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PODCAST

Longevity Roadmap

Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.

health & fitness alternative health

All Episodes

29:14

144: Why the Brain is Especially Vulnerable to Aging

Longevity Roadmap ·

2025/07/14

In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain’s heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier. The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics,

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29:57

143: The Longevity Divident with Prof Jay Olshansky

Longevity Roadmap ·

2025/07/07

In this conversation, Professor S. Jay Olshanskydiscusses the evolution of aging science, the realistic limits of human life expectancy, and the concept of the Longevity Dividend, which emphasizes the health and economic benefits of modulating the aging process. He also explores the potential of biomarkers in predicting longevity, the societal implications of an aging population, and the ethical considerations surrounding advancements in longevity science. Learn more about Professor S. Jay

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29:43

142: The Gut-Muscle Axis with Dr. Michael Lustgarten

Longevity Roadmap ·

2025/06/30

In this episode, Dr. Michael Lustgarten discusses his research on the gut microbiome, serum metabolome, and muscle health in older adults. He shares insights from his journey into the world of aging, the importance of data in health optimization, and the emerging concept of the gut-muscle axis. Dr. Lustgarten emphasizes the significance of metabolites in predicting longevity and the need for personalized health tracking. He also addresses the balance of exercise and the role of fecal microbiota

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29:21

141: A Thermostat for Your Body Fat

Longevity Roadmap ·

2025/06/23

In this conversation, Dr. Stephan J. Guyenet joins Dr. Buck Joffrey to discuss the complex mechanisms of body fat regulation, focusing on the role of the lipostat and leptin. He explains how the body regulates fatness through hormonal signals and the implications of leptin resistance in obesity. The discussion also covers practical strategies for weight management, the impact of stress and sleep on leptin levels, and critiques of the carbohydrate insulin model of obesity. Learn more about Dr

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29:35

140: Inside the Inflammatory Clock - Measuring and...

Longevity Roadmap ·

2025/06/16

Dr. David Furman and Dr. Buck Joffrey discuss the complexities of immune aging, the role of inflammation in age-related diseases, and how artificial intelligence is being utilized to enhance research in this field. He introduces the concept of the inflammatory age clock, which measures biological aging through immune system signals, and explores potential therapeutic interventions, including nutraceuticals and therapeutic plasma exchange. The discussion also touches on the future of aging research,

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22:14

139: Rebuilding the Aging Brain - The Role of Neural...

Longevity Roadmap ·

2025/06/09

In this conversation, Dr. Tara Walker discusses the fascinating topic of adult neurogenesis, the brain's ability to produce new neurons throughout life. She explains how this process is crucial for cognitive function and how it declines with age. The discussion highlights the significant role of exercise in boosting neurogenesis and introduces selenium as a key factor in this process. Dr. Walker also explores the implications of her research for cognitive health, particularly in the context of

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57:08

138: Sleep Impact on Longevity and Health with The...

Longevity Roadmap ·

2025/06/02

Sleep is the secret weapon for a longer, healthier life—and Dr. Michael Breus is here to show you how to use it. In this episode of Longevity Roadmap, Buck Joffrey dives deep into the science of sleep with the world-renowned sleep doctor himself. Discover why sleep is the third pillar of longevity, how REM sleep and deep sleep fuel physical and emotional restoration, and what your chronotype reveals about your ideal sleep patterns. From the effects of sleep deprivation on metabolism and aging to

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42:56

137: Dr. Joan Mannick - Targeting mTOR to Improve...

Longevity Roadmap ·

2025/05/26

What if targeting a single cellular pathway could slow aging and boost immunity? Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role of mTOR in aging, immune response, and antiviral immunity. Learn how selective mTOR inhibition could extend healthspan without compromising muscle mass, improve vaccine response in older adults, and unlock

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42:59

136: Why is Vitamin D So Important in Health and...

Longevity Roadmap ·

2025/05/19

Vitamin D is more than a vitamin—it's a hormone that influences everything from your immune system to cardiovascular health, cognition, and longevity. In this conversation, Dr. Michael Holick breaks down the science of vitamin D synthesis, the truth about sun exposure vs. supplements, and why vitamin D deficiency is far more common—and more dangerous—than most people realize. You'll learn how skin pigmentation, UVB exposure, and supplementation protocols impact your vitamin D levels, and why D3 is

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31:55

135: The Aging Brain - From Memory Lapses to...

Longevity Roadmap ·

2025/05/12

Is your memory decline normal—or something more? Clinical neuropsychologist Dr. Mitchell Clionsky breaks down what healthy aging looks like from a cognitive perspective and where concern might be warranted. He introduces the Memory Orientation Screening Test (MOST)—a powerful yet quick tool to assess cognitive health—and shares insights from decades of evaluating memory, dementia, brain injuries, and CTE. From preventive strategies that could reduce dementia risk by nearly 50%, to how technology is

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44:51

134: Can You Boost Stem Cells Naturally?

Longevity Roadmap ·

2025/05/05

What if your body already had everything it needs to heal itself—naturally? In this episode, neurophysiologist and stem cell researcher Dr. Christian Drapeau breaks down the science of stem cell therapy, explaining how adult stem cells, embryonic stem cells, and exosomes play a central role in regenerative medicine and longevity. Discover how aging affects the body’s ability to mobilize stem cells, how injury signals guide them, and why immune system function is tightly linked to stem cell

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33:23

133: Can We Reverse Immune System Aging? T Cells,...

Longevity Roadmap ·

2025/04/28

Is it possible to rejuvenate the immune system as we age? In this episode, Dr. Alessio Lanna breaks down the science of immune aging, focusing on the critical role of T cells, telomere shortening, and senescence. He explains how T cells lose their effectiveness over time—and shares emerging research on how intercellular telomere transfer and the ESMAC complex may help reverse immune senescence. Learn how pharmacological interventions could unlock new possibilities for health, longevity, and immune

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51:51

132: Dr. Mark Tarnopolsky's Mitochondrial Cocktail...

Longevity Roadmap ·

2025/04/21

Are your mitochondria aging faster than you are? In this episode, Dr. Mark Tarnopolsky breaks down the central role of mitochondria in aging, longevity, and overall metabolic health. Learn how mitochondrial dysfunction drives age-related decline, including neurodegenerative diseases, and what you can do about it. From the paradox of oxidative stress to the risks of overusing antioxidants, this conversation unpacks what actually supports mitochondrial health—including a clinical “mitochondrial

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01:01:39

131: Matt Kaeberlein - Aging, mTOR, Epigenetic...

Longevity Roadmap ·

2025/04/14

What if aging isn’t just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the

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35:12

130: Does the Gut Control the Brain?

Longevity Roadmap ·

2025/04/07

Dr. Michael Gershon—legendary Columbia professor and author of The Second Brain—joins us to explain why your intestines might just be running the show. From guinea pig guts that "blew back" to the real reason stress wrecks your digestion, this episode dives deep into the mysterious world of the enteric nervous system. Prepare for gut science, serotonin surprises, and a Woody Allen–esque dose of humor from the father of neurogastroenterology himself. Learn more about Dr. Michael Gershon:

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41:45

129: Does Too Much Muscle Shorten Your Life?

Longevity Roadmap ·

2025/03/31

Can muscle growth and longevity coexist? Dr. Keith Baar breaks down the science of exercise, diet, and aging—focusing on the mTOR pathway, muscle hypertrophy, and how resistance vs. endurance training impacts long-term health. Learn how personalized health strategies, isometric exercises, and ketogenic diets influence aging and muscle preservation. This episode is packed with actionable insights for anyone serious about optimizing fitness, metabolism, and longevity. Learn more about Dr. Keith Baar:

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40:45

128: C15 - The Most Underrecognized Anti-Aging...

Longevity Roadmap ·

2025/03/24

Could an essential fatty acid discovered in Navy dolphins unlock the secret to healthier aging? In this episode of Longevity Roadmap, Dr. Stephanie Venn-Watson reveals the groundbreaking science behind C15, an essential fatty acid linked to longevity and reduced disease risk. Learn how metabolomics uncovered the connection between higher C15 levels and healthier dolphins—and why this matters for humans. Dr. Venn-Watson explains how C15 deficiency can accelerate aging, increase the risk of fatty

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32:27

127: The Impact of Depression on Longevity and...

Longevity Roadmap ·

2025/03/17

Suicide rates are rising—and the impact on longevity is profound. In this eye-opening episode of Longevity Roadmap, Dr. Peter Franz dives deep into the intersection of mental health, suicide prevention, and lifespan. He explores why nearly 50% of Americans experience depression, how loneliness accelerates suicide risk, and why digital interventions offer new hope. We also unpack the demographics most at risk, the physiology behind depression and suicidal thoughts, and the critical role of reducing

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36:59

126: Fahy Protocol - Regrow the Thymus, Reverse Your Age

Longevity Roadmap ·

2025/03/10

Can we reverse aging by regenerating the thymus? In this groundbreaking conversation, Dr. Greg Fahy shares his pioneering research on the thymus gland’s role in immune function, longevity, and epigenetic age reversal. We dive deep into the TRIM study, which demonstrated for the first time that thymus regeneration in humans is possible—and may even turn back the clock on biological aging. Dr. Fahy also explores how growth hormone plays a role in reversing age-related thymic decline, the controversies

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28:40

125: Reversing Skin Age - Tackling Senescence with OS-01

Longevity Roadmap ·

2025/03/03

Visit oneskin.co/BUCK and use code BUCK at checkout for 15% off your first purchase! Dr. Carolina Reis Olivera shares her journey in aging and longevity research, highlighting the development of the OS-01 peptide—a breakthrough targeting cellular senescence to improve skin health. She delves into the biology of skin aging, the impact of senescent cells, and the cutting-edge strategies OneSkin is using to combat age-related skin conditions. The conversation also explores clinical trials, product

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166 results

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