PODCAST

ClinicalNews.Org

Ralph Turchiano

My Personal Biomedical Research Feed - Ralph Turchiano, CEO Alchepharma

health & fitness alternative health

All Episodes

00:08:09

The Liver & Weight Connection: New Curcumin Research...

ClinicalNews.Org ·

2025/06/22

The Liver & Weight Connection: New Curcumin Research Ep. 1246 JUN 2025SummaryA 12-month, double-blind, placebo-controlled trial has revealed that daily supplementation with 1500 mg of curcumin offers significant benefits for both liver health and weight management in individuals with Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). The study demonstrated remarkable improvements in liver health markers for the curcumin group compared to the placebo group

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00:08:25

Bergamot for Cholesterol: How It Works & Is It Safe?...

ClinicalNews.Org ·

2025/06/15

This video explores the significant potential of bergamot, particularly its Bergamot Polyphenolic Fraction (BPF), in managing cholesterol levels, based on a review in Nutrients. Bergamot primarily lowers cholesterol by inhibiting HMG-CoA reductase, the same enzyme targeted by statins, with compounds like brutieridin and melitidin playing a key role ; in vitro studies have shown up to a 30-40% reduction in cholesterol synthesis in liver cells. Clinical trials demonstrate notable LDL-C reductions, for

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00:05:00

Vitamin D Slows Biological Aging? New 4-Year Study on...

ClinicalNews.Org ·

2025/06/08

Vitamin D Slows Biological Aging? New 4-Year Study on Telomeres! Ep. 1244 JUN 2025A recent sub-study of the large-scale VITamin D and OmegA-3 TriaL (VITAL), published in The American Journal of Clinical Nutrition, has revealed significant findings regarding vitamin D and cellular aging. Researchers analyzed leukocyte telomere length (LTL) in 1,054 participants over four years. The results showed that daily supplementation with 2,000 IU of vitamin D3 significantly reduced telomere shortening compared

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00:08:54

Beetroot Juice: Maximize Strength & Speed Up...

ClinicalNews.Org ·

2025/06/01

A recent randomized, double-blind, crossover trial published in Nutrients investigated the effects of short-term beetroot juice (BJ) supplementation on resistance-trained males. Eleven healthy men (average age 21.3±1.9 years) consumed either beetroot juice, providing 450 mg of nitrate per day, or a nitrate-free placebo. The study found that BJ supplementation significantly enhanced high-intensity resistance performance. Specifically, participants completed more repetitions at 80% of their

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00:07:39

New Hope for Muscle Loss: Lactoferrin + Creatine Ep....

ClinicalNews.Org ·

2025/05/25

A recent study in mice explored how a combination of two supplements, lactoferrin and creatine, might help with age-related muscle loss, a condition called sarcopenia. Scientists induced sarcopenia in mice, causing their muscle mass and function to decline. For 8 weeks, these mice were given lactoferrin, creatine, or a mixture of both. The results were promising: the group of mice receiving both lactoferrin and creatine showed the most significant improvements. For example, the lean body content in

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00:06:59

Monk Fruit Extract: Zero-Calorie Sweetener,...

ClinicalNews.Org ·

2025/05/11

Monk Fruit Extract: Zero-Calorie Sweetener, Surprising Benefits? Ep. 1241 MAY 2025A recent PRISMA-guided systematic review published in Nutrients synthesized findings from randomized controlled trials (RCTs) to assess the impact of monk fruit extract (MFE) on metabolic health, lipid profiles, inflammation, and regulatory considerations. The review included a number of RCTs (note: while some search results indicated 10, others mentioned 5 included studies; refer to the final published article for the

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00:06:37

Stressed? Ashwagandha May Lower Cortisol (Up to 33%):...

ClinicalNews.Org ·

2025/05/11

Unlock the science behind Ashwagandha and stress! A pivotal 2023 systematic review published in Nutrients meticulously analyzed the current evidence on Withania somnifera's effect on the primary stress hormone, cortisol. By synthesizing data from nine clinical studies involving stressed human subjects, researchers investigated Ashwagandha's potential to modulate the hypothalamic-pituitary-adrenal (HPA) axis. The compelling finding? Supplementation with Ashwagandha for periods ranging from 30

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00:09:07

More Than Mood: Curcumin's Wide-Ranging Health Impact...

ClinicalNews.Org ·

2025/05/04

A 2024 randomized controlled trial published in the journal Nutrients investigated curcumin's effects on obese patients managing both type 2 diabetes and depression. The primary finding was a highly significant improvement in depression scores (measured by PHQ-9) for the group receiving curcumin compared to the placebo group over 12 months.Importantly, the positive benefits extended substantially beyond mood improvement. The study revealed several other markedly positive secondary outcomes in

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00:06:05

Pomegranate Extract Significantly Lowers Blood...

ClinicalNews.Org ·

2025/04/27

A recent 12-week randomised controlled trial involving healthy adults aged 55-70 yielded significant positive findings regarding pomegranate extract's effect on blood pressure. While the study might not have shown significant differences compared to placebo across all initially measured markers, it revealed important reductions within the group taking pomegranate extract daily. Specifically, participants supplementing with pomegranate extract saw a statistically significant average decrease in

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00:07:52

Astragalus: New Anti-Aging Research Ep. 1237 APR 2025

ClinicalNews.Org ·

2025/04/20

This video explores a comprehensive review published in the journal Nutrients focusing on Astragalus membranaceus and its potential role in delaying aging. What's fascinating is the breadth of mechanisms discussed: the review highlights how active phytochemicals in Astragalus root – like specific polysaccharides, flavonoids, and saponins – exert powerful antioxidant, anti-inflammatory, and immune-regulating effects. These properties are linked to protecting cells from damage and dysfunction

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00:07:33

Stop Muscle Loss: New Research on Nutrition Ep/ 1236...

ClinicalNews.Org ·

2025/04/13

This research overview explores nutritional approaches to combat muscle loss, also known as sarcopenia, a common age-related issue. The study emphasizes the critical role of diet in maintaining muscle health and strength. Key nutrients like protein, vitamin D, leucine, creatine, and HMB are discussed regarding their impact on muscle protein synthesis, directly affecting the progression of sarcopenia. The review highlights that personalized dietary strategies, tailored to individual needs, combined

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00:07:43

Magnesium for Migraine Relief: New Study Highlights...

ClinicalNews.Org ·

2025/04/06

A recent review published in Nutrients explored the potential benefits of magnesium supplementation for migraine management. The research analyzed existing studies and found that magnesium may play a significant role in alleviating migraine symptoms. Specifically, the review indicates that magnesium can influence neurological pathways involved in migraine attacks, potentially reducing their frequency and severity. The review points to magnesium's ability to modulate neurotransmitter function and

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00:07:52

Keyfobell Powder: A Natural Growth Hormone...

ClinicalNews.Org ·

2025/03/30

This research explored the potential of Keyfobell Powder (KFB), a novel extract, to mimic the longitudinal bone growth effects of somatropin (human growth hormone) through the upregulation of IGF-1. KFB is composed of a mixture of Astragalus membranaceus water extract, red ginseng (Panax ginseng C.A. Meyer) 30% ethanolic extract, and Cervi Parvum Cornu 50% ethanolic extract, mixed in a ratio of 1:1.1:7.4. The study found that KFB supplementation significantly increased IGF-1 levels, leading to

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00:05:21

4X Thicker Hair? Gynostemma pentaphyllum Clinical...

ClinicalNews.Org ·

2025/03/23

4X Thicker Hair? Gynostemma pentaphyllum Clinical Trial Results Ep. 1233 MAR 2025A recent randomized, double-blind, placebo-controlled clinical trial published in Nutrients (2025) investigated the therapeutic potential of Gynostemma pentaphyllum extract for enhancing hair health. The study involved participants experiencing hair thinning. After 24 weeks, the Gynostemma pentaphyllum group showed a threefold increase in hair elasticity and density and a fourfold increase in hair diameter compared to

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00:05:38

Yacon Syrup: A Healthy Sweetener for Weight Loss? Ep....

ClinicalNews.Org ·

2025/03/16

This systematic review, published in Nutrients in 2025, examined the multifaceted health impacts of Yacon syrup, focusing on its role as a natural sweetener and its potential benefits for weight management and overall well-being. Yacon syrup, derived from the Yacon plant, is valued for its sweet taste and high content of fructooligosaccharides (FOS), which function as prebiotics. This review highlights several potential benefits: Yacon syrup can serve as a lower-calorie alternative to refined

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00:05:55

Slowing Down Aging: The Power of Vitamin D, Omega-3,...

ClinicalNews.Org ·

2025/03/09

This research, a component of the larger DO-HEALTH trial, specifically examined the impact of vitamin D, omega-3 fatty acids, and exercise on DNA methylation clocks, indicators of biological aging, in a subset of approximately 777 older adults. While the broader DO-HEALTH trial included over 2,000 participants, this particular study focused on those with available DNA methylation data. The researchers found that a combined intervention of vitamin D, omega-3, and exercise led to a noticeable slowing

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00:07:22

Breakthrough in Depression Research: Lycopene and...

ClinicalNews.Org ·

2025/03/02

This groundbreaking study has shed light on the potential of lycopene, a powerful antioxidant found in tomatoes, to combat depression-like behavior in mice subjected to chronic social defeat stress, a model for chronic stress. Researchers found that lycopene treatment significantly alleviated these behaviors. The study's key discovery centers around synaptic plasticity, the brain's ability to modify and strengthen connections between neurons, which is often impaired by stress. The research

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00:05:37

Hope for Heart Failure: New Research on Tricaprin Ep....

ClinicalNews.Org ·

2025/02/23

Hope for Heart Failure: New Research on Tricaprin Ep. 1229 FEB 2025This study explored the potential benefits of tricaprin, a natural supplement, for individuals with a specific, less common type of heart failure. This particular form of heart failure makes it difficult for the body to process certain fats. The research suggests that tricaprin may offer a promising approach for improving both survival rates and the overall health of the heart in these patients. The study followed a small group of

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00:05:32

Anti-Graying Effects of Luteolin Ep. 1228 FEB 25

ClinicalNews.Org ·

2025/02/16

A new study published in the journal Antioxidants investigated the effects of luteolin, a natural compound found in plants, on hair graying in mice. The researchers found that both external (topical) and internal (oral) administration of luteolin significantly reduced the number of gray hairs in the mice. The study also revealed that luteolin works by improving the signaling between cells involved in hair pigmentation, ultimately leading to a reduction in hair graying. These findings suggest that

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00:07:29

Brussels Chicory: The New Superfood for Athletes? Ep....

ClinicalNews.Org ·

2025/02/09

This research article investigated the effects of Brussels chicory on exercise performance and recovery in untrained college students. The study found that consuming Brussels chicory juice daily for 7 days increased time to exhaustion during high-intensity exercise by 8.3% in men and 12.2% in women. This improvement in performance was observed despite no significant changes in maximal oxygen consumption (VO2 max). Additionally, Brussels chicory consumption promoted post-exercise recovery, evidenced

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