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PODCAST

Oncology for the Inquisitive Mind

Michael Fernando and Josh Hurwitz

Cancer is a fascinatingbut rapidly evolvingdiscipline- it"s a full-time job just keeping up to date. In this podcast,Dr Michael Fernando and Dr Joshua Hurwitz explorethe latest trials, research, and practice-changing updates,as well asregular interviews with renowned oncology specialists.Ideal for thosestarting their trainingjourney, established specialistsandanyone interested in medical science, oncological practice,or terrible jokes. Preferably all three. Hosted on Acast. See acast.com/privacy for

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All Episodes

35:36

165. ASCO 2025 - Palliative Care with Dr. Janet Abrahm

Oncology for the Inquisitive Mind ·

2025/06/23

In this episode, Dr. Janet Abrahm shares transformative insights from ASCO 2025, focusing on palliative care and supportive care in oncology. Topics discussed include the role of exercise in cancer survival, cannabis use for symptom management, and the challenges of chemotherapy-induced peripheral neuropathy. We also highlight the importance of communication with patients, particularly in the context of grief and transition to palliative care, as well as the pervasive issue of burnout among oncology

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30:30

164. ASCO 2025 - Lung Cancer with Dr. Ned McNamee

Oncology for the Inquisitive Mind ·

2025/06/22

In this episode, Dr. Ned McNamee discusses the latest advancements in lung cancer treatment presented at ASCO 2025, focusing on significant studies such as the Phase 3 DeLLphi-304 study and Checkmate 816. They explore the implications of these findings for clinical practice, including the challenges of managing immune-related side effects and the potential for neoadjuvant immunotherapy to improve patient outcomes. The conversation also touches on the economics of oncology and the surprising results

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35:04

163. ASCO 2025 - Genitourinary Cancers (Bladder and...

Oncology for the Inquisitive Mind ·

2025/06/19

Today, we cover ASCO 2025 in the genitourinary space, specifically bladder and renal cancer. Dr. Enrique Grande, a renowned oncologist and Program and Clinical Research lead of MD Anderson Cancer Centre, Madrid, joins us. This is a mega episode where we cover AMPLITUDE, JAVELIN MEDLEY, CHECKMATE 901 and NIAGARA, advancing urothelial cancer care; SEAR 02 and the CReST trial, pushing boundaries in bladder cancer; CHECKMATE 214; LITESPARK-005 and LITESPARK-004, showcasing belzutifan’s promise; and

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34:52

162. ASCO 2025 - Genitourinary Cancers (Prostate)...

Oncology for the Inquisitive Mind ·

2025/06/16

Today, we’re joined by Professor Anthony Joshua, head of Medical Oncology at St. Vincent’s Hospital, Sydney, and a global leader in prostate cancer and melanoma. In this episode, Professor Joshua discusses multiple trials including AMPLITUDE, advancing prostate cancer therapies; CAN 2409, exploring immunotherapy; ARANOTE, showing darolutamide’s impact on progression-free survival; the prognostic significance of PSA 0.2; and the landmark STAMPEDE study. Join us for a deep dive into these

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45:59

161. ASCO 2025 - Breast Cancer with Dr. Adam Brufsky

Oncology for the Inquisitive Mind ·

2025/06/15

In this episode, we unpack game-changing insights from ASCO 2025 with a spotlight on breast cancer. Joining us is Dr. Adam Brufsky, a trailblazing oncologist and professor at the University of Pittsburgh, with 30 years of experience, whose expertise has helped shape the direction of treatment. Trials discussed include the SERENA-6 trial, which examines camizestrant plus CDK4/6 inhibitors in HR-positive, ESR1 mutation breast cancer; the DESTINY-Breast09 trial, highlighting trastuzumab deruxtecan in

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25:44

160. ASCO 2025 - Plenary Part 2

Oncology for the Inquisitive Mind ·

2025/06/11

In our second plenary episode, we're spotlighting two pivotal phase 3 trials: SERENA-6, which explores ctDNA-guided treatment with camizestrant to delay progression in HR-positive, HER2-negative advanced breast cancer with ESR1 mutations, and NIVOPOSTOP, a landmark study showing improved disease-free survival with adjuvant nivolumab in high-risk, resected head and neck squamous cell carcinoma. Join us as we unpack these practice-changing findings with expert insight and a couple of dad jokes along

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31:01

159. ASCO 2025 - Plenary Part 1

Oncology for the Inquisitive Mind ·

2025/06/07

This year, Michael and Josh bring you the American Society of Clinical Oncology (ASCO) 2025. To keep it fresh, we're doing things a little differently, but rest assured, we'll bring along a global host of experts to deliver the very best from the practice-changing, thought-provoking, design-defining trials you know and love from this podcast.This episode focuses on adjuvant atezolizumab in the colon cancer space and the use of perioperative durvalumab in the gastric cancer space. Both are exciting

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20:03

158. Back to Basics - Metastatic Urothelial (Bladder)...

Oncology for the Inquisitive Mind ·

2025/05/31

This week, we talk about metastatic bladder cancer. The last two years have seen drastic changes in this space, with the addition of immunotherapy and ADCs in a first-line setting. While exceptionally effective, toxicity and patient selection remain challenging. The other big issue with what's best for the second line? That's the golden question.Studies discussed in the episode:EV-302THORFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter

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19:05

157. Back to Basics - Early Bladder Cancer

Oncology for the Inquisitive Mind ·

2025/05/24

This week, we explore MIBC (Muscle-Invasive Bladder Cancer). The two trials finally compare chemotherapy regimens (DDMVAC vs cisplatin and gemcitabine) and the utilisation of durvalumab in a sandwich perioperative approach.A must listen to episode comparing the complexities of early bladder cancer, and the options available.Studies discussed in the episode:VESPERNIAGARAFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us

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24:26

156. Back to Basics - Prostate Cancer - Biochemical...

Oncology for the Inquisitive Mind ·

2025/05/17

As we "EMBARK" on our next Prostate Cancer adventure via the "SOLAR" system to "SATURN," Michael and Josh explore the idea of biochemical recurrence in prostate cancer and the role of radiotherapy in tumour-directed therapy for de novo versus recurrent PSMA PET–defined oligo-M1 prostate cancer. Both excellent studies raise the question of newer technologies and how we apply this information to trials that already exist.Studies discussed in the episode:EMBARKSOLAR/SATURNFor more episodes, resources

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24:13

155. Back to Basics - Theranostics and Prostate Cancer

Oncology for the Inquisitive Mind ·

2025/05/10

Marie Curie's life work laid the foundations for theranostics. This week, we talk about Lutetium, a rare earth metal, and its role in Prostate Cancer. Lutetium-177 PSMA therapy isa radiation therapy that targets prostate cancer. It is used in the advanced, metastatic, and castrate-resistant space. Lutetium is bound to a protein called PSMA. PSMA is overexpressed in many prostate cancers and can be used to target these cancer cells via the membrane antigen.Studies discussed in the

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22:09

154. Back to Basics - Non Metastatic and Metastatic...

Oncology for the Inquisitive Mind ·

2025/05/03

Prostate Cancer has a multitude of presentations, but when metastatic, it usually spreads directly to the lymph nodes or the bones. This episode focuses on the contentious definition of "M0 Castrate Resistant Prostate Cancer (CRPC)", also known as Nonmetastatic CRPC. Does this definition exist, and what role will PSMA PET have in this cohort of patients? The second trial, TITAN looks at apalutamide, another ARPI/ARSI and how it compares to it's cousins who are fighting for the top spot in the

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31:41

153. Inflammatory Breast Cancer with Dr Massimo...

Oncology for the Inquisitive Mind ·

2025/04/26

This week, we interview Dr. Cristofanilli, a globally recognised expert in inflammatory breast cancer research and precision medicine. With decades of clinical experience and groundbreaking contributions to translational research, he has transformed the way we approach metastatic breast cancer, leading advances in liquid biopsy, molecular profiling, and targeted therapies.Dr Cristofanilli serves as the Director of Breast Medical Oncology, Associated Director of Precision Oncology at the Meyer Cancer

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23:32

152. Back to Basics - High Volueme in Metastatic...

Oncology for the Inquisitive Mind ·

2025/04/05

Today, we discuss the role of triplet therapy (ie, chemotherapy and androgen receptor signalling inhibitor and ADT) in high-volume metastatic hormone-sensitive prostate cancer and whether darolutamide is equivalent to the other androgen receptor signalling inhibitors in the castrate-sensitive space. Two good trials, and as always, some interesting discussion points.Studies discussed in the episode:ARASENSARANOTEFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us

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18:07

151. Back to Basics - Androgen Receptor Pathway...

Oncology for the Inquisitive Mind ·

2025/03/29

The rise and rise of Androgen Receptor Pathway (or Signalling) Inhibitors has changed the world of metastatic prostate cancer forever. What was once a cancer with a finite number of treatment options has flourished into a chasm of therapies, many more effective and less toxic than their therapeutic grandparents.Studies discussed in the episode:ARCHESENZAMETFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a

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21:14

150. Back to Basics - Recurrence-score assays in...

Oncology for the Inquisitive Mind ·

2025/03/22

Our final breast cancer episode is here! Today we are talking about the role of Gene Expression Assays in breast cancer management. The specific questions we asked include when can we de-escalate, and which cohort of patients can these assays be used? There's lots more to this episode, but we explore the role of Oncotype Dx!Studies discussed in the episode:TAILORxRxPonderFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us

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24:30

149. Back to Basics - Metastatic Hormone Sensitive...

Oncology for the Inquisitive Mind ·

2025/03/15

This week, we prematurely dive into prostate cancer (one breast episode remaining - whoops!), where we explore the early pivotal trials, including the role of abiraterone in metastatic hormone-sensitive prostate cancer and the use of docetaxel in high and low-volume prostate cancer.Studies discussed in the episode:LATITUDESTAMPEDEFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject,

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19:14

148. Back to Basics - Metastatic Triple Positive...

Oncology for the Inquisitive Mind ·

2025/03/08

As our breast cancer journey comes close to finishing, it was always the destiny of your cohost's on Oncology for the Inquisitive Mind to talk about HER2-positive breast cancer. This week, we target both antibody-drug conjugate therapy and targeted therapy (trastuzumab deruxtecan and pertuzumab). While HER2-positive cancer's survival is one of the best for metastatic disease, this was not always the case. Studies discussed in the episode:DESTINY 03 CLEOPATRA TrialFor more episodes, resources and

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19:18

147. Back to Basics - Metastatic Triple Negative...

Oncology for the Inquisitive Mind ·

2025/03/01

Metastatic Triple Negative Breast Cancer is one of the most challenging breast cancer subtypes to treat. Recurrence rates can be as high as 40%. This episode covers the role of immunotherapy and antibody-drug conjugates in the advanced space. Once again, targetable receptors are lacking but research is underway!Studies discussed in the episode:KEYNOTE 355ASCENTFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at

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24:43

146. Back to Basics - BRCA mutation and Breast Cancer...

Oncology for the Inquisitive Mind ·

2025/02/22

It's been an "Olympic" ride to get here, and this is our penultimate breast cancer episode! Today, we talk about the BRCA mutations and how they impact both breast cancer and outcomes using targeted therapy. BRCA is a tumour suppressor gene.Today, we explore olaparib and its role in the adjuvant and metastatic setting for breast cancer.Studies discussed in the episode:OLYMPIAOLYMPIADFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If

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202 results

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