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PODCAST

Practical Neurology Podcast

The Practical Neurology Podcast is the essential guide for the everyday life of all neurologists. Just like our journal Practical Neurology, this podcast is useful for everyone who sees neurological patients and who wants to keep up-to-date and safe in managing them. In other words, this is a podcast for jobbing neurologists who plough through the tension headaches and funny turns week in and week out. Subscribe to enjoy deep dives into each journal issue with editors Prof. Philip Smith and Dr

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All Episodes

36:15

Diagnosing neuromuscular junction disorders: red...

Practical Neurology Podcast ·

2024/12/11

The often challenging diagnosis of neuromuscular junction (NMJ) disorders can be explained by suspicious red flags for the key differential diagnoses (mimics) and atypical presentations (chameleons). In the latest Editor's Choice paper podcast, PN's podcast editor Dr. Amy Ross Russell interviews Dr Stephen Reddel and Dr Shadi El-Wahsh, both from the Concord Hospital, New South Wales, Australia, and the authors of Neuromuscular junction disorders: mimics and chameleons. Please subscribe to the

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49:24

Upward tingling, racing glaucoma and the toppling...

Practical Neurology Podcast ·

2024/11/18

Neuromuscular junction disorders can present in a variety of challenging ways, with the potential to mislead neurologists. Journal editors Prof. Philip Smith and Dr. Geraint Fuller begin with this subject as they talk through the latest issue Practical Neurology, for December 2024. The conversation moves to neck flexion and brain zaps, reflects on the undiminished importance of "general" neurology, and also touches on maternal epilepsy risks, frailty's impact on stroke patients, timely recognition

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36:20

Postpartum paraesthesia, and myasthenia with melanoma...

Practical Neurology Podcast ·

2024/10/31

The immune system is a recurring feature in the cases discussed in this edition of the Case Reports podcast. The first paper details the cases of two young women, sisters, presenting with overlapping conditions but resulting in tragically different outcomes (1:16). Both were in their twenties, had given birth recently, and developed limb weakness along with several other neurological symptoms. https://pn.bmj.com/content/24/5/422Our second case is a 72-yo woman with a range of symptoms including

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36:59

Neurotoxicology's top offenders

Practical Neurology Podcast ·

2024/10/10

"Could this presenting syndrome be caused by a neurotoxin?"Oftentimes neurologists will pass over toxins when diagnosing. Yet disease caused by neurotoxins is widespread, with many having quite typical syndromes. In the studio to discuss this is the first author of the October 2024 Editors' Choice paper, Dr. Frederick Vonberg¹. He draws attention to some hobbies and occupations to watch out for, the global prevalence of lead poisoning, presentations of botulism, and the origin of the infamous Mad

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46:11

Oligoclonal bands, methotrexate use, and inconclusive...

Practical Neurology Podcast ·

2024/09/13

The surgical sieve and Occam's razor may sound like familiar diagnostic metaphors, but what about Crabtree's bludgeon? These are just a few of the tools touched on by journal editors editors Prof. Philip Smith and Dr. Geraint Fuller, as they discuss the October 2024 issue of Practical Neurology. They cover recent publications on oligoclonal bands, neurotoxicology, methotrexate, carotid artery disease, epilepsy surgery, and how unsolved cases remain part of the "art of neurology". To finish, there is

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33:29

Midnight tetraparesis, and morning dysarthria - Case...

Practical Neurology Podcast ·

2024/09/04

This month's cases both feature sudden onset neurological syndromes. The first case (1:23) is that of a 26-yo Brazilian man who awoke from sleep with weakness in all four limbs. The signs suggest a possibility of Guillain-Barré syndrome or polio. A normal cranial nerve examination follows, with no unusual findings - https://pn.bmj.com/content/24/4/342 A 69-yo woman is the subject of the second case (14:33), after she presents with sudden onset unsteadiness and slurred speech when getting out of

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37:56

Lessons and pitfalls of whole genome sequencing

Practical Neurology Podcast ·

2024/08/19

Genetic testing is a useful tool for any practising neurologist, but they must know how to interpret the results. This Editors' Choice podcast features two experts on the subject, Prof. Mary Reilly¹ and Dr. Christopher Record¹. They're in the studio to talk through their paper, covering the technology of genome sequencing itself, testing strategies, clinical use cases, and the constant changes in this developing field.Read the paper: Lessons and pitfalls of whole genome sequencing 1. Centre for

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42:07

Charcot-Marie-Tooth, steroid safety, and dusting off...

Practical Neurology Podcast ·

2024/07/24

Journal editors Prof. Philip Smith and Dr. Geraint Fuller discuss the August 2024 issue of Practical Neurology, with room for mystery, history and practical advice. In particular, they cover topics like whole genome sequencing, foot surgery for Charcot-Marie-Tooth disease, safe prescribing in steroids, and fertility treatment for the epileptic. There are also good reasons for dusting off the old optokinetic nystagmus drum, and a touching story of neuro palliative care.Read the Highlights -

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41:25

Vacant spells, and bodybuilding hazards - Case Reports

Practical Neurology Podcast ·

2024/07/15

Two highly unusual cases in this edition of Case Reports. The first case describes a 64-yo woman presenting to the emergency department with a five day history of bizarre behaviours (1:45). A BBC radio show prompts her, out of character, to reflect aloud about her childhood, and she experiences recurrent periods of unresponsiveness followed by intense agitation. She was kept in hospital for scans and discharged after two weeks, but returned soon after with a similar presentation - (link)A lifetime

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39:31

Why are brain banks so important, and what can they...

Practical Neurology Podcast ·

2024/06/27

Neurodegenerative disease is the subject of this month's Editors' Choice podcast, with Dr. Patrick Cullinane¹ and Dr. Zane Jaunmuktane.¹ They join the podcast for an overview of brain examination, explaining the process of protein misfolding, the spread of pathology through the brain, and what new discoveries can tell us about old diseases.Read the paper: Pathology of neurodegenerative disease for the general neurologist 1. Queen Square Brain Bank for Neurological Disorders, UCL Queen Square

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42:29

Valproate restriction, sexual dysfunction, and...

Practical Neurology Podcast ·

2024/05/30

Journal editors Prof. Philip Smith and Dr. Geraint Fuller discuss the June 2024 issue of Practical Neurology, covering some of the interesting articles published this month. A number of difficult challenges and tradeoffs are featured, relating to recent men-only guidance for sodium valproate use, folic acid dosing for women with epilepsy, post-mortem brain donation, and sexual dysfunction caused by neurological medication. There is also some insight into the treatment of hepatic encephalopathy

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34:21

Ptosis with paroxysmal cough, and "just another...

Practical Neurology Podcast ·

2024/05/14

The first of this episode's two case reports features a 62-yo man, referred from ophthalmology with a drooping eyelid, chronic coughing, and excess sweating in the face provoked by eating (1:21). An MR scan finds abnormal deposits in his brain - (link)The second report describes two patients (17:05), firstly a 70-yo man presenting with abnormal facial movements and weight loss, and secondly a 90-yo woman with abnormal movements of her right arm and leg. Routine blood tests at presentation for both

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41:46

A new guideline for spontaneous intracranial hypotension

Practical Neurology Podcast ·

2024/04/23

The first multidisciplinary consensus guideline for the diagnosis and treatment of spontaneous intracranial hypotension (SIH) has recently been published by the UK SIH Specialist Interest Group. Group members Prof. Manjit Matharu (1), Dr. Indran Davagnanam (2), and Mr. Parag Sayal (3) join Dr. Amy Ross-Russell to explain their recommendations. They discuss the impact this condition has on patients, the possible presentations, and approaches for diagnosis and treatment.Read the article:

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47:57

An underappreciated vitamin, eponymous syndromes, and...

Practical Neurology Podcast ·

2024/03/20

Journal editors Prof. Philip Smith and Dr. Geraint Fuller discuss the April 2024 issue of Practical Neurology, covering some of the interesting articles published this month. Topics include inconsistencies observed in functional gait, the consequences of restrictive diets with reduced riboflavin, and a guideline to managing patients with spontaneous intracranial hypotension. In syndromic sightings there's a scattering of Ehlers-Danlos, Strachan and Alzheimer's to name but a few. Plus, some

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44:51

Tonic-clonic seizures, and persistent abdominal pain...

Practical Neurology Podcast ·

2024/03/06

The first case for this issue's discussion is one of a young man with a history of involuntary jerks and photosensitivity (1:20). Several more seizures followed his initial presentation with a general tonic-clonic seizure. A number of examinations were done including an MR scan and EEG - (link)Case two involves a 69-yo woman who developed non-convulsive status epilepticus, having been examined as a gastroenterology inpatient for abdominal pain (22:20). A positive PCR for Whipple’s disease in stools

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42:45

Making the most of electroencephalography, with Dr....

Practical Neurology Podcast ·

2024/02/16

Neurophysiologists may "lock ourselves away in rooms looking at screens with wiggly lines on", but what are the applications in a clinical context for electroencephalography (EEG)?In this deep-dive episode, podcast editor Dr. Amy Ross Russell is joined by Dr. Nick Kane (1), an author of the Editors' Choice for the Feb 2024 issue, "Electroencephalography in encephalopathy and encephalitis". They discuss the strategy of serial EEGs in epilepsy diagnosis, neuroinflammation in both autoimmune and

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41:55

Gait analysis, CBT, and neurology book clubs -...

Practical Neurology Podcast ·

2024/01/23

Journal editors Prof. Philip Smith and Dr. Geraint Fuller discuss the February 2024 issue of Practical Neurology, covering some of the interesting articles published this month. The papers discussed touch on the use of electroencephalography (EEG) for encephalopathies, neurologists' role in the integration of cognitive behavioural therapy (CBT) in treatment, key signs to look for in walking patients, and how rising temperatures due to climate change may affect our brains. The final topic of

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40:11

Periocular pain, and sciatic nerve thickening - Case...

Practical Neurology Podcast ·

2024/01/12

In the first case this episode, a 69-yo woman has developed severe pain around her right eye with blurring to the vision on that side (1:08), which prompts use of a "rediscovered" treatment technique by the ophthalmology department - (https://pn.bmj.com/content/23/6/527). The second case (15:23) is that of a 45-yo man with progressive pain in his lower limbs, hyperaesthesia and then weakness, who was initially diagnosed with meralgia paraesthetica by tele-medicine examination -

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26:03

Artificial intelligence for neurologists, with Prof....

Practical Neurology Podcast ·

2023/12/29

With artificial intelligence (AI) being declared the solution to many of the challenges faced in our personal and professional lives, Prof. James Teo (1) joins the podcast to set us straight on where AI tools fit into neurological practice. This discussion follows the publication of the December 2023 Editors' Choice paper, "Artificial intelligence (AI) for neurologists: do digital neurones dream of electric sheep?" (https://pn.bmj.com/content/23/6/476) (1) Institute of Psychiatry, Psychology &

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24:00

Climate change and the brain, with Prof. Sanjay Sisodiya

Practical Neurology Podcast ·

2023/12/01

In this extra episode of the PN podcast, recorded to coincide with the COP28 summit, podcast editor Dr. Amy Ross-Russell (1) speaks to Prof. Sanjay Sisodiya (2) about his paper, "The hot brain: Practical climate change advice for neurologists". They discuss the role that neurologists have to play in treating and guiding patients as they find themselves exposed to shifts in their habitual climate. Read the paper: https://pn.bmj.com/content/early/2023/11/10/pn-2023-003777 (1) Neurology, University

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