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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

03:13

🦧💥🧠 Lead, Language & Legacy: How Lead Shaped Human...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/27

🧠💥 Could lead poisoning have helped shape human evolution? A bold new hypothesis suggests that Homo sapiens may have survived while Neanderthals and Denisovans vanished—thanks to genetic defenses against environmental lead. 🧬 By analyzing fossil teeth 🦷 and testing brain organoids 🧪, researchers found that ancient lead exposure disrupted key language-related genes (like FOXP2)—but not in modern human variants. 👣 Sometimes, evolution turns adversity into advantage. 📖 Published in Science

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03:46

🧬 How HMGN1 Gene Hijacks the Heart in Trisomy 21...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/26

🚨 New in Nature 🧬: Groundbreaking study reveals how HMGN1, a dosage-sensitive epigenetic regulator on chromosome 21, reprograms atrioventricular cardiomyocytes into a ventricular fate—driving congenital heart defects in Down syndrome 💔🫀. Using hiPSCs, single-cell RNA sequencing, and a CRISPRa CROP-seq screen, researchers pinpoint HMGN1 as a causal gene. Strikingly, reducing its dosage in a trisomy 21 mouse model reversed ventricular septal defects (VSDs) 🔧🐭. This is a model for dissecting

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05:28

🧯 No Smoke, Still Fire – Rethinking Lung Cancer in...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/26

🚭 Lung Cancer in Nonsmokers – a hidden epidemic affecting up to 20% of global cases 🌍. Unlike tobacco-related disease, this form often strikes younger, female, and Asian populations, with EGFR and ALK mutations driving tumors 🔬. Despite low mutation burden and no smoking history, these patients benefit immensely from targeted therapies like osimertinib and lorlatinib 🎯. Yet, there’s no USPSTF recommendation for screening in this group 😔. We must push for awareness, early detection, and

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04:08

🥾4000 Steps, 2 Days a week, 1 Big Difference

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/25

👟 Just 2 Days Can Make a Difference! 🧓📉 In a large cohort of 13,547 older women (mean age 72), walking ≥4,000 steps/day on even 1–2 days/week was linked to a 26% lower mortality and 27% lower cardiovascular disease risk 💥. Those walking ≥3 days/week had even greater benefits! 📉 Higher step thresholds (up to 7,000/day) showed further mortality reduction—but step volume, not frequency, drove outcomes. 🧠 Message? There’s no “perfect pattern”—even weekend walks count. 💡 Time to rethink activity

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04:11

🧓 Macrophages Lost, 💉 Capillaries Impaired, 🔄 Aging...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/25

🧓 Aging skin, fading flow. This 2025 Nature study uncovers how dermal capillary-associated macrophages (CAMs) decline with age—preceding microvascular dysfunction and impaired blood flow. 🧬 Using intravital imaging and macrophage fate mapping in mice (and validating in humans!), the authors reveal that CAMs are not replenished unless triggered by injury or CSF1. 🛠️ Fascinatingly, local CSF1–Fc therapy restored CAMs and rejuvenated perfusion in aged skin. A compelling case for targeting

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06:44

SELECT TRIAL: Semaglutide, Central Fat, and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/24

🫀📉 Published in The Lancet (Oct 22, 2025): SELECT trial investigators report that semaglutide reduced MACE by 20% in patients with obesity but without diabetes—independent of weight loss. Waist circumference, not weight, tracked with outcomes, yet explained only 33% of the benefit. This landmark analysis redefines GLP-1RAs as disease-modifying agents, not just weight-loss drugs. 👉 Read here: https://doi.org/10.1016/S0140-6736(25)01375-3 #SELECTTrial #Semaglutide #Cardiovascular #Obesity #GLP1RA

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06:59

“Roots & Remedies 🌱💡: Women’s Hair Loss Uncovered

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/24

Hair Loss in Women” (The New England Journal of Medicine 2025; DOI 10.1056/NEJMcp2412146) 📄, and it’s a must‑listen for anyone in clinical practice or research. The piece highlights that female‑pattern hair loss increases with age and is closely tied to hormonal status, and that treatments span from topical 5% minoxidil or low‑dose oral minoxidil to anti‑androgens and adjunctive non‑drug approaches.

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04:52

🧠💊⚖️ “Mood, Metabolism, and Meds: Decoding...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/23

🔍 New in The Lancet! A massive network meta-analysis of 94 RCTs (105,435 patients) reveals that antidepressants impact far more than mood 🧠—they alter weight ⚖️, glucose 🩸, BP 💓, lipids 🧬, and liver enzymes 🧪. Agomelatine 🌙 may lower weight, while nortriptyline 📈 raises heart rate. Time to rethink side-effect profiles when prescribing! 📚 Pills, Pressure, and Physiology — catch the full summary & clinical pearls now! #Antidepressants #CardiometabolicHealth #Depression #PrecisionMedicine

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07:40

Genome, Gender, and Her Burden of Blue: The Genetics...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/23

🧬 Her Genes, His Risk, Our Mind 💡 New insights from Thomas et al., Nature Communications (2025) — summarized beautifully by Na Cai in Nature News & Views. Women carry a heavier polygenic burden for major depressive disorder (MDD), with ~6,000 female-specific variants and stronger genetic links to metabolic traits like BMI and metabolic syndrome. 🧠 Men show a unique X-chromosome signal (IL1RAPL1), pointing to sex-specific biology in depression. Precision psychiatry must evolve to be sex-aware,

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04:33

🦷 “Mouth to Myocardium to Mortality: How Oral...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/22

🦷🫀 New Findings Linking Oral Health to Heart Attacks! 🧬🧫 Groundbreaking research in JAHA reveals that viridans streptococci, common oral bacteria, form biofilms in atherosclerotic plaques that evade immune detection. These stealthy invaders trigger innate and adaptive immune responses, correlating with plaque rupture, myocardial infarction, and sudden cardiac death. The study combines autopsy data, endarterectomy samples, immunohistochemistry, TLR activation assays, and genome-wide expression to

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04:23

Why Alzheimer Hits Women Harder: 🧬 From APOE4 to...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/22

🧠 Why Does Alzheimer’s Affect More Women Than Men? New insights from JAMA Medical News reveal that the answer goes far beyond longevity. 🌸 Biology, hormones, and even social factors intertwine — from estrogen decline and X chromosome genetics to APOE4 risks and underdiagnosis due to stronger verbal memory. Women make up two-thirds of all Alzheimer’s cases, yet most clinical trials overlook sex-based analyses. As researchers call for more inclusive designs, one thing is clear — understanding

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04:58

🌀 From Dizzy to Steady: Time Restricted Eating Tames...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/21

🚨 New Study Alert 🕒 Can when you eat improve how you feel? This open-label pilot study shows that Time-Restricted Eating (TRE) — limiting food intake to an 8–10 hour window — significantly improved: ✅ Quality of Life (↑ SF-36 & ↓ MAPS scores) ✅ Orthostatic Heart Rate (↓ by 11 bpm, p < 0.0001) ✅ Mitochondrial ATP production (↑, p < 0.05) TRE may offer a safe, feasible, and non-pharmacological tool for managing Postural Orthostatic Tachycardia Syndrome (POTS) — especially in the Long COVID era. 📄

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03:32

Dr RR Baliga's Philosophical Discourses: Guru Nanak...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/21

🌟 Guru Nanak (1469–1539 CE): The Voice of Oneness & Compassion 🌟 From Ik Onkar (One God) to Seva (selfless service), Guru Nanak’s message transcends faith — reminding us that true spirituality lies in equality, honesty, and compassion. 🕊️ His principles — Naam Japo (meditate), Kirat Karo (work honestly), Vand Shhako (share with others) — continue to inspire communities and caregivers alike. 👩‍⚕️👨‍⚕️ 💡 In medicine, his teaching “Serve all, see the divine in all” beautifully aligns with our

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05:24

📉 Low Risk ≠ No Risk: CAC 🧠 Adds Predictive Power

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/20

🚨 New Study Alert 🩺 Think you’re low-risk? Think again. This MESA study shows that even “low-risk” individuals may harbor hidden coronary artery calcium (CAC) — and it matters. 📈 Adding CAC scoring significantly improved ASCVD risk prediction, reclassifying up to 18% into statin-eligible groups. 🧠 Implication? Precision prevention may start with a scan. 🔗 Read in American Journal of Preventive Cardiology: https://doi.org/10.1016/j.ajpc.2025.101329 #Cardiology #CAC #RiskStratification

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07:15

🧬 Aging Hearts, Arrested Cells: The Cellular Villain...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/20

🧬 Cellular senescence is more than just a marker of aging — it’s a key driver of ❤️ cardiovascular disease. From the p53/p21 and p16/Rb axes to mTOR, SIRT1/6, NF-κB, and ROS/DDR, these molecular pathways halt cell division, fuel inflammation 🔥, and impair cardiac repair. Emerging data spotlight the roles of 💣 SASP, 🧓 senescent MSCs, and 🎯 microRNAs in accelerating vascular aging. Time to rethink how we tackle heart disease — at the cellular level. 🫀 📄 Based on: The role of cellular

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05:14

Leveraging Opportunistic CAC Detection from Routine...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/19

🚨 Hidden heart risks in plain sight? 🫀🩻 The latest AHA Scientific Statement unveils the power of opportunistic coronary artery calcium (CAC) detection on routine noncardiac chest CTs. With AI-driven automation, we can now detect subclinical atherosclerosis, improve preventive therapy, and bridge disparities—all without additional imaging or cost. 💡 Think Smart. Scan Smarter. Save Lives. 💊🛡️ 📄 Circulation. 2025;152:e•••–e••• 🔗 DOI: 10.1161/CIR.0000000000001382 🧠 #Cardiology #CAC

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06:16

🛑 Retinas, Wrists & Risks: The Injury Epidemic in...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/19

🚨 Pickleball’s Popularity Comes at a Price 🎾👁️ As the fastest-growing sport in the U.S. hits 20M players, injuries—especially eye and orthopedic—are rising sharply 📈. New data from JAMA Ophthalmology and JAMA News & Analysis reveal alarming trends: retinal detachments, fractures, falls, and more—mostly in players over 50 👵🧓. Time to talk prevention: 🥽 eye protection, 🦶 proper footwear, 🏋️‍♂️ conditioning, and ✅ awareness. Stay safe on the court—don’t let fun turn into a fracture! 🛡️💥

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04:03

⚖️🧠🔻 “Heavy Yet Heart Healthy?”

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/18

🧬 New insights from Nature Medicine! Researchers reveal that obesity caused by MC4R deficiency — the most common monogenic form — is paradoxically linked to lower LDL-cholesterol, triglycerides, and blood pressure 💡. Despite severe obesity, these individuals show a “metabolically healthier” profile, likely due to altered central melanocortin signaling and reduced sympathetic tone 🧠💓. These findings challenge traditional views on obesity and open doors for MC4R-targeted therapies to reduce

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04:20

⚡ From Sample to Sequence to Solution Revolutionizing...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/18

🚼 Game-changer in the NICU! Same-day genome sequencing using Sequencing by Expansion (SBX) delivered actionable results in under 7 hours for critically ill infants 🧬⏱️. Two life-altering diagnoses—including KCNQ2-related epilepsy—were identified faster than any existing rapid test. Published in The New England Journal of Medicine 📰. Precision care, now on a NICU clock. 🔗 Read more: https://www.nejm.org/doi/full/10.1056/NEJMc2512825 #Genomics #NICU #PrecisionMedicine #WGS #NEJM

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08:23

Desi Vessels, Dense Plaques, Diagnostic Gaps 🩻🧱📉...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/17

🩺 Desi Hearts, Hidden Plaques, Bold Truths 💓🫀📊 In the Atherosclerosis journal, Manubolu et al. use AI-powered CCTA to expose an alarming reality: 🧬 Young South Asians have high-risk plaque—even when CAC = 0. 📉 Risk scores fail to capture this. 📸 CCTA sees what traditional tools miss. It’s time to personalize prevention for Desi hearts. #CCTA #DesiHeart #PrecisionMedicine #ASCVD #PlaqueParadox #Atherosclerosis #ManuboluStudy #DigitalCardiology

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