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PODCAST

Translating Aging

On Translating Aging, we talk with the worldwide community of researchers, entrepreneurs, and investors who are moving longevity science from the lab to the clinic. We bring you a commanding view of the entire field, in the words of the people and companies who are moving it forward today. The podcast is sponsored by BioAge labs, a clinical-stage biotechnology company developing therapies to extend human healthspan by targeting the molecular causes of aging.

science life sciences

All Episodes

32:16

Discovering Healthspan Interventions through...

Translating Aging ·

2023/07/12

Mitchell Lee is the CEO and co-founder of Ora Biomedical, a Seattle-based biotech company using large-scale phenotypic drug screening in C. elegans to discover small molecule therapeutics that extend lifespan and healthspan.In this episode, Chris and Mitch discuss Ora's approach to drug discovery, which focuses on function and phenotype rather than specific targets or mechanisms. Using their proprietary "WormBot" platform, Ora screens thousands of compounds in parallel to identify molecules that

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42:31

Synergizing Synbio & Longevity: A Panel Discussion at...

Translating Aging ·

2023/05/31

This special episode features a panel discussion moderated by Chris Patil at the 2023 SynBioBeta conference. The panel brings together leaders from the synthetic biology and longevity communities to explore opportunities for collaboration and cross-pollination between these fields. Panelists discuss the talent bottleneck in longevity research, challenges in translating new discoveries into therapies, the need for improved communication and education, and a shared vision for transforming health and

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22:50

Nurturing the Next Generation of Leaders in Aging...

Translating Aging ·

2023/05/17

In this episode of Translating Aging, host Chris Patil is joined by Dr. Courtney Hudson-Paz, the Founder and Program Director of the Time Initiative, an organization whose mission is to build a network of undergraduate leaders in aging biology.Courtney takes us on a journey into the world of aging biology and the mission of the Time Initiative, highlighting how this groundbreaking organization is cultivating the next generation of leaders. She shares her insights into the importance of early

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40:25

Epigenetic Reprogramming Therapies to Extend...

Translating Aging ·

2023/05/03

Jacob Kimball is the Head of Research and co-founder of NewLimit, a company aiming to develop epigenetic reprogramming therapies to treat age-related diseases and extend human healthspan.In this episode, Chris and Jacob have an in-depth discussion about NewLimit’s mission and approach. They explore how NewLimit is leveraging epigenetics and machine learning to search for new ways to reverse cell aging without changing cell identity. NewLimit is systematically testing combinations of biological

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37:52

A New Approach for Cardiovascular Disease (Dr....

Translating Aging ·

2023/03/15

In today’s episode, Chris is joined by Dr. Matthew "Oki" O'Connor, CEO for Scientific Affairs at Cyclarity Therapeutics, a company focused on eliminating arterial plaque, a prevalent issue in old age. Dr. O'Connor shares his insights on the causes and effects of atherosclerosis, the leading cause of death worldwide, and how aging contributes to plaque build-up. The podcast emphasizes the need for a paradigm shift in addressing cardiovascular disease and highlights the importance of new approaches to

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40:59

Targeting Pathologic Cells to Preserve Biological...

Translating Aging ·

2023/02/22

Dr. Marco Quarta, CEO and Co-founder of Rubedo Life Sciences, joins Chris on today’s episode to discuss his company’s strategy of targeting pathologic cells to develop therapeutics for chronic degenerative conditions. The conversation covers the evolving definition of senescence and the challenges of identifying and classifying pathologic cells, which vary across different tissues and indications. Marco also announces the upcoming Senotherapeutic Summit in November, which will bring together

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41:20

Bone Marrow Banking for Cell Therapy Material at...

Translating Aging ·

2023/01/25

In today’s episode, Chris sits down with Kevin Caldwell, CEO, Co-Founder, and President of Ossium Health, a company that aims to improve human health and longevity through bioengineering - specifically using stem cell science to create materials for cell therapies. Together, they discuss Ossium’s approach: processing and banking of bone marrow from organ donors, which can then be cryopreserved and used for various clinical applications such as bone marrow transplants for blood cancer patients and

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41:26

Hacking the Complex System of Aging (Peter Fedichev,...

Translating Aging ·

2022/12/14

This week, we welcomes Peter Fedichev, an entrepreneur and scientist with over 20 years of experience in academic research and biotech business who has co-founded three biotech companies. He’s currently the co-founder & CEO of GERO, a longevity startup on a mission to hack aging.In this episode, Chris and Peter discuss GERO’s goal to accelerate our understanding of aging and create a therapy that will significantly extend a healthy human lifespan. First, they talk about the relationship between

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32:57

Understanding Aging to Develop Interventions (Morten...

Translating Aging ·

2022/11/16

This week, Chris welcomes Morten Scheibye-Knudsen, Associate Professor at the University of Copenhagen, who’s on a mission to understand, modulate and treat aging and age-related diseases. His research group, The Scheibye-Knudsen Lab, is trying to understand the cellular and organismal consequences of DNA damage & repair with the aim of developing interventions for aging. Morten is also one of the chairs and chief organizers of the highly successful aging research and Drug Discovery conference,

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37:07

Optimizing Healthspan through Longevity Medicine (Dr....

Translating Aging ·

2022/10/12

Optimizing Healthspan through Longevity Medicine (Dr. Andrea Maier – The Center for Healthy Longevity)Dr. Andrea Maier is an internal medicine specialist, geriatrician, and researcher whose work focuses on age-related disease, cellular senescence, and the translation of longevity science into clinical practice. Among her academic appointments are professorships at the Free University, Amsterdam and the Netherlands, the University of Melbourne in Australia, and the National University of Singapore,

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44:03

Investing in Longbio True Believers (Sebastian...

Translating Aging ·

2022/09/28

In today’s episode, Chris welcomes Sebastian Brunemeier, a biotech VC and company builder focused on longevity and regenerative medicine. Sebastien is the Co-Founder and General Partner of Healthspan Capital, a longevity VC firm that invests in biotechnology startups developing therapies to slow or reverse aging, and the CEO and Co-Founder of ImmuneAGE Pharma, a new company based on a drug discovery platform for immune rejuvenation.At Healthspan Capital, Sebastian is looking to invest in fellow

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27:08

Investing in Longevity (Nils Regge, Apollo Health...

Translating Aging ·

2022/09/14

Joining Chris on the podcast today is Nils Regge, Co-founder and Managing Director of Apollo Health Ventures. As a social entrepreneur, company creator, and biotech expert, Nils built Apollo Health Ventures in 2016 to help health tech companies develop methods to prevent and reverse the aging process and extend the healthy human life span.At Apollo, Nils makes use of his dealmaking skills, business knowledge, and prior experience growing startups to help boost the success of biotech and health

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36:21

Safe & Synergistic Combination Drugs to Promote...

Translating Aging ·

2022/08/24

In this episode of the BioAge podcast, Ann Beliën joins Chris Patil today to share the story behind Rejuvenate Biomed, and her journey into the longevity sector. She started her career at Johnson & Johnson after receiving her postdoctoral degree, and during her tenure, she worked in scientific, operational, and strategic roles. Twenty years later, she became the founder and CEO of Rejuvenate Biomed, a Belgian company evaluating combinations of safe and synergistic drugs that target physical

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22:10

Building Longevity Companies in Europe (Marc P....

Translating Aging ·

2022/08/10

Today’s guest on the podcast is Marc Bernegger, a serial tech entrepreneur who has been following developments in the field of longevity since 2009. Recently he became a founding partner of the Swiss company, Maximon, whose core missions is building companies and providing support to longevity entrepreneurs.Marc has worked for over a decade between two continents at this point, and his interest in longevity has never been more intense. From aging skin to gut microbiomes, there’s a lot of work and

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31:55

Defining and Measuring the Aging Process (Dr. Vadim...

Translating Aging ·

2022/07/27

Joining Chris today is Dr. Vadim Gladyshev, Professor of Medicine at Harvard Medical School, Director of Redox Medicine at Brigham and Women's Hospital, and a member of the National Academy of Sciences. The Gladyshev lab studies redox biology and trace elements as they relate to cancer, reproduction, and aging. Today, Dr. Gladyshev shares with us how his research group investigates the aging process and how aging is quantified in academic research.Dr. Gladyshev begins by discussing how he got

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24:47

AI and Robotics in Longevity Biotech (Alex Zhavoronkov)

Translating Aging ·

2022/07/06

Joining Chris today is Alex Zhavoronkov, CEO and Co-founder of Insilico Medicine, an artificial intelligence–driven pharma-technology company with a mission to accelerate drug discovery and development. Alex is a lifelong advocate for longevity biotech and the author of The Ageless Generation: How Advances in Biomedicine Will Transform the Global Economy. Today, Alex shares the accomplishments that Insilico Medicine has achieved in drug discovery and how AI and robotics come into play.The episode

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43:09

The Impact of Muscle Aging on Longevity (Dr. Bill Evans)

Translating Aging ·

2022/06/22

Back in the host's chair this week, Bob Hughes welcomes Dr. Bill Evans, one of the world's foremost experts on muscle aging, to the podcast. Bill is adjunct professor of Human Nutrition at University of California Berkeley and an adjunct professor of medicine in the Geriatrics Program at Duke. Previously, he was vice president and head of Muscle Metabolism Discovery Performance Unit at GlaxoSmithKline and he was also president of the Muscle and Health Division at KineMed. He was also president of

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43:33

Eliminating Senescent Cells by Activating the Immune...

Translating Aging ·

2022/06/08

This week’s episode of Translating Aging features Robin Mansukhani, CEO and Co-founder of Deciduous Therapeutics, a company that aims to positively impact human healthspan by developing medicines which activate the endogenous immune mechanism responsible for the elimination of senescent cells. Today, Robin shares his insights on how senescent cells develop and how Deciduous Therapeutics eliminates them.Robin begins by explaining what causes the growth of senescent cells. He explains that not all

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34:05

Bringing Talent into the Longevity Industry’s...

Translating Aging ·

2022/05/18

In today’s episode of Translating Aging, Chris welcomes Mark Hamalainen, the founder and director of LessDeath, to discuss how to encourage the influx of talents into the longevity field. LessDeath is an organization on a mission to support the growth and effectiveness of the longevity industry’s workforce. Today, Mark shares with us his experience in the longevity space, why he founded LessDeath, and what to expect at the upcoming LessDeath Longevity Summer Camp.Noting that his experience in the

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49:57

VitaDAO - Democratizing Longevity Research through...

Translating Aging ·

2022/05/04

On today’s episode of Translating Aging, Chris welcomes Tyler Golato and Laurence Ion to talk about VitaDAO, a collective accelerating research in human longevity and decentralized drug development. The pair start the conversation off by discussing their company’s roots - a previous business venture that sought to change the incentive structures around drug development. VitaDAO was created as a means to support biological longevity research through decentralized means.They go on to discuss VitaDAO’s

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61 results

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