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PODCAST

Y Combinator Startup Podcast

We help founders make something people want. The Y Combinator Podcast is where builders talk about building. From the earliest days of an idea to scaling a company that changes the world, YC partners and founders share real stories, lessons, and tactics from the frontlines.

technology

All Episodes

00:42:01

The Future of Software Creation with Replit CEO Amjad...

Y Combinator Startup Podcast ·

2025/09/12

Amjad Masad is the co-founder & CEO of Replit, now valued at $3B after a recent $250M Series C. He's spent nearly a decade making programming accessible to all—and with the rise of AI, that vision is closer than ever.In this talk from AI Startup School on June 17, 2025, Amjad traces the arc of computing from mainframes to personal computers to a future where AI agents can create software on demand. He predicts that the value of traditional software will approach zero, fundamentally reshaping

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00:50:42

The FDE Playbook for AI Startups with Bob McGrew

Y Combinator Startup Podcast ·

2025/09/08

Bob McGrew helped build some of the most influential technologies of the past two decades. Bob was an early engineer at PayPal, an early executive at Palantir, and was recently Chief Research Officer at OpenAI - where he led the development of ChatGPT, GPT-4 and the o1 reasoning model.During his time at Palantir, he was a pioneer of the Forward Deployed Engineer (FDE) model, a strategy that is at the heart of the AI boom today. On this episode of The Lightcone, he explains how FDEs became central to

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00:27:55

Michael Truell: Building Cursor at 23, Taking on...

Y Combinator Startup Podcast ·

2025/09/03

Michael Truell on June 17th, 2025 at AI Startup School in San Francisco.At 25, Michael Truell has already built Cursor into one of the fastest-growing companies in AI coding, hitting $100M ARR in just a year. In this fireside chat with YC General Partner Diana Hu, he shares the lessons that came from years of failed projects with his co-founders, why he believes programming is still essential even as AI changes how we code, and how Cursor is taking on GitHub Copilot with the conviction that all of

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00:12:31

GPT-OSS vs. Qwen vs. Deepseek: Comparing Open Source...

Y Combinator Startup Podcast ·

2025/08/29

OpenAI recently released its first open-weights model since GPT-2, entering a field led by DeepSeek and Alibaba's Qwen.YC's Ankit Gupta breaks down everything you need to know about these top OSS models, including what sets them apart under the hood. He’ll compare their approaches to mixture-of-experts, long-context training, and post-training techniques that shape reasoning and alignment—and explore how different design choices lead to surprisingly similar performance.

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00:45:25

How This 25-Year-Old Built A $675M Legal AI Startup...

Y Combinator Startup Podcast ·

2025/08/26

In this episode of Founder Firesides, YC General Partner Gustaf Alströmer is joined by Max Junestrand, co-founder and CEO of Legora, one of the fastest-growing legal AI startups in the world. In just 13 months, Max and his team scaled from 10 to 100 people, raised $80M, and cracked the challenge of selling to one of the most skeptical industries. Max shares insights on building a successful vertical AI company, selling to conservative markets, and sheds light on what the future of legal tech looks

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00:18:38

The Sales Playbook for Founders | Startup School

Y Combinator Startup Podcast ·

2025/08/15

Navigating B2B sales for the first time can feel slow and overwhelming.Drawing from his experience founding Monzo and GoCardless, YC's Tom Blomfield shares his playbook for running a tight sales process that lands real, recurring revenue. He walks through each step—free and paid pilots, opt-out contracts, long-term deals—and shows how to prove value and close customers.

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00:40:36

Figma CEO Dylan Field: How AI Will Transform Design

Y Combinator Startup Podcast ·

2025/08/08

Dylan Field on June 17th, 2025 at AI Startup School in San Francisco.Dylan Field co-founded Figma to bring the design process online and make it multiplayer. From a meme maker built on WebGL to a design platform powering millions, Figma’s journey hit a major milestone with its IPO last week.In this conversation, Dylan shares the early challenges of building in the browser, the early risks and pivotal choices that shaped Figma’s growth, the principles that guided its product and community, and how he

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00:46:15

The Finance Startup Bringing Agentic AI to Wall Street

Y Combinator Startup Podcast ·

2025/07/31

Brothers Chaz and Arnie Englander started Model ML after building and selling two YC companies. What began as a tool to help them analyze deals has grown into a full AI-powered workspace purpose-built for financial services, empowering firms to create automations and workflows that reflect exactly how their teams operate. And it's already being used by 10% of the world's top investment banks and private equity firms to automate everything from client-ready PowerPoint decks to deep-dive

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00:40:47

Scaling and the Road to Human-Level AI | Anthropic...

Y Combinator Startup Podcast ·

2025/07/29

Jared Kaplan on June 16th, 2025 at AI Startup School in San Francisco.Jared Kaplan started out as a theoretical physicist chasing questions about the universe. Then he helped uncover one of AI’s most surprising truths: that intelligence scales in a predictable, almost physical way.That insight became foundational to the modern era of large language models—and led him to co-found Anthropic.In this talk, he walks through how that discovery reshaped the path to human-level AI, what it means for future

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00:43:41

Building a Brand People Will Care About | Karri...

Y Combinator Startup Podcast ·

2025/07/25

For this episode of Design Review, YC’s Aaron Epstein is joined by Karri Saarinen, co-founder & CEO of Linear, one of the top designer-founders working today. Together, they'll review several sites from the YC community with an eye for how to build and maintain a high-quality brand.Thank you to these companies for volunteering to have their sites reviewed*:Sprites AI (https://www.sprites.ai)GigaML (https://gigaml.com)UnReal Milk (https://www.unrealmilk.com)Confident AI

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00:44:52

Chelsea Finn: Building Robots That Can Do Anything

Y Combinator Startup Podcast ·

2025/07/22

Chelsea Finn on June 17th, 2025 at AI Startup School in San Francisco.From MIT through her PhD at Berkeley, where she pioneered meta‑learning methods, and Google Brain, Chelsea Finn has built her career around teaching machines how to learn. Now an Assistant Professor at Stanford and co‑founder of Physical Intelligence, she’s using that foundation to bring learning-driven robotics into messy, real-world environments rather than confined lab setups.In this talk, Chelsea traces the evolution of her

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00:35:50

Replit CEO Amjad Masad: Coding Agents, Autonomy, and...

Y Combinator Startup Podcast ·

2025/07/17

Amjad Massad started Replit to make programming accessible to anyone, anywhere. What began as a tool for learning to code has grown into a platform pushing the limits of AI-assisted software creation and recently surpassed $100M in ARR.On The Breakdown with Tom and Dave, Amjad shares the journey from his early days in Jordan, working on open-source projects, to leading Replit through major pivots from "teach a billion people to code" to "let anyone build software." He discusses

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00:27:12

John Jumper: AlphaFold and the Future of Science

Y Combinator Startup Podcast ·

2025/07/15

John Jumper on June 16, 2025 at AI Startup School in San Francisco.John Jumper is a physicist-turned-computational biologist who led DeepMind’s AlphaFold team—and earned the 2024 Nobel Prize in Chemistry for solving protein folding, a decades-old scientific challenge. In this talk, he shares how a deep learning breakthrough at CASP14 turned into AlphaFold 1 and then AlphaFold 2, delivering atomic accuracy predictions and revolutionizing biology. He explains the scientific puzzle behind protein

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00:43:12

Aravind Srinivas: The Race to Build the AI Browser of...

Y Combinator Startup Podcast ·

2025/07/11

Aravind Srinivas on June 16, 2025 at AI Startup School in San Francisco.Aravind Srinivas started Perplexity with one goal: to rethink how we search, browse, and interact with information online. In this conversation, he shares the journey from hacking together a natural-language-to-SQL search tool to building a product used by millions around the world.He talks about the big bet on the AI-powered browser, why agents—not just chatbots—are the next step, and how speed, accuracy, and focus help a

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00:43:57

Andrew Ng: Building Faster with AI

Y Combinator Startup Podcast ·

2025/07/10

Andrew Ng on June 16, 2025 at AI Startup School in San Francisco.Andrew Ng has helped shape some of the most influential movements in modern AI—from online education to deep learning to AI entrepreneurship. In this talk, he shares what he’s learning now: why execution speed matters more than ever, how agentic workflows are changing what startups can build, and why concreteness beats vagueness when turning ideas into products. He reflects on the rise of AI coding assistants, the shifting bottlenecks

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00:34:47

François Chollet: The ARC Prize & How We Get to AGI

Y Combinator Startup Podcast ·

2025/07/03

François Chollet on June 16, 2025 at AI Startup School in San Francisco.François Chollet is a leading voice in AI. He's the creator of the Keras library, author of Deep Learning with Python, and the founder of the ARC Prize, a global competition aimed at measuring true general intelligence.He's spent years thinking deeply about what intelligence actually is—and why scaling up today’s AI models isn’t enough to reach it.In this talk, he walks through the limits of pretraining and memorized

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00:44:21

Fei-Fei Li: Spatial Intelligence is the Next Frontier...

Y Combinator Startup Podcast ·

2025/07/01

A fireside with Dr. Fei-Fei Li on June 16, 2025 at AI Startup School in San Francisco.Dr. Fei-Fei Li is often called the godmother of AI—and for good reason. Before the world had AI as we know it, she was helping build the foundation.In this fireside, she recounts the creation of ImageNet, a project that helped ignite the deep learning revolution by providing the data backbone modern computer vision needed. She walks through the early belief in data-driven methods, the shock of seeing convolutional

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00:35:46

Legendary Consumer VC Predicts The Future Of AI Products

Y Combinator Startup Podcast ·

2025/06/27

Kirsten Green, founder of Forerunner Ventures, has backed some of the most iconic consumer brands of the past two decades — from Warby Parker to Chime to Dollar Shave Club. In this conversation with Garry, she shares how great products (not marketing tricks) still win, why AI is unlocking a new kind of emotional relationship between consumers and technology, and what founders can learn from the messy creative stage we're in right now. She also breaks down how shifts in distribution, wellness,

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00:40:29

Satya Nadella: Microsoft's AI Bets, Hyperscaling,...

Y Combinator Startup Podcast ·

2025/06/25

A fireside with Satya Nadella on June 17, 2025 at AI Startup School in San Francisco.Satya Nadella started at Microsoft in 1992 as an engineer. Three decades later, he’s now Chairman & CEO, navigating the company through one of the most profound technological shifts yet: the rise of AI.In this conversation, he shares how Microsoft is thinking about this moment— from the infrastructure needed to train frontier models, to the social permission required to use that compute. He draws parallels to

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00:42:44

Sam Altman: The Future of OpenAI, ChatGPT's Origins,...

Y Combinator Startup Podcast ·

2025/06/21

A fireside with Sam Altman at AI Startup School in San Francisco.Sam Altman grew up obsessed with technology, broke into the Stanford mainframe as a kid, and dropped out to start his first company before turning 20.In this conversation, he traces the path from early startup struggles to building OpenAI—sharing what he’s learned about ambition, the weight of responsibility, and how to keep building when the whole world is watching. He opens up about the hardest moments of his career, the limits of

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307 results

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