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PODCAST

Talking Biotech with Dr. Kevin Folta

Talking Biotech is a weekly podcast that uncovers the stories, ideas and research of people at the frontier of biology and engineering. Each episode explores how science and technology will transform agriculture, protect the environment, and feed 10 billion people by 2050. Interviews are led by Dr. Kevin Folta, a professor of molecular biology and genomics.

science life sciences

All Episodes

35:42

Kleptoplasty and a Solar-Powered Animal

Talking Biotech with Dr. Kevin Folta ·

2021/05/08

A solar-powered animal? There are species of sea slugs that consume algae, then integrate the chloroplasts into their own digestive cells. There they function to fix carbon and essentially power the organism. This phenomenon is known as kelptoplasty- stealing the autotrophic capacities of one organism for the slug’s benefit. This week’s podcast is a conversation with Dr. Sonia Cruz, a Principal Researcher at the University of Averio. Her work seeks to unravel many of the intriguing

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51:12

Methylation Clocks, Aging and Disease

Talking Biotech with Dr. Kevin Folta ·

2021/05/01

The basis of aging and long-term degenerative disease have been formidable questions for scientists. Over the last decade several “methylation clocks” have been devised to examine modifications of DNA that match well with developmental state and disease presentation. Dr. Ekaterina Rogaeva from the University of Toronto studies methylation clocks, especially as they associate with specific neurodegenerative diseases. The discoveries in this discipline delineate diagnostic patterns of

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37:16

The GalSafe Pig and Xenotransplantation

Talking Biotech with Dr. Kevin Folta ·

2021/04/24

Last week’s episode covered Alpha Gal Syndrome, the tick-induced allergy to beef and pork. The same immunological response could also limit a recipient’s access to xenography or xenotransplantation, that is, the introduction of pig and cow tissues and organs for human benefit. From valves to tendons to organs, the use of non-human animal parts is becoming increasingly common, but so is the instance of immune response to them due to a response to alpha gal. Today’s guest is Dr. John

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28:19

Alpha Gal Syndrome

Talking Biotech with Dr. Kevin Folta ·

2021/04/17

You find a tick on your skin and remove it. The next day you eat a sausage and wind up in the emergency room in anaphylaxis. After that, you can’t eat beef or pork without experiencing an intense allergic reaction. This is alpha-gal syndrome, an allergy induced by the saliva of ticks bearing a simple oligosaccharide (compound sugar), and the body mounts an immune response against it. The same oligosaccharide is also found in beef and pork. This strange condition is becoming

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72:01

Bioluminescence, Antibiotic Resistance, and Science...

Talking Biotech with Dr. Kevin Folta ·

2021/04/10

Today’s podcast is an interview with New Zealander of the Year Dr. Siouxsie Wiles. Dr. Wiles’ program uses bioluminesence as a marker to follow bacterial growth and disease progression. Her work seeks to identify new antimicrobial compounds. However, Dr. Wiles has become a go-to person in the discussion of COVID19, and has led public discourse on the realities of the pandemic. Her written work, video and cartoons around COVID19 have contributed to New Zealand’s low incidence rate, and

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51:40

Identifying Rare Compounds with A.I.

Talking Biotech with Dr. Kevin Folta ·

2021/04/03

While genomics approaches have opened a universe of new compounds in plants, the vast majority remain uncharacterized. Brightseed has employed an artificial intelligence platform to scan for novel compounds, with a goal to identify new chemicals that may play a role in human health. Today’s podcast features Dr. Jim Flatt, CEO and Co-Founder of Brightseed. He discusses the company’s pilot products and the pipeline of compounds that may enhance human health. www.brightseedbio.com #

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65:03

Your DNA Sequence, Benefits and Risks

Talking Biotech with Dr. Kevin Folta ·

2021/03/27

Your DNA contains all of the information that makes you, you. With increasing understanding of the genetic basis of disease, the information in every cell may help anticipate, correct, or otherwise treat latent medical issues. The good news is that the cost of obtaining your personal DNA sequence is now less than the cost of a couple of concert tickets. At the same time, how is that information safeguarded? Who has access to it? Can it be used to exclude you from insurance coverage or open

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29:28

Combating Vaccine Hesitancy

Talking Biotech with Dr. Kevin Folta ·

2021/03/20

The COVID19 vaccines were produced in record time, an amazing feat. However, additional challenges have been revealed in their distribution. Perhaps the most formidable barrier is the very last one– executing the vaccination. For years anti-vaccination groups have soiled the internet and public discourse with false or exaggerated claims of vaccine dangers. They have appealed to the emotional weak spots of concerned parents and the conspiratorial leanings of fringe science and politics to

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64:19

Misinformation vs. An Honest Conversation

Talking Biotech with Dr. Kevin Folta ·

2021/03/13

This week’s podcast is a dissection of another popular podcast that features self-proclaimed experts in genetic engineering (familiarly GMO), and the falsehoods they propagate. Podcasts are great conduits to spread scientific information, but non-scientific views thrive also. It is amazing to listen to the bad information, and the participants’ willing acceptance and amplification that goes unchallenged. The episode is not mentioned by name, nor are the participants. This is not a personal

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28:24

An App to Identify On-Target Gene Editing Variation

Talking Biotech with Dr. Kevin Folta ·

2021/03/06

At its core, gene editing works to break gene function by creating errors in a DNA sequence at a specific location. The process works by creating a precise cut that is repaired by the cell’s repair mechanisms, and those processes can be error prone. Those errors are the basis of the gene’s disruption. But in a population of cells, how do you account for and catalog all of the changes? Kevin Bloh is a research associate and a Ph.D. student with Christiana Care / University of Delaware.

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61:25

COVID19 Testing and Personal Cancer Screenings

Talking Biotech with Dr. Kevin Folta ·

2021/02/27

One of the major failures of addressing the COVID19 pandemic is the breakdown of testing. The NFL and White House were able to maintain business as usual because of daily, accurate testing. When the disease is detected, its spread can be controlled. Jo Bhakdi of Quantgene talks about testing and how his company has scaled up testing solutions to at least apply them commercially to businesses wishing to maintain operations and protect their employees. We talk about testing and how it may

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90:05

Greenpeace Beginnings, and Golden Rice

Talking Biotech with Dr. Kevin Folta ·

2021/02/20

Dr. Patrick Moore was a founding member of Greenpeace. In the years past its inception he worked tirelessly on ecological issues. Over time, he saw the group’s positions as less than scientific, leading to his defection. Soon after he became a leading advocate for the deployment of Golden Rice, the pro-Vitamin A rice that was invented to alleviate blindness and illness caused by a missing micronutrient in the Developing World. We discuss his roots, his efforts for Golden Rice, and

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49:37

New Technology to Save Bananas

Talking Biotech with Dr. Kevin Folta ·

2021/02/13

Bananas and other tropical crops have tremendous value, not just to farmers in the Developing World, but also as products that are enjoyed widely in highly industrialized nations. However, crops like bananas and coffee are threatened by pathogens that could severely curtail cultivation and availability. Tropic Biosciences is taking on these problems using a unique approach– using gene editing to adjust genetics in a way that attacks the pathogen without consequence in the original plant

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34:58

Gene Editing and Recovery from Radiation

Talking Biotech with Dr. Kevin Folta ·

2021/02/06

Radiation is a natural energy that constantly bombards us. At the same time we have harnessed its power for medical imaging, therapeutics, energy and warfare. Collateral damage from radiation exposure, even in critical therapeutic contexts, can have profound effects on cellular health and ultimately survival. Dr. Fyodor Urnov of the University of Berkeley and the Innovative Genomics Institute is part of a team seeking to use gene editing as molecular medicine to speed recovery from

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42:02

SARS-CoV2: Immune Response and RNA Vaccines

Talking Biotech with Dr. Kevin Folta ·

2021/01/30

The story of biotechnology’s response to the pandemic is an amazing one, and we continue coverage of these events as they arise. Today guest host Dr. Asha Brunings speaks with virus and immunology expert Dr. Brianne Baker. They discuss various topics of immunology with respect to the virus, discussing the new variants, the new vaccines, and a deep dive in to the mechanisms of immunity to the COVID19 symptom spectrum.Follow Dr. Barker ; @BioProfBarker Follow Dr. Brunings: @AshaBrunings And

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51:33

Amazing Products from Algae

Talking Biotech with Dr. Kevin Folta ·

2021/01/23

Algae efficiently convert carbon dioxide into oils, and they are now being bred to generate a suite of compounds that may be synthesized into fuel and polymers that are the basis of biodegradable plastics. Dr. Steve Mayfield is a Professor at the University of California San Diego, and the Director of the California Center for Algal Biotechnology. His work with algae shows how this rapidly growing photosynthetic organism can generate everything from fuels to plastics, from gasoline to

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30:18

Targeting Cancers with Gene Editing

Talking Biotech with Dr. Kevin Folta ·

2021/01/16

Certain aggressive cancers have profound effects on lifespan and quality of life. Patient prognosis can be grim, and therapies are harsh. Dr. Dan Peer of the University of Tel Aviv leads a group that has targeted gliomas and ovarian cancer with gene editing. Specifically, lipid nanoparticles are produced that target cancer cells, and introduce gene editing hardware that specifically inactivates genes required for cell division. The breakdown in proliferation impedes the cells’ growth. In

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37:26

GE Crops: What do Consumers Really Think?

Talking Biotech with Dr. Kevin Folta ·

2021/01/09

Consumers have many opinions about food, and are continually bombarded by information from manufacturers to self-proclaimed experts. To gauge what they really think economists formulate approaches to learn what they are thinking and how they might behave in a purchasing scenario. Dr. Stuart Smyth has studied the interface between consumers and agricultural biotechnology. In this episode he presents the work from his group’s recent publication that discusses how consumers ultimately feel

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45:08

2020 Science Stories

Talking Biotech with Dr. Kevin Folta ·

2021/01/02

The COVID-19 pandemic overshadowed an incredible year of innovation in biotechnology. Today’s podcast is a simulcast between the Science Facts and Fallacies with Cameron English and Talking Biotech. We discuss six science stories that were true highlights of an incredible year in science, along with stories that help us understand the state of the science/society interface.# COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing

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53:32

Immune Response to COVID19 and its Vaccines

Talking Biotech with Dr. Kevin Folta ·

2020/12/26

The COVID19 vaccines have the potential to squelch a dangerous pandemic. However, the public has many questions about their safety and efficacy that could limit their broad administration. Some of the questions concern the immune system, how it is affected by the vaccine, why two doses are necessary, and if the response is durable. Today’s podcast interviews Dr. Asha Brunings about the immunology of the COVID vaccine and the disease itself.# COLABRATalking Biotech is brought to you by

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