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PODCAST

Oncology for the Inquisitive Mind

Michael Fernando and Josh Hurwitz

Cancer is a fascinatingbut rapidly evolvingdiscipline- it"s a full-time job just keeping up to date. In this podcast,Dr Michael Fernando and Dr Joshua Hurwitz explorethe latest trials, research, and practice-changing updates,as well asregular interviews with renowned oncology specialists.Ideal for thosestarting their trainingjourney, established specialistsandanyone interested in medical science, oncological practice,or terrible jokes. Preferably all three. Hosted on Acast. See acast.com/privacy for

health & fitness medicine

All Episodes

20:03

158. Back to Basics - Metastatic Urothelial (Bladder)...

Oncology for the Inquisitive Mind ·

2025/05/31

This week, we talk about metastatic bladder cancer. The last two years have seen drastic changes in this space, with the addition of immunotherapy and ADCs in a first-line setting. While exceptionally effective, toxicity and patient selection remain challenging. The other big issue with what's best for the second line? That's the golden question.Studies discussed in the episode:EV-302THORFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter

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19:05

157. Back to Basics - Early Bladder Cancer

Oncology for the Inquisitive Mind ·

2025/05/24

This week, we explore MIBC (Muscle-Invasive Bladder Cancer). The two trials finally compare chemotherapy regimens (DDMVAC vs cisplatin and gemcitabine) and the utilisation of durvalumab in a sandwich perioperative approach.A must listen to episode comparing the complexities of early bladder cancer, and the options available.Studies discussed in the episode:VESPERNIAGARAFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us

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24:26

156. Back to Basics - Prostate Cancer - Biochemical...

Oncology for the Inquisitive Mind ·

2025/05/17

As we "EMBARK" on our next Prostate Cancer adventure via the "SOLAR" system to "SATURN," Michael and Josh explore the idea of biochemical recurrence in prostate cancer and the role of radiotherapy in tumour-directed therapy for de novo versus recurrent PSMA PET–defined oligo-M1 prostate cancer. Both excellent studies raise the question of newer technologies and how we apply this information to trials that already exist.Studies discussed in the episode:EMBARKSOLAR/SATURNFor more episodes, resources

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24:13

155. Back to Basics - Theranostics and Prostate Cancer

Oncology for the Inquisitive Mind ·

2025/05/10

Marie Curie's life work laid the foundations for theranostics. This week, we talk about Lutetium, a rare earth metal, and its role in Prostate Cancer. Lutetium-177 PSMA therapy isa radiation therapy that targets prostate cancer. It is used in the advanced, metastatic, and castrate-resistant space. Lutetium is bound to a protein called PSMA. PSMA is overexpressed in many prostate cancers and can be used to target these cancer cells via the membrane antigen.Studies discussed in the

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22:09

154. Back to Basics - Non Metastatic and Metastatic...

Oncology for the Inquisitive Mind ·

2025/05/03

Prostate Cancer has a multitude of presentations, but when metastatic, it usually spreads directly to the lymph nodes or the bones. This episode focuses on the contentious definition of "M0 Castrate Resistant Prostate Cancer (CRPC)", also known as Nonmetastatic CRPC. Does this definition exist, and what role will PSMA PET have in this cohort of patients? The second trial, TITAN looks at apalutamide, another ARPI/ARSI and how it compares to it's cousins who are fighting for the top spot in the

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31:41

153. Inflammatory Breast Cancer with Dr Massimo...

Oncology for the Inquisitive Mind ·

2025/04/26

This week, we interview Dr. Cristofanilli, a globally recognised expert in inflammatory breast cancer research and precision medicine. With decades of clinical experience and groundbreaking contributions to translational research, he has transformed the way we approach metastatic breast cancer, leading advances in liquid biopsy, molecular profiling, and targeted therapies.Dr Cristofanilli serves as the Director of Breast Medical Oncology, Associated Director of Precision Oncology at the Meyer Cancer

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23:32

152. Back to Basics - High Volueme in Metastatic...

Oncology for the Inquisitive Mind ·

2025/04/05

Today, we discuss the role of triplet therapy (ie, chemotherapy and androgen receptor signalling inhibitor and ADT) in high-volume metastatic hormone-sensitive prostate cancer and whether darolutamide is equivalent to the other androgen receptor signalling inhibitors in the castrate-sensitive space. Two good trials, and as always, some interesting discussion points.Studies discussed in the episode:ARASENSARANOTEFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us

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18:07

151. Back to Basics - Androgen Receptor Pathway...

Oncology for the Inquisitive Mind ·

2025/03/29

The rise and rise of Androgen Receptor Pathway (or Signalling) Inhibitors has changed the world of metastatic prostate cancer forever. What was once a cancer with a finite number of treatment options has flourished into a chasm of therapies, many more effective and less toxic than their therapeutic grandparents.Studies discussed in the episode:ARCHESENZAMETFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a

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21:14

150. Back to Basics - Recurrence-score assays in...

Oncology for the Inquisitive Mind ·

2025/03/22

Our final breast cancer episode is here! Today we are talking about the role of Gene Expression Assays in breast cancer management. The specific questions we asked include when can we de-escalate, and which cohort of patients can these assays be used? There's lots more to this episode, but we explore the role of Oncotype Dx!Studies discussed in the episode:TAILORxRxPonderFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us

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24:30

149. Back to Basics - Metastatic Hormone Sensitive...

Oncology for the Inquisitive Mind ·

2025/03/15

This week, we prematurely dive into prostate cancer (one breast episode remaining - whoops!), where we explore the early pivotal trials, including the role of abiraterone in metastatic hormone-sensitive prostate cancer and the use of docetaxel in high and low-volume prostate cancer.Studies discussed in the episode:LATITUDESTAMPEDEFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject,

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19:14

148. Back to Basics - Metastatic Triple Positive...

Oncology for the Inquisitive Mind ·

2025/03/08

As our breast cancer journey comes close to finishing, it was always the destiny of your cohost's on Oncology for the Inquisitive Mind to talk about HER2-positive breast cancer. This week, we target both antibody-drug conjugate therapy and targeted therapy (trastuzumab deruxtecan and pertuzumab). While HER2-positive cancer's survival is one of the best for metastatic disease, this was not always the case. Studies discussed in the episode:DESTINY 03 CLEOPATRA TrialFor more episodes, resources and

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19:18

147. Back to Basics - Metastatic Triple Negative...

Oncology for the Inquisitive Mind ·

2025/03/01

Metastatic Triple Negative Breast Cancer is one of the most challenging breast cancer subtypes to treat. Recurrence rates can be as high as 40%. This episode covers the role of immunotherapy and antibody-drug conjugates in the advanced space. Once again, targetable receptors are lacking but research is underway!Studies discussed in the episode:KEYNOTE 355ASCENTFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at

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24:43

146. Back to Basics - BRCA mutation and Breast Cancer...

Oncology for the Inquisitive Mind ·

2025/02/22

It's been an "Olympic" ride to get here, and this is our penultimate breast cancer episode! Today, we talk about the BRCA mutations and how they impact both breast cancer and outcomes using targeted therapy. BRCA is a tumour suppressor gene.Today, we explore olaparib and its role in the adjuvant and metastatic setting for breast cancer.Studies discussed in the episode:OLYMPIAOLYMPIADFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If

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19:41

145. Back to Basics - Metastatic Hormone Receptor...

Oncology for the Inquisitive Mind ·

2025/02/15

Metastatic Hormone Receptor-Positive Breast Cancer truly represents the frontier of Medical Oncology, with life expectancy creeping up to and beyond five years. This week, we discuss Monaleesa-2 (Ribociclib), Paloma-2 (Palbociclib) and, of course, highlight the importance of Monarch-3 (Abemaciclib). The great CDK debate continues, and while the phase three trials have a clear winner, it's important to discuss the benefits and cons of each.Studies discussed in the episode:MONALEESA-2PALOMA-2MONARCH-3

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25:49

144. Back to Basics - Early Triple Negative Breast...

Oncology for the Inquisitive Mind ·

2025/02/08

Early Triple Negative Breast Cancer remains an aggressive variant of all breast cancers, affecting those under 40 more and has a higher propensity for being in those with BRCA1/2 mutations. It represents about 15% of all breast cancers.This week, we explore the benefit of immunotherapy (pembrolizumab), looking at improved complete pathological response as a surrogate marker for OS and the role of capecitabine in the adjuvant setting.Studies discussed in the episode:CREATE-XKEYNOTE-522For more

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20:57

143. San Antonio Breast Cancer Symposium 2024 - Part 2

Oncology for the Inquisitive Mind ·

2025/02/01

Our second SABCS (San Antonio Breast Cancer Symposium) episode covers everything (else) you need to know from 2024. In this episode, we dive into the role of trastuzumab deruxtecan in HR +ve, HER2 low cancers, perioperative atezolizumab in tnbc, the use of a novel ADC (SHR-A1811) and the role of tumour mutational burden in triple-negative cancer.Studies discussed in the episode:DESTINY-Breast06Neoadj atezoFASCINATE-NKEYNOTE-522For more episodes, resources and blog posts, visit

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28:06

142. San Antonio Breast Cancer Symposium 2024 - Part 1

Oncology for the Inquisitive Mind ·

2025/01/26

Welcome back to Oncology for the Inquisitive Mind, where we head back to late 2024 and cover some pivotal trials and ideas from the San Antonio Breast Cancer Conference 2024.This episode broadly covers hormone receptor-positive breast cancer and looks at another CDK comparison (real-world data). While the idea is not new, the potential implications from well-gathered "phase 4" data is a curious discussion point. Other topics include the ESR1 mutation and Imlunestrant, Patritumab Deruxtecan in

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24:04

141. Back to Basics - The role of endocrine therapy...

Oncology for the Inquisitive Mind ·

2024/12/21

Before immunotherapy, targeted chemotherapy (ADCs) and precision oncology, there was endocrine therapy, the forefather (or mother) of effective treatment to reduce breast cancer recurrence as well as delay disease progression. This episode dives into a past of phenomenal improvement in the adjuvant breast cancer space. How long should one take endocrine therapy? We cover all the facts you need to know as a clinician or if you are curious from a patient/learning perspective.Studies discussed in the

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19:21

140. Back to Basics - Adjuvant HER2 Breast Cancer...

Oncology for the Inquisitive Mind ·

2024/12/14

HER2 Breast Cancer is complicated, and this week, we explore those with residual disease post neoadjuvant therapy (KATHERINE) and the idea of de-escalation in a subpopulation of HER2-positive breast cancer patients (PERSEPHONE). The advent of a new class of drugs leads to excitement, unanswered questions and boundless opportunities. With ADC (antibody-drug conjugates) making their mark on traditional chemotherapy, the landscape of everything we treat is slowly changing. Studies discussed in the

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24:31

139. Back to Basics - Early HER2 breast cancer

Oncology for the Inquisitive Mind ·

2024/12/08

Human epidermal growth factor receptor 2 (HER2) is overexpressed in multiple cancers, including breast, gastric, colorectal, and epithelial ovarian cancers. However, this receptor's complexity doesn't stop there. It has multiple subdomains and various responses to drugs, and the complete picture is yet to be understood.This week, we explore the original wonder drug (Trastuzumab) in the early breast cancer space and its compatriot, Pertuzumab. Josh highlights the association between pathological

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195 results

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