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Science TLDR

Ten-minute paper summaries for scientists and experts.Two episodes a week: Mondays feature the top-scoring paper from a curated weekly digest of T cell engager, bispecific antibody, and protein engineering literature. Fridays cover the top trending paper on PubMed — any field, whatever"s catching the research community"s attention that week.Hosted by Raymond Ruff, a protein scientist working in translational immunotherapeutics. Audio is generated with NotebookLM; the host prompt aims for measured

science

All Episodes

21:36

Episode 69: Novel bispecific T-cell engagers...

Science TLDR ·

2026/05/25

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Novel bispecific T-cell engagers overcoming acquired EGFR resistance](https://doi.org/10.1080/19420862.2026.2674236) **Authors:** Lennart Kühl, Ann-Kathrin Löffler, Oliver Seifert, Dennis Michler, et al. **Journal:** mAbs, 2026 **Why it matters:** Acquired resistance to EGFR-targeted antibody therapies remains a major barrier in colorectal and head-and-neck cancers, and this study presents an

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23:48

Episode 68: The lived experience of rejection...

Science TLDR ·

2026/05/22

**Paper:** [The lived experience of rejection sensitivity in ADHD — A qualitative exploration](https://doi.org/10.1371/journal.pone.0314669) **Authors:** Annabel Rowney-Smith, Beth Sutton, Lisa Quadt, Jessica A. Eccles **Journal:** PLOS One, 2024 **Why it matters:** Emotional dysregulation — and rejection sensitivity in particular — affects the majority of adults with ADHD yet remains largely absent from standard diagnostic criteria, leaving a significant dimension of patient suffering

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21:09

Episode 67: Deep peptide recognition profiling...

Science TLDR ·

2026/05/18

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery](https://doi.org/10.1038/s41587-026-03128-x) **Authors:** Nan Wang, Hugh Yeh, Ben Lai, Jason Perera, Kevin M. Jude, et al. **Journal:** Nature Biotechnology, 2026 **Why it matters:** Mapping how T cell receptors actually recognize peptides — rather than inferring it from sequence alone — opens a

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19:57

Episode 66: The political polarization of health...

Science TLDR ·

2026/05/15

**Paper:** [The political polarization of health outcomes in the USA](https://doi.org/10.1038/s41562-026-02474-9) **Authors:** Elizabeth Elder, Neil A. O'Brian **Journal:** Nature Human Behaviour, 2026 **Why it matters:** Political ideology has emerged as a measurable social determinant of health in the United States, with conservative Americans showing widening gaps in both clinical biomarkers and mortality that persist after accounting for COVID-19, geography, and demographic

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21:34

Episode 65: Enable CAR T cell immunotherapy in...

Science TLDR ·

2026/05/11

**Paper:** [Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager](https://doi.org/10.1016/j.omton.2026.201201) **Authors:** Moon Jung Choi, Eui Young So, Bedia Akosman, Young Eun Lee, et al. **Journal:** Molecular Therapy Oncology, 2026 **Why it matters:** Glioblastoma has resisted every modern immunotherapy due to its physical and immunological defenses, and this study presents a multimodal platform that

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23:43

Episode 64: Climate-driven depopulation and...

Science TLDR ·

2026/05/08

**Paper:** [Climate-driven depopulation and adaptation realities in America's coastal ground zero](https://doi.org/10.1038/s41893-026-01820-z) **Authors:** Torbjörn E. Törnqvist, Brianna Castro, Jesse M. Keenan, Jayur M. Mehta, Zhixiong Shen **Journal:** Nature Sustainability, 2026 **Why it matters:** The central U.S. Gulf Coast — identified by the IPCC as the single most exposed low-elevation coastal zone globally this century — offers an empirical test case for how geology, archaeology, and

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21:28

Episode 63: Engineering of acidic pH-responsive...

Science TLDR ·

2026/05/04

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Engineering of acidic pH-responsive anti-CD3 binding antibodies](https://doi.org/10.1080/19420862.2026.2658902) **Authors:** Grégory La Sala, Katharina B. Kroell, Mudita Pincha, Christian Gassner, et al. **Journal:** mAbs, 2026 **Why it matters:** Tumor-selective T-cell engagers could dramatically reduce the on-target, off-tumor toxicity that limits current CD3-directed cancer

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23:16

Episode 62: Impact of high-power short-duration...

Science TLDR ·

2026/05/01

**Paper:** [Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study](https://doi.org/10.1186/s12916-023-03180-3) **Authors:** Wei-Jie Chen, Chun-Xia Gan, Yang-Wei Cai, Yang-Yang Liu, et al. **Journal:** BMC Medicine, 2023 **Why it matters:** Even when catheter ablation successfully restores heart rhythm, microscopic clots can silently lodge in the brain — and this trial tests whether a

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20:57

Episode 61: Improving mitochondria and ER stability...

Science TLDR ·

2026/04/24

**Paper:** [Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology](https://doi.org/10.1002/ctm2.336) **Authors:** Barış Genç, Mukesh Gautam, Öge Gözütok, Ina Dervishi, Santana Sanchez, et al. **Journal:** Clinical and Translational Medicine, 2021 **Why it matters:** NU-9 is the first compound shown to halt upper motor neuron degeneration — the cortical neurons whose loss defines ALS, primary lateral

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22:39

Episode 60: A trophoblast glycoprotein specific...

Science TLDR ·

2026/04/22

**Paper:** [A trophoblast glycoprotein specific 5T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies](https://doi.org/10.1016/j.clim.2026.110707)**Authors:** Milon de Jong, Rok Žiberna, Myrthe Veth, Elisabetta Michielon, et al. **Journal:** Clinical Immunology, 2026 **Why it matters:** Solid tumors have largely resisted bispecific T cell engager therapies due to on-target toxicity in healthy tissue, and this study presents a

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11:55

A trispecific antibody engaging T cells with tumour...

Science TLDR ·

2025/12/24

https://doi.org/10.1038/s41551-025-01569-4

en

14:45

Language models cannot reliably distinguish belief...

Science TLDR ·

2025/11/07

https://doi.org/10.1038/s42256-025-01113-8

en

19:20

Spatially organized inflammatory myeloid-CD8+ T cell ...

Science TLDR ·

2025/11/06

https://doi.org/10.1101/2025.06.06.657162

en

16:37

SARS-CoV-2 mRNA vaccines sensitize tumours to immune...

Science TLDR ·

2025/10/28

https://doi.org/10.1038/s41586-025-09655-y

en

14:34

Guidelines for Early Food Introduction and Patterns...

Science TLDR ·

2025/10/22

https://doi.org/10.1542/peds.2024-070516

en

15:29

Improving dual targeting selectivity in T-cell...

Science TLDR ·

2025/10/16

https://doi.org/10.1080/19420862.2025.2570748

en

16:07

A genetic common factor underlying self-reported math...

Science TLDR ·

2025/10/11

https://doi.org/10.1038/s41380-025-03237-0

en

13:57

Profiling Hinge Plasticity in Intact Monoclonal...

Science TLDR ·

2025/09/15

https://doi.org/10.1021/acs.biochem.5c00274

en

17:02

The impact of CD3 affinity-attenuation on T cell...

Science TLDR ·

2025/09/12

DOI: 10.1080/17460441.2025.2522088

en

19:23

Glycan shielding enables TCR-sufficient allogeneic...

Science TLDR ·

2025/08/29

https://doi.org/10.1016/j.cell.2025.07.046

en

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