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PODCAST

The Poison Lab

Clinical Toxicology LLC

Dive into the captivating world of poisons with The Poison Lab! Hosted by Clinical Toxicologist Ryan Feldman (@EMPoisonPharmD), who has over a decade of managing poisoning and drug overdose via poison centers and in the emergency department. Also occasional co-hosted by his robo cohost Toxo! (@LabPoison). This show unpacks the fascinating history, cutting-edge science, and life-saving medical management of toxins from around the globe. From stories of those impacted to expert insights from pioneers

education life sciences

All Episodes

01:41:48

Episode #30: Bromazolam, Etonitazene, and Carfentanil...

The Poison Lab ·

2024/05/01

In this episode Ryan interviews Dr. Alex Krotulski PhD from the Center for Forensic Science Research and Education. Together take a look at trends in novel opioids, benzodiazepines, stimulants, hallucinogens, synthetic cannabinoids, and "hemp products" that are showing up in your patients, drug products, and fatal overdoses. The conversation takes places around the Center for Forensic Science Research and Education quarterly report on Novel Psychoactive Substances found in patients and drug

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01:35:06

Episode #29- Toxiologists vs The internet with Dr....

The Poison Lab ·

2024/02/29

Case report for mystery caseReview paper cited by Dr. ArensCase 1 Some also contain CALCIUM NITRATE and can cause methemoglobinemiaCase 2Case 3

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00:01:44

Episode #29 Mystery Poisoning

The Poison Lab ·

2023/12/22

Do you think you know the cause of these symptoms? Send your guesses to toxtalk1@gmail.com to take part in episode 18

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01:34:00

Episode #28- A very NACCT Holiday- High Yield...

The Poison Lab ·

2023/12/21

In this episode Ryan is joined by a guest panel (Dr. Grant Comstock MD, Dr. Joshua Trebach MD, Dr. Emily Kiernan DO, and Dr Frank Paloucek PharmD, DABAT) to review nine of the most interesting or clinically impactful research abstracts that were presented at the 2023 North American Congress of Clinical Toxicology (NACCT) in Montreal Canada. If you didn't get a chance to read all 363 research abstracts from some of Toxicology's best and brightest this year, tune in for a high yield review as well as

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00:51:31

Episode #26-APAPalooza. A North American Congress of...

The Poison Lab ·

2023/11/19

In this episode, Ryan dives into cutting-edge research on the treatment of acetaminophen (APAP) overdose, featuring interviews with authors of several key abstracts from the North American Congress of Clinical Toxicology (NACCT) in Montreal Canada (Abstracts and posters available in the show notes). We get first looks insights into research evaluating the impact of fomepizole high risk acetaminophen overdose, as well as who gets fomepizole for acetaminophen overdose and dies. Then we evaluate the

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00:50:38

Episode #25-AHA 2023 Management of Poisoning Cardiac...

The Poison Lab ·

2023/10/15

In this episode, Ryan sits down with Dr. Eric Lavonas MD, a seasoned EM resuscitation guideline writer, emergency medicine physician, medical toxicologist, and lead author of the latest update to the American Heart Association's guidelines for the management of cardiac arrest and life-threatening toxicity due to poisoning. They have an in-depth discussion as they explore the key aspects of the 2023 AHA treatment recommendations and the rationale behind each decision point. A great review to discover

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00:15:30

High Yield Highlight- 2023 American Heart Association...

The Poison Lab ·

2023/10/15

In this episode Ryan does a high yield "just the facts" break down of the recently released "2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care". Tune in to learn about the most recent treatment recommendations made by AHA via a panel of toxicology experts. This was released alongside a

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01:37:38

Episode #24- The Poison Lab Does Psilocybin- A Deep...

The Poison Lab ·

2023/09/20

In this enlightening episode, Ryan engages in a deep conversation with Dr. Paul Hutson, PharmD, a renowned researcher in the field of psilocybin and director of the Transdisciplinary Center for Research in Psychoactive Substances at the University of Wisconsin Madison. Dr. Hutson shares his extensive knowledge and insights into the promising role of psilocybin in the treatment of depression and substance use disorder. Throughout the discussion, they delve into the research that supports the use of

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00:02:20

New Podcast Artwork & Tox Trinkets!

The Poison Lab ·

2023/09/04

New Art and New Tox Trinkets. If you want to share your tox joy in the real world, find some trinkets here: https://www.etsy.com/shop/thepoisonlab

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00:53:04

Episode #23- Acetaminophen Poisoning Management: US &...

The Poison Lab ·

2023/08/18

Mini episode- High-yield over view of Management of Acetaminophen Poisoning in the US and Canada Consensus Statement In this Ryan sits down with Dr. Richard Dart MD, PhD. He is the lead author of the recently released "Management of Acetaminophen Poisoning in the US and Canada Consensus Statement" from the American Academy of Clinical Toxicology, American College of Medical Toxicology, Americans Poisons Centers, and the Canadian Association of Poison Centers. Listen to be informed on the most recent

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00:13:11

High Yield Highlight-Consensus Statement on...

The Poison Lab ·

2023/08/18

This episode is a a high yield "just the facts" break down of the recently released "Management of Acetaminophen Poisoning in the US and Canada Consensus Statement" from the American Academy of Clinical Toxicology, American College of Medical Toxicology, Americans Poisons Centers, and the Canadian Association of Poison Centers. Listen to be informed on the most recent treatment recommendations. This was released alongside a full interview with the consensus statement corresponding author Dr. Richard

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01:28:32

Episode #22- Toxicologists vs the Internet (#9) With...

The Poison Lab ·

2023/08/09

Dr. Frank Paloucek, PharmD, DABAT (@itsalltox) joins the show. He was one of the very first emergency medicine pharmacists and one of the original board-certified clinical toxicologists (DABAT). He is now a proudly retired professor emeritus at The Univeristy of Illinois at Chicago. In his tenure there he spent nearly 20 years as the program director for their clinical pharmacy residency, was an integral part of the Toxikon Consortium toxicology fellowship, and coauthored the text book "Poisoning

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01:17:04

Episode# 21- The Undead Patient: The Complexity of...

The Poison Lab ·

2023/06/06

In this episode Ryan explores the concept of brain death and the implications of drug overdoses causing false positive diagnosis of brain death. He is joined by an author of the ACMT Position statement on brain death in overdose (Dr. Andrew Stolbach MD) as well as authors of two case reports (neuro critical care physician Dr. Ranier Reyes and emergency physician Dr. Doug Stranges) involving bupropion where patients had absent brain stem reflexes after overdose but made a full neurologic recovery. We

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01:30:25

Episode #20- Toxicologists vs the Internet (#8) With...

The Poison Lab ·

2023/04/12

Dr. Adam Blumenberg, MD (@ABlumenbergMD) Join's the show. He is an emergency medicine physician, medical toxicologist, and Assistant Professor at Columbia University Medical Center in New York City. He hosts his own toxicology youtube series (www.ToxicHistory.com) and has developed multiple free medical education software programs in toxicology (www.toxicrunner.net) and medical simulation (www.medsimstudio.com). Most impressively, he has produced his own free base lidocaine crystals on a stove top,

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00:07:07

High yield highlight- Managing a Bupropion overdose

The Poison Lab ·

2023/02/26

Ready for a high-octane dose of knowledge? 🔥🧠 Ryan's got you covered with this electrifying mini-episode on managing a bupropion overdose! 💊💥 Beware - there are plenty of pitfalls you'll want to avoid. Check out the full episode and other mini-episodes for even more tips and tricks! 🎧👀Bupropion is the #1 antidepressant cause of major (life threatening) reported to U.S. Poison CentersIt is difficult to manage due toPotential for delayed seizuresUnique cardiogenic shock in overdosePotential

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01:30:40

Episode #19- A Prescription for Heartache (&...

The Poison Lab ·

2023/02/15

What do bath salts, face eating zombies, and antidepressants have in common? In this episode Ryan has a number of guests (Dr Filip, Dr Olives, Dr Reyes) join to discuss a unique heart breaking poisoning that is now the number one cause of major life threatening effects in antidepressant overdose in the United States. Check out the mini episodes for more!This antidepressant is the #1 cause of major (life threatening) effects in overdose reported to U.S. Poison CentersIt is difficult to manage due

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00:13:19

Mini Episode: Bridging the Gap- Bupropion's not your...

The Poison Lab ·

2023/02/15

Rohr 2004- Gap junction blockade can cause a wide QRS Vink 2004 Connexin 43 is the most important protein for connexon formation and cardiac signal transmissionCallier 2012- Bupropion does not block sodium channels, and does exhibit similar effects on the cardiac action potential as known gap junction Burnham 2014 Bupropion has an IC50 for connexin 43 >50 uMol, larger than other drugs such as fluoextine and lamotrigineShaikh Quereshi 2014 Bupropion interferes with connexin43 production and

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00:25:47

Mini Episode: Who Seizes in Bupropion Overdose with...

The Poison Lab ·

2023/02/15

TL;DRYour patient can seize 8-24 hours in, usually they have neurologic symptoms and tachycardia before handTachycardia may be masked by coingestions and symptoms may be very delayedDo not discharge a patient without discussing observation time with a toxicologist or poison centerDo not dismiss tachycardia and anxiety as situational in a bupropion overdoseSpiller 1994- Review of instant release product overdoses Shepherd 2004- Seizures in primarily sustained release productsMost seizures had

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01:27:46

2022 North American Congress of Clinical Toxicology...

The Poison Lab ·

2022/12/29

All published abstracts can be found here AbstractsCategory 1: Amlodipine VasoplegiaAbstract 1: Vasodilation in patients with calcium channel blocker poisoning treated with high dose insulin: a comparison of amlodipine versus non-dihydropyridinesStudy of HDI on propranolol poisoned pigsStudy of Minnesota HDI protocolAbstract 2: Amlodipine anxiety: a 10-year review of amlodipine associated fatalitiesAbstract 3: Extracorporeal membrane oxygenation utilization for vasoplegic shock due to pediatric

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00:01:44

Episode 19 Mystery Case

The Poison Lab ·

2022/12/09

Do you think you know the cause of these symptoms? Send your guesses to toxtalk1@gmail.com to take part in episode 18

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