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PODCAST

No Priors: Artificial Intelligence | Technology | Startups

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world"s leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm

technology entrepreneurship

All Episodes

44:48

A New Operating System for Physicians with...

No Priors: Artificial Intelligence | Technology |... ·

2025/09/05

How does a new technology get adopted by 40% of American doctors in just 18 months? In an era where the golden age of biotechnology has also created a dark age of physician burnout, OpenEvidence found the answer by fundamentally changing how doctors access critical information. OpenEvidence founder Daniel Nadler sits down with Sarah Guo and Elad Gil to discuss how his company solved the semantic search problem in medicine. He talks about the strategy of treating doctors as consumers, striking the

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40:53

Reshaping America’s Economy for the Superintelligence...

No Priors: Artificial Intelligence | Technology |... ·

2025/08/28

AI doomers say that the technology will be the ultimate job-killer. But Jacob Helberg wants people to see AI as a tech that will boost, not replace, human workers and give them superpowers. Under Secretary of State for Economic Growth, Energy, and the Environment Jacob Helberg joins Sarah Guo and Elad Gil to talk about AI’s role in reshoring manufacturing in America, supply chain security, and transforming the US energy grid. He also discusses the CapEx revolution, why he sees opportunity for tech

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42:11

How Agentic AI is Transforming The Startup Landscape...

No Priors: Artificial Intelligence | Technology |... ·

2025/08/21

Andrew Ng has always been at the bleeding edge of fast-evolving AI technologies, founding companies and projects like Google Brain, AI Fund, and DeepLearning.AI. So he knows better than anyone that founders who operate the same way in 2025 as they did in 2022 are doing it wrong. Sarah Guo and Elad Gil sit down with Andrew Ng, the godfather of the AI revolution, to discuss the rise of agentic AI, and how the technology has changed everything from what makes a successful founder to the value of small

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47:17

Chips, Neoclouds, and the Quest for AI Dominance with...

No Priors: Artificial Intelligence | Technology |... ·

2025/08/14

What would it take to challenge Nvidia? SemiAnalysis Founder and CEO Dylan Patel joins Sarah Guo to answer this and other topical questions around the current state of AI infrastructure. Together, they explore why Dylan loves Android products, predictions around OpenAI’s open source model, and what the landscape of neoclouds looks like. They also discuss Dylan’s thoughts on bottlenecks for expanding AI infrastructure and exporting American AI technologies. Plus, we find out what question Dylan would

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44:47

The Shifting Value of Content in the AI Age with...

No Priors: Artificial Intelligence | Technology |... ·

2025/08/07

Cloudflare has spent nearly fifteen years making the Internet faster, more reliable, and more secure. So now that AI systems are changing the way we interact with the Internet, Cloudflare wants to help level the playing field for content creators. Sarah Guo and Elad Gil sit down with Matthew Prince, co-founder and CEO of Cloudflare to discuss the evolution of the internet from search to AI, including Cloudflare’s role in facilitating that shift. Matthew talks about how AI assistants are changing the

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36:47

America’s Plan to Dominate the Full AI Stack with...

No Priors: Artificial Intelligence | Technology |... ·

2025/07/31

Sriram Krishnan was never interested in policy. But after seeing a gap in AI knowledge at senior levels of government, he decided to lend his expertise to the tech-friendly Trump administration. Senior White House Policy Advisor on AI Sriram Krishnan joins Elad Gil and Sarah Guo to talk about America’s AI Action Plan, a recent executive order that outlines how America can win the AI race and maintain its AI supremacy. Sriram discusses why winning the AI race is important and what that looks like, as

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32:58

The Power of Quality Human Data with SurgeAI Founder...

No Priors: Artificial Intelligence | Technology |... ·

2025/07/24

In the generative AI revolution, quality data is a valuable commodity. But not all data is created equally. Sarah Guo and Elad Gil sit down with SurgeAI founder and CEO Edwin Chen to discuss the meaning and importance of quality human data. Edwin talks about why he bootstrapped Surge instead of raising venture funds, the importance of scalable oversight in producing quality data, and the work Surge is doing to standardize human evals. Plus, we get Edwin’s take on what Meta’s investment into Scale AI

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62:54

Asimov: Building An Omniscient RL Oracle with...

No Priors: Artificial Intelligence | Technology |... ·

2025/07/17

Superintelligence, at least in an academic sense, has already been achieved. But Misha Laskin thinks that the next step towards artificial superintelligence, or ASI, should look both more user and problem-focused. ReflectionAI co-founder and CEO Misha Laskin joins Sarah Guo to introduce Asimov, their new code comprehension agent built on reinforcement learning (RL). Misha talks about creating tools and designing AI agents based on customer needs, and how that influences eval development and the

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44:43

Why Platforms Win and Point Solutions Fail with...

No Priors: Artificial Intelligence | Technology |... ·

2025/07/10

As a three-time founder, Parker Conrad has one piece of advice for aspiring entrepreneurs—don’t do it. The Rippling co-founder and CEO joins Sarah Guo to talk about what he learned from the crash at Zenefits, why most advice to founders is wrong, and how building a real platform—not a point solution—is the only way to win in SaaS. The two get into founder psychology, the myth of learning from failure, and what true ownership looks like inside a company. He also shares why AI won’t shrink teams

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49:27

Chai-2: The AI Model Accelerating Drug Discovery with...

No Priors: Artificial Intelligence | Technology |... ·

2025/07/03

AI has already fueled breakthroughs in biotechnology—but now, further advances in AI are poised to fuel pharmaceutical discoveries as well. Sarah Guo sits down with Joshua Meier and Jack Dent, co-founders of Chai Discovery, whose newly launched Chai-2 designs bespoke antibodies that bind to their targets at a jaw-dropping 20% rate. Jack and Joshua talk about the implications for Chai-2’s success rate at discovering antibodies for the pharmaceutical industry, how structure prediction is pivotal in

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42:08

Meet AlphaEvolve: The Autonomous Agent That Discovers...

No Priors: Artificial Intelligence | Technology |... ·

2025/06/26

Much of the scientific process involves searching. But rather than continue to rely on the luck of discovery, Google DeepMind has engineered a more efficient AI agent that mines complex spaces to facilitate scientific breakthroughs. Sarah Guo speaks with Pushmeet Kohli, VP of Science and Strategic Initiatives, and research scientist Matej Balog at Google DeepMind about AlphaEvolve, an autonomous coding agent they developed that finds new algorithms through evolutionary search. Pushmeet and Matej

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45:21

The Operating System for Self Driving Cars (and...

No Priors: Artificial Intelligence | Technology |... ·

2025/06/17

When will fully autonomous vehicles see widespread adoption? According to Applied Intuition, that future is closer than you may think. Applied Intuition’s CEO, Qasar Younis, and CTO, Peter Ludwig, talk with Elad Gil about how now is the best time to both work on self-driving vehicle technology and monetize it. Qasar and Peter discuss the advantages of developing their own OS in-house for their autonomous applications, self-driving technology’s potential to drive re-shoring of vehicle manufacturing

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41:25

Will we have Superintelligence by 2028? With...

No Priors: Artificial Intelligence | Technology |... ·

2025/06/12

What happens when you give AI researchers unlimited compute and tell them to compete for the highest usage rates? Ben Mann, Co-Founder, from Anthropic sits down with Sarah Guo and Elad Gil to explain how Claude 4 went from "reward hacking" to efficiently completing tasks and how they're racing to solve AI safety before deploying computer-controlling agents. Ben talks about economic Turing tests, the future of general versus specialized AI models, Reinforcement Learning From AI Feedback (RLAIF), and

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35:53

Teaching AI to Understand the Physical World, with...

No Priors: Artificial Intelligence | Technology |... ·

2025/06/05

In this episode of No Priors, Sarah and Elad are joined by Dr. Fei-Fei Li, AI pioneer, co-director of Stanford’s Human-Centered AI Institute, and founder of World Labs. Fei-Fei shares why she’s building at the intersection of embodiment and intelligence, and what today’s AI systems are still missing. From the early days of ImageNet to her vision for the next generation of robotics, she unpacks the human and technical motivations behind World Labs. They also discuss the challenges of 3D world

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25:13

AI Consolidation, Biotech Opportunities, and World...

No Priors: Artificial Intelligence | Technology |... ·

2025/05/29

In this episode of No Priors, Sarah and Elad unpack the current state of the AI market - whether it’s consolidating, what’s enabling or blocking key mergers, and where the most promising untapped opportunities lie, particularly in biotech. They also explore the rise of world models and how AI’s novel methods for understanding complex systems may ultimately reshape how humans approach discovery and problem-solving. Show Notes: 0:00 Is the AI market consolidating into clear winners? + the physics

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31:34

AI is Making Enterprise Search Relevant, with Arvind...

No Priors: Artificial Intelligence | Technology |... ·

2025/05/15

Arvind Jain joins Sarah and Elad on this episode of No Priors. Arvind is the founder and CEO of Glean, an AI-powered enterprise search platform. He previously co-founded Rubrik and spent over a decade as an engineering leader at Google. In this episode, Arvind shares how LLMs are transforming enterprise search, why most tools in the space have failed, and the opportunity to build apps powered by internal knowledge. He discusses how much customization is still needed on top of foundation models, what

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32:14

Gaming as the Future of Education with Duolingo CEO...

No Priors: Artificial Intelligence | Technology |... ·

2025/05/08

On this episode of No Priors, Sarah talks to Luis von Ahn, founder and CEO of Duolingo, the world’s most popular education app with over 116 million monthly users and a market cap of approximately $17 billion. Controversially, it has recently committed to being “AI-first.” They discuss why motivation is the biggest challenge in education, how Duolingo harnesses game mechanics and behavioral insights to keep learners engaged, and the company’s efforts to leverage AI to personalize education at scale

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39:13

O3 and the Next Leap in Reasoning with OpenAI’s Eric...

No Priors: Artificial Intelligence | Technology |... ·

2025/05/01

This week on No Priors, Elad and Sarah sit down with Eric Mitchell and Brandon McKinzie, two of the minds behind OpenAI’s O3 model. They discuss what makes O3 unique, including its focus on reasoning, the role of reinforcement learning, and how tool use enables more powerful interactions. The conversation explores the unification of model capabilities, what the next generation of human-AI interfaces could look like, and how models will continue to advance in the years ahead.Sign up for new

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30:45

Inside Deep Research with Isa Fulford: Building the...

No Priors: Artificial Intelligence | Technology |... ·

2025/04/24

On this episode of No Priors, Sarah sits down with Isa Fulford, one of the masterminds behind deep research. They unpack how the initiative began, the role of human expert data, and what it takes to build agents with real-world capability and even taste. Isa shares the differences between deep research and OpenAI’s o3 model, the challenges around latency, and how she sees agent capabilities evolving. Plus, OpenAI has announced that deep research is free for all US users starting today.Sign up for

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40:53

Predicting the Earth with Josh Goldman: How KoBold...

No Priors: Artificial Intelligence | Technology |... ·

2025/04/17

This week on No Priors, Sarah and Elad are joined by Josh Goldman, cofounder and president of KoBold Metals. KoBold is using AI to transform how we discover critical minerals like lithium and cobalt, making the exploration process faster, more precise, and more scalable than traditional methods. In this episode, Josh explains how KoBold is rethinking the fundamentals of mineral exploration by combining unique datasets, scientific modeling, and predictive algorithms. They dive into the company’s

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151 results

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