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PODCAST

Cannabinoid and Psychedelic Pharmacology and Drug Development

Jim Mitchell and Google NotebookLM

Explore Cannabinoid and Psychedelic Pharmacology with AI-Powered Learning.Welcome to a groundbreaking approach to mastering cannabinoid and psychedelic pharmacology and the FDA drug development pathway! This podcast series, powered by Google’s Notebook LM, offers a cutting-edge, AI-guided learning experience tailored for formal classes or self-directed study.Each 30-day series delves deep into the science of cannabinoid and psychedelic pharmacology, exploring molecular signaling pathways,

science chemistry

All Episodes

15:48

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the fascinating world of cholinergic receptors, focusing on muscarinic and nicotinic receptors and their roles in the nervous system. The discussion covers how these two distinct receptor types, both activated by acetylcholine, serve different functions - from rapid muscle movements to slower regulatory processes. The episode delves into their connection to Alzheimer's disease, potential therapeutic approaches, and the complex interactions between different

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16:42

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode provides a comprehensive exploration of GABA and glutamate neurotransmitter systems in the brain. The discussion covers how these neurotransmitters work as the brain's "brake pedal" and "gas pedal" respectively. It delves into various receptor types including GABA A, GABA B, and different glutamate receptors (AMPA, NMDA, and kainate). The episode explains complex concepts like synaptic integration, receptor mechanisms, and how imbalances in these systems can lead to conditions

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18:30

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode offers an in-depth exploration of serotonin receptors and their complex signaling pathways. The discussion covers the two main families of serotonin receptors (GPCRs and ion channels), their various subtypes, and the concept of cellular microdomains. The conversation delves into how these receptors influence diverse physiological processes from mood regulation to digestion, and examines the intricate molecular mechanisms involved in serotonin signaling. The episode also

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25:10

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode provides an in-depth exploration of dopamine receptors and their crucial role in brain function. The discussion covers the two main receptor families (D1 and D2), explaining how they work at the cellular level through G-protein signaling and cAMP modulation.The episode delves into cutting-edge concepts like cellular microdomains and explains how these specialized cellular compartments affect dopamine signaling. It also examines the broader implications for understanding

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15:24

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This episode explores the fascinating world of mechanoreceptors and specialized senses, diving deep into how our bodies detect and process various sensory inputs. The discussion covers hair cells in the inner ear and their role in hearing and balance, mechanosensitive ion channels, the structure and function of the cochlea, and the semicircular canals. The conversation extends to touch receptors in the skin, blood pressure regulation through baroreceptors, and even the emerging research on

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24:32

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the intricate world of vision and photoreceptors, focusing on how rods and cones enable us to see. The discussion delves into the molecular mechanisms of vision, particularly the phototransduction cascade, where light triggers rhodopsin activation leading to changes in cyclic GMP levels. The episode also covers how signals travel from photoreceptors through the retina to the brain via ganglion cells and the optic nerve.

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24:01

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode provides a comprehensive exploration of olfactory receptors and how our sense of smell works. The discussion covers the molecular mechanisms of smell detection, from odor molecules binding to receptors through the complex signaling cascade involving G proteins and cAMP. The episode delves into specialized structures called glomeruli in the olfactory bulb that process smell signals, and examines how the brain interprets different scent combinations through combinatorial coding

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38:41

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the fascinating science of taste receptors and how they work. The hosts discuss how specialized cells in our taste buds use GPCRs (G protein-coupled receptors) and ion channels to detect different tastes. They break down the mechanisms behind sweet, bitter, and umami detection through GPCRs, while explaining how sour and salty tastes work through ion channels. The conversation also covers how taste signals are processed by the brain, debunks common myths about tongue

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18:35

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this engaging podcast episode, the hosts explore the fascinating world of sensory receptors - the specialized cells that allow us to experience and interact with our environment. They break down the five main types of sensory receptors: chemoreceptors (for taste and smell), photoreceptors (for vision), mechanoreceptors (for touch and pressure), thermoreceptors (for temperature), and nociceptors (for pain). The discussion covers how these receptors convert external stimuli into electrical signals

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18:00

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the fascinating world of cell adhesion and its medical applications. The discussion covers how cells stick together through specialized surface molecules, the role of cell adhesion in diseases like thrombosis and cancer, and groundbreaking developments in tissue engineering. The episode also delves into complex cellular signaling mechanisms, including microdomains and their role in cell communication. The conversation highlights how understanding these molecular

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23:53

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the intricate process of immune cell trafficking, focusing on selectins - specialized molecules that guide white blood cells from the bloodstream to sites of infection or injury. The discussion covers the three main types of selectins (E-, P-, and L-selectin), their specific roles in cell adhesion, and the fascinating "rolling" phenomenon that allows white blood cells to patrol blood vessels effectively. The episode also delves into how these molecular interactions are

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20:46

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the fascinating world of cadherins and cell adhesion. The discussion breaks down how these essential proteins work as molecular "glue" to hold cells together, requiring calcium to function. The hosts explain different types of cadherins (E-cadherin for epithelial tissues, N-cadherin for neural tissues, and P-cadherin for placenta)and dive into how they form specialized adherens junctions. The conversation also covers how cadherins interact with the cytoskeleton,

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12:38

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores integrin signaling cascades, focusing on the key kinases FAK and Src. The discussion breaks down how these molecular components work together to control cell movement, proliferation, and survival. The episode uses clear analogies and explanations to describe complex cellular processes, from how integrins act as cellular "feelers" to how FAK and Src regulate cell behavior. It also covers research techniques used to study these pathways and their implications for diseases

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27:52

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This engaging podcast episode explores the fascinating world of integrins, essential proteins that act as cellular "glue and movers". The discussion breaks down how these remarkable molecules function as bridges between cells and their environment, using the alpha and beta subunits to create specific connections. The episode covers key concepts including:- How integrins enable vital processes like wound healing, immune responses, and embryonic development- The dynamic nature of focal adhesions and

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20:47

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the intricate world of cellular communication networks, focusing on how cells organize and control their signaling pathways. The discussion covers key concepts like microdomains and A-kinase anchoring proteins (AKAPs), which act as cellular "zip codes" for precise signal delivery. The conversation then delves into thyroid hormone receptors and their role as master regulators in development and metabolism, before examining glycine's function as an inhibitory

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20:48

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the complex interactions between three major developmental signaling pathways: Notch, Hedgehog, and Wnt. The discussion delves into how these pathways communicate and regulate each other, particularly in stem cells and tissue regeneration. The conversation covers various aspects including microdomains, kinase anchoring proteins (AKAPs), and their roles in cellular signaling. Special attention is given to the implications for cancer development and potential therapeutic

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22:41

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode provides an in-depth exploration of the Wnt/β-catenin signaling pathway. The discussion covers the pathway's fundamental mechanisms, including how Wnt ligands interact with LRP and Frizzled co-receptors to trigger cellular responses. The episode explains how β-catenin functions as a crucial cellular switch, its role in gene regulation, and its connection to cancer development, particularly in colon cancer. The conversation also delves into research methods, from cell culture

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18:55

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This episode explores the fascinating world of Hedgehog signaling, a crucial cellular communication system that guides embryonic development and adult stem cell function. The discussion breaks down the complex pathway, explaining how the Sonic Hedgehog protein (Shh) interacts with the Patched receptor (Ptch) and Smoothened (Smo) to control cell development and differentiation. The episode also covers the pathway's role in disease, particularly in cancer development, and explores potential

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15:06

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode provides a comprehensive exploration of Notch signaling, a crucial cell-to-cell communication system. The discussion breaks down the complex process of how cells use Notch receptors and their ligands (Delta and Jagged) to communicate and determine cell fate. The conversation covers the step-by-step molecular mechanisms, the role of proteases like gamma-secretase, and how disruptions in Notch signaling can lead to various diseases including cancer. The hosts use engaging

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23:36

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores TLR (Toll-like receptor) therapeutics, discussing how these immune system "alarm bells" can be manipulated to treat various diseases. The discussion covers key drug candidates like IMO-8400 for autoimmune diseases and R848 for cancer treatment. The episode delves into challenges like off-target effects, the importance of personalized medicine, and the role of the gut microbiome in treatment outcomes. It also examines how lifestyle factors such as diet, exercise, sleep,

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252 results

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