey

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2024/05/08

By now, I imagine most of you have interacted with ChatGPT in some way. You can use it to summarize a document, brainstorm a campaign or plan a vacation away from technology. The capabilities are mind-boggling and the BS (if you detect it) is amusing. All that aside, how can you use an internal vertical GPT to serve your customers? I spoke to Ian Birkby, CEO of AZONetwork about Azthena, the internal vertical GPT they built as an AI assistant deployed on their various websites to help users find

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35:12

Bacteriophage as Antimicrobials Against Group B Strep...

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2024/05/01

Could bacteriophage be an alternative to antibiotics for Group B Strep (GBS) in pregnant women? GBS is a commensal bacteria, found harmlessly in the gut of some people. But it is an opportunistic pathogen that can cause significant disease - sepsis, meningitis, lung injury and bacteremia - in newborns exposed to it in the vaginal tract during birth, for example. Lucy Furfaro is an Emerging Leadership Fellow at the University of Western Australia in Perth. I spoke to her about her research in this

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24:09

Ethylene and the Fresh Produce Supply Chain

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2024/04/24

When I’m eating blueberries from Chile here in California, I assume that they arrived by air after being picked a couple of days ago. That isn’t necessarily true. Delivery by sea could take weeks from the time they are picked by the grower until they arrive on the shelf at my local grocery store.In this episode, I talked to Tristan Kaye, Director of Global Marketing and Business Development at It's Fresh about the challenges of shipping fresh produce across the planet while avoiding waste and

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43:53

Building a Good Life Outside of Academia

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2024/04/17

If you have a PhD in life science, are working toward one, or just considering it with an eye toward getting an academic job, the math is not in your favor. There are way more PhDs than the number of academic slots available. How that gets resolved with respect to your career was the core of my discussion with Ali Divan, Founder of Trulitica, where he is helping life science PhDs get into biotech. Don’t miss the SPECIAL OFFER at the bottom of this post.For many, there is a mismatch between

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26:36

The 3 Rs and the Role of Small Animals in Research

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2024/04/10

Reduce. Refine. Replace. These are the three Rs of animal research. The intent is to reduce the number of animals used, refine methods to be efficient and humane and replace animals with other models where possible.This cc: Life Science episode is sponsored content, courtesy of MediLumine.I talked to Stephen Marchant, Founder and CEO of MediLumine about the importance of animal research, how imaging in small animals is different from humans and innovations that support the 3Rs of laboratory animal

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23:17

Vertical Farming Meets Design of Experiments

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2024/03/27

AgBio, sustainability and DoE all come together in this episode. Tim Cuthbertson is the Chief Science Officer at VelociGro where they are using Design of Experiments to optimize plant growth media for vertical farming.I was curious to learn about the concept of vertical farming and how it can make an impact relative to the massive acreage involved in traditional agriculture. There are scenarios where it makes a lot of sense. First of all, greenhouse-grown produce is nothing new. Tomatoes are the

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57:52

Opportunities and Challenges: A Primer for Founders

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2024/03/21

Thomas Farb-Horch is the CEO of Thrive Bioscience. He has founded 18 companies. Seven of those turned out to be unicorns (sold at a valuation of >1 billion dollars).I was curious to know how he had identified so many opportunities correctly. BTW, Tom is not a scientist and has no advanced degrees in case you were thinking that was a requirement.He credits his success to being observant and inquisitive. That means keeping your eyes open for problems and asking why things are the way they are. The

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33:29

Using ChatGPT to Optimize Your Market Geographically

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2024/01/24

Kurt Mussina is the CEO of Paradigm Clinical Research. Their model involves dedicated sites chosen for access to their desired patient and physician populations to participate in clinical trials. Access to historically underrepresented populations for both patients and healthy volunteers is a key requirement.One can imagine it takes a lot of effort to figure that out from demographic data etc. Kurt shared with me their approach using ChatGPT with some plugins not only for determining the best places

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35:05

Breaking Through the Cannabis Cloud

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2024/01/10

Up to this point, I have resisted doing any episodes around cannabis because 1. I’m a little old-school 2. I probably don’t know enough and 3. I want to avoid, in the words of my guest, “being painted with green paint” and tainting the brand.Separating emotions from logic, however, if there are cannabis components that could be effective therapies, it would be foolish to ignore them. There is already one cannabis-derived compound approved by the FDA. Epidiolex is pharmaceutical-grade cannabidiol

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35:40

Commercializing Diagnostics: Engineering and Mindset

cc: Life Science Podcast ·

2023/12/27

This week, I talked to Dr. Michael Harman, an executive advisor, and consulting partner at Harmon Consulting about commercializing medical diagnostics, exploring various aspects from technology development to market trends and the integration of different scientific disciplines.I asked Michael about the process of transitioning laboratory technology into clinically viable products. He described a series of well-defined steps, starting from concept generation to prototyping and feasibility testing,

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28:02

Mining the Microbiome for Possibilities

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2023/12/20

When it comes to chemical reactions, if you can imagine it, somewhere out there a microbe is already doing it. This was something we used to say in graduate school. The challenge is finding that microbe among the billions that exist in environments all around us.Surehka Karudapuram is the VP, Commercial Operations at Isolation Bio where they are helping researchers solve that needle in a haystack problem. In this episode we talked about the what, the how and the why.Check this out:Isolation Bio

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