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PODCAST

No Priors: Artificial Intelligence | Technology | Startups

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world"s leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm

technology entrepreneurship

All Episodes

39:13

O3 and the Next Leap in Reasoning with OpenAI’s Eric...

No Priors: Artificial Intelligence | Technology |... ·

2025/05/01

This week on No Priors, Elad and Sarah sit down with Eric Mitchell and Brandon McKinzie, two of the minds behind OpenAI’s O3 model. They discuss what makes O3 unique, including its focus on reasoning, the role of reinforcement learning, and how tool use enables more powerful interactions. The conversation explores the unification of model capabilities, what the next generation of human-AI interfaces could look like, and how models will continue to advance in the years ahead.Sign up for new

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30:45

Inside Deep Research with Isa Fulford: Building the...

No Priors: Artificial Intelligence | Technology |... ·

2025/04/24

On this episode of No Priors, Sarah sits down with Isa Fulford, one of the masterminds behind deep research. They unpack how the initiative began, the role of human expert data, and what it takes to build agents with real-world capability and even taste. Isa shares the differences between deep research and OpenAI’s o3 model, the challenges around latency, and how she sees agent capabilities evolving. Plus, OpenAI has announced that deep research is free for all US users starting today.Sign up for

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40:53

Predicting the Earth with Josh Goldman: How KoBold...

No Priors: Artificial Intelligence | Technology |... ·

2025/04/17

This week on No Priors, Sarah and Elad are joined by Josh Goldman, cofounder and president of KoBold Metals. KoBold is using AI to transform how we discover critical minerals like lithium and cobalt, making the exploration process faster, more precise, and more scalable than traditional methods. In this episode, Josh explains how KoBold is rethinking the fundamentals of mineral exploration by combining unique datasets, scientific modeling, and predictive algorithms. They dive into the company’s

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41:52

From Job Displacement to AI Trainers, Brendan Foody...

No Priors: Artificial Intelligence | Technology |... ·

2025/04/10

On this episode of No Priors, Sarah and Elad sit down with Brendan Foody, CEO and cofounder of Mercor, to discuss the company’s rapid growth and their vision for the future of the labor market. They dive into how AI is reshaping the workforce in real, tangible ways and what skills are worth investing in today. Brendan shares insights on evaluating talent in an AI-driven world, including how models might identify outlier or 10x candidates and even assess “taste.” The conversation also touches on the

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27:44

Public Markets, Image Gen, and Specialized Models,...

No Priors: Artificial Intelligence | Technology |... ·

2025/04/03

In this episode of No Priors, Sarah and Elad examine the current state of AI. They break down the recent dip in public markets, how tariffs could impact the tech industry, and where opportunities remain in large language models. They highlight the opportunities in more specialized models, new approaches to model development, and how the market is beginning to standardize with integrations like the Model Context Protocol (MCP). The episode ends with a look at early consumer AI applications and what

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38:42

Conversations Are the Source of Truth in Healthcare...

No Priors: Artificial Intelligence | Technology |... ·

2025/03/27

In this episode of No Priors, Elad and Sarah chat with Shiv Rao, MD, founder and CEO of Abridge. They dive into how Abridge is reshaping healthcare by creating AI tools that enhance clinical documentation and improve doctor-patient interactions. Shiv shares his thoughts on building trust with established healthcare systems, giving agency and time back to clinicians, and what makes the healthcare AI opportunity different today. They also discuss Abridge’s approach to developing and launching AI

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35:14

The Robotics Revolution, with Physical Intelligence’s...

No Priors: Artificial Intelligence | Technology |... ·

2025/03/20

This week on No Priors, Elad speaks with Chelsea Finn, cofounder of Physical Intelligence and currently Associate Professor at Stanford, leading the Intelligence through Learning and Interaction Lab. They dive into how robots learn, the challenges of training AI models for the physical world, and the importance of diverse data in reaching generalizable intelligence. Chelsea explains the evolving landscape of open-source vs. closed-source robotics and where AI models are likely to have the biggest

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50:34

Copilot, Agent Mode, and the New World of Dev Tools...

No Priors: Artificial Intelligence | Technology |... ·

2025/03/13

This week on No Priors, Sarah and Elad talk with GitHub CEO Thomas Dohmke about the rise of AI-powered software development and the success of Copilot. They discuss how Copilot is reshaping the developer workflow, GitHub’s new Agent Mode, and competition in the developer tooling market. They also explore how AI-driven coding impacts software pricing, the future of open source vs. proprietary APIs, and what Copilot’s success means for Microsoft. Plus, Thomas shares insights from his journey growing

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36:24

National Security Strategy and AI Evals on the Eve of...

No Priors: Artificial Intelligence | Technology |... ·

2025/03/05

This week on No Priors, Sarah is joined by Dan Hendrycks, director of the Center of AI Safety. Dan serves as an advisor to xAI and Scale AI. He is a longtime AI researcher, publisher of interesting AI evals such as "Humanity's Last Exam," and co-author of a new paper on National Security "Superintelligence Strategy" along with Scale founder-CEO Alex Wang and former Google CEO Eric Schmidt. They explore AI safety, geopolitical implications, the potential weaponization of AI, along with policy

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40:32

Building the Platform for Scientific Breakthrough,...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/27

This week on No Priors, Sarah sits down with Noubar Afeyan, Co-founder and CEO of Flagship Pioneering, the biotech firm behind groundbreaking companies like Moderna. They explore how Flagship creates the conditions for scientific breakthroughs, tackles regulatory uncertainty, and pushes the boundaries of discovery. Noubar shares insights on AI’s role in healthcare, the challenges of bringing new therapies to market, and lessons learned from past pandemics. He also discusses Flagship’s platform

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57:40

Virtual Cell Models, Tahoe-100 and Data for AI-in-Bio...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/25

On this week’s episode of No Priors, Sarah Guo is joined by leading members of the teams at Vevo Therapeutics and the Arc Institute – Nima Alidoust, CEO/Co-Founder at Vevo Therapeutics; Johnny Yu, CSO/Co-Founder at Vevo Therapeutics; Patrick Hsu, CEO/Co-Founder at Arc Institute; Dave Burke, CTO at Arc Institute; and Hani Goodarzi, Core Investigator at Arc Institute. Predicting protein structure (AlphaFold 3, Chai-1, Evo 2) was a big AI/biology breakthrough. The next big leap is modeling entire human

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38:14

Building Hard Tech in Hard Markets: Kyle Vogt on...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/20

Kyle Vogt joins Sarah and Elad on this week’s episode of No Priors. A serial entrepreneur, Kyle co-founded Twitch, transforming live streaming, and later Cruise, the autonomous vehicle company acquired by GM for $1 billion. Now he’s taking on AI-powered home robotics with The Bot Company. In this episode, Kyle shares his journey building transformative tech companies, the challenges of scaling autonomous systems, and why he believes home robots are the next frontier. They also discuss the parallels

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49:35

How Harvey AI is Changing the Legal Industry with...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/14

This week on No Priors, Sarah sits down with Harvey cofounder and CEO Winston Weinberg. Harvey is one of the leading application layer AI companies, building domain-specific AI for law firms, professional service providers, and the Fortune 500. They are already working with companies like Bridgewater, KKR, PWC, and O’Melveny with over $500M in funding from OpenAI, Sequoia, Kleiner, GV and Elad and Sarah. In this episode, Sarah and Winston cover AI product strategy, the future of professional

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22:32

DeepSeek, Deep Research, and 2025 Predictions with...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/07

This week on No Priors, Sarah and Elad celebrate the 100th episode! They dive into the biggest AI stories of 2025, breaking down DeepSeek—truth vs. hype, the rapid consumer adoption, and the real cost of training the models. They debate model commoditization and the value of being a frontier model provider vs. building on existing work. Plus, they unpack OpenAI’s new Deep Research release and the latest on Stargate. Finally, they share bold predictions for 2025, covering robots, autonomous vehicles,

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27:11

Rick Caruso on LA’s Wildfires, Policy Failures, and...

No Priors: Artificial Intelligence | Technology |... ·

2025/01/30

This week on No Priors, Elad sits down with Rick Caruso, LA real estate developer and runner-up in the 2022 mayoral race. With experience serving under three LA mayors, as well as on the police commission and the board of water and power, Rick offers a unique perspective on the systemic failures that contributed to the devastation of the January 2025 wildfires in communities like the Palisades and Altadena. He discusses the steps he took to build more resilient infrastructure in his properties and

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37:59

What Can We Do About Wildfires? With Convective...

No Priors: Artificial Intelligence | Technology |... ·

2025/01/23

This week on No Priors, Sarah and Elad sit down with Bill Clerico, founder of Convective Capital, an early stage venture fund focused on technology-driven solutions for wildfire mitigation and climate resilience. The wildfires in Los Angeles have caused unprecedented property damage and immense hardship for countless individuals and families. This episode is devoted to diving into understanding what happened and what we can do in the future. Bill shares his insights into the increasing severity of

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30:09

How AI Agents Are Transforming Customer Support, with...

No Priors: Artificial Intelligence | Technology |... ·

2025/01/16

Today on No Priors, co-founder and CEO of Decagon, Jesse Zhang, joins Elad to discuss the future of agentic customer support. Decagon provides AI-powered customer interactions for companies like Rippling, Notion, Duolingo, Classpass, Substack, Vanta, Eventbrite, and more. Jesse shares the thesis behind starting Decagon, why he sees customer support as the ideal entry point for agentic technology, and what areas of AI excite him most. They also discuss voice-based interfaces, issues with latency in

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23:36

Erik Bernhardsson on Creating Tools That Make AI Feel...

No Priors: Artificial Intelligence | Technology |... ·

2025/01/09

Today on No Priors, Elad chats with Erik Bernhardsson, founder and CEO of Modal Labs, a platform simplifying ML workflows by providing a serverless infrastructure designed to streamline deployment, scaling, and development for AI engineers. Erik talks about his early work on Spotify’s ML algorithms, what Modal offers today, and his vision for building an end-to-end solution for AI engineers. They dive into GPU trends, cloud vs on-premise setups, and when to train custom models vs use off-the-shelf

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27:07

The Best of 2024 with Sarah Guo and Elad Gil

No Priors: Artificial Intelligence | Technology |... ·

2024/12/26

2024 has been a year of transformative technological progress, marked by conversations that have reshaped our understanding of AI's evolution and what lies ahead. Throughout the year, Sarah and Elad have had the privilege of speaking with some of the brightest minds in the field. As we look back on the past months, we’re excited to share highlights from some of our favorite No Priors podcast episodes. Featured guests include Jensen Huang (Nvidia), Andrej Karpathy (OpenAI, Tesla), Bret Taylor

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31:18

Revolutionizing Customer Success with Agency’s Elias...

No Priors: Artificial Intelligence | Technology |... ·

2024/12/19

Today on No Priors, Sarah sits down with Elias Torres, CEO and founder of Agency, an AI agent for customer success teams. Elias shares his journey from growing up in Nicaragua to founding several companies, leading engineering at HubSpot, and selling Drift for $1B. He also discusses his work consulting with OpenAI in 2022, which deepened his understanding of the business opportunity LLMs presented and inspired him to start Agency. In this episode, Elias offers a unique perspective on the future of

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134 results

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