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PaperPlayer biorxiv cell biology

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Diverse mechanisms control amino acid-dependent...

PaperPlayer biorxiv cell biology ·

2023/08/04

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.04.551922v1?rss=1 Authors: Silao, F. G. S., Valeriano, V. D., Uddström, E., Falconer, E., Ljungdahl, P. O. Abstract: Candida albicans has the remarkable capacity to neutralize acidic growth environments by releasing ammonia derived from the catabolism of amino acids. The molecular components and mechanisms controlling this capacity remain poorly understood. Here, we present an integrative model with the cytosolic NAD+-dependent

Optogenetic strategies for optimizing the performance...

PaperPlayer biorxiv cell biology ·

2023/08/04

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.03.551799v1?rss=1 Authors: Yao, Y., Lou, X., Du, G., Jin, L., Li, J., Liu, J., Chen, Y., Cheng, S., Zhao, T., Ke, S., Zhang, L., Zhang, P., Xu, Y., He, L., Li, H. Abstract: High-performance biosensors are crucial for elucidating the spatiotemporal regulatory roles and dynamics of membrane lipids, but there is a lack of improvement strategies for biosensors with low sensitivity and low-content substrates detection. Here we

Sulfolobus acidocaldarius adhesion pili power...

PaperPlayer biorxiv cell biology ·

2023/08/04

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.04.552066v1?rss=1 Authors: Charles-Orszag, A., van Wolferen, M., Lord, S. J., Albers, S.-V., Mullins, D. Abstract: Type IV pili are ancient and widespread filamentous organelles found in most bacterial and archaeal phyla where they support a wide range of functions, including substrate adhesion, DNA uptake, self aggregation, and cell motility. In most bacteria, PilT-family ATPases disassemble adhesion pili, causing them to

Lactate activates the mitochondrial electron...

PaperPlayer biorxiv cell biology ·

2023/08/04

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.02.551712v1?rss=1 Authors: Cai, X., Ng, C. C., Jones, O., Fung, T. S., Ryu, K., Li, D., Thompson, C. B. Abstract: Lactate has long been considered a cellular waste product. However, we found that as extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates mitochondrial electron transport chain (ETC) activity. The resulting increase in mitochondrial ATP synthesis suppresses glycolysis and

Comprehensive genome editing confers...

PaperPlayer biorxiv cell biology ·

2023/08/04

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.03.551705v1?rss=1 Authors: Murray, R., Navarrete, N. R. R., Desai, K., Chowdhury, M. R., Chilakapati, S. R., Chong, B., Messana, A., Sobon, H., Rocha, J., Musenge, F., Camblin, A., Ciaramella, G., Sitkovsky, M., Maldini, C., Hatfield, S. Abstract: Biochemical and immunological negative regulators converge to inhibit tumor-reactive Chimeric Antigen Receptor T (CAR-T) cells, which may explain clinical failures of CAR-T cell

hGRAD - a versatile 'one-fits-all' system...

PaperPlayer biorxiv cell biology ·

2023/08/04

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.04.551933v1?rss=1 Authors: Muller-McNicoll, M., Zarnack, K., McNicoll, F., Keller, M., Sliskovic, I., Okuda, E. K., Riegger, R. J., Arnold, B. Abstract: Nuclear RNA binding proteins (RBPs) are difficult to study because they often belong to large protein families and form extensive networks of auto- and cross-regulation. They are highly abundant and often localize to condensates with a slow turnover, requiring long depletion

Presence of the ER-Golgi intermediate compartment...

PaperPlayer biorxiv cell biology ·

2023/08/03

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.03.551802v1?rss=1 Authors: Tojima, T., Suda, Y., Jin, N., Kurokawa, K., Nakano, A. Abstract: Cargo traffic through the Golgi apparatus is mediated by cisternal maturation, but it remains largely unclear how the cis-cisternae, the earliest Golgi sub-compartment, is generated. Here, we use high-speed, high-resolution confocal microscopy to analyze the spatiotemporal dynamics of a diverse set of proteins that reside in and around

Inhibition of Topoisomerase 2 catalytic activity...

PaperPlayer biorxiv cell biology ·

2023/08/03

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.01.551420v1?rss=1 Authors: Amoiridis, M., Meaburn, K., Verigos, J., Gittens, W. H., Ye, T., Neale, M. J., Soutoglou, E. Abstract: DNA replication and transcription generate DNA supercoiling, which can cause topological stress and intertwining of daughter chromatin fibers, posing challenges to the completion of DNA replication and chromosome segregation. Type II topoisomerases (Top2s) are enzymes that relieve DNA supercoiling and

Lysosomal release of amino acids at ER three-way...

PaperPlayer biorxiv cell biology ·

2023/08/03

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.01.551382v1?rss=1 Authors: Choi, H., Liao, Y.-C., Yoon, Y. J., Grimm, J. B., Lavis, L., Singer, R. H., Lippincott-Schwartz, J. Abstract: One-third of the mammalian proteome is comprised of transmembrane and secretory proteins that are synthesized on endoplasmic reticulum (ER). Here, we investigate the spatial distribution and regulation of mRNAs encoding these membrane and secretory proteins (termed 'secretome' mRNAs)

Immunoregulatory macrophages modify local pulmonary...

PaperPlayer biorxiv cell biology ·

2023/08/03

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551394v1?rss=1 Authors: Fernandez-Gonzalez, A., Mukhia, A., Nadkarni, J., Willis, G., Reis, M., Zhumka, K., Vitali, S., Liu, X., Galls, A., Mitsialis, S. A., Kourembanas, S. Abstract: Objective: Macrophages play a central role in the onset and progression of vascular disease in pulmonary hypertension (PH) and cell-based immunotherapies aimed at treating vascular remodeling are lacking. This work evaluates the effect of

Chaperone Complexes From The Endoplasmic Reticulum...

PaperPlayer biorxiv cell biology ·

2023/08/03

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.01.551134v1?rss=1 Authors: Dabsan, S., Zur, G., Gilad, A., Igbaria, A. Abstract: The Endoplasmic Reticulum (ER) is an essential sensing organelle responsible for the folding and secretion of almost one-third of eukaryotic cells' total proteins. The ER contains numerous enzymes and chaperones which assist in oxidative protein folding and other posttranslational modifications. However, environmental, chemical, and genetic

Discretised flux balance analysis for...

PaperPlayer biorxiv cell biology ·

2023/08/03

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.01.551453v1?rss=1 Authors: Chew, Y. H., Spill, F. Abstract: Metabolites have to diffuse within the sub-cellular compartments they occupy to specific locations where enzymes are, so reactions could occur. Conventional flux balance analysis (FBA), a method based on linear programming that is commonly used to model metabolism, implicitly assumes that all enzymatic reactions are not diffusion-limited though that may not always be

IST1 regulates select endosomal recycling pathways

PaperPlayer biorxiv cell biology ·

2023/08/02

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551359v1?rss=1 Authors: Clippinger, A. K., Naismith, T. V., Yoo, W., Jansen, S., Kast, D., Hanson, P. I. Abstract: ESCRTs (Endosomal Sorting Complex Required for Transport) are a modular set of protein complexes with membrane remodeling activities that include the formation and release of intralumenal vesicles (ILVs) to generate multivesicular endosomes. While most of the 12 ESCRT-III proteins are known to play roles in ILV

The ciliary MBO2 complex targets assembly of inner...

PaperPlayer biorxiv cell biology ·

2023/08/02

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551375v1?rss=1 Authors: Fu, G., Augspurger, K., Sakizadeh, J., Reck, J., Bower, R., Tritschler, D., Gui, L., Nicastro, D., Porter, M. E. Abstract: Ciliary motility requires the spatiotemporal coordination of multiple dynein motors by regulatory complexes located within the 96 nm axoneme repeat. Many organisms can alter ciliary waveforms in response to internal or external stimuli, but little is known about the specific

The Crk4-Cyc4 complex regulates G2 phase of...

PaperPlayer biorxiv cell biology ·

2023/08/02

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551351v1?rss=1 Authors: Hawkins, L. M., Wang, C., Chaput, D., Batra, M., Marsilia, C., Awshah, D., Suvorova, E. Abstract: Division of apicomplexan parasites differs drastically from the division of their host cells. A fraction of apicomplexans divides in the traditional binary mode, such as Toxoplasma gondii in asexual stages, whereas the vast majority instead divide in a multinuclear fashion. Such variety of replication

Myogenetic oligodeoxynucleotide induces myocardial...

PaperPlayer biorxiv cell biology ·

2023/08/02

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551374v1?rss=1 Authors: Ishioka, M., Nihashi, Y., Sunagawa, Y., Umezawa, K., Shimosato, T., Kagami, H., Morimoto, T., Takaya, T. Abstract: An 18-base myogenetic oligodeoxynucleotide (myoDN), iSN04, acts an anti-nucleolin aptamer and induces myogenic differentiation of skeletal muscle myoblasts. This study investigated the effect of iSN04 on murine embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). In the

Disordered C-terminal domain drives spatiotemporal...

PaperPlayer biorxiv cell biology ·

2023/08/02

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551302v1?rss=1 Authors: Ling, Y. H., Ye, J., Yu, C., Liang, C., Park, G., Corden, J., Wu, C. Abstract: Efficient gene expression demands RNA Polymerase II (RNAPII) to find chromatin targets precisely in space and time. How RNAPII manages this complex diffusive search in a 3D nuclear space remains largely unknown. The disordered carboxy-terminal domain (CTD) of RNAPII, which is essential for recruiting transcription-associated

Dynamic proximity interaction profiling suggests that...

PaperPlayer biorxiv cell biology ·

2023/08/02

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551286v1?rss=1 Authors: Turan, G., Olgun, C. E., Ayten, H., Toker, P., Ashyralyyev, A., Savas, B., Karaca, E., Muyan, M. Abstract: YPEL2 is a member of the evolutionarily conserved YPEL family involved in cellular proliferation, mobility, differentiation as well as senescence and death. However, the mechanism by which YPEL2, or YPEL proteins, mediates its effects is yet unknown. Proteins perform their functions in a network

Induced pluripotent stem cell-derived human...

PaperPlayer biorxiv cell biology ·

2023/08/02

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551225v1?rss=1 Authors: Baert, L., Rudy, S., Pellisson, M., Doll, T., Rocchetti, R., Kaiser, M., Mäser, P., Müller, M. Abstract: The parasite Leishmania donovani is one of the species causing visceral leishmaniasis in humans, a deadly infection claiming up to 40,000 lives each year. The current drugs for leishmaniasis treatment have severe drawbacks and there is an urgent need to find new anti-leishmanial compounds

Mitochondrial Ca2+ uniporter (MCU) variants form...

PaperPlayer biorxiv cell biology ·

2023/08/02

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551242v1?rss=1 Authors: Polina, I., Mishra, J., Cypress, M. W., Landherr, M., Valkov, N., Chaput, I., Nieto, B., Mende, U., Zhang, P., Jhun, B. S., O-Uchi, J. Abstract: MCU is widely recognized as a responsible gene for encoding a pore-forming subunit of highly mitochondrial-specific and Ca2+-selective channel, mitochondrial Ca2+ uniporter complex (mtCUC). Here, we report a novel short variant derived from the MCU gene

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