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PODCAST

The Optispan Podcast with Matt Kaeberlein

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that

science

All Episodes

00:53:01

Ask a Longevity Scientist: Testosterone, "Miracle"...

The Optispan Podcast with Matt Kaeberlein ·

2025/06/19

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein tackles your burning questions on testosterone therapy, trending supplements like astaxanthin and C15, hyperbaric oxygen, and more. Get science-backed insights and learn what truly matters for starting your health and longevity journey.0:00 - Intro: Ask Matt Anything!0:42 - Testosterone Therapy: My Personal Journey3:12 - Hormone Health: What to Measure &

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01:08:23

Scientist Fact-Checks Controversial Medical Takes:...

The Optispan Podcast with Matt Kaeberlein ·

2025/06/10

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein reacts to controversial takes on supplements, MRIs, protein, and rapamycin from Dr. Eric Topol. This video breaks down the evidence behind popular health trends, helping you separate science from hype.0:00 - Setting the Stage: Expert Reaction1:03 - Experts Selling Supplements: Credibility Lost?2:30 - MRIs & CGMs: Lifesaving or Misleading?7:16 - Protein

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01:23:33

Gut Microbiome Expert: The HIDDEN Side Of Health...

The Optispan Podcast with Matt Kaeberlein ·

2025/06/05

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Sean Gibbons, a leading microbiome expert, sits down with me to decode the complex world of your gut bacteria. Learn about good vs. bad bacteria, the impact of antibiotics and aging, and how diet and probiotics can influence your journey to better health.0:00 - Intro: What IS Your Microbiome?7:55 - Good vs. Bad Bacteria? The Real Story14:06 - Antibiotics & Your Gut's

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00:29:51

LiveLong Conference: Takeaways on Longevity Science &...

The Optispan Podcast with Matt Kaeberlein ·

2025/05/02

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Matt Kaeberlein & Dr. Kevin White share takeaways from the LiveLong Experience conference, covering Therapeutic Plasma Exchange (TPE) insights, Hormone Replacement Therapy (HRT) debates, longevity science, and navigating misinformation vs. fact.0:00 Intro: LiveLong Conference Vibe & Overview2:35 NHL, TBI & Psychedelics (Daniel Carcillo Talk)5:34 Therapeutic Plasma

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00:40:16

This Simple Test Can Reveal Your Risk Of Heart...

The Optispan Podcast with Matt Kaeberlein ·

2025/04/29

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Matt Kaeberlein reviews his personal Cleerly CCTA scan results with Prime Health Associates founder Dr. Kevin White, analyzing soft vs. calcified heart plaque, assessing cardiovascular risk, and discussing the value of early detection for longevity.0:00 Intro: What is a Cleerly CCTA Scan?1:31 Why Scan? The Value of Early Heart Disease Detection3:49 The Scan Experience (Prep,

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01:13:17

The Hidden Health Toll Of Grief (and the 4 Tasks that...

The Optispan Podcast with Matt Kaeberlein ·

2025/04/24

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Help Texts CEO Emma Payne discusses the profound impact of grief on health (physical/mental), effective coping strategies (Warden's Tasks), and how text-based support can help navigate loss and foster post-traumatic growth.0:00 Intro: Grief's Impact on Health & Biology1:12 Defining Grief: Lost Connection & Blunt Force Trauma2:55 How Grief Disrupts the Pillars of

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00:43:04

Rapamycin: The Worst Longevity Idea Ever Conceived? |...

The Optispan Podcast with Matt Kaeberlein ·

2025/04/22

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/Dr. Matt Kaeberlein fact-checks Dr. Chris Masterjohn's essay calling rapamycin the "Worst Longevity Idea Ever," correcting misinformation about side effects (cataracts, glucose, heart) and benefits using scientific data from mouse and human studies.0:00 Intro: Tackling the "Worst Longevity Idea Ever" Essay1:06 Who is Dr. Chris Masterjohn? Expertise Questioned3:20 Debunking Mouse Claims:

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01:18:28

Siim Land: Biohacking Longevity, Health Span Truths &...

The Optispan Podcast with Matt Kaeberlein ·

2025/04/17

Subscribe to our channel: https://www.youtube.com/@optispanBiohacking expert Siim Land joins Matt Kaeberlein to discuss optimizing health span with science-based lifestyle tips (diet, exercise, sleep), key biomarkers, and navigating longevity misinformation & biological age clock hype.0:00 Introduction: Meet Siim Land2:41 Defining Longevity: Health Span vs Lifespan4:31 The Longevity Escape Velocity Debate12:21 Navigating Longevity Hype, Misinformation & Credibility28:56 Biohacking Case

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00:16:12

The Science of Aging Well: "A Practical Approach to...

The Optispan Podcast with Matt Kaeberlein ·

2025/04/15

Subscribe to our channel: https://www.youtube.com/@optispanSign up for the Optispan Newsletter: https://www.optispan.life/Read or get your copy of Matt's Scientific American Article: https://www.scientificamerican.com/custom-media/healthspan/In this episode, Dr. Matt Kaeberlein reads and discusses his insightful article, "A Practical Approach to HealthSpan Medicine," featured in the Scientific American special issue "HealthSpan: The Science of Aging Well."Discover the future of healthcare focused on

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00:56:38

Longevity Experts Discuss Their Health Advice &...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/27

Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein is joined by Dr. Marcus Ranney and Dr. Brian Kennedy, leading experts in longevity science. Recorded at the Rise for Aging Conference in Bangalore, India, they discuss India’s growing role in longevity research, the impact of AI in aging and healthcare, and unique health challenges in India, such as diet, diabetes, and metabolic health. They also explore innovative healthcare solutions, including digital health records,

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01:00:35

Brain Aging & Alzheimer’s Prevention: The Future of...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/18

Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Christin Glorioso, founder of NeuroAge Therapeutics, explore groundbreaking advancements in brain aging and Alzheimer's prevention. Learn how cutting-edge brain age testing—combining MRI, cognitive assessments, blood biomarkers, and genetics—can predict Alzheimer’s risk decades in advance. Discover the impact of lifestyle factors like diet, exercise, and sleep on cognitive decline, plus the latest in

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01:15:32

Gut Health: Science-Backed Tips For Leaky Gut, IBS, &...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/13

Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Mary Pardee sit down to discuss insights on gut health, digestion, and common GI issues like IBS and constipation. This video covers practical approaches to improving gut function, debunking myths, and identifying effective solutions for long-term wellness, all while attempting to separate fact from fiction in the world of gut health.0:00 - Introduction to Gut Health & Microbiome1:47 - IBS and Digestive

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00:14:33

The Truth About Biological Age Tests | 104

The Optispan Podcast with Matt Kaeberlein ·

2025/03/11

Subscribe to our channel: https://www.youtube.com/@optispanMatt Kaeberlein dives into the controversial world of biological age tests. Many direct-to-consumer tests claim to measure your biological age, but are they accurate or useful? Based on extensive research and clinical experience, we uncover why these tests are statistically meaningless, lack regulatory validation, and fail to provide actionable health insights. Instead, we highlight proven biomarkers that actually contribute to longevity and

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00:55:07

Dr. Kevin White: Concierge Medicine & Its Impacts On...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/06

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, we dive into concierge medicine, how it differs from traditional primary care, and why more people are opting for personalized healthcare. Dr. Kevin White shares insights on longevity medicine, proactive health strategies, and the benefits of direct physician access. We discuss the costs, the role of insurance, advanced diagnostics, and the future of AI in concierge medicine.0:00 - Intro & Concierge Medicine Overview3:15

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00:50:54

Dr. Kevin White: Concierge Medicine & Its Impacts On...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/06

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, we dive into concierge medicine, how it differs from traditional primary care, and why more people are opting for personalized healthcare. Dr. Kevin White shares insights on longevity medicine, proactive health strategies, and the benefits of direct physician access. We discuss the costs, the role of insurance, advanced diagnostics, and the future of AI in concierge medicine.0:00 - Intro & Concierge Medicine Overview3:15

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00:42:42

Thomas Delauer: NEW Nutrition, Exercise, and Mindset...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/04

Subscribe to our channel: https://www.youtube.com/@optispanThomas DeLauer & I (Dr. Matt Kaeberlein) discusses his evolving perspectives on nutrition, exercise, and health optimization. Thomas shares how his views on insulin, low-carb diets, and fructose have shifted, his approach to training for strength and longevity, and the importance of sleep, emotional well-being, and recovery. Delauer also touches on peptides, supplements, and wearable tech, providing valuable takeaways for those looking

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00:21:21

My Biggest Health & Longevity Breakthroughs at 54 | 101

The Optispan Podcast with Matt Kaeberlein ·

2025/02/27

Subscribe to our channel: https://www.youtube.com/@optispanI share the top health and longevity strategies that have transformed my energy, fitness, and well-being at 54 - From hormone optimization (TRT) and resistance training to diet improvements, alcohol reduction, and preventative diagnostics.0:00 - Reflections on Turning 54 & Longevity Mindset1:42 - Hormone Optimization: The Biggest Game-Changer3:28 - Diet & Alcohol Reduction: Key Health Improvements4:56 - Exercise & Resistance

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01:31:13

Dr. Greg Fahy: Thymus Regeneration & Boosting The...

The Optispan Podcast with Matt Kaeberlein ·

2025/02/25

Subscribe to our channel: https://www.youtube.com/@optispanDr. Greg Fahy discusses his groundbreaking research on thymus regeneration, immune system rejuvenation, and the role of growth hormone, DHEA, and metformin in reversing aging-related immune decline. He explains the TRIM protocol, the impact of thymic involution on longevity, and the potential for improving vaccine response and overall health. This conversation explores immune function, senescent cell clearance, and epigenetic aging

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00:58:44

The Benefits Of Testosterone Replacement Therapy...

The Optispan Podcast with Matt Kaeberlein ·

2025/02/20

Subscribe to our channel: https://www.youtube.com/@optispanIs testosterone therapy right for you? In this episode, Matt Kaeberlein & Kevin White explore the benefits, risks, and misconceptions of testosterone replacement therapy (TRT). Learn about low testosterone symptoms, when to get tested, and the differences between primary and secondary hypogonadism. We also cover treatment options like injections, creams, and Clomid, plus the impact on heart health, longevity, and mental well-being.0:00 -

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00:42:12

The Effects of Rapamycin on APOE4 Carriers & Brain...

The Optispan Podcast with Matt Kaeberlein ·

2025/02/11

Subscribe to our channel: https://www.youtube.com/@optispanIn this video we discuss current studies relating to Rapamycin use and it's effects on brain function, specifically for APOE4 carriers. This data may (or may not) provide evidence to support the claim that Rapamycin can be beneficial for those with the APOE4 variant.0:00 - Introduction1:58 - Should APOE4 Carriers Take Rapamycin? 3:30 - What is APOE and APOE4? 13:06 - Why Knowing Your APOE Status Matters 15:03 - The Case for Rapamycin

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