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PODCAST

Cannabinoid and Psychedelic Pharmacology and Drug Development

Jim Mitchell and Google NotebookLM

Explore Cannabinoid and Psychedelic Pharmacology with AI-Powered Learning.Welcome to a groundbreaking approach to mastering cannabinoid and psychedelic pharmacology and the FDA drug development pathway! This podcast series, powered by Google’s Notebook LM, offers a cutting-edge, AI-guided learning experience tailored for formal classes or self-directed study.Each 30-day series delves deep into the science of cannabinoid and psychedelic pharmacology, exploring molecular signaling pathways,

science chemistry

All Episodes

19:43

30 Day Cannabinoid Pharmacology Podcast - Day 15...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Dive deep into the fascinating world of cannabinoids and their potential role in treating mental health conditions. This comprehensive episode explores how CBD and THC interact with our body's endocannabinoid system to potentially address anxiety, depression, and PTSD. Learn about cutting-edge research, from CBD's promising effects on social anxiety to THC's potential impact on PTSD-related sleep disturbances. We'll break down the complex science into digestible concepts, discussing everything from

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14:04

30 Day Cannabinoid Pharmacology Podcast - Day 14 ECS...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Join us for a fascinating exploration of the endocannabinoid system (ECS) and its crucial role in regulating metabolism and appetite. Discover how this complex network, first unveiled in the 1990s, acts as your body's internal "air traffic control", orchestrating everything from hunger signals to fat storage. We break down the intricate science of CB1 receptors and their impact on appetite, energy balance, and metabolic health in clear, engaging terms. Learn how THC and other cannabinoids interact

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21:09

30 Day Cannabinoid Pharmacology Podcast - Day 13...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Join us for a deep dive into the fascinating world of cannabinoids and their potential role in cancer treatment. From the groundbreaking discovery of the endocannabinoid system in the early 90s to cutting-edge research on cell death pathways, we explore how these compounds might help fight cancer. Learn about the intricate cellular mechanisms, from receptor binding to programmed cell death, and discover how researchers are investigating cannabinoids both as standalone treatments and as complementary

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23:42

30 Day Cannabinoid Pharmacology Podcast - Day 12...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Join us for a fascinating deep dive into the intricate world of cannabinoids and their role in managing inflammation and autoimmune diseases. Discover how these remarkable compounds interact with our body's own endocannabinoid system, a complex network only discovered in the early 90s. From the specialized CB1 and CB2 receptors to the intricate cellular signaling cascades, we break down the science into digestible concepts while exploring potential therapeutic applications for conditions like

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14:07

30 Day Cannabinoid Pharmacology Podcast - Day 11 ECS...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Take a deep dive into the fascinating world of cannabinoid-based pain management as we unravel the intricate molecular pathways that make it possible. Learn how CB1 and CB2 receptors act as cellular gatekeepers, orchestrating a complex cascade of events that doesn't just mask pain, but fundamentally changes how our bodies process it.From G-proteins acting as molecular messengers to the sophisticated MAPK pathway, discover how cannabinoids work at multiple levels to provide relief. This episode

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34:16

30 Day Cannabinoid Pharmacology Podcast - Day 10 ECS...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Dive deep into the fascinating world of cannabinoids and their remarkable potential for brain protection. Join us as we explore the endocannabinoid system (ECS), discovered in the 1990s by Dr. Rafael Mechoulam, and uncover how this intricate biological system acts as our brain's internal defense mechanism. From the molecular dance of G-proteins to the complex signaling cascades that protect our neurons, we break down the science behind cannabinoid neuroprotection in clear, engaging terms.Learn how

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17:57

30 Day Cannabinoid Pharmacology Podcast - Day 9...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Dive deep into the fascinating world of the endocannabinoid system (ECS), your body's remarkable internal balancing mechanism. In this episode, we explore how this intricate system acts as the conductor of a biological orchestra, orchestrating harmony across your nervous, immune, and endocrine systems.Learn about the groundbreaking discoveries of Dr. Machoulam, who identified the body's own cannabis-like molecules - anandamide and 2-AG. We break down complex cellular signaling pathways into

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11:07

30 Day Cannabinoid Pharmacology Podcast - Day 8...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Join us for a fascinating deep dive into the intricate world of cannabinoid receptor signaling. Learn how these cellular "antennas" - CB1 and CB2 receptors - respond to both plant-derived cannabinoids and our body's own endocannabinoids. Our expert guides will break down complex cellular pathways into digestible concepts, exploring how these molecular signals influence everything from mood and memory to pain perception.Discover the crucial roles of key players like G-proteins, cyclic AMP, and the

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21:24

30 Day Cannabinoid Pharmacology Podcast - Day 7 GPR55...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Join us for a fascinating exploration into the frontier of cannabinoid research as we venture beyond the well-known CB1 and CB2 receptors. Discover the mysterious GPR55 receptor and its surprising roles in blood pressure, bone density, and cancer cell growth. Learn about TRPV1, the pain-sensing receptor that responds to both chili peppers and cannabinoids, and how it's opening new avenues for pain management.We'll delve into the groundbreaking research on PPARs - nuclear receptors that act as

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11:07

30 Day Cannabinoid Pharmacology Podcast - Day 6 TRP...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Description: Join us for a fascinating deep dive into the intricate relationship between cannabinoids and TRP channels, particularly TRPV1 and TRPM8. Dr. Rafael Mechoulam's groundbreaking research laid the foundation for our understanding of the endocannabinoid system, but we're now discovering an exciting new frontier beyond the classical CB1 and CB2 receptors.Learn how TRPV1 channels respond to heat and spicy compounds like capsaicin, while TRPM8 channels mediate our sensation of cold and menthol

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21:37

30 Day Cannabinoid Pharmacology Podcast - Day 5...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Description: Join us for a deep dive into the fascinating world of synthetic cannabinoids and their therapeutic potential. In this comprehensive episode, we explore how these laboratory-created molecules interact with the body's endocannabinoid system. Our expert hosts break down complex cellular pathways into digestible concepts, examining everything from receptor binding mechanisms to downstream signaling cascades.Learn about the groundbreaking discoveries in cannabinoid research, including how

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22:26

30 Day Cannabinoid Pharmacology Podcast - Day 4...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Dive deep into the fascinating world of endocannabinoids as we explore anandamide and 2-AG, the body's natural cannabis-like molecules. Discovered in the early 1990s, these crucial signaling molecules are revolutionizing our understanding of human biology. Learn how these compounds are produced on demand, their intricate roles in cellular signaling, and their impact on everything from mood and pain perception to inflammation and cell survival.Join us as we break down complex cellular pathways into

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11:22

30 Day Cannabinoid Pharmacology Podcast - Day 3 CB2...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Dive deep into the fascinating world of CB2 receptors, crucial cellular gatekeepers primarily found on immune cells. In this episode, our experts break down the complex molecular mechanisms behind how these remarkable proteins function as cellular antennas, constantly scanning for cannabinoid signals.Learn how CB2 receptors trigger intricate signaling cascades through G-protein coupled receptor activation, leading to profound changes in immune cell behavior. Discover how this molecular machinery

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15:57

30 Day Cannabinoid Pharmacology Podcast - Day 2 CB1...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Dive deep into the fascinating world of CB1 receptors, the remarkable cellular gatekeepers that help maintain balance throughout our body. Join our expert hosts as they unravel how these complex proteins are woven into cell membranes and function as crucial signaling molecules.Discover how CB1 receptors are distributed throughout the body, from their headquarters in the central nervous system to their presence in the hippocampus, basal ganglia, and even the gut. Learn about their role in memory

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19:10

30 Day Cannabinoid Pharmacology Podcast - Day 1...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

oin us for a fascinating deep dive into the world of cannabinoid pharmacology, where we unravel the intricate workings of the body's endocannabinoid system. In this episode, our expert hosts break down complex scientific concepts into digestible insights, exploring how CB1 and CB2 receptors act as cellular gatekeepers.Discover how these remarkable receptors influence everything from pain management and inflammation to potential treatments for various conditions. We'll journey through the cellular

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9:14

30 Day Cannabinoid Pharmacology Podcast - Day 0...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Embark on a comprehensive 30-day journey into the fascinating world of cannabinoid pharmacology. In this introductory episode, our experts break down complex scientific concepts into digestible daily segments, exploring the intricate workings of the endocannabinoid system (ECS) and its profound impact on our bodies.From understanding the differences between THC and CBD to discovering how over 100 different cannabinoids interact with our body's natural systems, this series combines cutting-edge

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11:13

30 Day FDA and ICH Drug Development Regulations -...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

In this engaging episode of The Deep Dive, listeners test their knowledge of drug development through a fun quiz show format. Topics include clinical trial phases, FDA and ICH guidelines, and myths about drug safety and regulations. Key takeaways cover the stages of clinical trials, global harmonization efforts, impurity management, and the importance of post-market surveillance. A lively and informative exploration of the intricate world of pharmaceuticals.

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11:53

30 Day FDA and ICH Drug Development Regulations -...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

This playful episode of The Deep Dive transformed the intricate world of drug development into a game show adventure. From decoding technical terms like "batches" and "tamper-evident features" to debunking myths about natural products and biosimilars, listeners learned about the rigorous processes behind every pill. The rapid-fire lightning round reinforced key insights, including the importance of preclinical testing, ethical considerations, and post-market surveillance. Whether tackling orphan

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26:10

30 Day FDA and ICH Drug Development Regulations - Day...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Join us for the conclusion of our 30-day deep dive into drug development regulations, a journey spanning clinical trials, biologics, biosimilars, and the evolving regulatory landscape. Reflect on the rigorous processes ensuring medication safety and efficacy, from clinical trials to post-market surveillance. As we transition into exploring cannabinoids and psychedelics, we’ll tackle their science, potential benefits, ethical challenges, and regulatory hurdles. Stay curious and engaged as we unlock

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26:10

30 Day FDA and ICH Drug Development Regulations - Day...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/01/29

Step into the future of drug development as we explore personalized medicine, AI innovations, and global harmonization. Discover how treatments are tailored to individual genetic profiles, how AI accelerates drug discovery and enhances safety, and how international collaboration is breaking down regulatory barriers. From targeted cancer therapies to multinational clinical trials, learn how these trends are reshaping healthcare, improving efficiency, and fostering equity on a global scale. A

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252 results

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