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PODCAST

ACR Journals On Air

American College of Rheumatology

Welcome to "ACR Journals on Air," the ACR"s newest podcast series featuring interviews, commentary, and analysis on research from our three peer-reviewed journals. Join us each episode for engaging discussions with authors and independent experts about recently published studies, their implications for clinical care, and how they move the field of rheumatology forward. Whether it"s an expert analysis of a manuscript or deep dive with an author – our goal is the same – to understand the impact of

health & fitness medicine

All Episodes

47:22

ANA In All of Us

ACR Journals On Air ·

2025/03/18

This week, we explore the genetics behind the production of antinuclear antibodies (ANA) in individuals without clinical autoimmune disease, using data from the All of Us registry. Our guest, Dr. Mehmet Hocaoglu shares insights into the significance of understanding ANA positivity and its potential genetic underpinnings, highlighting how large-scale genome-wide association studies (GWAS) can predict susceptibility to autoimmune conditions. We cover the study's methodology, the unique All of Us

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48:10

Immunology for the Rheumatologist: Fever Pitch

ACR Journals On Air ·

2025/03/04

In this episode, our host is joined by Dr. Peter Nigrovic, an expert in Macrophage Activation Syndrome (MAS). Dr. Nigrovic, delves into the complexities of MAS. The discussion covers the syndrome's history, diagnostic challenges, mechanisms of inflammation, and the latest treatment strategies, including cytokine blockade, JAK inhibitors, and chemotherapy options. Dr. Nigrovic also reflects on his unique career journey, offering valuable insights into combining clinical practice and research, while

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40:02

Immunology for the Rheumatologist: NETs in Lupus

ACR Journals On Air ·

2025/01/21

In this episode we explore the role of Neutrophil Extracellular Traps (NETs) in systemic lupus erythematosus (SLE). Dr. Mariana Kaplan, Chief of the Systemic Autoimmunity Branch at the National Institute of Arthritis Musculoskeletal and Skin Diseases, joins the discussion to break down the complex immunological mechanisms driving lupus, focusing on the contribution of NETs and Low-Density Granulocytes (LDGs) to disease activity and tissue damage. The conversation delves into the potential for these

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48:37

Immunology for the Rheumatologist: Type I Interferon...

ACR Journals On Air ·

2024/12/10

In this episode, we sit down with Dr. Victoria Werth, a leading expert in dermatology and autoimmune diseases, to explore the study Understanding the Role of Type I Interferons in Cutaneous Lupus and Dermatomyositis: Toward Better Therapeutics. Dr. Werth delves into the complex immune mechanisms that drive skin manifestations in cutaneous lupus and dermatomyositis, two challenging autoimmune conditions. She explains how Type I interferons contribute to inflammation and tissue damage, and how

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36:58

Opioids and SARDs

ACR Journals On Air ·

2024/11/26

In this episode, we explore the findings of a groundbreaking study analyzing opioid treatment trends for adults with and without systemic autoimmune and inflammatory rheumatic diseases (SARDs) from 2006 to 2019. The study, based on national data from the United States, sheds light on how individuals with conditions like rheumatoid arthritis, lupus, and ankylosing spondylitis are impacted by opioid use compared to the general population.

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25:21

ACR Convergence 2024: Sponsoring Women in Science

ACR Journals On Air ·

2024/11/18

As our weekend here in Washington D.C. draws to an end, we turn our spotlight on an important and timely conversation from the "Sponsoring Women in Science" session. In this episode, we sit down with Dr. Elizabeth Volkmann and Dr. Carol Feghali-Bostwick to explore the challenges women face in advancing their careers in the sciences. Our guests share insights on how to address the barriers that often impede career development for women, discuss strategies for fostering support and mentorship, and

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30:28

ACR Convergence 2024: New Mechanisms in...

ACR Journals On Air ·

2024/11/16

Get ready for an electrifying episode of Convergence 2024! We’re diving deep into the cutting-edge world of autoinflammatory diseases with renowned experts Drs. Grant Schulert and Arthur Kaser. Join us as they unravel the complexities of refractory and complicated systemic juvenile idiopathic arthritis (SJIA). Discover the revolutionary insights into SJIA at the single-cell level, explore the fascinating transcriptional diversity of normal and low-density granulocytes, and learn how groundbreaking

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32:50

DECT and Gout Remission

ACR Journals On Air ·

2024/11/12

This week we're joined by two leading experts in gout remissions, Dr. Nicola Dalbeth and Dr. Dansoa Tabi-Amponsah to explore the exciting advances in gout treatment, with a particular focus on Dual-Energy CT (DECT) imaging and its role in achieving gout remission. We dive into how DECT technology is transforming our ability to visualize urate crystals in joints, its implications for patient care, and the potential it holds for long-term gout management and remission.

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51:03

Immunology for the Rheumatologist: The Devil Is in...

ACR Journals On Air ·

2024/10/29

In another installment in the ongoing Arthritis & Rheumatology immunology series, guest David S. Pisetsky, MD, PhD, author of Unique Interplay Between Antinuclear Antibodies and Nuclear Molecules in the Pathogenesis of Systemic Lupus Erythematosus, takes us on a deep dive into research in SLE on how the combination of ANAs and immunologically active DNA can create new structures that can promote inflammation throughout the body as well as drive organ inflammation and damage.

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42:40

The SLEek Study

ACR Journals On Air ·

2024/10/15

This week, our next guest, ACR Master Dr. Joan T. Merrill, joins us to discuss her latest study which endeavored to evaluate the efficacy and safety of upadacitinib and elsubrutinib in those with systemic lupus erythematosus (SLE). Join us for an in-depth analysis of the SLEek Study, its findings regarding the efficacy of these medications and Dr. Merrill’s conclusions.

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35:17

Life Events and Autoimmune Disease

ACR Journals On Air ·

2024/10/01

For those with rheumatic disease, everyday challenges can mean an increase in disease flare. However, research is increasingly pointing to the idea that psychosocial stressors could even heighten the risk of developing rheumatic diseases. Dr. Christine Parks looked deeper into this among those with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in her latest study Life Events, Caregiving, and Risk of Autoimmune Rheumatic Diseases in the Women's Health Initiative Observational

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32:03

Pain in Psoriatic Arthritis

ACR Journals On Air ·

2024/09/17

This week, we explore a groundbreaking study on the prevalence of fibromyalgia and widespread pain in patients with psoriatic arthritis with first author and ACR Master, Dr. Philip J. Mease. In his latest article, titled: Prevalence of Fibromyalgia and Widespread Pain in Psoriatic Arthritis: Association with Disease Severity Assessment in a Large US RegistryUID , Dr. Mease explains what the presence of these conditions reveals about disease severity and how they converge.

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33:50

Self-Driving Research

ACR Journals On Air ·

2024/09/03

As the dawn of the Ai revolution marches on, scientific research and clinical medicine are adopting new and more streamlined ways to investigate and serve our patients. Today, we look at how Ai-driven, large language models (LLMs) might aid our field’s researchers in analyzing data from patient interviews. Dr. Bella Mehta, corresponding author of A Novel Approach for Mixed-Methods Research Using Large Language Models: A Report Using Patients’ Perspectives on Barriers to Arthroplasty , joins us this

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49:34

More Than the Sum of its Parts

ACR Journals On Air ·

2024/08/20

Genetic conditions, inherited personality traits, brain chemistry...these are but a few of the well-known biological determinants of health and are but a small sample of factors that can determine how severe disease may affect a patient. But what role can social factors play in determining a patient’s health? What of the ‘Social Determinants of Health (SDoH)’? Dr. Shivani Garg set out to identify these factors and understand how they play a role in determining the severity of symptoms in those with

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31:32

When Can We Wean Remission Maintenance Therapy in...

ACR Journals On Air ·

2024/08/06

The process of weaning our patients off biologic disease-modifying antirheumatic drug (b-DMARD) therapy is not unfamiliar in our clinics. However, when attending to our patients, many complications and questions arise. Specific guidance is needed, but where do we turn? Thankfully, our latest guest, Dr. Paul Emery, may have some answers. His latest study, Predicting Flare in Patients With Rheumatoid Arthritis in Biologic Induced Remission, on Tapering, and on Stable Therapy attempted to “identify

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24:19

Calprotectin in Antiphospholipid Syndrome

ACR Journals On Air ·

2024/07/23

To better understand the mechanisms that drive antiphospholipid syndrome (APS), Dr. Yu Zuo and his team, evaluated the presence of circulating calprotectin (cCLP) to detect any clinical associations or even the mechanistic role among a cohort of primary APS and aPL-positive patients. Dr. Zuo sits down with us this week to discuss whether calprotectin can be a functional biomarker for those with APS thrombocytopenia and what the future holds for this study’s conclusions.

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44:16

The Quest for Prevention in Autoimmune Disease

ACR Journals On Air ·

2024/07/09

Benjamin Franklin once said: “An ounce of prevention is worth a pound of cure”. This week, we have the opportunity to see this realized in a recent clinical study entitled, Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial. Our guest is the study’s first author, Dr. Karen Costenbader. She explains the results of this research, which suggests Vitamin D and marine n-3 fatty acids play a significant

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32:53

What Came First

ACR Journals On Air ·

2024/06/25

Caring for our patients means reducing symptoms and occurrences of flare-ups. However, caring for their whole self means a watchful eye on how chronic disease symptoms impact their daily life and mental health. Discovering patterns between depression and anxiety and such chronic diseases, like ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis, was the focus of Dr. Alyssa Howren’s latest study. Today, we take a look at this study, titled: “What Came First?” Population-Based

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27:47

History Matters

ACR Journals On Air ·

2024/06/11

When disease strikes, time becomes a critical resource our patients cannot afford to waste. For those with axial spondyloarthritis (axSpA), an inordinate amount of time often goes by before a proper diagnosis is made, resulting in delays for crucial treatments to be rendered. The reasons for this delay in diagnosis, particularly among those with axSpA are diverse, complicated and not well-understood. Our guest, Dr. Gregory McDermott, attempted to better understand this diagnostic delay with his

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35:58

The RENEW Study in Scleroderma

ACR Journals On Air ·

2024/05/28

Systemic Sclerosis (SSc) is a painful and debilitating disease that our patients suffer from. However, a newly published study has concluded that there are some self-management interventions patients can engage with that have shown to improve fatigue, particularly for those newly diagnosed with SSc. Today, we review the procedures, interventions, results and conclusions of this study, titled: Effects of a Resilience-Building Energy Management Program on Fatigue and Other Symptoms in Systemic

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