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PODCAST

Touching Base

Genetic Engineering & Biotechnology News (GEN)

Touching Base is the dynamic podcast series from the editors of GEN (Genetic Engineering & Biotechnology News). Each episode features a rotating cast of senior editors including John Sterling, Kevin Davies, Julianna LeMieux, Alex Philippidis, Uduak Thomas, Corinna Singleman and Fay Lin who delve into emerging stories, exchange ideas, and debate the latest trends in biotech. Additionally, they talk to some of the leading voices in the industry about what"s now and next. Hosted on Acast. See

science life sciences

All Episodes

32:32

Genetic Engineering at Asilomar, Stand Up for...

Touching Base ·

2025/03/14

GEN editors discuss both the news and history of DNA and genetic engineering. We present a recap of the 50th anniversary Asilomar conference, delving into some of the history from the 1975 Asilomar conference and relating to the current discussions around genetic engineering. Science has been under fire recently and many people attended the Stand Up for Science Rally at one of a few dozen locations across the United States. One of the speakers at the rally in Washington, DC, was former NIH director

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25:42

AI Models Writing DNA and Designing Enzymes, Some...

Touching Base ·

2025/02/28

In honor of Rare Disease Day, we discuss news from Healx, a clinical-stage biotech, which has dosed the first patient in a Phase II trial of its new drug for neurofibromatosis type 1. In the world of AI, the Arc Institute in collaboration with Nvidia has dropped Evo 2, the “largest publicly accessible AI model for biology to date,” for designing genomes. Additionally, new work from Nobel Laureate, David Baker, uses AI to generate enzymes from scratch. We also dig into the big announcements from

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19:20

Recursion Clinical Trial, CRISPR Delivery methods,...

Touching Base ·

2025/02/14

Season 2 Episode 1 (February 14, 2025): This week, the GEN editors discussed some interesting and developing stories around AI, including an in depth dialogue about what Recursion has been doing lately. They also discussed gene editing updates in delivery systems, Cas12 preclinical work, and AgBio. The discussion was rounded out with a look forward into takeover targets for 2025.Featuring Alex Philippidis (Senior Business Editor, GEN), Fay Lin, PhD, (Editor, GEN Biotechnology), Uduak Thomas (Senior

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47:08

DNA Day: Deep Dive

Touching Base ·

2024/04/26

Episode 19 (April 26, 2024): This week, the GEN editors celebrated DNA Day by sharing some stories about their favorite observations and applications of DNA research.Featuring Kevin Davies, PhD (Editorial Director, GEN), John Sterling (Editor in Chief, GEN), Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Fay Lin, PhD (Senior Editor, GEN Biotechnology), Jonathan Grinstein, PhD (Senior Editor, GEN), and moderated by Corinna Singleman, PhD (Managing Editor, GEN and

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22:10

How Biotechs Are Plugging AI into Drug Discovery...

Touching Base ·

2024/04/19

Episode 18 (April 19, 2024):Biology’s exploding data streams continue to leverage artificial intelligence (AI) tools to streamline drug development. How do we define AI in drug discovery? Who are notable players in the space? How do humans fit into these growing computational pipelines?This week, Jonathan Grinstein, PhD (Senior Editor, GEN) and Fay Lin, PhD (Senior Editor, GEN Biotechnology) unpack one of the fastest growing topics in the biotech field, AI in drug discovery.Listed below are key

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34:15

Launch of Nvelop Therapeutics for Delivery of Genetic...

Touching Base ·

2024/04/12

Episode 17 (April 12, 2024): This week, the GEN editors discuss the launch of Nvelop Therapeutics,a new start-up leveraging approaches developed by gene editing pioneers David Liu, PhD, and J. Keith Joung, MD, PhD, to advance delivery of genetic cargo. The GEN editors also recaphighlights from the American Association for Cancer Research (AACR) annual meeting held in San Diego, California.Featuring Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Julianna LeMieux,

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31:54

Dried Blood COVID Dx, Cryo-Shocked Tumor Cell...

Touching Base ·

2024/04/05

Episode 16 (April 5, 2024): This week, the GEN editors discussed deep proteome profiling of home-sampled dried blood spots to assess the effects of SARS-CoV-2 in mildly symptomatic or asymptomatic, rapid liquid nitrogen treatment for converting tumor cells into carriers for gene editing tools that target cancer in vivo, Verve Therapeutics’ pausing of a clinical trial due to a serious adverse event, Iambic Therapeutics’ advancement of its first AI-designed candidate into the clinic, and the launch of

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36:28

AI in Drug Discovery and Precision Medicine: Nvidia...

Touching Base ·

2024/03/29

Episode 15 (March 29, 2024): From the expansion ofNvidia's generative artificial intelligence (AI) platform for drug discovery to AI notetakers that coach doctors to be more human, the GEN editors discuss the latest news in AI from two conferences in California: Nvidia GTC (San Jose) and Precision Med TRI-CON (San Diego).Featuring Alex Philippidis (Senior Business Editor, GEN), Fay Lin, PhD (Senior Editor, GEN Biotechnology), Jonathan D. Grinstein, PhD (Senior Editor, GEN), moderated by Corinna

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19:20

Optimizing Nanoparticles and Messenger RNAs with...

Touching Base ·

2024/03/22

Episode 14 (March 22, 2024):This week, the GEN editors cover identifying receptors and proteins for cellular uptake and intracellular processing of nanoparticles, and a new mRNA structure by adding multiple “tails” to the molecules that boosted mRNA activity levels in cells by 5 to 20 times.Featuring Jonathan D. Grinstein, PhD, (Senior Editor, GEN), Uduak Thomas (Senior Editor, GEN), and moderated by Fay Lin, PhD, (Senior Editor, GEN Biotechnology)Listed below are key references to the GEN stories,

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24:51

NanoString Finds a Buyer, Slide Tags Enter in Early...

Touching Base ·

2024/03/15

Episode 13 (March 15, 2024): This week, the GEN editors discussed business news from NanoString, Curio, and Cellares.Featuring Alex Philippidis (Senior Business Editor, GEN), Uduak Thomas (Senior Editor, GEN), Jonathan Grinstein, PhD, (Senior Editor, GEN), and moderated by Corinna Singleman, PhD, (Managing Editor, GEN and IPM).Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:The State of Omics 2024 Registration

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23:59

International Women’s Day, Nanoparticles and...

Touching Base ·

2024/03/08

Episode 12 (March 8, 2024): Featuring Julianna LeMieux (Deputy Editor-in-Chief, GEN), Uduak Thomas (Senior Editor, GEN), and Alex Philippidis (Senior Business Editor, GEN), moderated by Fay Lin (Senior Editor, GEN Biotechnology)This week, the GEN editors cover a recent interview with the Lost Women of Science, advances in delivery with lipid nanoparticles, Novo Nordisk’s expansion in the Boston area, and how organoids derived from amniotic fluid show promise for understanding fetal diseases.Listed

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26:01

Moderna Gets Back to Its Roots, Form Bio and Ginkgo...

Touching Base ·

2024/03/01

Episode 11 (March 1, 2024): After being diverted by the SARS-CoV-2 pandemic to develop and manufacture COVID-19 vaccines, Moderna gets back to advancing rare disease mRNA therapeutics; a look at rare autoimmune diseases that fly below the public radar; Form Bio announced a partnership with Ginkgo Bioworks to bring their AI out of the computer and into gene therapy production by optimizing genetic payloads.Listed below are key references to the GEN stories, media, and other items discussed in this

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43:06

Prime Editing for Isogenic iPSCs, PRINT, Universal In...

Touching Base ·

2024/02/23

Episode 10 (February 23, 2024): Researchers from Francis Collins’ lab developed an efficient CRISPR prime editing protocol to generate isogenic-induced pluripotent stem cell (iPSC) lines carrying heterozygous or homozygous alleles for putatively causal single nucleotide variants. An RNA-based system known as PRINT can create and introduce site-specific, safe, and stable transgenes into the human genome. Astellas Pharma and Kelonia announced a nearly $800 million research collaboration and license

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43:37

CRISPRed Pigs, Exscientia Fires CEO, & AGBT Roundup;...

Touching Base ·

2024/02/16

Episode 9 (February 16, 2024): Using CRISPR-Cas9 technology, British animal genetics firm Genus has generated a population of pigs that are resistant to the deadly porcine reproductive and respiratory syndrome (PRRS) virus. Exscientia has fired its founder, CEO, and principal executive officer Andrew Hopkins, PhD, and removed him from the company’s board, after it concluded that he engaged in “inappropriate” relationships with two employees. Julianna LeMieux, PhD, Deputy Editor in Chief at GEN,

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44:39

Intellia and Ultragenyx’s Clinical Updates, Novo...

Touching Base ·

2024/02/09

Episode 8 (February 9th, 2024): Intellia and Ultragenyx gave updates on their clinical trials for gene therapies for inherited rare diseases. Novo Holdings, which manages the assets of the foundation that controls Novo Nordisk, agreed to buy Catalent for $16.5 billion to keep up with the high demand for its hit drugs Wegovy and Ozempic. Spatial biology tools developer NanoString Technologies filed for bankruptcy, blaming the $31 million jury award assessed against it last November in a patent

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48:47

Genome Interpretation, Nanoparticles, Gene Therapy,...

Touching Base ·

2024/02/02

Episode 7 (February 2, 2024): Simplify Genomics launches genome interpretation platform, COUR’s nanoparticles for autoimmunity, gene replacement therapy for heart condition, CG Oncology and ArriVent IPOs; an interview with Nautilus Biotechnology co-founders, Sujal Patel and Parag Mallick.Listed below are key references to the GEN stories, media and other items discussed in this episode of Touching Base:Human Longevity Spin-Out Aims to Tap into Variant Interpretation MarketBy Uduak Thomas, GEN,

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44:55

Restoring Hearing Loss, CAR T Manufacturing,...

Touching Base ·

2024/01/26

Episode 6 (January 26, 2024):11-year-old regains hearing after gene therapy; Kyverna uses blood draw instead of apheresis for CAR T manufacturing; DNA production technology with GSK and Elegen, StockWatch with Nvidia and Recursion; an interview with renowned cardiologist, Eric Topol, MDListed below are key references to the GEN stories, media and other items discussed in this episode of Touching Base:Gene Therapy Restores Hearing in 11-Year-Old After Just One MonthGEN, January 24th, 2024GSK and

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37:45

Alzheimer’s Disease, Monkey Cloning, Cytokinetics...

Touching Base ·

2024/01/18

Episode 5 (January 19, 2024); RNAs to address Alzheimer’s disease; monkey cloned via somatic cell nuclear transfer; Cytokinetics stock roller coaster; an interview with founder and CEO of 1910 Genetics, Jen Nwankwo, PhD.Listed below are key references to the GEN stories, media and other items discussed in this episode of Touching Base:·Alzheimer’s Disease Linked to Toxic Short RNAsGEN, January 18, 2024.·Rhesus Monkey Cloned via Somatic Cell Nuclear TransferGEN, January 16, 2024.·StockWatch: M&A

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43:49

J.P. Morgan 2024: Illumina, 10x, Danaher, AI;...

Touching Base ·

2024/01/11

Episode 4 (January 12, 2024): Takeaways from the J.P. Morgan Health Care conference: Illumina, Danaher, 10x, Empress Therapeutics; an interview with Liberate Bio’s Shawn Davis and Walter Strapps.Listed below are references to relevant GEN stories discussed in this episode of Touching Base:JPM: Illumina’s new CEO spells out 2024 priorities, presents preliminary Q4 2023 resultsBy Alex Philippidis, GEN, January 10, 2024.JPM: Prime Medicine eyes 2024 IND for first prime editing therapyBy Alex

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38:18

Novartis and Voyager, JPM Ahead, Epigenetic...

Touching Base ·

2024/01/05

Episode 3 (January 5, 2024): Interview with Co-founder and CEO of Moonwalk Biosciences and former CTO of Illumina, Alex Aravanis; Neuro gene therapy with Novartis and Voyager; GEN reporters look forward to the 2024 J.P. Morgan Healthcare Conference Listed below are key references to the GEN stories, media and other items discussed in this episode of Touching Base:Novartis, Voyager Ink Up-to-$1.3B Expansion of Neuro Gene Therapy CollaborationBy Alex Philippidis, GEN, January 2, 2024.Moonwalk

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42 results

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