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PODCAST

This Podcast Will Kill You

Exactly Right and iHeartPodcasts

This podcast might not actually kill you, but Erin Welsh and Erin Allmann Updyke cover so many things that can. In each episode, they tackle a different topic, teaching listeners about the biology, history, and epidemiology of a different disease or medical mystery. They do the scientific research, so you don’t have to. Since 2017, Erin and Erin have explored chronic and infectious diseases, medications, poisons, viruses, bacteria and scientific discoveries. They’ve researched public health

science

All Episodes

78:47

Ep 210 Histoplasmosis: Bats, birds, and budding yeast

This Podcast Will Kill You ·

2026/05/19

Once thought to be a rare, always fatal disease, histoplasmosis is now recognized as one of the most prevalent fungal infections in North America. It infects hundreds of thousands of people every year, and its distribution is growing. In this episode, we dissect this abundant fungus, examining how it makes us sick, who tends to get sick, and what we can do about it. We also take you through the history of this fungus, a story that features a surprise discovery, more evidence that everything is

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51:02

Special Episode: Dr. Olivia Weisser & The Dreaded Pox

This Podcast Will Kill You ·

2026/05/12

In a time when smallpox, tuberculosis, measles, and typhus ran rampant through the streets of London, there was another disease that instilled even more fear than these other killers: syphilis. So feared and so stigmatized was syphilis that it was sometimes called “the secret disease.” A diagnosis would not only sentence you to a drawn-out and painful illness possibly resulting in death, it also labeled you as an outcast and not fit for polite company. Skyrocketing infection rates drove

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59:11

Ep 209 Dietary Guidelines Part 2: Why is there...

This Podcast Will Kill You ·

2026/05/05

If you’ve come across the latest dietary guidelines, a few things may have caught your attention: a big ol’ steak front and center in the new “inverted pyramid”, beef tallow and butter recommended as “healthy” fats, a declaration that the war on protein is ending. “Since when have we been at war with protein?” you may reasonably ask. In part 2 of our episodes on dietary guidelines, we get to the bottom of the latest iteration of these guidelines and

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57:58

Ep 208 Dietary Guidelines Part 1: Who’s behind these...

This Podcast Will Kill You ·

2026/04/28

Over the decades, dietary guidelines have taken a diverse array of shapes, from pamphlets to wheels, from plates to pyramids. In many cases, the shapes have changed more than the recommendations they contain. This week and next, we explore those recommendations - who’s making them, how they have changed over time, and how closely they align with what we should be eating. First, we delve into the long history of dietary guidelines and how their intentions have evolved as the food landscape

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50:06

Special Episode: Adam Kucharski & Proof

This Podcast Will Kill You ·

2026/04/21

Why do we believe what we believe? Is what we believe the truth? How can we convince others of our beliefs? If you’ve ever found yourself pondering these questions, you know that the answers are rarely clear-cut. We need to form beliefs in order to navigate the world, but how skilled are we at evaluating evidence for those beliefs or weighing new data that contradicts them? In this week’s TPWKY book club episode, Adam Kucharski, Professor at the London School of Hygiene and Tropical

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75:20

Ep 207 Tear Gas: How can a chemical weapon be “humane”?

This Podcast Will Kill You ·

2026/04/14

Tear gas is an expected, normalized part of protests today. But its use in international war is banned. How can that be? That’s just one of the questions we investigate in this episode. First, we take you through the long history of tear gas and its emergence alongside deadlier chemical weapons before discussing how its use became routine, fueled by industry interests. Then we delve into what’s in tear gas that causes the painful physical reaction and consider whether claims of

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72:38

Ep 206 Oropouche Virus: More than a smidge worrisome

This Podcast Will Kill You ·

2026/04/07

Though discovered relatively recently, Oropouche virus has been making headlines as an emerging vector-borne infectious disease on the rise. Not transmitted by the usual suspects (like ticks and mosquitoes), this virus is instead spread through the bites of midges or no-see-ums. Since these arthropods are already widely distributed and their range is growing thanks to climate change, this is a recipe for potential disaster. In this episode, we take you through the story of Oropouche virus, from how

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79:29

Ep 205 Cancer Part 4: Where do things stand today?

This Podcast Will Kill You ·

2026/03/31

For the entirety of our species’ history, our approach to cancer has largely been to react, to design new therapies and better combinations of treatments. This energy has certainly been well-spent, but what if we didn’t have to use treatment at all? Or what if we could minimize the use of aggressive therapies? Prevention and screening represent two under-appreciated pillars of cancer care, and we’re using this final installment in our cancer miniseries to show some appreciation. To

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92:47

Ep 204 Cancer Part 3: How do we treat it?

This Podcast Will Kill You ·

2026/03/24

A century and a half ago, the list of effective cancer treatments was essentially a single entry: surgery. Today, in 2026, you’d need pages to contain the number of treatments available, and multiple notebooks to delineate all of the various therapies currently in development. It is nothing short of a revolution. Of course, no revolution is perfect, and many cancer treatments are ineffective or carry risks of serious side effects. In part 3 of our cancer series, we delve into all facets of

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45:30

Special Episode: Lawrence Ingrassia & A Fatal...

This Podcast Will Kill You ·

2026/03/17

For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellular dynamics underlying cancer, and what they found finally allowed grief-stricken families to put a name and explanation to their experience. It wasn’t simply bad luck. It was genetics: a heritable mutation in a key tumor suppressor gene that greatly increases the risk of developing cancer in your

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78:30

Ep 203 Cancer Part 2: Why does it happen?

This Podcast Will Kill You ·

2026/03/10

Each of our cells can become cancerous. It’s an uncomfortable, yet unavoidable truth. Nor is it a truth restricted to our species - cancer is a consequence of complex life. The features that make a cell cancerous are those that, under other circumstances, are beneficial, essential even, for an individual’s growth and survival. How is that possible? In the second installment in our series, we’re putting cancer under the microscope to consider the qualities that underlie a cancer

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96:20

Ep 202 Cancer Part 1: What is it?

This Podcast Will Kill You ·

2026/03/03

Cancer has touched every one of us in some capacity, and learning of a diagnosis inspires many more questions than it answers. In this four-part series on cancer, we aim to lay a foundation of knowledge that will help make sense of this multifaceted disease. We begin our four-part series on cancer by asking a deceptively simple question: what is cancer? As we’ll discover over the course of these episodes, there is not one answer but many. After all, cancer is not one disease but many. In this

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56:25

Special Episode: Jon Adams and Edmund Ramsden & Rat City

This Podcast Will Kill You ·

2026/02/24

What happens if you put a bunch of rats in an enclosure and provision them with unlimited food and water? Researcher John B. Calhoun was committed to finding out. Results from Calhoun’s “rat utopia” experiments from the mid-20th century revealed a behavioral dark side that emerged as space grew increasingly limited, ultimately leading to complete population collapse. As headlines conveyed dire warnings about global overpopulation, Calhoun’s work served to reinforce those

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81:54

Ep 201 Poop Part 2: Flushed away

This Podcast Will Kill You ·

2026/02/17

Poop is an incredibly valuable and massively underutilized resource. However, most of us don’t see it that way because of our evolutionarily ingrained disgust towards poop. Flush toilets and intricate sewer systems have revolutionized health and hygiene by whisking our poop far away where we don’t have to think about it. But that poop has gotta go somewhere, and eventually, not thinking about it isn’t going to be an option. Similarly, not thinking about our individual poop is

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71:56

Ep 200 Poop Part 1: How the sausage gets made

This Podcast Will Kill You ·

2026/02/10

It might be stinky and it might be unpleasant to behold, but we all do it. For many of us, our poop is out of sight, out of mind once we flush it away. But for the next hour and fifteen minutes or so, we’re going to bring it back into mind as we delve into the rich world of poop. This episode, the first of a two-part miniseries on poop, features a wide cast of characters all with some role in the production or management of poo, like our intestinal tract with its sphincters and microbiota,

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60:03

Special Episode: Nicola Twilley & Frostbite

This Podcast Will Kill You ·

2026/02/03

For much of the world, refrigeration is such a commonplace technology that we rarely stop to wonder at the many ways it has transformed our lives. From the foods we grow to where we grow them, from how they taste to what we eat, refrigeration has dramatically - and quite recently - changed our relationship to food, our health, and the environment. AsNicola Twilleydescribes inFrostbite: How Refrigeration Changed our Food, Our Planet, and Ourselves, progress, as it so often does, comes at a cost

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70:47

Ep 199 Sleep Part 2: Predictably unpredictable

This Podcast Will Kill You ·

2026/01/27

Now that we know just how critical sleep is, we’re all making sure we get the amount we need, right? Unfortunately no. One-third to one-half of Americans are not getting enough sleep, according to public health guidelines. Why is that? Hypotheses abound, but many point the finger of blame at different aspects of modern society such as screen time, artificial light, a sedentary lifestyle. These narratives suggest that sleep in industrialized societies today is not just different but worse than

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74:00

Ep 198 Sleep Part 1: Sleeping with one eye open

This Podcast Will Kill You ·

2026/01/20

Sleep is a universal experience. It’s not just the lion that sleeps tonight - it’s also the butterfly, the chicken, the jellyfish, the dog, the snake, the worm, and of course the human. What is this widespread physiological process whose spell we are all under? What purpose (or purposes) does it serve? Why do we sleep the way we do? These are just some of the questions we’re going to get into in this week’s episode, the first half of our two-parter on sleep. We break down the

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57:32

Special Episode: Daniel Stone & American Poison

This Podcast Will Kill You ·

2026/01/13

The widespread use of leaded gasoline in the 20th century led to one of the world’s biggest public health and environmental disasters, the effects of which are still present today. Since its development in the 1920s, leaded gasoline has been linked to premature death, cognitive impairment, and behavioral issues in millions around the globe. How was such a toxic substance permitted to be sold, despite the tireless efforts of industrial medicine warriors like Alice Hamilton? InAmerican Poison: A

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76:24

Ep 197 Detox: Enemas for everyone

This Podcast Will Kill You ·

2026/01/06

Ah, the new year. After the last month and a half of indulgent food and drink, disrupted schedules, and laying around the house, who doesn’t feel like they’re in need of a whole-body cleanse? There are plenty of companies who are more than happy to provide that product or service that promises to flush away toxins from your skin, gut, blood, brain, you name it. But what exactly are they selling you? In this episode, we explore the deep roots of the ever-expanding detox industry and the

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