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PODCAST

Breakthroughs

Northwestern University Feinberg School of Medicine

Breakthroughs is a podcast about groundbreaking research and the scientists leading these discoveries at Northwestern University Feinberg School of Medicine. We are driven by our mission to transform the practice of medicine and profoundly impact human health beyond the individual patient. We believe better answers only come from discovery.

health & fitness medicine

All Episodes

35:30

Understanding Gut Microbiome Science with Jeffrey...

Breakthroughs ·

2024/10/07

Jeffrey Gordon, MD, often called “the father of microbiome research,” is the 2024 recipient of the Mechthild Esser Nemmers Prize in Medical Science. In this episode, Gordon discusses the impacts of his long career in gut microbiome research, which has profoundly transformed our understanding of human health. Specifically, he shares the evolution of groundbreaking approaches to treating malnutrition and childhood undernutrition with microbiota-targeted therapies.

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23:03

Overcoming Hormone Therapy Resistance in Prostate...

Breakthroughs ·

2024/09/16

The MYC oncogene is notorious in the cancer research world because it is implicated in many advanced or aggressive cancers such as treatment-resistant prostate cancer. In this episode, Sarki Abdulkadir, MD, PhD, shares how his team bucked the conventional notion that the MYC gene is “undruggable” and uncovered a handful of compounds that block MYC gene activity, making prostate cancer tumors sensitive to hormone therapy and opening up a potential new therapeutic target for treatment-resistant

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21:27

How to Measure Biological Age with John Wilkins, MD

Breakthroughs ·

2024/07/22

A team of Northwestern Medicine scientists are conducting a new longitudinal cross-sectional study to investigate why some people see to age faster than others. In this episode, John Wilkins, MD, associate director of the Human Longevity Laboratory at the Potocsnak Longevity Institute, shares details of the study, which will eventually include a variety of interventions aimed at slowing down the aging process.

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20:10

A Compelling New Lupus Discovery with Jaehyuk Choi,...

Breakthroughs ·

2024/07/10

Northwestern Medicine physician-scientist Jaehyuk Choi, MD, PhD joins the show again to discuss another breakthrough. This time for lupus, a chronic autoimmune condition affecting 300,000 Americans that can cause inflammation in many body parts, including joints, skin, kidneys, blood cells, brain, heart and lungs. Findings by Choi and his lab members not only elucidate the underlying mechanisms of lupus but also suggest potential therapeutic strategies.

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27:36

Uncovering Insights into Cancer and Alzheimer's with...

Breakthroughs ·

2024/05/20

For decades, Marcus Peter, PhD, has drilled into an area of research focused on cell death and the roles of toxic and protective short RNAs, with the goal of developing a novel form of cancer treatment. Now, this same line of research has led Peter’s team to uncover new insights into the cause of Alzheimer's disease. In this episode, Peter explains his pioneering work in investigating RNA interference in diseases and explains how his lab’s latest novel discovery may have relevance to an array of

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20:11

The Evolution of Digital Pathology with Lee Cooper, PhD

Breakthroughs ·

2024/05/06

New advances in digital pathology are revolutionizing the analysis of disease, paving the way for greater accuracy and efficiency when it comes to diagnostics, predicting outcomes and treatment. In this episode, Lee Cooper, PhD, discusses the future of digital and computational pathology and his research on machine learning and pathology, including a recent study published in Nature Medicine on using AI in predicting clinical outcomes for breast cancer patients.

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23:33

Driving Innovations in Biostatistics with Denise...

Breakthroughs ·

2024/04/22

Northwestern University Feinberg School of Medicine is home to a team of premier faculty and staff biostatisticians who are a driving force of data analytic innovation and excellence. In this episode, Denise Scholtens, PhD, a leader in biostatistics at Feinberg, discusses the growing importance of the field of biostatistics and how she leverages her skills to collaborate on several projects in Maternal and Fetal Health.

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22:32

Leading Pediatric Obesity Research with Justin Ryder,...

Breakthroughs ·

2024/04/05

Northwestern Medicine scientists are at the forefront of research investigating the most effective ways of treating obesity in children and teens and improving their access to care. In this episode, Justin Ryder, PhD, a clinical and translational obesity scientist at Feinberg, talks about the use of new GLP-1–based medications for childhood obesity and his work on several NIH-funded projects focused on understanding how pediatric obesity impacts chronic disease risk and how biology drives weight

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25:00

Discovering New ALS Therapeutic Avenues with...

Breakthroughs ·

2024/03/25

An estimated 32,000 Americans are currently living with ALS, or amyotrophic lateral sclerosis, a progressive neurodegenerative disease that attacks motor neurons in the brain and spinal cord. Northwestern investigators have uncovered novel cellular mechanisms involved in two types of genetic ALS that might lead to future targeted therapies. Evangelos Kiskinis, PhD, shares insights on these findings recently published in Science Advances and Cell Reports.

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23:40

Pursuing Deeper Understanding of Inflammation with...

Breakthroughs ·

2024/03/11

Inflammation is a common feature of many diseases and Northwestern Medicine investigators have identified how a calcium channel contributes to inflammation in the brain and lungs. This could aid in finding new types of therapeutics for inflammation-related diseases and conditions. In this episode, Murali Prakriya, PhD, discusses the evolution of this groundbreaking research in ion channels as well as his latest findings published in Nature Communications.

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30 results

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