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PODCAST

The Metabolic Classroom with Dr. Ben Bikman

Welcome to The Metabolic Classroom, a nutritionand lifestyle podcast focused on metabolism, which is how our bodies use energy, and the truth behind why we get sick and fat. Every week, Dr. Ben Bikman shares valuable insights that you can apply in your own life and share with friends and loved ones. The Metabolic Classroom is brought to you by BenBikman.com and InsulinIQ.com. Hosted on Acast. See acast.com/privacy for more information.

health & fitness nutrition

All Episodes

23:16

How the MTHFR Gene Affects Our Metabolic Health

The Metabolic Classroom with Dr. Ben Bikman ·

2025/06/23

📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Dr. Bikman explores the MTHFR gene and how common mutations can affect overall metabolic health. Ben explains the biochemical role of the MTHFR enzyme in the methylation cycle, its influence on homocysteine levels, and its downstream impact on DNA repair, neurotransmitter synthesis, and detoxification.Ben also

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26:43

Creatine Demystified: Brain, Muscle & Metabolic Benefits

The Metabolic Classroom with Dr. Ben Bikman ·

2025/06/15

📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Dr. Bikman breaks down the true nature and benefits of creatine—a molecule often misunderstood as merely a muscle-building supplement. Creatine plays a critical role in cellular energy production by helping regenerate ATP, especially in high-energy tissues like skeletal muscle and the brain. While our bodies produce creatine

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24:11

Can Nattokinase Improve Heart & Metabolic Health?

The Metabolic Classroom with Dr. Ben Bikman ·

2025/06/09

📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Dr. Bikman dives into the science behind nattokinase, an enzyme derived from natto—a fermented soybean staple in Japan. Nattokinase has gained attention for its cardiovascular benefits, especially its ability to dissolve blood clots. Ben explains the enzyme’s key role in degrading fibrin, the primary structural protein in clots, and

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20:54

The China Study Revisited - Science vs. Storytelling

The Metabolic Classroom with Dr. Ben Bikman ·

2025/06/02

📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this episode of The Metabolic Classroom, Dr. Bikman critically examines the claims made in The China Study, a popular book advocating for a plant-based diet based on correlational data from the China-Cornell-Oxford Project. While the book suggests that animal protein causes cancer and chronic disease, Ben emphasizes that correlation is not causation and points out

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27:23

Does the HCG Diet Actually Work? What the Studies...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/05/27

📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider on Ben’s website: https://www.benbikman.comDuring this Metabolic Classroom lecture, Dr. Bikman unpacks the history, claims, and science behind the controversial HCG diet.Originally popularized in the 1950s by Dr. Albert Simeons, the diet pairs daily HCG hormone injections with an extremely low-calorie diet (around 500 calories/day). Simeons claimed that HCG helps target problem fat areas, preserve muscle, and

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24:11

How Lectins Disrupt Insulin, Gut Health, and Immunity

The Metabolic Classroom with Dr. Ben Bikman ·

2025/05/18

📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider on Ben’s website: https://www.benbikman.comIn this lecture, Dr. Bikman introduces lectins as harmful plant-derived proteins often found in carbohydrate-rich foods like legumes, grains, and nightshades. While these molecules serve as plant defense mechanisms, in humans they can bind to gut lining cells, disrupting tight junctions and increasing gut permeability (leaky gut). This disruption allows bacterial fragments

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22:59

How Lipoprotein Lipase (LPL) Determines Where Your...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/05/12

In this Metabolic Classroom lecture, Dr. Bikman dives into the central metabolic role of lipoprotein lipase (LPL)—a largely unsung but crucial enzyme that governs whether fat is burned or stored and even where it accumulates in the body.LPL is anchored to capillary walls in tissues like fat, muscle, heart, and lactating mammary glands. It acts as a metabolic gatekeeper, hydrolyzing triglycerides from circulating lipoproteins (like chylomicrons and VLDL) into free fatty acids. Depending on the

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19:06

The Metabolic Effects of Fluoride

The Metabolic Classroom with Dr. Ben Bikman ·

2025/05/05

Dr. Ben Bikman opens this lecture with a comprehensive overview of fluoride’s history in public health, highlighting its original role in preventing dental cavities. However, he shifts the focus to its lesser-known systemic effects, particularly on metabolic health.Ben emphasizes emerging evidence that chronic exposure to fluoride—from water, toothpaste, and other products—can disrupt fat cell function and insulin sensitivity, both key pillars of metabolic regulation.Dr. Bikman explains how fluoride

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28:49

How Fat Hormones Affect Appetite, Inflammation, and...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/04/28

In this Metabolic Classroom lecture, Dr. Ben Bikman explores the critical yet often overlooked role of fat tissue as an endocrine organ, not just a passive energy storage site.Fat secretes dozens of bioactive hormones, collectively called adipokines, that influence everything from appetite and insulin sensitivity to inflammation and cardiovascular risk. He focuses primarily on leptin, adiponectin, and PAI-1 (plasminogen activator inhibitor-1), detailing how each one affects whole-body metabolism and

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31:42

Cortisol & Insulin Resistance: How Cortisol Drives...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/04/21

This week, Dr. Bikman dives deep into the metabolic role of cortisol, the body’s primary glucocorticoid. He explains that while cortisol is essential for survival—mobilizing energy during fasting or stress—chronically elevated levels can wreak metabolic havoc.Cortisol is produced by the adrenal cortex under direction from the hypothalamic-pituitary-adrenal (HPA) axis. Its main role is to ensure energy availability, stimulating glycogen breakdown, muscle catabolism, and fat breakdown in specific

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29:54

“Fast” vs. “Slow” Insulin Resistance: The Two Paths...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/04/14

In this lecture, Dr. Bikman presents a framework for understanding the two primary patterns of insulin resistance onset—what he terms “fast” and “slow” insulin resistance.“Fast” insulin resistance happens quickly and can often be reversed just as rapidly. It’s typically triggered by three major factors: elevated insulin (from frequent carb consumption), stress hormones like cortisol and epinephrine, and inflammation (from infection, injury, or autoimmune activity). These triggers lead to the

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31:48

Cold Therapy & Metabolism, Metabolic Health Benefits...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/03/28

During this week’s Metabolic Classroom lecture, Ben explores the metabolic power of cold therapy, explaining how brief, controlled exposure to cold can significantly enhance metabolic function.He starts with a deep dive into brown adipose tissue (BAT), which is rich in mitochondria and burns calories to generate heat. Cold exposure activates BAT through norepinephrine, leading to mitochondrial uncoupling and energy expenditure without producing ATP. Interestingly, even white fat can be transformed

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29:07

Seed Oils and Insulin Resistance: What the Science...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/03/24

During this week’s Metabolic Classroom lecture, Dr. Ben Bikman explores the connection between seed oils—specifically linoleic acid—and insulin resistance, a growing area of interest and controversy in the metabolic health world.Ben begins by detailing the historical rise of seed oils like soybean, corn, sunflower, and canola oil in the human diet. Once used for industrial purposes, they have now become the most common source of dietary fat, with soybean oil consumption increasing from zero to over

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36:25

Fat Metabolism Deep Dive: Saturated, Mono, and Poly...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/03/13

(📢 NOTE: We apologize for the sound glitch starting at 2 minutes. Dr. Bikman’s lectures are recorded LIVE, and our production team didn’t want to interrupt him. 🙂 )Dr. Ben Bikman’s Metabolic Classroom lecture this week explores fat metabolism and the differences between saturated, monounsaturated, and polyunsaturated fats. He begins by explaining that fat is more than just stored energy—it serves as fuel, structure, and biochemical signaling molecules. He categorizes fats based on saturation

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24:54

Could We Use GLP-1 Drugs like Ozempic & Mounjaro...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/03/06

In this Metabolic Classroom lecture, Dr. Bikman explores GLP-1 receptor agonists (such as Ozempic and Mounjaro) and how to use them more effectively.Ben first explains how GLP-1 is naturally produced in the gut and helps regulate glucagon suppression, slows gastric emptying, and promotes satiety. However, he highlights research showing that individuals with obesity have a blunted GLP-1 response to carbohydrates, which may contribute to overeating. He suggests that GLP-1 drugs could be used more

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25:36

Natural Ways to Boost GLP-1

The Metabolic Classroom with Dr. Ben Bikman ·

2025/02/28

For this week’s Metabolic Classroom lecture, Dr. Bikman focuses on natural ways to boost GLP-1 (Glucagon-Like Peptide-1), a powerful gut hormone involved in appetite control, blood sugar regulation, and metabolic health.Ben begins by explaining that GLP-1 is secreted in response to food intake, influencing glucagon suppression, slowing gastric emptying, and activating satiety centers in the brain. However, research shows that individuals with obesity tend to have a blunted GLP-1 response,

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24:01

How Bilirubin Affects Fat Burning, Inflammation &...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/02/24

Dr. Bikman’s lecture this week explores the metabolic roles of bilirubin, a molecule typically associated with liver disease and jaundice but now emerging as a key player in metabolism, oxidative stress, and fat regulation.Bilirubin is produced from the breakdown of red blood cells and is transported to the liver, where it undergoes conjugation to become water-soluble and is then excreted into bile.While historically viewed as a waste product, recent research suggests that bilirubin plays a

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23:02

Peptides & Metabolism - Fat Loss, Muscle Growth, and...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/02/13

Dr. Bikman’s Metabolic Classroom lecture this week explores peptides and their effects on metabolism, fat loss, muscle growth, and overall health.Ben begins by defining peptides as short chains of amino acids that act as signaling molecules in the body. While some peptides occur naturally, others are synthetically developed for therapeutic purposes. He explains that peptides are gaining popularity in fitness, anti-aging, and metabolic health, influencing fat loss, muscle repair, insulin sensitivity,

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25:10

Acne & Insulin Resistance: Why Your Diet Matters More...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/02/04

Learn more about becoming an Insider: https://www.benbikman.comIn this week’s lecture, Dr. Bikman explores the metabolic origins of acne, challenging the conventional view that acne is purely a skin issue. While acne is often attributed to excess oil production, clogged pores, bacteria, and inflammation, Ben highlights how metabolic factors—especially insulin—play a significant role.Insulin directly stimulates sebaceous glands, increasing oil production, and also triggers the release of androgens

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28:26

How ADHD Medications Affect Fat Burning, Insulin &...

The Metabolic Classroom with Dr. Ben Bikman ·

2025/01/31

Learn more about becoming an Insider: https://www.benbikman.comIn this week’s episode of the Metabolic Classroom lectures, Dr. Ben Bikman explores the metabolic impact of ADHD medications and whether ADHD itself has metabolic roots.Ben explains how stimulant medications (like Adderall and Ritalin) primarily work by increasing dopamine and norepinephrine, enhancing focus but also suppressing appetite and stimulating fat breakdown. This can lead to weight loss but may also contribute to binge eating

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