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PODCAST

Freely Filtered, a NephJC Podcast

Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.

health & fitness medicine

All Episodes

01:28:08

Freely Filtered 68: Inpatient hypertension

Freely Filtered, a NephJC Podcast ·

2024/03/16

The Filtrate:Joel TopfSwapnil HiremathJordy CohenAC GomezWith Special Guest:Tim Anderson @TimAndersonMDEditor:Priya Yenebere Show NotesClinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older Adults NephJC Summary | PubMed | JAMA Internal MedicineThe Jordy AC collab: An Interactive Ambulatory Nephrology Curriculum for Internal Medicine Interns: Design, Implementation, and Participant Feedback (PubMed)Clinical Outcomes After Intensifying Antihypertensive Medication

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00:47:44

Freely Filtered 67: NephMadness and Animal House

Freely Filtered, a NephJC Podcast ·

2024/03/07

Animal House RegionNephMadness description by Tiffany TruongEditorial by Kelly Hyndman @DrKeeksPhD They May Look Cute, But Are All Animals Sweet?The Filtrate:Joel TopfSwapnil HiremathSophia AmbrusoJosh WaitzmanWith Special Guest:Kelly HyndmanEditor:Sophia AmbrusoShow NotesAnimal House 2018 with Mark Zeidel, MD (AJKDblog)Animal House 2021 with Kelly Hyndman (AJKDBlog)Animal House 2022 with Kelly Hyndman (AJKDBlog)Mount Desert Island Summer Junket (Website)First person account go a Gila Monster bite

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01:15:09

Freely Filtered 66: NephJC Summer Book Club

Freely Filtered, a NephJC Podcast ·

2024/02/28

How Medicine Works, and When It Doesn’tAmazonThe Filtrate:Joel TopfJosh WaitzmanJennie LinWith Special Guest:Jade TeakellPerry WilsonEditor:Joel TopfShow NotesUnderstanding Medical Research: Your Facebook Friend is Wrong. CourseraIllusory truth effect (Wikipedia)Number needed to treat (Wikipedia)NNT at MedPage Today: NNT on NephJC Deaths of Despair:Suicide (CDC 2001-2021)Drug Overdose (CDC 2001-2021)Steve Jobs delayed therapy for his treatable pancreatic cancer (ABC News)Residents are unionizing at

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01:10:36

Freely Filtered 065: BEST Fluids

Freely Filtered, a NephJC Podcast ·

2024/02/10

The Filtrate:Joel TopfNayan AuroraSophia AmbrusoWith Special Guest:Michael CollinsEditor:Nayan AuroraShow Notes:Twitter is now X (NYT)Michael Collins (the astronaut, not the real one)PlasmaLyte by BaxterNephJC BEST Fluids summaryEarly Goal Directed Therapy for Sepsis NEJM manuscript which changed practice patterns and welcomed in an era of massive fluid resuscitation.PLUS Trial NEJMSPLIT Trial JAMABaSICS NephJC SummarySALTED and SMART NephJC SummaryAdaptive minimization wikipediaBEST Fluids

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01:32:08

Freely Filtered 064: Freely Filtered with The...

Freely Filtered, a NephJC Podcast ·

2023/11/12

The Filtrate:Joel TopfSwapnil HiremathSophia AmbrusoAC GomezJosh WaitzmanJennie LinNayan AroraThe CurbsidersMatt F. Watto (@DoctorWatto)Paul Nelson Williams, America’s primary care physician (@PaulNWilliamz)With Special Guest:JD Foster (@KidneyVet)Sayed Tabatabai (@TheRealDoctorT) Nephrologist in Austin and the author of These Vital SignsMichelle Rheault (@rheault_m) Chief of Pediatric Nephrology at the University of Minnesota and lead author of the DUPLEX TrialEditor:Joel TopfShow Notes:Lily

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02:05:22

Freely Filtered 063: Late Breaking and High Impact...

Freely Filtered, a NephJC Podcast ·

2023/11/03

The Filtrate:Joel TopfSwapnil HiremathSophia AmbrusoAC GomezWith Special Guest:Amit Garg (@AmitXGarg) Nephrologist at Western University, London, and lead PI of the EnAKT LKD trial.Susan Q. McKenzie (LinkedIn) Co-Founder & Chair, Transplant Ambassador Program. President of the Kidney Patient and Donor Alliance of Canada.Editor:Joel TopfShow Notes:Late Braking and High Impact Clinical Trial press releaseJAMA Internal MedicineMyTEMP trial Personalised cooler dialysate for patients receiving

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01:31:17

Freely Filtered 062: Inaxaplin for APOL1 Kidney Disease

Freely Filtered, a NephJC Podcast ·

2023/09/25

The Filtrate:Joel TopfJennie LinJosh WaitzmanWith Special Guest:AC Gomez MedPeds nephrology fellow at Mass General/Brigham and Boston Children’s | TwitterGentian Hall Assistant Professor of Medicine Duke Department of MedicineEditor:Sophia AmbrusoShow Notes:APOL1 review by the OG Scientists APOL1 Nephropathy: From Genetics to Clinical ApplicationsMYH9 and APOL1 connection: The population genetics of chronic kidney disease: insights from the MYH9–APOL1 locusMartin Pollack LabVertex LabWorldwide

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01:18:11

Freely Filtered 061: Bicarb in Transplant

Freely Filtered, a NephJC Podcast ·

2023/09/24

Bicarbonate did not slow the loss of GFR in this well done Swiss, single-blind study of transplant patients.The Filtrate:Joel TopfNayan AroraSwapnil HiremathPirya YenebereWith Special Guest:Nav Tangri nephrologist and epidemiology at the University of ManitobaEditor:Nayan AroraShow Notes:Arsenal FCThe London study that kicked it all off!de Brito-Ashurst, I., Varagunam, M., Raftery, M. J., & Yaqoob, M. M. (2009). Bicarbonate supplementation slows progression of CKD and improves nutritional

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01:02:29

Freely Filtered 059: Furosemide v Torsemide

Freely Filtered, a NephJC Podcast ·

2023/07/03

The Filtrate:Joel TopfNayan AroraSophia AmbrusoWith Special Guest:Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA. His Google Schoolar page is better than yours. And returning for her fourth time (why do we keep inviting her back?)Sadiya Khan @heartDocSadiya Assistant Professor of Medicine (Cardiology) and Preventative Medicine at Northwestern Feinberg School of Medicine. LinkEditor:Priya YenebereShow Notes:Diuretic Therapy review by. Craig Brater

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01:42:42

Freely Filtered 060: HCTZ v Kidney Stones, The...

Freely Filtered, a NephJC Podcast ·

2023/06/25

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanNayan AroraSophia AmbrusoWith Special Guest:Megan Prochaska Assistant professor of medicine at University of Chicago John Asplin Medical Director Consultant LithoLink (Twitter)Editor:Joel TopfShow Notes:The LithoLink websiteStone Camp tweetPrevention of Repeated Episodes of Kidney Stones in Adults: A Clinical Practice Guideline From the American College of Physicians (link)NOSTONE in the NEJM and NephJCFred Coe Google Scholar | YouTube |

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01:19:57

Freely Filtered 058: HCTZ v Chlorthalidone, The...

Freely Filtered, a NephJC Podcast ·

2023/05/02

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanJordy CohenWith Special Guest:Areef ishani lead author and Chief of Medicine VA MinneapolisEditor:Nayan AroraShow Notes:MRFIT switches diuretics and finds better outcomes. Swapnil shows how many studies he is familiar with by spewing out a string of them.Chlorthalidone wins: ALLHAT, MRFIT, SPRINT, HYVET, CLICK (not mentioned by Swap but by Jordy later)HCTZ loses: HOPE3, ACCOMPLISHDiuretic half-lifes NEJM reviewEdarbyclor: Azilsartan and

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01:21:41

Freely Filtered 057: NephMadness 2023 TMA

Freely Filtered, a NephJC Podcast ·

2023/03/11

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanSophia AmbrusoWith Special Guest:Anna Vinakova Associate Professor of Medicine at Virginia Commonwealth University. NephMadness Executive. Vanuja Java is a transplant nephrologist at Washington University in St. Louis, MO. Her research involves functional characterization of genetic variants in complement-mediated diseases. She co-chairs the ClinGen complement gene curation expert panel.Editor:Sophia AmbrusoShow Notes:#NephMadness 2023: Thrombotic

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00:01:16

Say "Hi" to the #NephMadness PodCrawl

Freely Filtered, a NephJC Podcast ·

2023/03/01

Welcome to the NephMadness PodCrawlThe idea behind a podcrawl is for a variety of podcasts to coordinate on timing and topic to push a theme and get each other’s listeners to explore all of the podcasts. One of thefirst goals behind NephMadness was to build a community and in the early years of Twitter, NephMadness was central to the formation of #NephTwitter and defining the ethos that makes our online community kind, intelligent, vibrant, and interesting. The NephMadness Podcrawl hopes to inspire

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01:21:21

Freely Filtered 056: MyTEMP

Freely Filtered, a NephJC Podcast ·

2023/02/07

The Filtrate:Joel TopfSwapnil HiremathNayan AroraSophia AmbrusoWith Special Guest:Amit Garg @AmitXGarg, Nephrologist at Western University, London, and lead PI of the MYTEMP trial.Editor:Joel TopfShow Notes:MyTEMP in pubmed: Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trialMyTEMP Summary on NephJCIt’s really cold in OntarioThe NephTrials blog summary on Pragmatic TrialsThe pragmatic TiME trial on longer time on dialysis

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01:18:12

Freely Filtered 055: STOP ACE!

Freely Filtered, a NephJC Podcast ·

2023/01/29

The Filtrate:Joel TopfSwapnil HiremathJordy Cohen With Special Guest:Laurie Tomlinson. @Roxytonin Nephrologist at University Hospitals Sussex and research hero of Jordy. Editor: Priya Yenebere Show Notes:STOP-ACE in pubmed: Renin-Angiotensin System Inhibition in Advanced Chronic Kidney DiseaseSTOP-ACE Summary in NephJC Prior data showing preservation of renal function by stopping ACEi: The impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney

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01:31:28

Freely Filtered 054: EMPA Kidney!

Freely Filtered, a NephJC Podcast ·

2022/12/25

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanSophia AmbrusoPriya Yenebere With Special Guest:Brendon Neuen, Secretariat of the SGLT2 Trialists Consortium and cool guy on Twitter. Editor: Sophia AmbrusoShow Notes:Joel’s Conflict of Interest Statement. Sophia is also conflicted with Astra Zeneca and Brendon with everybody in the SGLT2i space.Joel starts off with a history of SGLT2iEMPA-REG Outcomes. First!CANVAS. OMG this signal is reproducible!CREDENCE (🎧). It works in a dedicated population

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01:04:34

Freely Filtered 053: The Kidney Week Draft

Freely Filtered, a NephJC Podcast ·

2022/12/11

The Filtrate:Joel TopfSwapnil HiremathNayan AroraSophia AmbrusoEditor: Nayan AroraShow Notes:Joel’s Conflict of Interest StatementThe Draft Board EMPA-Kidney is “off the board”Lunch Symposium on Current and Future Approaches to the Diagnostic Assessment and Management of AKI in Patients with Cirrhosis provided by an educational grant from Mallinckrodt PharmaceuticalsThe CONFIRM Trial Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome in NephJCClinical Practice Session

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01:09:56

Freely Filtered 052: Acetazolamide for Acute...

Freely Filtered, a NephJC Podcast ·

2022/11/26

The Filtrate:Joel TopfJordy CohenNayan AroraSophia AmbrusoSpecial Guests:Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA returns for his second episode (SODIUM-HF). His Google Schoolar page is better than yours. David Ellison @dhekidney is professor of medicine at Oregon Health Science University and head of the Oregon Clinical & Translational Institute. Show Notes:Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome (The CARESS

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01:09:45

Freely Filtered 051: Pip Tazo and Vanco: Nephrotoxin...

Freely Filtered, a NephJC Podcast ·

2022/10/17

The Filtrate:Joel TopfSwapnil HiremathNayan AroraPriya YenebereSpecial Guests:Todd Miano, PharmD, PhD @Miano81 Assistant Professor of Epidemiology, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine.Show Notes:Early Pip/Tazo article showing nephrotoxicity. Covered by NephJCLinazolid vs Vanco RCT showing excess AKI with Vanco. Yes Vance is a lot less toxic than it was in the Mississippi mud days but your attending telling you it is no longer nephrotoxic is wrong

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01:29:35

Freely Filtered 050: CLASSIC Trial

Freely Filtered, a NephJC Podcast ·

2022/10/08

The Filtrate:Joel TopfSwapnil HiremathJennie LinSpecial Guests:Priya Yenebere @PriRenalAKI Transplant nephrologist at Indiana University School of Medicine. She is a current NSMC Intern. J Pedro Teixeira @NephCrit_NM ICU Nephrologist at the University of New Mexico.Editor: Priya YenebereShow Notes:Critical Care Nephrology Critical Care Nephrology: Core Curriculum 2020 by Benjamin R Griffin, Kathleen D Liu, and J Pedro Teixeira.Critical Care Rheumatology Dual-Trained Rheumatologists Take

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